M.W=100-150 | - Page 8 of 348 - Indole Building Blocks

Kumar, Sanjeev team published research on Tetrahedron Letters in 2020 | 19005-93-7

Formula: C9H7NO, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Previous studies have identified that indole-oxidases are present in P. putida, whose major ligands are heterocyclic substrates and have an interesting affinity when the substrate is indole. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. These enzymes oxidize the ring so the substrate turns into Indigo. Formula: C9H7NO.

Kumar, Sanjeev;Parshuram Satpute, Dinesh;Nikhil Vaidya, Gargi;Nagpure, Mithilesh;Kumar Lokhande, Shyam;Meena, Deepak;Kumar, Dinesh research published 《 Micellar catalysis enabled synthesis of indolylbenzothiazoles and their functionalization via Mn(II)-catalyzed C₂-H amination using pyridones》, the research content is summarized as follows. The sustainable synthesis of indolylbenzothiazloes was reported utilizing TPGS-750-M enabled nanomicellar catalysis in water. The reactions do not require addnl. catalysts and/or oxidants and proceed at room temperature Subsequently, the indole rings were functionalized to construct novel tris-heterocyclic scaffolds via benzothiazole directed Mn(II)-catalyzed C₂-H amination utilizing pyridones as the amine partner.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hosseini-Sarvari, Mona team published research on Journal of Organometallic Chemistry in 2020 | 19005-93-7

Recommanded Product: 1H-Indole-2-carbaldehyde, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings. Recommanded Product: 1H-Indole-2-carbaldehyde.

Hosseini-Sarvari, Mona;Akrami, Zahra research published 《 Visible-light assisted of nano Ni/g-C₃N₄ with efficient photocatalytic activity and stability for selective aerobic C-H activation and epoxidation》, the research content is summarized as follows. A selective, economical, and ecol. protocol has been described for the oxidation of Me arenes and their analogs ArCH₂R (Ar = 3-nitrophenyl, 1-naphthyl, furan-2-yl, etc.; R = H, Me, Ph, pyridin-2-yl) and 9H-fluorene to the corresponding carbonyl compounds ArC(O)R and 9H-fluoren-9-one and epoxidation reactions of alkenes, e.g., 1,3-cyclohexadiene with mol. oxygen (O₂) or air as a green oxygen source, under mild reaction conditions. The nano Ni/g-C₃N₄ exhibited high photocatalytic activity, stability, and selectivity in the C-H activation of Me arenes, methylene arenes, and epoxidation of various alkenes under visible-light irradiation without the use of an oxidizing agent and under base free conditions.

Hua, Shixian team published research on European Journal of Medicinal Chemistry in 2020 | 19005-93-7

Application In Synthesis of 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Indole, first isolated in 1866, has the molecular formula C8H7N, and it is commonly synthesized from phenylhydrazine and pyruvic acid, 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. although several other procedures have been discovered.Indole is a colourless solid having a pleasant fragrance in highly dilute solutions. It melts at 52.5° C (126.5° F). Application In Synthesis of 19005-93-7.

Hua, Shixian;Chen, Feihong;Gou, Shaohua research published 《 Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase》, the research content is summarized as follows. A combination therapeutic regimen via introducing tryptophan 2,3-dioxygenase inhibitors into microtubule inhibitors was performed and evaluated for their antitumor activity. Thereinto, HT2, composed of combretastatin A-4 (CA-4) and tryptophan-2,3-dioxygenase (TDO) inhibitor by a linker, displayed the most potent activity with 10-fold higher than its parent CA-4 against HepG2, A549 and HCT-116 cancer cell lines. Mechanism studies suggested that HT2 inhibited tubulin polymerization and cell migration, caused G2 phase arrest, induced apoptosis by mitochondrial mediated apoptotic pathway, concurrent depolarized the mitochondria membrane potentials and caused reactive oxygen species (ROS) production in HepG2 cells. Moreover, HT2 could enhance T-cell immune responses in vitro by releasing a TDO inhibitor to suppress TDO expression and blockade kynurenine production As expected, HT2 could remarkably promote the antitumor activity of CA-4 in either immunocompetent H22 or immunodeficient A549 tumor xenograft models without observable toxic effects. More importantly, HT2 increased the level of splenic and tumor-infiltrated T cells and in turn effectively boosted the inhibition effect in H22 xenografted tumor growth. Collectively, this immunochemotherapeutic strategy can be applied to promote chemotherapeutic effect.

Huang, Guang team published research on Journal of Medicinal Chemistry in 2020 | 19005-93-7

Huang, Guang;Murillo Solano, Claribel;Melendez, Joel;Shaw, Justin;Collins, Jennifer;Banks, Robert;Arshadi, Arash Keshavarzi;Boonhok, Rachasak;Min, Hui;Miao, Jun;Chakrabarti, Debopam;Yuan, Yu research published 《 Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines》, the research content is summarized as follows. There is an urgent need to develop new efficacious antimalarials to address the emerging drug-resistant clin. cases. Our previous phenotypic screening identified styrylquinoline UCF501 as a promising antimalarial compound To optimize UCF501, we herein report a detailed structure-activity relationship study of 2-arylvinylquinolines, leading to the discovery of potent, low nanomolar antiplasmodial compounds against a Plasmodium falciparum CQ-resistant Dd2 strain, with excellent selectivity profiles (resistance index < 1 and selectivity index > 200). Several metabolically stable 2-arylvinylquinolines are identified as fast-acting agents that kill asexual blood-stage parasites at the trophozoite phase, and the most promising compound I also demonstrates transmission blocking potential. Addnl., the monophosphate salt of I exhibits excellent in vivo antimalarial efficacy in the murine model without noticeable toxicity. Thus, the 2-arylvinylquinolines represent a promising class of antimalarial drug leads.

Jian, Kaixia team published research on Organic Chemistry Frontiers in 2022 | 19005-93-7

19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., Formula: C9H7NO

Jian, Kaixia;Li, Bingnan;Zhu, Shuxian;Xuan, Qingqing;Song, Qiuling research published 《 Chemoselective reduction of α,β-unsaturated ketones to allylic alcohols under catalyst-free conditions》, the research content is summarized as follows. An ever more expedient, green and general method for the chemoselective reductions of exo- and endo-α,β-unsaturated cycloketones, e.g., RCH=R¹ (R = Ph, thiophen-2-yl, 6-bromopyridin-3-yl, cyclohexyl, etc.; R¹ = 2-oxocyclobutylidene, 2-oxocyclopentylidene, etc.) and acyclic α,β-unsaturated ketones R²CH=CHC(O)R³ (R² = Ph, 2,6,6-trimethylcyclohex-2-en-1-yl, thiophen-2-yl, etc.; R³ = Me, Ph, naphthalen-2-yl, etc.) and (2E)-2-methyl-3-phenylprop-2-enal in the presence of H₃N.BH₃ under catalyst-free conditions was described. The polarized H₃N.BH₃ preferred to coordinate with the polarized C=O bond, forming a six-membered transition state, and then the reduced products were furnished via a concerted double hydrogen transfer process. The process well explained the absolute chemoselectivity.

Kam, Caleb M. team published research on Future Medicinal Chemistry in 2020 | 19005-93-7

Kam, Caleb M.;Tauber, Amanda L.;Levonis, Stephan M.;Schweiker, Stephanie S. research published 《 Design, synthesis and evaluation of potential inhibitors for poly(ADP-ribose) polymerase members 1 and 14》, the research content is summarized as follows. Poly(ADP-ribose) polymerase (PARP) members PARP1 and PARP14 belong to an 18-member superfamily of post-translational modifying enzymes. A library of 9 novel non-NAD analog amine compounds was designed, synthesized and evaluated for inhibitory activity against PARP1 and PARP14. Both in silico studies and in vitro assays identified compound 2 as a potential PARP1 inhibitor, inhibiting activity by 93 ± 2% (PARP14 inhibition: 0 ± 6%), and 7 as a potential PARP14 inhibitor, inhibiting activity by 91 ± 2% (PARP1 inhibition: 18 ± 4%), at 10-μm concentration Key in silico interactions with TYR907 in PARP1 and TYR1620 and TYR1646 in PARP14 have been identified. Compound 2 and compound 7 have been identified as potential leads for the development of selective PARP inhibitors.

Fang, Zhuangjie team published research on Natural Product Research in 2021 | 19005-93-7

Safety of 1H-Indole-2-carbaldehyde, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Fang, Zhuangjie;Chen, Siqiang;Zhu, Yiguang;Li, Jie;Khan, Imran;Zhang, Qingbo;Zhang, Changsheng research published 《 A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457》, the research content is summarized as follows. A new uridine derivative 11457A, and a new indole derivative 11457B, together with a known compound 1H-indole-2-carbaldehyde, were characterized from the fermentation broth of the actinomycete Pseudonocardia sp. SCSIO 11457, an isolate associated with the scleractinian coral Galaxea fascicularis. Upon detailed spectroscopic anal., 11457A was identified as a uridine analog, and 11457B was elucidated as an indole derivative 2-hydroxy-1-(1H-indol-2-yl)pentane-1,4-dione. Biol. evaluation indicated that none of compounds showed antibacterial activities against pathogenic bacteria or cytotoxic activities against human cancer cell lines.

Faramarzi, Zeinab team published research on Heterocycles in 2021 | 19005-93-7

Faramarzi, Zeinab;Kiyani, Hamzeh research published 《 Organocatalyzed three-component synthesis of isoxazol-5(4H)-ones under aqueous conditions》, the research content is summarized as follows. The three-component cyclocondensation was performed using various frequently available aryl/heteroaryl aldehydes, hydroxylamine hydrochloride and β-ketoesters in water as a green reaction medium at 80°C. In this reaction, isoxazol-5(4H)-ones were obtained in the presence of 2-aminopyridine as an efficient and low-cost organocatalyst. The present methodol. offered sustainable approach with appreciable yields of the desired heterocycles. This procedure has expectant features, including shorter reaction times, easy separation of pure products, avoiding the hazardous organic solvents, simplicity exptl. procedure, operationally simple and eco-friendly. The heterocyclic structures were characterized using phys. properties and anal. of spectral data.

Ganwir, Prerna team published research on Research on Chemical Intermediates in 2022 | 19005-93-7

Ganwir, Prerna;Bandivadekar, Priyanka;Kudale, Pawan;Chaturbhuj, Ganesh U. research published 《 Catalyst-free, one-pot expeditious synthesis of polyhydroquinolines and 2-amino-4H-chromenes》, the research content is summarized as follows. The present work highlights a rapid, efficient, eco-friendly protocol for synthesizing one-pot polyhydroquinolines via Hantzsch reaction and 2-amino-4H-chromene derivatives under catalyst-free condition. The present mild and greener method uses ethanol: water (1:1) without catalyst at room temp and 90°C. The structurally diverse substrates were selected to ascertain the ability of the current approach to handle different functional groups, including ketones as one of the substrates. The current methodol. is economical and environmentally friendly for the three and four-component reaction of aliphatic, acyclic, aromatic, heterocyclic aldehydes in shorter reaction time, simple workup procedure, no catalyst with excellent yields, and high atom efficiency are the added advantages of this protocol.

Gao, Yongzhi team published research on Journal of Medicinal Chemistry in 2021 | 19005-93-7

Gao, Yongzhi;van Haren, Matthijs J.;Buijs, Ned;Innocenti, Paolo;Zhang, Yurui;Sartini, Davide;Campagna, Roberto;Emanuelli, Monica;Parsons, Richard B.;Jespers, Willem;Gutierrez-de-Teran, Hugo;van Westen, Gerard J. P.;Martin, Nathaniel I. research published 《 Potent inhibition of nicotinamide N-methyltransferase by alkene-linked bisubstrate mimics bearing electron deficient aromatics》, the research content is summarized as follows. Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide (vitamin B3) to generate 1-methylnicotinamide (MNA). NNMT overexpression has been linked to a variety of diseases, most prominently human cancers, indicating its potential as a therapeutic target. The development of small-mol. NNMT inhibitors has gained interest in recent years, with the most potent inhibitors sharing structural features based on elements of the nicotinamide substrate and the S-adenosyl-L-methionine (SAM) cofactor. We here report the development of new bisubstrate inhibitors that include electron-deficient aromatic groups to mimic the nicotinamide moiety. In addition, a trans-alkene linker was found to be optimal for connecting the substrate and cofactor mimics in these inhibitors. The most potent NNMT inhibitor identified exhibits an IC₅₀ value of 3.7 nM, placing it among the most active NNMT inhibitors reported to date. Complementary anal. techniques, modeling studies, and cell-based assays provide insights into the binding mode, affinity, and selectivity of these inhibitors.