Tag: M.W:100-200

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tailor, Sanita B.; Manzotti, Mattia; Smith, Gavin J.; Davis, Sean A.; Bedford, Robin B. researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).Safety of 2-Phenylpyridine.They published the article 《Cobalt-Catalyzed Coupling of Aryl Chlorides with Aryl Boron Esters Activated by Alkoxides》 about this compound( cas:1008-89-5 ) in ACS Catalysis. Keywords: biaryl preparation transmetalation key step kinetics linear free energy; aryl chloride boron reagent alkoxide Suzuki coupling cobalt catalyst. We’ll tell you more about this compound (cas:1008-89-5).

The cobalt-catalyzed Suzuki biaryl cross-coupling of aryl chloride substrates with aryl boron reagents, activated with more commonly used bases, remained a significant unmet challenge in the race to replace platinum group metal catalysts with Earth-abundant metal alternatives. This highly desirable process can be realized using alkoxide bases, provided the right counterion is employed, strict stoichiometric control of the base is maintained with respect to the aryl boron reagent, and the correct boron ester is selected. Potassium tert-butoxide works well, but any excess of the base first inhibits and then poisons the catalyst. Lithium tert-butoxide performs very poorly, while even catalytic amounts of lithium additives also poison the catalyst. Meanwhile, a neopentane diol-based boron ester is required for best performance. As well as delivering this sought-after transformation, a detailed mechanistic and computational investigations to probe the possible mechanism of the reaction has been discussed and explains the unexpected exptl. observations.

If you want to learn more about this compound(2-Phenylpyridine)Safety of 2-Phenylpyridine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1008-89-5).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 2-Phenylpyridine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Visible-Light-Driven C4-Selective Alkylation of Pyridinium Derivatives with Alkyl Bromides.

Reported herein is a general strategy for the photochem. cross-coupling between N-amidopyridinium salts and various alkyl bromides under photocatalyst-free conditions, granting facile access to various C4-alkylated pyridines. This approach exploits the intriguing photochem. activity of electron donor-acceptor (EDA) complexes between N-amidopyridinium salts and bromide, which provides a photoactive handle capable of generating silyl radicals and driving the alkylation process. The robustness of this protocol was further demonstrated by the late-stage functionalization of complex compounds, e.g., dehydroepiandrosterone and oxaprozin, under mild and metal-free conditions.

Here is a brief introduction to this compound(1008-89-5)Quality Control of 2-Phenylpyridine, if you want to know about other compounds related to this compound(1008-89-5), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about BF3·Et2O-promoted one-pot expeditious and convenient synthesis of 2-substituted benzimidazoles and 3,1,5-benzoxadiazepines.SDS of cas: 2208-59-5.

2-Substituted benzimidazoles, e.g., I, and 3,1,5-benzoxadiazepines, e.g., II, have been synthesized in excellent yields. The cyclodehydration of N-acyl-1,2-phenylenediamines and N,N’-diacyl-1,2-phenylenediamines, prepared in situ from the corresponding 1,2-phenylenediamines, with acid chlorides gave benzimidazoles and 3,1,5-benzoxadiazepines, resp.

Here is a brief introduction to this compound(2208-59-5)SDS of cas: 2208-59-5, if you want to know about other compounds related to this compound(2208-59-5), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53924-05-3,7-Chloroindole,as a common compound, the synthetic route is as follows.,53924-05-3

A solution of phosphoryl chloride(1 .20 mL, 12.8 mmol) in DMF (40 mL) was treated with a solution of 7-chloro-1 A indole (2.00 g, 13.2 mmol) in DMF (10 mL) and stirred at 23 C for 3h, added to ice, the solvent evaporated. The aqueous residue was diluted with water (50 mL), basified with 3 M NaOH to pH 13 and extracted with CH2CI2(5 x 30 mL). Combined organic layers were dried over anhydrous MgS04, filtered and the solvent evaporated. Column chromatography (S1O2; EtOAc/Heptane 20:80 -> 50:50) of the crude gave 7-Chloro-1 A indole-S-carbaldehyde (1 .97 mg, 83%) as a pinkish solid.H NMR (400 MHz, DMSO-ofe) delta = 12.54 (s, 1 H, NH), 9.98 (s, 1 H, CHO), 8.39 (s, 1 H, H-Ar), 8.07 (dd, J= 7.8, 1 .0 Hz, 1 H, H-Ar), 7.36 (dd, J= 7.7, 1.0 Hz, 1 H, H-Ar), 7.23 (t, J= 7.8 Hz, 1 H, H-Ar).MS (ESI+, H20/MeCN) m/z {%): 180.0 (100, [M + H]+).

As the paragraph descriping shows that 53924-05-3 is playing an increasingly important role.

Reference：
Patent; EUROPEAN MOLECULAR BIOLOGY LABORATORY; WILL, David William; REID, George; CHARAPITSA, Iryna; LEWIS, Joe; (138 pag.)WO2018/229197; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.

(1) 2,3,3-trimethyl-5-methoxy-3H-indole (I4e) (1 mol), the bromoethanol (3 mol) was placed together in 20 mL of dry toluene and heated under reflux for 12 hours under nitrogen, cooled to room temperature, washed with anhydrous diethyl ether and recrystallized from acetone to give a white-yellow solid quaternary ammonium salt (I6d), after drying, store it for later use

31241-19-7, As the paragraph descriping shows that 31241-19-7 is playing an increasingly important role.

Reference：
Patent; Shenzhen University; Yang Zhigang; Qu Junle; (65 pag.)CN110128843; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10601-19-1,5-Methoxy-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

a. 5-Methoxy-1-methylindole-3-carboxaldehyde (43) 5-Methoxyindole-3-carboxaldehyde (300 mg, 1.71 mmol) was added in portions over 5 min to a suspension of sodium hydride (82 mg, 2.05 mmol, 60% dispersion in mineral oil) in DMF (8 mL) stirring under argon. The mixture was stirred for 30 min, methyl iodide (0.13 mL, 2.05 mmol) was added and the mixture was stirred for 1 h. Sodium bicarbonate (10%, 40 mL) was added and the mixture was extracted with EtOAc (4*). The combined organic layers were washed with sodium bicarbonate (10%, 2*) and saturated NaCl, dried (MgSO4), filtered and evaporated. Column chromatography of the crude product (50:50 EtOAc:hexanes) afforded 43 (320 mg, 99%) as a light yellow solid; Rf=0.35 (50:50 EtOAc:hexanes); mp=130-132 C.; lit mp=132-133 C.53; 1H NMR (CDCl3): delta 9.95 (s, 1H), 7.79 (d, 1H, J=2.4 Hz), 7.62 (s, 1H), 7.25 (d, J=8.8 Hz), 6.96 (dd, 1H, J=2.4 and 8.9 Hz), 3.90 (s, 3H), 3.85 (s, 3H)., 10601-19-1

The synthetic route of 10601-19-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Borch, Richard F.; Hernick, Marcy; Flader, Carolee; US2003/8850; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.162100-95-0,6-Fluoro-5-methyl-1H-indole,as a common compound, the synthetic route is as follows.

Diethylaluminum chloride 1 M in hexane (37.1 mL, 37.1 mmol) was added dropwise at 000 to a solution of 6-fluoro-1H-indole [CAS 399-51 -9] (3.34 g, 24.8 mmol) in CH2CI2 (100 mL). After stirring for 30 mm at 0CC, a solution of 2-(4- chloro-2-methoxyphenyl)acetyl chloride 9a? (6.3 g, 28.8 mmol) in CH2CI2 (100 mL) was added slowly at 0C. The reaction was stirred at 0C for 3 h. Ice-water wasadded and the precipitate was filtered off, washed with water and a small amount of CH2CI2. The solids were dried under vacuum at 70C overnight to give 2-(4- chloro-2-methoxyphenyl)-1 -(6-fluoro-1 H-indol-3-yl)ethanone 1 3b (4.9 g).

162100-95-0, The synthetic route of 162100-95-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JANSSEN PHARMACEUTICALS, INC.; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee Alice Marie-Eve; BONFANTI, Jean-Francois; COESEMANS, Erwin; KESTELEYN, Bart Rudolf Romanie; MARCHAND, Arnaud Didier M; RABOISSON, Pierre Jean-Marie Bernard; (96 pag.)WO2017/167952; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

227960-12-5, Methyl 5-methylindole-3-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methyl 5-methyl-1H-indole-3-carboxylate (200 mg, 1.06 mmol) used hydrolysis reaction (2 NNaOH water solution) to aord DX-01-03 (white solid, 150 mg, yield 81%). 1H-NMR (400 MHz,CD3OD): = 8.15 (d, J = 1.8 Hz, 1H, H-indolyl), 8.07 (s, 1H, H-indolyl), 7.39 (d, J = 8.3 Hz, 1H,H-indolyl), 7.15 (dd, J = 8.3, 1.1 Hz, 1H, H-indolyl), 2.46 (s, 3H, CH3). 13C-NMR (101 MHz, CD3OD): = 137.41, 134.35, 127.80, 127.00, 122.51, 120.09, 117.20, 113.08, 110.78, 21.77. HRMS (ESI): m/z [M + H]+calculated for C10H10NO2: 176.07061; found: 176.07094.

227960-12-5, As the paragraph descriping shows that 227960-12-5 is playing an increasingly important role.

Reference：
Article; Wen, Hui; Liu, Yuke; Wang, Shufang; Wang, Ting; Zhang, Gang; Chen, Xiaoguang; Li, Yan; Cui, Huaqing; Lai, Fangfang; Sheng, Li; Molecules; vol. 24; 11; (2019);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21296-93-5,5-Chloro-2,3-dimethyl-1H-indole,as a common compound, the synthetic route is as follows.

General procedure: Thus, the general reaction conditions for pyrroleporphyrin are obtained: at -20C,B-noise 2 (0.15 mmol, 1.5 eq) was added to 1 (0.11 mmol, 1 0 0 equiv),CP3 (1 · 8mg, 2 · 5mol%)In a solution of DCM (1 .0 mL), the reaction was stirred at -20 C until TLC showed 1 to disappear. The reaction mixture was directly purified by column chromatography on silica gel eluting with PE/EA (10/1 to 4/1) to give pure product 5 as a white solid., 21296-93-5

As the paragraph descriping shows that 21296-93-5 is playing an increasingly important role.

Reference：
Patent; South University of Science and Technology of China; Tan Bin; Qi Liangwen; (16 pag.)CN107417690; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10601-19-1,5-Methoxy-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Compounds 7-9 were synthesized from the corresponding compounds 4-6. A solution of compounds 4-6 (60 mmol) in THF (30 mL) were added dropwise to a suspension of NaH (3.60 g, 60% dispersion in mineral oil, 150 mmol) in THF (30 mL) at 0 C. After stirring for 15 min, the heterogeneous mixture was treated with iodomethane (5.04 mL, 79.2 mmol) at room temperature for 1 h. Then the reaction mixture was cooled to 0 C, quenched with saturated NH4Cl (60 mL), and extracted with ether (3 * 50 mL). The organic layers were combined, washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo to give 1-Methyl-1H-indole-3-carboxaldehyde (7-9), a light brown solid. The crude 7-9 were used in the next step without any further purification., 10601-19-1

As the paragraph descriping shows that 10601-19-1 is playing an increasingly important role.

Reference：
Article; Wang, Yan-Ting; Qin, Ya-Juan; Yang, Na; Zhang, Ya-Liang; Liu, Chang-Hong; Zhu, Hai-Liang; European Journal of Medicinal Chemistry; vol. 99; (2015); p. 125 – 137;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles