Tag: M.W:100-200

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Cyclometalated Ruthenium Catalyst Enables Ortho-Selective C-H Alkylation with Secondary Alkyl Bromides, the main research direction is arene alkyl bromide ruthenium catalyst regioselective alkylation; alkyl arene preparation; phenylethanimine alkyl bromide ruthenium catalyst regioselective alkylation; acetophenone alkyl preparation.Computed Properties of C11H9N.

The use of a cyclometalated Ru-complex, RuBnN, as the catalyst results in a complete switch of the inherent meta-selectivity to ortho selectivity in the Ru-catalyzed sp2 C-H alkylation reaction with unactivated secondary alkyl halides was demonstrated. The high catalytic activity of RuBnN allowed mild reaction conditions that resulted in a transformation of broad scope and versatility. Preliminary mechanistic studies suggested that a bis-cycloruthenated species was the key intermediate undergoing oxidative addition with the alkyl bromides, thus avoiding the more common SET pathway associated with meta-selectivity.

Compound(1008-89-5)Computed Properties of C11H9N received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Phenylpyridine), if you are interested, you can check out my other related articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: 2208-59-5. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Quantitative structure-activity relationships (QSAR) of smooth muscle relaxation and 2-substituted, benzimidazole derivatives. Author is Buyukbingol, Erdem; Safak, Cihat; Ozturk, Yusuf; Sahin, M. Fethi.

A series of the 2-substituted benzimidazole derivatives were tested for smooth muscle relaxation activity in rats. The pD2 and potency values were then analyzed in terms of hydrophobic (logP), electronic (dipole moment), and stereochem. (νw) factors by linear and multiple regression anal. The activity is depended parabolically on logP with the 2 other factors involved in the regression model. A correlation of pD2 with dipole moment was observed In all other model attempts the nonsignificant correlation led to suggest that mol. shape and size of the compounds would be unimportant in their smooth muscle relaxation activity in term of νw.

From this literature《Quantitative structure-activity relationships (QSAR) of smooth muscle relaxation and 2-substituted, benzimidazole derivatives》,we know some information about this compound(2208-59-5)HPLC of Formula: 2208-59-5, but this is not all information, there are many literatures related to this compound(2208-59-5).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Dipyrrinato-Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation, published in 2021-04-11, which mentions a compound: 1008-89-5, mainly applied to dipyrrinato iridium complex preparation antimicrobial photodynamic inactivation therapy; crystal structure dipyrrinato iridium complex antimicrobial photodynamic inactivation therapy; mol structure dipyrrinato iridium complex; dipyrromethane oxidation chloroanil reagent; (dipyrrinato)iridium(III) complexes; antimicrobial photodynamic inactivation; dipyrrins; glycosylation; photodynamic therapy, Application of 1008-89-5.

The generation of bio-targetable photosensitizers is of utmost importance to the emerging field of photodynamic therapy and antimicrobial (photo-)therapy. A synthetic strategy is presented in which chelating dipyrrin moieties were used to enhance the known photoactivity of Ir(III) metal complexes. Formed complexes can thus be functionalized in a facile manner with a range of targeting groups at their chem. active reaction sites. Dipyrrins with N- and O-substituents afforded (dipy)iridium(III) complexes via complexation with the resp. Cp*-Ir(III) and ppy-Ir(III) precursors (dipy = dipyrrinato, Cp* = pentamethyl-η5-cyclopentadienyl, ppy = 2-phenylpyridyl). Similarly, electron-deficient [Ir(III)(dipy)(ppy)2] complexes could be used for post-functionalization, forming alkenyl, alkynyl and glyco-appended Ir(III) complexes. The phototoxic activity of these complexes was assessed in cellular and bacterial assays with and without light; the [Ir(III)(Cl)(Cp*)(dipy)] complexes and the glyco-substituted Ir(III) complexes showing particular promise as photomedicine candidates. Representative crystal structures of the complexes are also presented.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Khan, Danish; Parveen, Iram; Shaily; Sharma, Saurabh published the article 《Design, Synthesis and Characterization of Aurone Based α,β-unsaturated Carbonyl-Amino Ligands and their Application in Microwave Assisted Suzuki, Heck and Buchwald Reactions》. Keywords: diaryl aminomethylenebenzofuranone preparation; arylboronic acid aryl bromide palladium catalyst Suzuki Miyaura coupling; biaryl preparation; bromobenzene alkene palladium catalyst microwave assisted Mizoroki Heck reaction; phenyl alkene preparation; bromobenzoic acid aniline palladium catalyst microwave Buchwald Hartwig reaction; phenylamino benzoic acid preparation.They researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).SDS of cas: 1008-89-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1008-89-5) here.

A new series of phosphine-free aurone-based α,β-unsaturated carbonyl-amino bidentate ligands I [R1 = 2-furanyl, Ph, 3-4-dimethoxyphenyl, etc.; R2 = Ph, 3-nitrophenyl, 1-naphthyl, etc.] were synthesized and characterized via different anal. techniques such as IR, 1H-NMR, 13C-NMR and mass spectrometry. Moreover, the structure of ligand I [R1 = 2-furanyl; R2 = 2-nitrophenyl] was also characterized by single-crystal X-ray diffraction. The synthesized ligands I with the PdCl2 salt showed excellent catalytic activity in the Suzuki-Miyaura, Mizoroki-Heck and Buchwald-Hartwig reactions. A broad range of substrates including heterocycles, chalcones and sterically hindered coupling partners were well tolerated in the developed protocol. Addnl., the metal complex formed in the catalytic cycle was characterized by 1H-NMR spectroscopy and mass spectrometry.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nguyen, Thanh Binh; Ermolenko, Ludmila; Dean, William A.; Al-Mourabit, Ali researched the compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole( cas:2208-59-5 ).Safety of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole.They published the article 《Benzazoles from Aliphatic Amines and o-Amino/Mercaptan/Hydroxyanilines: Elemental Sulfur as a Highly Efficient and Traceless Oxidizing Agent》 about this compound( cas:2208-59-5 ) in Organic Letters. Keywords: benzazole preparation alkylamine aniline coupling sulfur oxidizing agent. We’ll tell you more about this compound (cas:2208-59-5).

A novel remarkably simple solvent-free and catalyst-free synthesis of benzazoles from alkylamines and o-hydroxy/amino/mercaptan anilines using elemental sulfur as traceless oxidizing agent has been developed.

From this literature《Benzazoles from Aliphatic Amines and o-Amino/Mercaptan/Hydroxyanilines: Elemental Sulfur as a Highly Efficient and Traceless Oxidizing Agent》,we know some information about this compound(2208-59-5)Safety of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, but this is not all information, there are many literatures related to this compound(2208-59-5).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Shankar, Bhaskaran; Rajakannu, Palanisamy; Kumar, Surendra; Gupta, Deepak; Kannan, Tharanikkarasu; Sathiyendiran, Malaichamy published an article about the compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole( cas:2208-59-5,SMILESS:C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1 ).Category: indole-building-block. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2208-59-5) through the article.

A self-assembled neutral tetrarhenium mol. chair, [((OC)3Re(μ-CA)Re(CO)3)2(μ-EpBim)2] (H2CA = chloranilic acid, EpBim = 2-(4-pyridyl)-1-ethylbenzimidazole), was prepared using orthogonal tritopic acceptors, angular ditopic N-donors (∼ 80°), and linear bis-chelating bridging donors in a 1-step process.

From this literature《Self-assembled tetranuclear metallacyclic chair using orthogonal tritopic acceptors, angular ditopic donors, and bischelating bridging motifs》,we know some information about this compound(2208-59-5)Category: indole-building-block, but this is not all information, there are many literatures related to this compound(2208-59-5).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1008-89-5, is researched, Molecular C11H9N, about Mitochondrial targeted rhodium(III) complexes: Synthesis, characterized and antitumor mechanism investigation, the main research direction is rhodium phenylpyridine imidazophenanthrolinyldiphenylaniline complex preparation anticancer phosphorescence lifetime; Apoptosis; Mitochondrial; ROS; Rhodium complexes.Recommanded Product: 1008-89-5.

Recently, rhodium complexes have received intensive attentions due to their tunable chem. and biol. properties as well as attractive antitumor activity. In this work, two imidazole triphenylamino rhodium complexes [Rh(ppy)2L1]PF6 (Rh1) and [Rh(ppy)2L2]PF6 (Rh2) (ppy = 2-phenylpyridine, L1 = 4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)-N,N-diphenylaniline, L2 = N-(4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenyl)-4-methyl-N-(p-tolyl)aniline) have been synthesized and characterized. Both complexes display stronger anticancer activity against a various of cancer cells than cisplatin and they can effectively localize to mitochondria. Further mechanism studies show that Rh1 induce caspase-dependent apoptosis through mitochondrial damage, down-regulate the expression of B-cell lymphoma-2 (Bcl-2)/Bcl2-associated x (Bax) and reactive oxygen species (ROS) elevation. Our work provides a strategy for the construction of highly effective anticancer agents targeting mitochondrial metabolism through rational modification of rhodium complexes.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2208-59-5, is researched, SMILESS is C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1, Molecular C12H9N3Journal, Zeitschrift fuer Anorganische und Allgemeine Chemie called Hydrothermal Synthesis of Five New Coordination Polymers Based on Benzophenone-2, 4′-dicarboxylic Acid and N-Donor Spacers, Author is Xu, Jiakun; Sun, Xiaochun; Fan, Yuhua; Sun, Mi; Bi, Caifeng, the main research direction is zinc nickel benzophenonedicarboxylate coordination polymer preparation fluorescence; crystal structure zinc nickel benzophenonedicarboxylate coordination polymer.HPLC of Formula: 2208-59-5.

Five new coordination polymers, [[Ni2(L)2(4,4′-bipy)3]·H2O]n (1), [Ni2(L)2(O)(bpp)2]n (2), [Zn(L)(bib)0.5]n (3), [Zn(L)(PyBIm)]n (4), and [Zn3(L)2(OH)(Im)]n (5) [H2L = benzophenone-2,4′-dicarboxylic acid, 4,4′-bipy = 4,4′-bipyridine, bpp = 1,3-bis(4-pyridyl)propane, PyBIm = 2-(4-pyridyl)benzimidazole, and Im = imidazole] were synthesized under hydrothermal conditions. Structure determination revealed that compound 1 is a 3-dimensional network and exhibits a 4-connected metal-organic framework with (42.63.8) topol., whereas compounds 2, 3, 4, and 5 are two-dimensional layer structures. In compounds 2-4, dinuclear metal clusters are formed through carboxylic groups. In compound 5, trinuclear metal clusters are formed through μ3-OH and carboxylic groups. The carboxylic groups exhibit three coordination modes in compounds 1-5: monodentately, bidentate-chelating, and bis-monodentately. Also, the luminescent properties for compounds 3, 4, and 5 were studied.

There is still a lot of research devoted to this compound(SMILES：C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1)HPLC of Formula: 2208-59-5, and with the development of science, more effects of this compound(2208-59-5) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A Mild Method for Electrochemical Reduction of Heterocyclic N-Oxides, published in 2020-06-01, which mentions a compound: 1008-89-5, Name is 2-Phenylpyridine, Molecular C11H9N, Safety of 2-Phenylpyridine.

Deoxygenation of heteroaromatic N-oxides is commonly accomplished using chem. or enzymic methods. In this work, we report on an expedient protocol for electrochem. reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring. Thus, e.g., 2-phenylpyridine N-oxide → 2-phenylpyridine (89% isolated) by carring out the reaction in an undivided electrochem. cell with two graphite electrodes in 1:1 MeCN/water mixture using LiBF4 as supporting electrolyte.

There is still a lot of research devoted to this compound(SMILES：C1(C2=CC=CC=C2)=NC=CC=C1)Safety of 2-Phenylpyridine, and with the development of science, more effects of this compound(1008-89-5) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Excited-State Behavior of 2-(4′-Pyridyl)benzimidazole in Aqueous Solution: Proton-Transfer Processes and Dual Fluorescence, published in 1995-10-05, which mentions a compound: 2208-59-5, mainly applied to excited state reaction pyridylbenzimidazole proton transfer; photolysis pyridylbenzimidazole proton transfer, Synthetic Route of C12H9N3.

The excited-state acid-base behavior of 2-(4′-pyridyl)benzimidazole in aqueous solution has been studied over a wide range of acidity by UV absorption and fluorescence spectroscopy. The species detected in the lowest electronically excited singlet state turned out to be identical to those of the ground state: the anion A, the neutral mol. N, the monocation C protonated at the benzimidazole N3, the monocation T protonated at the pyridyl nitrogen, and the dication D. Nevertheless, the strong increase in the basicity of the pyridyl nitrogen atom in the excited state induces different excited-state proton-transfer processes. The dual fluorescence of 4PBI at neutral pH is explained by the protonation of N* to give T*. On the basis of the steady-state data together with the fluorescence decay measurements at several acidities, a mechanism is proposed to explain the acid-base behavior of 4PBI in the first excited singlet state.

There is still a lot of research devoted to this compound(SMILES：C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1)Synthetic Route of C12H9N3, and with the development of science, more effects of this compound(2208-59-5) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles