Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.162100-95-0,6-Fluoro-5-methyl-1H-indole,as a common compound, the synthetic route is as follows.,162100-95-0

A solution of 6-fluoro-5-methyl-1 H-indole [CAS 162100-95-0] (1 .7 g, 1 1 .4 mmol) in CH2CI2 (100 mL) was cooled to 0C under N2-atmosphere. A solution of diethylalunninunn chloride 1 M in hexane (17.1 mL, 17.1 mmol) was added dropwise and the resulting mixture was kept at 0C for 15 min. A solution of 2-(4-chloro- 2-methoxyphenyl)acetyl chloride 1a (3.50 g, 16 mmol) in CH2CI2 (50 mL) was added dropwise. Stirring was continued at 0C for 1 h and at room temperature for 2 h. The reaction mixture was poured out in a stirring ice/Rochelle salt solution. After the ice had melted, the mixture was filtered over dicalite and the filter cake was washed several times with THF. The filtrates were combined. The layers were separated and the organic layer was washed with brine, dried over MgSO4, filtered and evaporated under reduced pressure. The solid residue was suspended in CH2CI2 (30 ml_), the precipitate was filtered off and dried under vacuum at 50C to provide 2-(4-chloro-2-methoxyphenyl)-1 -(6-fluoro-5-methyl-1 H-indol-3-yl)ethanone 7a (2.76 g).

As the paragraph descriping shows that 162100-95-0 is playing an increasingly important role.

Reference：
Patent; JANSSEN PHARMACEUTICALS, INC.; KATHOLIEKE UNIVERSITEIT LEUVEN; KESTELEYN, Bart, Rudolf, Romanie; BONFANTI, Jean-Francois; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; BARDIOT, Dorothee, Alice, Marie-Eve; MARCHAND, Arnaud, Didier, M; (68 pag.)WO2016/180696; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 2 in dichloromethane (30 mL) at 0 C was added dropwise 2 equivalents of 1 M BBr3 in dichloromethane and the mixture was stirred at room temperature for 12 h. Upon the completion of reaction as monitored by thin layer chromatography (TLC), the reaction mixture was washed with saturated aqueoussolution of sodium bicarbonate and the organic extracts were driedover Na2SO4, filtered, and evaporated to afford 3 as a brown solid in79% yield

31241-19-7, As the paragraph descriping shows that 31241-19-7 is playing an increasingly important role.

Reference：
Article; Saikiran, Maryala; Sato, Daisuke; Pandey, Shyam S.; Ohta, Takeshi; Hayase, Shuzi; Kato, Tamaki; Dyes and Pigments; vol. 140; (2017); p. 6 – 13;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Following a modified procedure [22], to a mixture of various substituted 2,3,3-trimethylindole (7.0 mmol), 2-formylpyrrole (1.78 g, 14 mmol), piperidine (12 mL,14 mmol) and ice acetic acid (16.5 mL, 21 mmol) in toluene (50 mL) were addedunder a Dean-Stark trap condition and the mixture was refluxed for 3 h. Thecompletion of the reaction was confirmed by TLC. The brown dark reaction mixturewas cooled, concentrated and separated by column chromatography. The correspondingproducts NDABs as a solid were obtained., 31241-19-7

As the paragraph descriping shows that 31241-19-7 is playing an increasingly important role.

Reference：
Article; Li, Yujiao; Yan, Jiaying; Cheng, Kai; Kong, Shuai; Zheng, Kaibo; Wang, Long; Zhang, Nuonuo; Research on Chemical Intermediates; vol. 43; 10; (2017); p. 5337 – 5344;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

31241-19-7, 5-Methoxy-2,3,3-trimethyl-3H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.70 g (9.00 mmol) of 2,3,3-trimethyl-6-methoxyindole 1 were weighed and 2.61 g (18.0 mmol) of 2-formylbenzopyrrole was weighed and 0.15 L of a toluene solution was measured.Take organic acid 0.24mL, 0.30mL organic base were heated and stirred, refluxed at 120 for 2 hours, dried and filtered to give a yellow compound 3.Take 1.99 g (4.50 mmol) of the above compound 3, take 35 mL of toluene solution and 2.80 mL of triethylamine, add 2.10 mL (17.50 mmol) of boron trifluoride etherate solution dropwise with stirring under electromagnetic agitation and raise the temperature to 120 C.,Condensing reflux 8 hours, TLC point plate test, the product was washed, extracted, dried, rotary evaporation, filtered to give compound 4:, 31241-19-7

31241-19-7 5-Methoxy-2,3,3-trimethyl-3H-indole 11095392, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; China Three Gorges University; Zhang Nuonuo; Li Yujiao; Yan Jiaying; Cheng Kai; Li Dejiang; (12 pag.)CN105925004; (2016); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

399-67-7, 7-Fluoro-1H-indole-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (5-Chloro-7-fluoro-1H-indole-2-yl)-carboxylic acid (5a) (50 mg, 0.23 mmol), N,N-diisopropylethylamine (82 mul, 0.47 mmol) and 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (89 mg, 0.23 mmol) were dissolved in 550 mul N,N-dimethylformamide. After stirring for 10 min 4-methyl-piperazin 6a (26 mul, 0.23 mmol) was added and the reaction mixture was stirred for 16 h at 20 C. The solvent was evaporated under reduced pressure and the crude product was purified using chromatography method P1, yielding 37 mg (53%) of the title compound.

399-67-7, The synthetic route of 399-67-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Engelhardt, Harald; De Esch, Iwan J.P.; Kuhn, Daniel; Smits, Rogier A.; Zuiderveld, Obbe P.; Dobler, Julia; Mayer, Moriz; Lips, Sebastian; Arnhof, Heribert; Scharn, Dirk; Haaksma, Eric E.J.; Leurs, Rob; European Journal of Medicinal Chemistry; vol. 54; (2012); p. 660 – 668;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76644-74-1,1H-Isoindol-3-amine hydrochloride,as a common compound, the synthetic route is as follows.,76644-74-1

To a solution of 3-amino-1H-isoindole hydrochloride (3.25 g, 19.3 mmol) and 5-methyl-3-oxo-hexanoic acid methyl ester (3.35 g, 21.2 mmol) in MeOH (96 mL) was added a 30 wt % sodium methoxide solution in methanol (7.2 mL, 38.5 mmol). The mixture was stirred at room temperature overnight. The volatiles were evaporated and the solid material was washed with hexane/ether to give 3.4 g of 2-isobutylpyrimido[2,1-a]isoindol-4(6H)-one. LC-MS (M+H): 241.1.

76644-74-1 1H-Isoindol-3-amine hydrochloride 2795203, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; TaiGen Biotechnology Co., Ltd.; US2008/292626; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2795-41-7,6-Fluoroindole-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A solution of indol-3-aldehyde 8 (1 mmol) and appropriate acetophenone (1 mmol) in ethanol (25 mL) was refluxed in the presence of piperidine (0.5 mL) for 24 h. After completion of reaction as confirmed by TLC, the mixture was poured into crushed ice (20 g), neutralized with acetic acid. Obtained solid was filtered, washed with cold water (20 mL) and dried and recrystallized from ethanol to obtain pure indolylchalcones 9a-m in 60-70% yields.

2795-41-7, 2795-41-7 6-Fluoroindole-3-carboxaldehyde 262903, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Article; Chaitanya; Reddy, P.O. Venkataramana; Nikhil, Kumar; Kumar, Anil; Shah, Kavita; Kumar, Dalip; Bioorganic and Medicinal Chemistry Letters; vol. 28; 17; (2018); p. 2842 – 2845;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

2795-41-7, 6-Fluoroindole-3-carboxaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2795-41-7, General procedure: Piperidine (0.08 mL) was added to methanol (25 mL) dissolved in substituted aldehydes 5-7 (0.18 mmol) and starting 2-indolinone derivatives 8-11 (0.18 mmol) which were prepared as described previously refPreviewPlaceHolder[6], refPreviewPlaceHolder[21], refPreviewPlaceHolder[22], refPreviewPlaceHolder[23], refPreviewPlaceHolder[24] and refPreviewPlaceHolder[25]. The mixture was refluxed for 5 h. For the targeted compounds 12-21 and 28-36, the mixture was evaporated to remove the solvent and the residue was purified by column chromatography (CH2Cl2/MeOH 100:1-10:1). For the targeted compounds 22-27, ethyl ether (15 mL) was added to the residue and the yellow precipitate was collected by filtration. The obtained precipitate was subjected to the hydrogen chloride saturated methanol to afford it as hydrochloride derivative. All the targeted compounds 12-36 show moderate to good yields under this reaction condition with the yields of 60-92%.

As the paragraph descriping shows that 2795-41-7 is playing an increasingly important role.

Reference：
Article; Zou, Hongbin; Zhang, Liang; Ouyang, Jingfeng; Giulianotti, Marc A.; Yu, Yongping; European Journal of Medicinal Chemistry; vol. 46; 12; (2011); p. 5970 – 5977;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5192-03-0,1H-Indol-5-amine,as a common compound, the synthetic route is as follows.

General procedure: General procedure (10): To a solution of aminoindole (1.0 equiv) and triethylamine (3.6 equiv) in dichloromethane (10 ml_ for 1.182 mmol of starting material), acetyl chloride (1.2 equiv) was added. The reaction was stirred at room temperature for 3 h. The mixture was poured into water and extracted with dichloromethane 3 times. The combined organic layer was washed with brine, dried over anhydrous sodium sulphate and concentrated in vacuo. Purification by flash silica gel column chromatography afforded the indole-acetamide product. Intermediate 17 A/-(1/-/-indol-5-yl)acetamide Intermediate 17 (177 mg, 1.016 mmol) was prepared as a clear oil from Intermediate 16 (156 mg, 1.182 mmol) according to general procedure (10) using 7:3 hexane/ethyl acetate as the eluent for flash silica gel column chromatography. Yield: 85%. 1H NMR (400 MHz, CDCI3) delta 8.27 (bs, 1 H), 7.80 (s, 1 H), 7.30 (d, J = 8.5 Hz, 2H), 7.20 (dd, J = 8.8, 2.0 Hz, 2H), 6.50 (s, 1 H), 2.18 (s, 3H)., 5192-03-0

The synthetic route of 5192-03-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NATIONAL UNIVERSITY OF SINGAPORE; LEE, Sang Hyun; DYMOCK, Brian William; KITAGAWA, Mayumi; SEE, Cheng Shang; (178 pag.)WO2016/200339; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

90924-06-4, 1-Methyl-4-indolecarboxylic Acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,90924-06-4

General procedure: To a stirred solution of 25 (115 mg, 0.5 mmol) in DCM (10 mL) was added carboxylic acid (0.5 mmol), HOBT (68 mg, 0.5 mmol) and EDCI·HCl (144 mg, 0.75 mmol). The mixture was stirred at room temperature overnight, and washed successively with water (5 mL) and brine (10 mL × 2). The organic layer was dried over anhydrous Na2SO4, and concentrated to give the crude product, which was purified by flash chromatography (hexane/EtOAc = 3:1-1:1) afforded 4a-w.

90924-06-4 1-Methyl-4-indolecarboxylic Acid 14987287, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Article; Xia, Guangxin; You, Xiaodi; Liu, Lin; Liu, Haiyan; Wang, Jianfa; Shi, Yufang; Li, Ping; Xiong, Bing; Liu, Xuejun; Shen, Jingkang; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 1 – 10;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles