Tag: M.W=100-150

SDS of cas: 123-11-5. In 2021 AM J PHYSIOL-HEART C published article about HEART-RATE-VARIABILITY; CIGARETTE-SMOKE; VENTRICULAR-TACHYCARDIA; MOUSE MODEL; VAPOR in [Abouassali, Obada; Chang, Mengmeng; Chidipi, Bojjibabu; Reiser, Michelle; Kanithi, Manasa; Soni, Ravi; Noujaim, Sami F.] Univ S Florida, Mol Pharmacol & Physiol, Morsani Coll Med, Tampa, FL 33620 USA; [Luis Martinez, Jose; Saiz, Javier] Univ Politecn Valencia, Ci2 B, Valencia, Spain; [McDonald, Thomas, V; Herweg, Bengt] Univ S Florida, Dept Med, Div Cardiol, Morsani Coll Med, Tampa, FL 33620 USA; [Calcul, Laurent] Univ S Florida, Coll Arts & Sci, Dept Chem, Tampa, FL 33620 USA in 2021, Cited 46. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

The usage of flavored electronic nicotine delivery systems (ENDS) is popular, specifically in the teen and young adult age-groups. The possible cardiac toxicity of the flavoring aspect of ENDS is largely unknown. Vaping, a form of electronic nicotine delivery, uses e-liquid to generate e-vapor, an aerosolized mixture of nicotine and/or flavors. We report our investigation into the cardiotoxic effects of flavored e-liquids. E-vapors containing flavoring aldehydes such as vanillin and cinnamaldehyde, as indicated by mass spectrometry, were more toxic in HL-1 cardiomyocytes than fruit-flavored e-vapor. Exposure of human induced pluripotent stem cell-derived cardiomyocytes to cinnamaldehyde or vanillin-flavored e-vapor affected the beating frequency and prolonged the field potential duration of these cells more than fruit-flavored e-vapor. In addition, vanillin aldehyde-flavored evapor reduced the human ether-a-go-go-related gene (hERG)-encoded potassium current in transfected human embryonic kidney cells. In mice, inhalation exposure to vanillin aldehyde-flavored e-vapor for 10 wk caused increased sympathetic predominance in heart rate variability measurements. In vivo inducible ventricular tachycardia was significantly longer, and in optical mapping, the magnitude of ventricular action potential duration alternans was significantly larger in the vanillin aldehyde-flavored e-vaporexposed mice than in controls. We conclude that the widely popular flavored ENDS are not harm free, and they have a potential for cardiac harm. More studies are needed to further assess their cardiac safety profile and long-term health effects. NEW & NOTEWORTHY The use of electronic nicotine delivery systems (ENDS) is not harm free. It is not known whether ENDS negatively affect cardiac electrophysiological function. Our study in cell lines and in mice shows that ENDS can compromise cardiac electrophysiology, leading to action potential instability and inducible ventricular arrhythmias. Further investigations are necessary to assess the long-term cardiac safety profile of ENDS products in humans and to better understand how individual components of ENDS affect cardiac toxicity.

SDS of cas: 123-11-5. Welcome to talk about 123-11-5, If you have any questions, you can contact Abouassali, O; Chang, MM; Chidipi, B; Martinez, JL; Reiser, M; Kanithi, M; Soni, R; McDonald, TV; Herweg, B; Saiz, J; Calcul, L; Noujaim, SF or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Aminocyanopyridines as anti-lung cancer agents by inhibiting the STAT3 pathway WOS:000474276900015 published article about FEEDBACK ACTIVATION; DRUG-RESISTANCE; DERIVATIVES; BREAST in [Xu, Lingyuan; Yang, Lehe; Fan, Shiqian; Wang, Liangxing; Huang, Xiaoying] Wenzhou Med Univ, Key Lab Heart & Lung, Affiliated Hosp 1, Div Pulm Med, Wenzhou 325000, Zhejiang, Peoples R China; [Qiu, Sensen; Xu, Haitang; Shen, Liqun] Guangxi Univ Nationalities, Coll Chem & Chem Engn, Nanning 530006, Peoples R China; [Xu, Lingyuan; Yang, Lehe; Cui, Ri; Zhao, Chengguang] Wenzhou Med Univ, Sch Pharmaceut Sci, Chem Biol Res Ctr, Wenzhou, Zhejiang, Peoples R China; [Liu, Xu] Guangxi Univ, Sch Med, Nanning, Guangxi, Peoples R China; [Fu, Weitao] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China in 2019.0, Cited 33.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. COA of Formula: C8H8O2

Lung cancer is a leading cause of cancer-related death worldwide. Cyanopyridines and aminocyanopyridines with carbon-nitrogen bonds have been proved to exert significant anticancer, antibacterial, and anti-inflammatory effects. In this study, we showed that aminocyanopyridine 3o and 3k displaying potent antitumor activity via inhibiting the signal transducer and activator of transcription 3 (STAT3) pathway. They blocked the constitutive STAT3 phosphorylation in a dose- and time-dependent manner and regulated the transcription of STAT3 target genes encoding apoptosis factors. Most importantly, 3o also inhibited interleukin-6-induced STAT3 activation and nuclear localization. Furthermore, 3o significantly inhibited the tumor growth of H460-derived xenografts. Taken together, these findings suggest that 3o and 3k are promising therapeutic drug candidates for lung cancer by inhibiting persistent STAT3 signaling.

COA of Formula: C8H8O2. Welcome to talk about 99-93-4, If you have any questions, you can contact Xu, LY; Qiu, SS; Yang, LH; Xu, HT; Liu, X; Fan, SQ; Cui, R; Fu, WT; Zhao, CG; Shen, LQ; Wang, LX; Huang, XY or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis and biological evaluation of beta-ionone oriented proapoptosis agents by enhancing the ROS generation WOS:000592396400013 published article about SPECIES-MEDIATED APOPTOSIS; THIOREDOXIN REDUCTASE; ANTICANCER; CURCUMIN; CHALCONES; CANCER; DERIVATIVES; INHIBITOR; DESIGN; CELLS in [Yang, Jie; Mu, Wen-Wen; Cao, Yu-Xin; Liu, Guo-Yun] Liaocheng Univ, Sch Pharm, 1 Hunan St, Liaocheng 252000, Shandong, Peoples R China in 2020.0, Cited 28.0. Product Details of 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

beta-ionone, a cyclic terpenoid compound present in many fruits, has been showed a broad spectrum of biological activities. In this paper, we synthesized a panel of beta-ionone derivatives and tested their anti-proliferation activity on cancer cell by the MTT assay. The results showed that most of the beta-ionone derivatives were more active than beta-ionone and curcumin. Particularly, the beta-ionone derivatives (1a, 1d and 1g) with ortho-substituents on the aromatic ring exhibited much stronger cytotoxicity than their corresponding metaand para-substituted compounds. Importantly, the cytotoxicity of the beta-ionone derivatives (1a, 1d and 1g) were relationship with their reactive oxygen species (ROS)-generation abilities, which could lead to the redox imbalance, lipid peroxidation, the loss of mitochondrial membrane potential (MMP), the activation of Bax and Caspase 3, followed by cell apoptosis. This work suggest that the ortho effect, the ROS-generation ability and drawing fluorine atom into drugs may play a potent role in enhancing the anticancer activity of beta-ionone derivatives.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Yang, J; Mu, WW; Cao, YX; Liu, GY or concate me.. Product Details of 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-51-6. In 2019.0 ANESTH ANALG published article about PROPYLENE-GLYCOL; INDOCYANINE-GREEN; BENZYL ALCOHOL; ADVERSE-REACTIONS; ANAPHYLACTOID REACTION; CONTACT-DERMATITIS; PANCREAS TRANSPLANTATION; CONTINUOUS-INFUSION; ALLERGIC REACTIONS; PROPOFOL in [Burbridge, Mark A.; Jaffe, Richard A.] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, 300 Pasteur Dr, Stanford, CA 94304 USA in 2019.0, Cited 76.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Medications used in anesthesiology contain both pharmacologically active compounds and additional additives that are usually regarded as being pharmacologically inactive. These additives, called excipients, serve diverse functions. Despite being labeled inert, excipients are not necessarily benign substances. Anesthesiologists should have a clear understanding of their chemical properties and the potential for adverse reactions. This report catalogs the excipients found in drugs commonly used in anesthesiology, provides a brief description of their function, and documents examples from the literature regarding their adverse effects.

Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Ai, HJ; Rabeah, J; Bruckner, A; Wu, XF in [Ai, Han-Jun; Rabeah, Jabor; Brueckner, Angelika; Wu, Xiao-Feng] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany; [Wu, Xiao-Feng] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China published Rhodium-catalyzed carbonylative coupling of alkyl halides with thiols: a radical process faster than easier nucleophilic substitution in 2021.0, Cited 44.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.

How to make a carbonylative coupling faster than the easier nucleophilic substitution? In this communication, a rhodium-catalyzed radical-based carbonylative coupling of alkyl halides with thiolphenols has been realized. Thioesters were isolated in good yields in general.

Welcome to talk about 150-76-5, If you have any questions, you can contact Ai, HJ; Rabeah, J; Bruckner, A; Wu, XF or send Email.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Natural product-based design, synthesis and biological evaluation of 2 ‘,3,4,4 ‘-tetrahydrochalcone analogues as antivitiligo agents WOS:000469026400051 published article about OXIDATIVE STRESS; SUBSTANCE-P; MELANOGENESIS; PIGMENTATION; IMPAIRMENT; SKIN in [Zhong, Hui; Zhou, Jia; An, Xiao-Hong; Hua, Ying-Rong; Lai, Yi-Fan; Zhang, Rui; Ahmad, Owais; Shang, Jing] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China; [Zhang, Ye] Guilin Med Univ, Sch Pharm, Guilin 541004, Peoples R China; [Zhang, Ye] Guangxi Normal Univ, Sch Chem & Pharm, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China in 2019.0, Cited 38.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A bioactive component, 2′,3,4,4′-tetrahydrochalcone (RY3-a) was first isolated from Vernohia anthelmintica (L.) willd seeds, and a set of its analogs, RY3-a-1-RY3-a-15 and RY3-c were designed and synthesized. Biological activity assays showed that RY3-c exhibited better melanogenesis and antioxidant activity and lower toxicity in comparison with RY3-a and butin. Further study tests showed that RY3-c exhibited better melanogenesis activity compared with the positive control 8-methoxypsoralan (8-MOP) in a vitiligo mouse model, suggesting that RY3-c is a good candidate antivitiligo agent. Mechanistic studies showed that RY3-c could repair cell damage induced by excessive oxidative stress and may exert melanin synthesis activity in the mouse melanoma B16F10 cell line by activating the mitogen-activated protein kinase (MAPK) pathway and the upregulation of c-kit.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhong, H; Zhou, J; An, XH; Hua, YR; Lai, YF; Zhang, R; Ahmad, O; Zhang, Y; Shang, J or concate me.. HPLC of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Ryu, IY; Choi, I; Jung, HJ; Ullah, S; Choi, H; Al-Amin, M; Chun, P; Moon, HR in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about MUSHROOM TYROSINASE; INHIBITORY-ACTIVITY; MOLECULAR DOCKING; MECHANISM; MELANOMA; DESIGN; FLAVONOIDS in [Ryu, Il Young; Choi, Inkyu; Jung, Hee Jin; Choi, Heejeong; Al-Amin, Md; Moon, Hyung Ryong] Pusan Natl Univ, Coll Pharm, Busan 46241, South Korea; [Ullah, Sultan] Scripps Res Inst, Dept Mol Med, Jupiter, FL 33458 USA; [Chun, Pusoon] Inje Univ, Coll Pharm, Gimhae 50834, Gyeongnam, South Korea; [Chun, Pusoon] Inje Univ, Inje Inst Pharmaceut Sci & Res, Gimhae 50834, Gyeongnam, South Korea in 2021, Cited 63. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Tyrosinase is considered a key contributor to melanogenesis, and safe, potent tyrosinase inhibitors are needed for medical and cosmetic purposes to treat skin hyperpigmentation and prevent fruit and vegetable browning. According to our accumulated SAR data on tyrosinase inhibitors, the ?-phenyl-?,?-unsaturated carbonyl scaffold in either E or Z configurations, can confer potent tyrosinase inhibitory activity. In this study, twelve indanedione derivatives were synthesized as chimeric compounds with a ?-phenyl-?,?-unsaturated dicarbonyl scaffold. Two of these derivatives, that is, compounds 2 and 3 (85% and 96% inhibition, respectively), at 50 ?M inhibited mushroom tyrosinase markedly more potently than kojic acid (49% inhibition). Docking studies predicted that compounds 2 and 3 both inhibited tyrosinase competitively, and these findings were supported by LineweaverBurk plots. In addition, both compounds inhibited tyrosinase activity and reduced melanin contents in B16F10 cells more than kojic acid without perceptible cytotoxicity. These results support the notion that chimeric compounds with the ?-phenyl-?,?-unsaturated dicarbonyl scaffold represent promising starting points for the development of potent tyrosinase inhibitors.

Recommanded Product: 4-Methoxybenzaldehyde. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Iridium-catalyzed Annulation of alpha,beta-Unsaturated Amides with Electron-deficient Conjugated Dienes WOS:000539416400020 published article about C-H FUNCTIONALIZATION; N-METHOXYBENZAMIDES; MULTICOMPONENT SYNTHESIS; OXIDATIVE ANNULATION; BOND ACTIVATION; VINYL ETHERS; BENZAMIDES; HYDROARYLATION; ALKYNES; ALKENES in [Murakami, Kotone; Nishimura, Takahiro] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi, Osaka 5588585, Japan; [Nagamoto, Midori] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan in 2020, Cited 71. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1. Application In Synthesis of (E)-2-Methylbut-2-enoic acid

Annulation of alpha,beta-unsaturated amides with electrondeficient 1,3-dienes gave 5,6-dihydropyridin-2(1H)-ones in the presence of a hydroxoiridium catalyst. The reaction proceeded via direct C-H alkylation of acrylamides with conjugated dienes, followed by intramolecular aza-Michael addition, thus giving dihydropyridinones stereoselectively in good yields.

Application In Synthesis of (E)-2-Methylbut-2-enoic acid. Bye, fridends, I hope you can learn more about C5H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Mohareb, RM; Ibrahim, RA; Alwan, ES in SLOVENSKO KEMIJSKO DRUSTVO published article about in [Mohareb, Rafat Milad; Alwan, Ensaf Sultan] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt; [Ibrahim, Rehab Ali; Alwan, Ensaf Sultan] Higher Inst Engn & Technol, New Cairo, Egypt; Yemen Drug Co Ind & Commerce YEDCO, Dept Qual Assurance, Sanaa, Yemen in 2021, Cited 42. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

In this work the multi-component reactions of either of the arylhydrazocyclohexan-1,3-dione derivatives 3a-c with either of benzaldehyde (4a), 4-chlorobenzaldehyde (4b) or 4-methoxybenzaldehyde (4c) and either malononitrile (5a) or ethyl cyanoacetate (5b) giving the 5,6,7,8-tetrahydro-4H-chromene derivatives 6a-r, respectively, are presented. The reaction of two equivalents of cyclohexan-1,3-dione with benzaldehyde gave the hexahydro-1H-xanthene-1,8(2H)-dione derivative 7. On the other hand, the multi-component reactions of compound 1 with dimedone and benzaldehyde gave 13. Both of 7 and 13 underwent heterocyclization reactions to produce fused thiophene, pyran and thiazole derivatives. Selected compounds among the synthesized compounds were tested against six cancer cell lines where most of them gave high inhibitions; especially compounds 3b, 3c, 6b, 6c, 6d, 6f, 6i, 6m, 6n, 8b, 14a, 15 and 16 being the most cytotoxic compounds. Further tests against the five tyrosine kinases c-Kit, Flt-3, VEGFR-2, EGFR, and PDGFR and Pim-1 kinase showed that compounds 3c, 6c, 6d, 6f, 6n, 14a and 15 were the most potent of the tested compounds toward the five tyrosine kinases and compounds 3c, 6c, 6d, 6n and 15 displayed the highest inhibitions toward Pim-1 kinase.

Welcome to talk about 123-11-5, If you have any questions, you can contact Mohareb, RM; Ibrahim, RA; Alwan, ES or send Email.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 J ORGANOMET CHEM published article about N-ALKYLATION; ALCOHOLS; AMINES; WATER; OXYGENATION; REDUCTION; CHEMISTRY; COPPER in [Li, Ming; Hsu, Yen-Pin; Liu, Yi-Hung; Peng, Shie-Ming; Liu, Shiuh-Tzung] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan in 2020.0, Cited 42.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Formula: C7H8O

Complexation of 1,8-naphthyridine(Np)-2-carboxylic derivatives L-1-L-3 [L-1 = Np-2-COOH, L-2 = Np-2-CONH2, L-3 = Np-2-CONHCH2Py] with [Ir(COD)(mu-OMe)](2) yielded the corresponding complexes [Ir(COD)(L-n)] (1 similar to 3, n = 1 similar to 3, respectively). The potential tridentate L-3 behaves as a bidentate donor in the complex 3. Treatment of L-1 with [Ir(COD)Cl](2) under nitrogen atmosphere gave a Ir(III) hydride complex [Ir(COD)(L-1)HCl] (4). However, carrying out the reaction in the presence of oxygen rendered a Ir(III) dichloride species [Ir(COD)(L-1)Cl-2] (5). All these complexes were characterized by spectroscopic analyses and X-ray single crystal determination. Catalytic activity of iridium complexes in amination of amines with alcohols was screened. It appears that iridium amido complexes 2 and 3 show excellent catalytic activity on amination of anilines with alcohols in the presence of Cs2CO3 at 120 degrees C. (c) 2020 Published by Elsevier B.V.

Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Li, M; Hsu, YP; Liu, YH; Peng, SM; Liu, ST or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles