Tag: M.W:100-200

40047-23-2, 6-Hydroxyindole-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of A (500 mg, 1.61 mmol) and 221-1 (286 mg, 1.61 mmol) and K2CO3 (446 g, 3.23 mmol) in DMSO (4 mL) is heated for 2 h at 140 ¡ãC and 10 h at 150 ¡ãC. The reaction is poured into H2O, extracted thrice with EtOAc, washed thrice with saturated aqueous NaHCO3, dried over Na2SO4, filtered and concentrated to give 221-2. The aqueous phase is acidified with concentrated HCl and extracted four times with EtOAc, washed with H20, dried over Na2SO4, filtered and concentrated to provide additional 221-2.

40047-23-2, As the paragraph descriping shows that 40047-23-2 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ABEYWARDANE, Asitha; BRUNETTE, Steven Richard; BURKE, Michael Jason; KIRRANE, Thomas Martin, Jr.; MAN, Chuk Chui; MARSHALL, Daniel Richard; PADYANA, Anil Kumar; RAZAVI, Hossein; SIBLEY, Robert; SMITH KEENAN, Lana Louise; SNOW, Roger John; SORCEK, Ronald John; TAKAHASHI, Hidenori; TAYLOR, Steven John; TURNER, Michael Robert; YOUNG, Erick Richard Roush; ZHANG, Qiang; ZHANG, Yunlong; ZINDELL, Renee M.; WO2014/14874; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1670-83-3,Indole-7-carboxylic acid,as a common compound, the synthetic route is as follows.,1670-83-3

Example 73; Preparation of 1H-Indole-7-carboxylic acid butyl-(4-tert-butyl-benzyl)-amide 77; To a solution of 110 mg of 1H-indole-7-carboxylic acid (0.68 mmol) and 220 mg of TBTU (0.68 mmol) in 10 ml DMF, were added 0.59 ml (3.42 mmol) of N,N-diisopropylethyl amine. After stirring for 5 min at rt, 150 mg (0.68 mmol) of butyl-(4-tert-butyl-benzyl)-amine were added. After stirring for 2 h at rt, the reaction mixture was diluted with 100 ml water and extracted twice with EtOAc. The combined organic phases were washed with water and brine, dried with magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (8 g silica gel; heptane/EtOAc 2:1) to give 209 mg (82%) of a light yellow viscous oil. MS (EI) 362.2 (M)+.

As the paragraph descriping shows that 1670-83-3 is playing an increasingly important role.

Reference£º
Patent; Conte-Mayweg, Aurelia; Kuehne, Holger; Luebbers, Thomas; Maugeais, Cyrille; Mueller, Werner; Pflieger, Philippe; US2006/30613; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

933-67-5, 7-Methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10 mL of Schlenk tube was added Eosin Y (0.01 mmol), sodium trifluoromethanesulfinate (0.3 mmol), triphenylphosphine(0.6 mmol), N-chlorophthalimide (0.3 mmol), evacuated and washed into dry nitrogen (this procedure was repeated three times)7-methylindole (0.2 mmol) was dissolved in the ultra-dry solvent acetonitrile and the resulting solution was passed through a syringe into a Schlenk tube. Room temperature, The reaction was allowed to stand under a white LED lamp and stirred for 6 hours. After completion of the reaction, the solvent was evaporated and the residue was passed through the residuePurification by silica gel column chromatography gave 40 mg of product, yield 87%.

933-67-5, The synthetic route of 933-67-5 has been constantly updated, and we look forward to future research findings.

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Patent; Nanjing University of Science and Technology; Cai Chun; Bu Meijie; (9 pag.)CN106748608; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.199526-97-1,4,6-Difluoroindole,as a common compound, the synthetic route is as follows.

d. EXAMPLE 4: 2-((1-(3-BROMOBENZYL)-4,6-DIFLUORO-1H-INDOL-3- YL)SULFONYL)-N-(PYRIDIN-2-YL)ACETAMIDE; [00443] Example 4 was prepared according to the following scheme.[00444] Step A. To a solution of 4,6-diflouro-indole (15.6 g, 0.102 mol) and methyl thioglycolate (9.1 mL, 0.102 mol) in methanol: water (240mL : 60 mL) was added iodine (26.0 g, 0.102 mmol) and potassium iodide (17.0 g, 0.102 mmol). The reaction mixture was stirred at ambient temperature for 60 hours. Methanol was removed in vacuo and the aqueous layer diluted with a saturated solution of sodium bicarbonate and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, evaporated in vacuo and the resulting residue was purified on a silica gel column (0-100% ethyl acetate:hexanes over 48 min) to afford the desired product (20. lg, 76% yield). 1H NMR (400 MHz, DMSOD6) 11.74 (s, 1H), 7.51 (d, J = 2.4 Hz, 1H), 7.09 (dd, J = 2.0, 9.6 Hz, 1H), 6.90-6.85 (m, 1H), 3.54 (s, 3H), 3.51 (s, 2H).

199526-97-1, As the paragraph descriping shows that 199526-97-1 is playing an increasingly important role.

Reference£º
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig, W.; CONN, P., Jeffrey; WOOD, Michael, R.; TARR, James, C.; BRIDGES, Thomas, M.; WO2011/163280; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.245-08-9,5H-Pyrido[3,2-b]indole,as a common compound, the synthetic route is as follows.,245-08-9

The compound a or b (5 g, 0.03 mol), 1, 3-dibromo benzene (2.8 g, 0.012 mol), copper iodide(1.04 g, 5.46 mmol), trans-1,2-diaminocyclohexane (1.33 g,10.92 mmol), and potassium phosphate tribasic (7.64 g, 0.036 mol) were dissolved in 1,4-dioxane (100 ml) and under N2 atmosphere. The mixture was allowed to stir at 110C for 48 h. After being cooled to room temperature, the mixture was diluted with THF. The copper catalyst and inorganic were removed by filtration under reduced pressure and the residue washed with dichloromethan(CH2Cl2), The organic layer was extracted with water and then CH2Cl2 was evaporated. The residue was recrystallized by CH2Cl2. The compound 1-4 were obtained as powder. 1,3-Bis(5H-pyrido[3,2-b]indol-5-yl)benzene (mCdP) (1) Yield:47% 1H NMR (500 MHz, CDCl3, ppm) delta 7.36 (2H, dd, J = 4.5 Hz, J = 8.5 Hz), 7.42 (2H, m), 7.58(4H, m), 7.72 (2H, dd, J = 2.0 Hz, J = 8.0 Hz), 7.80 (3H, m), 7.90 (1H, t, J = 8.0 Hz), 8.46(2H, d, J = 7.5 Hz), 8.64 (2H, dd, J = 1.5 Hz, J = 4.5 Hz). 13C NMR (125 MHz, CDCl3, ppm)delta 109.8, 116.6, 120.4, 121.1, 121.4, 122.8, 124.6, 125.8, 128.3, 131.6, 134.0, 138.7, 141.2, 142.5,143.0. EI-Mass (m/z): 410 [M+]

As the paragraph descriping shows that 245-08-9 is playing an increasingly important role.

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Article; Wang, Hedan; Zhu, Jun; Shen, Bowen; Wei, Bin; Wang, Zixing; Molecular Crystals and Liquid Crystals; vol. 651; 1; (2017); p. 133 – 141;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348640-06-2,4-Bromo-7-azaindole,as a common compound, the synthetic route is as follows.

A solution of 4-bromo-lH-pyrrolo[2,3-b]pyridine (LXXIV) (10 g, 50.8 mmol, 1.0 eq) in anhydrous THF (150 mL) was degassed (x 3) with a water pump, then cooled to 0C under Ar. NaH (60% in mineral oil) (2.436 g, 60.9 mmol, 1.2 eq) was added portion wise slowly under Ar. The reaction was stirred at 0C for 30 min. (2- (chloromethoxy)ethyl)trimethylsilane (10.15 g, 60.9 mmol, 1.2 eq) was added dropwise slowly. The reaction was stirred at room temperature for 2.5 h. The reaction mixture was added water (2 inL) then was concentrated in vacuo and water (50 inL) was added and extracted with EtOAc (x 3). The organic layer was washed with brine and dried over Na2S04. Flash chromatography (PE:ETOAc=10: 1) gave 4-bromo-l-((2-(trimethylsilyl)ethoxy)methyl)-lH-pyrrolo[2,3-b]pyridine (LXXXVII) as a yellow oil (14.38 g, 43.9 mmol, 86.6% yield). ESIMS found for Ci3Hi9BrN2OSi mlz 327.0 (M+H)., 348640-06-2

As the paragraph descriping shows that 348640-06-2 is playing an increasingly important role.

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Patent; SAMUMED, LLC.; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; HOOD, John; (253 pag.)WO2017/23996; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

52562-50-2, 5-Methyl-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (i) Preparation of the imines The aldehydes (0.20mmol) and 1,2-diaminoanthraquinone (0.24mmol) were dissolved separately in ethanol (4ml/mmol). The ethanolic solution of aldehyde and formic acid (0.04 ml/mmol of aldehyde) was added to the solution of 1,2-diaminoanthraquinone heated at reflux. The reaction mixture was heated under reflux overnight. (ii) Cyclisation of the imines After cooling, the ethanolic solution was evaporated and the crude imine was dissolved in a small volume of acetic acid (5 ml/mmol of imine). To this solution, lead tetraacetate was added (0.20mmol) and the mixture was stirred overnight at room temperature. Addition of water to the reaction mixture gave a solid which was isolated by filtration and purified by recrystalisation from diethyl ether/chloroform., 52562-50-2

52562-50-2 5-Methyl-1H-indole-3-carbaldehyde 259187, aindole-building-block compound, is more and more widely used in various fields.

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Article; Batista, Rosa M.F.; Oliveira, Elisabete; Costa, Susana P.G.; Lodeiro, Carlos; Raposo, M. Manuela M.; Supramolecular Chemistry; vol. 26; 2; (2014); p. 71 – 80;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

51417-51-7, 7-Bromoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,51417-51-7

A solution of 7-bromoindole (10.0 g, 51.0 mmol), di-tert-butyl dicarbonate (12.2 g, 56.1 mmol) and DMAP (623 mg, 5.1 mmol) in acetonitrile (100 mL) was stirred at room temperature for 72 h. The reaction mixture was concentrated under reduced pressure, diluted with EtOAc (500 mL), washed with water (300 mL) and brine (2X300 mL). The phases were separated and dried over Na2SO4, concentrated under reduced pressure to afford the title compound (15.1 g, 51.0 mmol, 100% yield) as a yellowish oil.

As the paragraph descriping shows that 51417-51-7 is playing an increasingly important role.

Reference£º
Patent; MARINEAU, Jason, J.; ZAHLER, Robert; CIBLAT, Stephane; WINTER, Dana, K.; KABRO, Anzhelika; ROY, Stephanie; SCHMIDT, Darby; CHUAQUI, Claudio; MALOJCIC, Goran; PIRAS, Henri; WHITMORE, Kenneth, Matthew; LUND, Kate-Iyn; SINKO, Bill; SPROTT, Kevin; (418 pag.)WO2018/13867; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

17380-18-6, 5-Cyanoindole-3-carboxyaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

14) Removal of triphenylphosphine oxide from 3-[2-(3.4-dichlorophenyl)-ethenyl]indole-5-carbonitrile reaction mixture using MgCl2(2.2 eq) n-Butyllithium (2.5M solution in hexanes, 3.6 ml) was added to a stirred solution of (3,4-dichlorobenzyl)triphenylphosphonium bromide (4.4 g) in tetrahydrofuran (20 ml) at 0-5C under nitrogen and the mixture then stirred at ambient temperature for 30 minutes. 3-Formylindole-5-carbonitrile (1.0 g) was added in portions over 5 minutes. The resulting mixture was stirred for 25 minutes, diluted with tetrahydrofuran (10 ml) and then heated under reflux for 2.5 hours. water (20 ml) followed by ethyl acetate (25 ml) were added to the cooled mixture and the layers were separated. The ethyl acetate layer was washed with water (2 x 30 ml) and then brine (30 ml), then dried (MgSO4) and the solvent removed in vacuo to give a residue which was analyzed by NMR for triphenylphosphine oxide content., 17380-18-6

As the paragraph descriping shows that 17380-18-6 is playing an increasingly important role.

Reference£º
Patent; BASF AKTIENGESELLSCHAFT; EP850902; (1998); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1075-35-0,5-Chloro-2-methylindole,as a common compound, the synthetic route is as follows.

A mixture of 5-chloro-2-methylindole (30.1 g; 0.18 mole) and 1-acetyl-imidazolidine-2-one (24 g; 0.18 mole) was added to phosphorous oxychloride (178 ml) and heated to 50 C. After 5 hours, phosphorous oxychloride was evaporated. The residue was treated with ethanol (250 ml) cautiously and maintained at reflux for 3.5 hours. The mixture was concentrated under reduced pressure to half of the orignal volume to obtain a precipitate, which was collected on a filter. The crystalline residue was treated with water, washed with ethylacetate, treated with 2N sodium hydroxide to pH 11 and stirred overnight. The precipitate was filtered, washed with water and t-butylmethylether and dried to give product (10.9 g, 26%), m.p. 213 C. [0467] 1H-NMR(DMSO): d 2.5 (s, 3H, CH-31), 3.55 (s, 4H, 2¡ÁCH-2), 6.30 (b, 1H, imidazolin), 7.04 (d, 1H 8.00 (s, 1H, H-4), 11.57 (b, 1H, NH-indol); MS (Ei 70 eV) m/Z 233M+., 1075-35-0

1075-35-0 5-Chloro-2-methylindole 70636, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Takeuchi, Kumiko; Jirousek, Michael Robert; Paal, Michael; Ruhter, Gerd; Schotten, Theo; US2004/9976; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles