Tag: M.W=100-150

Application In Synthesis of 4′-Hydroxyacetophenone. Dulac, M; Nagarathinam, C; Dansette, P; Mansuy, D; Boucher, JL in [Dulac, Martin; Nagarathinam, Citra; Dansette, Patrick; Mansuy, Daniel; Boucher, Jean-Luc] Univ Paris 05, CNRS, UMR 8601, Lab Chim & Biochim Pharmacol & Toxicol, 45 Rue St Peres, F-75006 Paris, France published Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes in 2019.0, Cited 30.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

The drug anetholedithiolethione (ADT) and its analogs have been extensively used as H2S donors. However, the mechanism of H2S formation from ADT under biologic conditions remains almost completely unknown. This article shows that only small amounts of H2S are formed during incubation of ADT and of its metabolite anetholedithiolone (ADO) with rat liver cytosol or with rat liver microsomes (RLM) in the absence of NADPH, indicating that H2S formation under these conditions is of hydrolytic origin only to a minor extent. By contrast, much greater amounts of H2S are formed upon incubation of ADT and ADO with RLM in the presence of NADPH and dioxygen, with a concomitant formation of H2S and para-methoxy-acetophenone (pMA). Moreover, H2S and pMA formation under those conditions are greatly inhibited in the presence of N-benzyl-imidazole indicating the involvement of cytochrome P450-dependent monooxygenases. Mechanistic studies show the intermediate formation of the ADT-derived 1,2-dithiolium cation and of the ADO sulfoxide during microsomal metabolism of ADT and ADO, respectively. This article proposes the first detailed mechanisms for the formation of H2S from microsomal metabolism of ADT and ADO in agreement with those data and with previously published data on the metabolism of compounds involving a C=S bond. Finally, this article shows for the first time that ADO is a better H2S donor than ADT under those conditions. SIGNIFICANCE STATEMENT Incubation of anetholedithiolethione (ADT) or its metabolite anetholedithiolone (ADO) in the presence of rat liver microsomes, NADPH, and O-2 leads to H2S. This article shows for the first time that this H2S formation involves several steps catalyzed by microsomal monooxygenases and that ADO is a better H2S donor than ADT. We propose the first detailed mechanisms for the formation of H2S from the microsomal metabolism of ADT and ADO.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles WOS:000460577700005 published article about PRENYLATED ISOFLAVONOIDS; NATURAL ISOFLAVONOIDS; MEDICINAL CHEMISTRY; FLUORINE; DERIVATIVES; DISCOVERY; DESIGN; INHIBITORS; BIOISOSTERES; LIGANDS in [Izquierdo, Javier; Jain, Atul D.; Schiltz, Gary E.] Northwestern Univ, Ctr Mol Innovat & Drug Discovery, Evanston, IL 60208 USA; [Abdulkadir, Sarki A.] Northwestern Univ, Dept Urol, Chicago, IL 60611 USA; [Abdulkadir, Sarki A.; Schiltz, Gary E.] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA; [Schiltz, Gary E.] Northwestern Univ, Dept Pharmacol, Chicago, IL 60611 USA in 2019.0, Cited 75.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Product Details of 99-93-4

The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF (3) ), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Izquierdo, J; Jain, AD; Abdulkadir, SA; Schiltz, GE or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4′-Hydroxyacetophenone. Authors Telu, JR; Kuntala, N; Kankanala, K; Banothu, V; Pal, S; Anireddy, JS in WILEY published article about in [Telu, Jhonsee Rani; Kuntala, Naveen; Anireddy, Jaya Shree] Jawaharlal Nehru Technol Univ Hyderabad, Ctr Chem Sci & Technol, Inst Sci & Technol, Hyderabad 500085, India; [Kankanala, Kavitha; Pal, Sarbani] MNR Degree & PG Coll, Dept Chem, Hyderabad, India; [Banothu, Venkanna] JNTUH, IST, Ctr Biotechnol, Hyderabad, India in 2021.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

We describe the synthesis, characterization, and in vitro antibacterial evaluation of a library of novel compounds based on 1,2,3-triazolo phosphonate framework along with the evaluation of DNA gyrase inhibitory potential of a promising molecule in silico. Preparation of these compounds was carried out via a multistep sequence comprising of the Abramov reaction followed by the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as the key steps. Various alpha-hydroxyphosphonate derivatives containing either a secondary or tertiary alcohol at the alpha position were prepared. When screened for their antibacterial activities in vitro using a Gram-positive (Staphylococcus aureus) and three Gram-negative (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) strains, majority of these derivatives exhibited reasonable to good effects with the analogue 5k being active against all the strains. The SAR analysis indicated that the activity was influenced by the position of the alpha-hydroxyphosphonate moiety as well as the substituent present on the benzene ring attached to the 1,2,3-triazole ring. Moreover, the compound 5k showed strong interactions with the DNA active site when docked into the DNA gyrase in silico. Thus, the 1,2,3-triazolo phosphonate derivative 5k appeared to be a novel and promising hit molecule that deserves further study as a potential antibacterial agent.

Safety of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Telu, JR; Kuntala, N; Kankanala, K; Banothu, V; Pal, S; Anireddy, JS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 CHEM SCI published article about ALDEHYDES; ARRAYS in [Liu, Mingxin; Tan, Lida; Cen, Yunen; Li, Chao-Jun] McGill Univ, Dept Chem, 801 Sherbrooke Ouest, Montreal, PQ H3A 0B8, Canada; [Liu, Mingxin; Tan, Lida; Cen, Yunen; Li, Chao-Jun] McGill Univ, FRQNT Ctr Green Chem & Catalysis, 801 Sherbrooke Ouest, Montreal, PQ H3A 0B8, Canada; [Liu, Mingxin; Mi, Zetian] Univ Michigan, Dept Elect Engn & Comp Sci, 1301 Beal Ave, Ann Arbor, MI 48109 USA; [Rashid, Roksana T.; Mi, Zetian] McGill Univ, Dept Elect & Comp Engn, 3480 Univ, Montreal, PQ H3A 0E9, Canada; [Cheng, Shaobo; Botton, Gianluigi] McMaster Univ, Dept Mat Sci & Engn, Canadian Ctr Electron Microscopy, 1280 Main St West, Hamilton, ON L8S 4M1, Canada in 2020.0, Cited 30.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. SDS of cas: 100-51-6

Employing photo-energy to drive the desired chemical transformation has been a long pursued subject. The development of homogeneous photoredox catalysts in radical coupling reactions has been truly phenomenal, however, with apparent disadvantages such as the difficulty in separating the catalyst and the frequent requirement of scarce noble metals. We therefore envisioned the use of a hyper-stable III-V photosensitizing semiconductor with a tunable Fermi level and energy band as a readily isolable and recyclable heterogeneous photoredox catalyst for radical coupling reactions. Using the carbonyl coupling reaction as a proof-of-concept, herein, we report a photo-pinacol coupling reaction catalyzed by GaN nanowires under ambient light at room temperature with methanol as a solvent and sacrificial reagent. By simply tuning the dopant, the GaN nanowire shows significantly enhanced electronic properties. The catalyst showed excellent stability, reusability and functional tolerance. All reactions could be accomplished with a single piece of nanowire on Si-wafer.

Welcome to talk about 100-51-6, If you have any questions, you can contact Liu, MX; Tan, LD; Rashid, RT; Cen, YN; Cheng, SB; Botton, G; Mi, ZT; Li, CJ or send Email.. SDS of cas: 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 BIOORG CHEM published article about IN-VITRO ANTIOXIDANT; 1,3-DIPOLAR CYCLOADDITION; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; CHIRAL NITRONES; RESOLUTION; ANALOGS in [Ghabi, Ameni; Brahmi, Jihed; Aouadi, Kaiss] Univ Monastir, Fac Sci Monastir, Lab Heterocycl Chem Nat Prod & React, Ave Environm, Monastir 5019, Tunisia; [Alminderej, Fahad; Messaoudi, Sabri; Aouadi, Kaiss] Qassim Univ, Coll Sci, Dept Chem, Buraydah 51452, Saudi Arabia; [Messaoudi, Sabri] Carthage Univ, Fac Sci Bizerte, Jarzouna 7021, Tunisia; [Vidal, Sebastien] Univ Claude Bernard Lyon 1, Univ Lyon, Inst Chim & Biochim Mol & Supramol, UMR CNRS 5246,Lab Chim Organ Glycochim 2, Batiment Lederer,1 Rue Victor Grignard, F-69622 Villeurbanne, France; [Kadri, Adel] Sfax Univ, Fac Sci Sfax, Dept Chem, BP 1171, Sfax 3000, Tunisia; [Kadri, Adel] Albaha Univ, Coll Sci & Arts Baljurashi, POB 1988, Albaha, Saudi Arabia in 2020.0, Cited 31.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Quality Control of 3-Hydroxybenzaldehyde

A series of novel isoxazolidines based on benzaldehyde derivatives have been synthesized from the cycloaddition of chiral menthone-based nitrone and allyl phenyl ethers. All synthetic compounds were assessed for their in vitro PPA, HPA and HLAG inhibitory activity. The results revealed that all targets exhibited better inhibitory effect against PPA (12.3 +/- 0.4 < IC50 < 38.2 +/- 0.9 mu M), HPA (10.1 +/- 0.4 < IC50 < 26.8 +/- 0.2 mu M) and HLAG (65.4 +/- 1.2 < IC50 < 274.8 +/- 1.1 mu M) when compared with the reference inhibitor, acarbose (IC50 = 284.6 +/- 0.3 mu M for PPA, 296.6 +/- 0.8 mu M for HPA, 780.4 +/- 0.3 mu M for HLAG) with the highest PPA inhibitory activity was ascribed to compound 3g against both PPA and HPA, and 3b against HLAG enzymes, respectively. Structural activity relationships (SARs) were also established for all synthesized compounds and the interaction modes of the most potent inhibitors (3g for PPA and HPA, 3b for HLAG) and the active site with residues of three enzymes were confirmed through molecular docking studies. Furthermore, a combination of molecular docking analysis with the in vitro activities can help to improve prediction success and encourages the uses of some of these molecules as potential alternatives toward the modulation of T2D. Quality Control of 3-Hydroxybenzaldehyde. Welcome to talk about 100-83-4, If you have any questions, you can contact Ghabi, A; Brahmi, J; Alminderej, F; Messaoudi, S; Vidal, S; Kadri, A; Aouadi, K or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Polysulfide Anions as Visible Light Photoredox Catalysts for Aryl Cross-Couplings WOS:000611083700057 published article about TRISULFUR RADICAL-ANION; REDUCTION; SULFUR; TRANSITION; ACTIVATION; THIOLS; BOND; PHOTOCATALYSIS; SULFOXIDES; HALIDES in [Li, Haoyu; Pang, Jia Hao; Wu, Xiangyang; Yeow, Edwin K. L.; Chiba, Shunsuke] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore; [Tang, Xinxin; Wu, Jie] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore in 2021.0, Cited 58.0. Computed Properties of C7H8O2. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

Polysulfide anions are endowed with unique redox properties, attracting considerable attentions for their applications in alkali metals-sulfur batteries. However, the employment of these anionic species in redox catalysis for small molecule synthesis remains underdeveloped due to their moderate-poor electrochemical potential in the ground state, whereas some of them are characterized by photoabsorptions in visible spectral regions. Herein, we disclose the use of polysulfide anions as visible light photoredox catalysts for aryl cross-coupling reactions. The reaction design enables single-electron reduction of aryl halides upon the photoexcitation of tetrasulfide dianions (S-4(2-)). The resulting aryl radicals are engaged in (hetero)-biaryl cross-coupling, borylation, and hydrogenation in a redox catalytic regime involving S-4(center dot-) and S-4(2-)/S-3(center dot-)/S-3(2-) redox couples.

Computed Properties of C7H8O2. Bye, fridends, I hope you can learn more about C7H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Free solvent oxidation of molecular benzyl alcohol by newly synthesized AuPd/titania catalysts published in 2019.0. HPLC of Formula: C7H8O, Reprint Addresses Saiman, MI (corresponding author), Univ Putra Malaysia, Fac Sci, Catalysis Sci & Technol Res Ctr PutraCat, Upm Serdang 43400, Selangor, Malaysia.; Saleh, TA (corresponding author), King Fahd Univ Petr & Minerals, Chem Dept, Dhahran 31261, Saudi Arabia.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

Oxidation of benzyl alcohol is one of the industrial reactions utilized to produce chlorine-free benzaldehyde. Interestingly, supported gold nanoparticle catalysts are efficient towards the oxidation reaction of alcohol without involving any solvents, hence following the terms of green technology. In this study, nanoparticles of bimetallic gold palladium supported on TiO2 were synthesized using the sol-immobilization method. The catalysts were structurally characterized using X-ray Diffraction (XRD), Transition Electron Microscopy (TEM), and Brunauer Emmett Teller (BET) instruments to get insight into the synergistic effect between both Au and Pd. The catalytic activities of the prepared catalysts were evaluated towards the oxidation of benzyl alcohol over tertbutyl hydroperoxide (TBHP). The results obtained from the catalytic evaluation of the prepared catalysts indicated that 0.5 wt% Au-0.5 wt% Pd/TiO2 is the best catalyst among other ratios with a 3.1 +/- 0.8 nm particle size and the TEM results reveal the consistency value of a particle for each Au Pd ratio. The prepared catalyst consists of 0.50 wt% Au and 0.50 wt% Pd/TiO2 which exhibited remarkably enhanced catalytic activity (>19%) and selectivity of benzaldehyde (80%) when compared to another metal loading of the Au Pd catalyst. The reusability of the prepared catalyst was evaluated more than five times, and the results indicated minimal loss in activity where a low concentration of gold was leached (0.05 mg/L) under optimal reaction conditions.

About Benzyl Alcohol, If you have any questions, you can contact JamJam, NM; Yap, YHT; Muhamad, EN; Saiman, MI; Saleh, TA or concate me.. HPLC of Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of Benzyl Alcohol. Recently I am researching about RING-OPENING POLYMERIZATION; OMEGA-PENTADECALACTONE; COMPLEXES; ALKOXIDE; ESTERS; ALCOHOLS; ACRYLATE; BHT, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP20H02735, JP15H05755, JP15H05810, JP15H05805]; Shorai Foundation for Science and Technology; Integrated Research Consortium on Chemical Sciences. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Ng, JQ; Arima, H; Mochizuki, T; Toh, K; Matsui, K; Ratanasak, M; Hasegawa, JY; Hatano, M; Ishihara, K. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

A highly chemoselective transesterification of methyl (meth)acrylates catalyzed by sterically demanding 2,6-di-tert-butyl-4-methylphenol-derived NaOAr or Mg(OAr)(2) was developed. The desired transesterification proceeded without the undesired Michael additions under mild reaction conditions at 25 degrees C, and various primary and secondary alcohols, diols, triol, and tetraol on a scale of up to 10 mmol could provide the corresponding functionalized acrylates in high yields. Transition states were proposed based on monomeric and dimeric active species, and computational density functional theory calculations strongly supported high chemoselectivity to minimize undesired Michael additions.

Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 J COORD CHEM published article about ARYLBORONIC ACIDS; OXIDATIVE HYDROXYLATION; CATALYZED HYDROXYLATION; ANTIOXIDANT ACTIVITY; BORONATE ESTERS; MILD; GREEN; METAL; CONVERSION; PRODUCTS in [Chutia, Rituparna; Chetia, Bolin] Dibrugarh Univ, Dept Chem, Dibrugarh 786004, Assam, India in 2020.0, Cited 47.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Safety of m-Methoxyphenol

An efficient base and H(2)O(2)free protocol was used for the synthesis of phenols from boronic acids using biogenic CuFe(2)O(4)magnetic nanoparticles as catalyst at room temperature in water and oxygen. The catalyst was prepared using the flowers ofLantana camara. The size of the nanoparticles was 4.27 nm. Base free and ligand free protocol, less time, excellent yields, room temperature, biogenic synthesis of the catalyst, use of O(2)as an environmentally friendly oxidant are the advantages of the present protocol. The recyclability of the catalyst was for 5 cycles without loss of magnetic property or catalytic activity.

Safety of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Chutia, R; Chetia, B or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Geng, YX; Li, DY; Zhang, SY; Wu, MJ; Yang, T; Wang, D; Yan, LX; Zhu, JG; Hu, XY; Zhao, YY; Yan, XQ; Lin, C in AMER INST PHYSICS published article about PLASMA in [Geng, Yixing; Li, Dongyu; Zhang, Siyuan; Wu, Minjian; Yang, Tong; Zhu, Jungao; Hu, Xiyao; Zhao, Yanying; Yan, Xueqing; Lin, Chen] Peking Univ, State Key Lab Nucl Phys & Technol, Beijing 100871, Peoples R China; [Geng, Yixing; Li, Dongyu; Zhang, Siyuan; Wu, Minjian; Yang, Tong; Zhu, Jungao; Hu, Xiyao; Zhao, Yanying; Yan, Xueqing; Lin, Chen] Peking Univ, Key Lab HEDP, Minist Educ, CAPT, Beijing 100871, Peoples R China; [Geng, Yixing; Li, Dongyu; Zhang, Siyuan; Wu, Minjian; Yang, Tong; Zhu, Jungao; Hu, Xiyao; Zhao, Yanying; Yan, Xueqing; Lin, Chen] Beijing Laser Accelerat Innovat Ctr, Beijing 101400, Peoples R China; [Wang, Dan; Yan, Lixin] Tsinghua Univ, Dept Engn Phys, Beijing 100084, Peoples R China in 2020, Cited 31. Recommanded Product: 80-59-1. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

We have studied the generation of terahertz (THz) radiation via the interaction of an intense femtosecond laser pulse with aluminum (Al) and plastic targets pre-ablated by a picosecond ablation pulse. The measurements of the plasma shadowgraph and 1D-MULTI simulations show a similar micrometer density scale length of the pre-ablated plasma for the two types of targets after ablation. It is found that for the Al target, the intensity of THz radiation increased obviously under the condition of ablation, and only with the appropriate ablation delay time, the cutoff energy and charge of the accelerated protons also increased. 2D-simulations using the EPOCH program indicate that the strong enhancement of THz for the Al target is due to the increased number of energetic electrons from the interaction between the main laser and the ablated plasma. However, for the plastic targets, the intensity of THz radiation was almost vanished in the case of ablation, but the accelerated protons still existed and the cutoff energy even tended to increase. However, due to the lack of ability to simulate the molecular structure, we cannot distinguish between Al and plastic targets in the simulation. The mechanism of radiation suppression by ablation of the plastic target needs further investigation.

Bye, fridends, I hope you can learn more about C5H8O2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 80-59-1

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles