Tag: M.W:100-200

474799-41-2, 6-Nitroindolin-2-one is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,474799-41-2

Triethylamine (3.91 rnL, 28.0 mmol) and Z4 (1.0 g, 5.61 mmol) are added successively to furan-2-carboxylic acid (1.32 g, 11.79 mmol) and TBTU (3.79 g, 11.79 mmol) in anhydrous DMF (5 mL) and the mixture is stirred for 24 h at RT. The reaction mixture is in poured into 1 N HCl: MeOH = 1 : 1, the precipitate is suction filtered and digested with iPrOH. Yield: 1.60 g (78 percent).Alternatively CH2Cl2 may be used as solvent. If no crystalline product is obtained, the reaction mixture is worked up by extraction and the residue is optionally chromatographed.

474799-41-2 6-Nitroindolin-2-one 17960994, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2008/152013; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

2380-86-1, 1H-Indol-6-ol is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To amixture of compound 10 (1.17 g, 8.78mmol) and Cs2CO3, (3.43 g, 10.54 mmol) in MeCN (30 mL)was added benzyl bromide (1.79 g, 10.54 mmol) and stirred at room temperature for6 h. After the reaction was completed, to the reaction mixture was added water,diluted and extracted with EtOAc. The combined organic extracts were washedwith water and brine, dried over anhydrous MgSO4, filtered, andconcentrated under reduced pressure. The residue was purified by silica gelcolumn chromatography (n-hexane:EtOAc = 2:1) to afford 1.41 g (6.32 mmol, 72percent) of the title compound 11 as gray solid; Rf= 0.34 (n-hexane : EtOAc = 2:1); 1H NMR (400MHz, CDCl3) delta 7.85 (NH, br s), 7.29-7.51 (6H, m), 6.96 (1H, d, J?= 2.0Hz), 6.81-6.88 (2H, m), 6.44 (1H, s), 5.03 (2H, s); 13C NMR (100MHz, CDCl3) delta 155.5, 137.5, 136.4, 128.6, 127.9, 127.6, 123.3, 122.4,121.3, 110.7, 102.4, 96.0, 70.7; IR (neat, cm-1) 3384,3030, 2859, 1625, 1455, 1091., 2380-86-1

The synthetic route of 2380-86-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gim, Hyo Jin; Li, Hua; Jeong, Ji Hye; Lee, Su Jeong; Sung, Mi-Kyung; Song, Mi-Young; Park, Byung-Hyun; Oh, Soo Jin; Ryu, Jae-Ha; Jeon, Raok; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3322 – 3336;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1075-35-0, 5-Chloro-2-methylindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 2-(3-pyrroline-1-yl) arylaldehydes 1 (0.5mmol, 1.0equiv), indoles 2 (0.55mmol, 1.1equiv) in ethylenechloride (5mL) was added diphenyl phosphite (0.1mmol, 0.1equiv). The mixture was stirred at ambient temperature overnight and the reaction was monitored by TLC. After completed, the reaction was concentrated under reduced pressure and purified by flash chromatography on silica gel (petroleum ether: ethyl acetate=20:1)., 1075-35-0

As the paragraph descriping shows that 1075-35-0 is playing an increasingly important role.

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Article; Lei, Xiantao; Xie, Hong-Yan; Chen, Si-Yuan; Teng, Kai-Shun; Wen, Xiaoan; Xu, Qing-Long; Sun, Hongbin; Tetrahedron; vol. 71; 24; (2015); p. 4098 – 4101;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

487-89-8, Indole-3-carboxaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 1.0 g of indole -3 – formaldehyde is dissolved in 15 ml in tetrahydrofuran, then the 0.5 g of […] add the above-mentioned solution, stirring at room temperature 5 h, then adding 1.5 g benzene sulfonyl chloride, continuing to stir 8 h. Thin-layer chromatographic monitoring. After the reaction, the reaction solution is added to quench the reaction, then ethyl acetate – extraction with water, dried with anhydrous sodium sulfate ethyl acetate, concentrated solution, to obtain 1.7 g solid compound II. Yield 86.5%., 487-89-8

As the paragraph descriping shows that 487-89-8 is playing an increasingly important role.

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Patent; Southern Medical University; Chen Jianjun; Li Gang; (11 pag.)CN109776528; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

194490-14-7, 5-Chloro-1H-indole-3-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

194490-14-7, To a solution of the suitable 3-cyanoindole 9 (7.03 mmol) inanhydrous DMF (10 mL) 3.61 mmol of K2CO3 and dimethyl carbonate(1.8 mL, 21.4 mmol) were added and the mixturewas heatedat 130 C for 3.5 h. After cooling (0e5 C),water and ice (25 mL)was slowly added under stirring. The oily suspension obtained wasextracted with diethyl ether (3 10 mL), the organic phase waswashed with water and brine, dried over Na2SO4 and the solventevaporated at reduced pressure to obtain the 3-cyano-1-methylindoles 10 in excellent yields. Analytical and spectroscopicdata are in accordance to those reported in literature [16].

The synthetic route of 194490-14-7 has been constantly updated, and we look forward to future research findings.

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Article; Bergonzini, Cecilia; Carbone, Daniela; Cascioferro, Stella; Cirrincione, Girolamo; Dekker, Henk; Diana, Patrizia; Funel, Niccola; Geerke, Daan; Giovannetti, Elisa; Mantini, Giulia; Parrino, Barbara; Peters, Godefridus J.; Petri, Giovanna Li; European Journal of Medicinal Chemistry; vol. 189; (2020);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35320-67-3,2-Methyl-1H-indol-4-ol,as a common compound, the synthetic route is as follows.

To a stirred solution of N-benzyl-2-chloro-5,6,7,8-tetrahydropyrido[2,3- d]pyrimidin-4-amine (150 mg, 0.548 mmol) in anhydrous dioxane (20 mL) were added 2-methyl-1H-indol-4-ol (80 mg, 0.55 mmol), Pd2(dba)3 (100 mg, 0.11 mmol), X-Phos (52 mg, 0.11 mmol) and Cs2CO3 (357 mg, 1.09 mmol). The reaction suspension was stirred at 100 oC for 2 hrs under N2. The inorganic salt and catalyst was removed via filtration. The filtrate was concentrated in vacuo. And the residue was purified via silica gel column (hexane/ethyl acetate) to afford 1-[4-(benzylamino)-5,6,7,8-tetrahydroquinazolin-2-yl]-2-methyl-indol-4- ol (120 mg, 51.3%) as yellow solid. LCMS (M+H+) m/z: Calcd: 385.20; Found: 385.2., 35320-67-3

As the paragraph descriping shows that 35320-67-3 is playing an increasingly important role.

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Patent; CLEAVE BIOSCIENCES, INC.; ZHOU, Han-Jie; WUSTROW, David; (498 pag.)WO2016/200840; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14430-23-0,5,6-Dimethoxyindole,as a common compound, the synthetic route is as follows.

Proceeding as in Example 2, Step (a), but replacing 5-chloro-1H-indole with 5,6-dimethyloxy-1H-indole, and then correspondingly as in Example 2, Steps (b) and (c), gave [2-(5,6-dimethyloxy-1H-indol-3-yl)-1,1-dimethylethyl]amine.

14430-23-0, As the paragraph descriping shows that 14430-23-0 is playing an increasingly important role.

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Patent; Syntex (U.S.A.) Inc.; US5436264; (1995); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

16136-52-0, 4-Cyanoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1H-indole-4-carbonitrile (6) (5g, 35.17mmol) in THF (100mL) was added NaH (1.3g, 52.75mmol) at 0C. The mixture was stirred for 5min and benzenesulfonyl chloride (6.5g, 42.21mmol) was then added. The reaction was allowed to room temperature and stirred for an additional 30min and then poured into a precooled saturated aqueous NH4Cl solution (300mL). The aqueous phase was separated and extracted with ethyl acetate (100mL¡Á3); the combined organic layers were washed with water (100mL) and brine (100mL), dried over Na2SO4, filtered and evaporated in vacuo. The residue was recrystallized (EtOAc) to give the 1-(phenylsulfonyl)-1H-indole-4-carbonitrile (7) (7.4g, yield 75%, purity 98%). MS (ESI) m/z 283.1 [M+H]+., 16136-52-0

The synthetic route of 16136-52-0 has been constantly updated, and we look forward to future research findings.

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Article; Wang, Xueyuan; Bai, Enhe; Zhou, Hui; Sha, Sijia; Miao, Hang; Qin, Yanru; Liu, Zhaogang; Wang, Jia; Zhang, Haoyang; Lei, Meng; Liu, Jia; Hai, Ou; Zhu, Yongqiang; Bioorganic and Medicinal Chemistry; vol. 27; 3; (2019); p. 533 – 544;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6146-52-7,5-Nitroindole,as a common compound, the synthetic route is as follows.,6146-52-7

General procedure: To a solution of indoles 1a-i (10mmol) in dry tetrahydrofuran (THF; 25mL), NaH (30mmol) was added. After the mixture was stirred 30min, CH3I (30mmol) in 5mL THF was added dropwise under 0C. The reaction mixture was stirred at room temperature for 12h in the dark. Then the reaction mixture was cooled to room temperature,diluted with 30mL saturated NH4Cl solution, and extracted with EtOAc (3¡Á30mL). The organic layer dried over anhydrous MgSO4 and concentrated in vacuo. The pure products 2a-i was obtained by column chromatography on silica gel (Petroleum ether/EtOAc=20:1) with yield of 90%-99%.

As the paragraph descriping shows that 6146-52-7 is playing an increasingly important role.

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Article; Xia, Qinqin; Bao, Xiaodong; Sun, Chuchu; Wu, Di; Rong, Xiaona; Liu, Zhiguo; Gu, Yugui; Zhou, Jianmin; Liang, Guang; European Journal of Medicinal Chemistry; vol. 160; (2018); p. 120 – 132;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

659737-57-2, 6-Hydroxyisoindolin-1-one is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

l,l’-(Azodicarbonyl)dipiperidine (252 mg, 1.0 mmol) was added to a solution of (+/-)-trans- fert-butyl 3-(hydroxymethyl)-4-(4-methoxyphenyl)pyrrolidine-l-carboxylate [(+/-)B6, 160 mg, 0.52 mmol], 6-hydroxyisoindolinone (82 mg, 0.55 mmol) and tributylphosphine (0.37 mL, 1.5 mmol) in anhydrous tetrahydrofuran (12 mL) at 0 C under nitrogen, after which the mixture was slowly warmed to room temperature, stirring for a total of 12 h. The mixture was treated with diethyl ether (60 mL) and the solids were removed by filtration under reduced pressure. The filtrate solvents were removed under reduced pressure and the residue was purified by flash column chromatography on silica gel, eluting with dichloromethane/methanol (9: 1), to afford (+/-)-trans-tert-bu y 4-(4-methoxyphenyl)-3-{[(3- oxoisoindolin-5-yl)oxy]methyl}pyrrolidine-l-carboxylate [(+/-)B8] as a white solid (110 mg, 48%): LCMS (M+H) 439., 659737-57-2

659737-57-2 6-Hydroxyisoindolin-1-one 11528364, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; TREVENA, INC.; CROMBIE SPEERSCHNEIDER, Aimee; YAMASHITA, Dennis SHINJI; PITIS, Philip Michael; HAWKINS, Michael John; LIU, Guodong; MISKOWSKI DAUBERT, Tamara Ann; YUAN, Catherine C.K.; BORBO KARGBO, Robert; HERR, Robert Jason; ROMERO, Donna; (125 pag.)WO2018/152293; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles