Tag: M.W:100-200

703-80-0, 3-Acetylindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

703-80-0, A solution of 0.80 g (5 mmol) of 3-acetylindole in 30 mL of dry THF was added and 0.4 g (2 eq) of NaH in an amount of 60% was added to the flask at 0 C. The mixture was stirred for 15 minutes and 1.3 mL (2 eq) CH3I, the reaction was gradually warmed to room temperature, the reaction 2 hours,TLC showed the disappearance of raw materials; 0 C slowly added ice water to quench the reaction, extracted 2-3 times with ethyl acetate, saturated sodium chloride solutionWashed once, dried over anhydrous sodium sulfate, and evaporated under reduced pressure to obtain 0.73g white solid1- (1-methyl-1H-indol-3-yl) ethanone,Yield: 92.0%.

As the paragraph descriping shows that 703-80-0 is playing an increasingly important role.

Reference£º
Patent; Hebei University of Science and Technology; Zhang Zhiwei; Li Hailing; Liu Shouxin; Dong Yu; Feng Juan; Li Junzhang; (20 pag.)CN106977515; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

113162-36-0, Methyl 4-fluoro-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To methyl 4-fluoro-1 h-indole-2-carboxylate (1.21 1 mmol, 234 mg) in N,N-dimethylformamide (10 ml) at 0 C was added sodium hydride (1.817 mmol, 72.7 mg). The reaction mixture was stirred for one hour at room temperature before iodomethane (1.817 mmol, 0.1 13 ml, 258 mg) was added. After stirring for three hours water was added and the product was extracted with dichloromethane and concentrated in vacuo to give methyl 4-fluoro-1 -methyl-1 H-indole-2-carboxylate (264 mg).

113162-36-0, As the paragraph descriping shows that 113162-36-0 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; MAN de,, Adrianus Petrus Antonius; REWINKEL,, Johannes Bernardus Maria; JANS,, Christiaan Gerardus Johannes Maria; RAAIJMAKERS,, Hans Cornelis Andreas; WIJKMANS,, Jacobus Cornelis Henricus Maria; WO2011/95556; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

52488-36-5, 4-Bromo-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,52488-36-5

To a solution of 4-bromo-1H-indole (LXX) (10 g, 50.8 mmol, 1 eq), DMAP (622 mg, 5.1 mmol, 0.1 eq) and TEA (10.6 ml, 76.1 mmol, 3 eq) in DCM (200 mL) was added Boc2O (14.4 mL, 61 mmol, 1.2 eq) at 0C. The reaction was warmed to room temperature and stirred for 2 h. Water (200 mL) was added and the mixture was extracted with DCM twice. The solvent was evaporated under vacuum to give tert-butyl 4-bromo-1H-indole-1-carboxylate (LXXI) as white solid (11.4 g, 38.5 mmol, 76% yield). 1H NMR (CDCI3, 400 MHz) delta ppm 1.68 (s, 9H), 6.64 (d, J=4Hz, 1H), 7.17 (t, J=8.4Hz, 1H), 7.39 (d, J=7.6Hz, 1H), 7.64 (d, J=3.2Hz, 1H), 8.11 (d, J=8.0Hz, 1H); ESIMS found for C13H14BrNO2 m/z 297.1 (M+H).

52488-36-5 4-Bromo-1H-indole 676494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; SAMUMED, LLC.; KC, Sunil, Kumar; WALLACE, David, Mark; CAO, Jianguo; CHIRUTA, Chandramouli; HOOD, John; (279 pag.)WO2017/23973; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

2338-71-8, 5-Fluoro-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The intermediate 1- (3,4,5-trimethoxyphenyl) propan-1-one (336 mg, 1.5 mmol)With 5-fluoro-1H-indole-3-carboxaldehyde (81.6mg, 0.5mmol) in ethanol (5mL) solution,Add piperidine (0.3mL) and stir at 95 C for 48h.The organic phase was spin-dried, and the remaining crude product was recrystallized from ethanol to obtain the target compound.(E) -3- (5-fluoro-1H-indol-3-yl) -2-methyl-1- (3,4,5-trimethoxyphenyl) prop-2-en-1-one94.1mg, yield 51%, 2338-71-8

As the paragraph descriping shows that 2338-71-8 is playing an increasingly important role.

Reference£º
Patent; Ningxia Medical University; Zhuang Chunlin; Shi Ying; Cong Hui; Zhang Wannian; Huang Jiaxuan; Yu Jianqiang; Xu Lijuan; Qu Zhuo; (21 pag.)CN110526854; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.387-43-9,4-Fluoroindole,as a common compound, the synthetic route is as follows.

Take 135 mg (1 mmol) of 4-fluoroindole, 132.6 mg (1.3 mmol) of 5-hydroxy-2-pentanone and 20.48 mg (0.04 mmol) of tris(pentafluorophenyl)boron in a 10 mL reaction tube. The reaction was stirred at 40 C, and monitored by TLC until hydrazine disappeared, extracted with 3¡Á20 mL ethyl acetate, and the organic phase was washed with saturated brine.The organic layer was dried over anhydrous sodium sulfate, and the solvent ethyl acetate was evaporated to dryness (methanol ethyl ether: 20:1) to afford 3-(tetrahydro-2-methyl-2-furanyl)-4-fluoro-1H-indole product 175 mg, yield: 80%.

387-43-9, As the paragraph descriping shows that 387-43-9 is playing an increasingly important role.

Reference£º
Patent; Huazhong University of Science and Technology; Wang Shijun; Xia Sang; Tang Xiangying; (18 pag.)CN109912579; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4771-48-6,4-Methyl-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

The intermediate 1- (3,4,5-trimethoxyphenyl) propan-1-one (448 mg, 2 mmol) was dissolved in a solution of piperidine (0.1 mL) in toluene (6 mL), and 4-methyl-1H-indole-3-carboxaldehyde (156.8mg, 0.8mmol), reacted at 130 C for 4h,The organic phase was spin-dried, and the remaining crude product was recrystallized from ethanol to obtain the target compound (E)-2-methyl-3-(4-methyl-1H-indol-3-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (1) 230mg,The yield was 51.3%.

4771-48-6, 4771-48-6 4-Methyl-1H-indole-3-carbaldehyde 2762437, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Ningxia Medical University; Zhuang Chunlin; Shi Ying; Cong Hui; Zhang Wannian; Huang Jiaxuan; Yu Jianqiang; Xu Lijuan; Qu Zhuo; (21 pag.)CN110526854; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.387-43-9,4-Fluoroindole,as a common compound, the synthetic route is as follows.

To a solution DMF (0.670 ml8.653 mmol) in dichloromethane (2.5 mL) cooled to -15 ¡ãC was added dropwise phosphorus oxychloride (0.400 mL; 4.291 mmol). After 15 min at -15 ¡ãC, a solution of 4-fluoro-1 /-/-indole (0.500 g; 3.700 mmol) in dichloromethane (2 mL) was added. The reaction mixture was allowed to warm to room temperature and was stirred at room temperature overnight. A saturated sodium bicarbonate solution was added and the reaction mixture was extracted with dichloromethane. The organic phase was dried over magnesium sulfate, filtered and concentrated under reduced pressure. Purification by flash chromatography on silica gel using ethyl acetate (50percent) in heptane as eluent furnished 0.144 g (24percent) of 4-fluoro- 1 H-indole-3-carbaldehyde as a beige solid. ESI/APCI(+): 164. ESI/APCI(-): 162 (M-H).

387-43-9, As the paragraph descriping shows that 387-43-9 is playing an increasingly important role.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee; CARLENS, Gunter; DALLMEIER, Kai; KAPTEIN, Suzanne; McNAUGHTON, Michael; MARCHAND, Arnaud; NEYTS, Johan; SMETS, Wim; WO2013/45516; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2338-71-8,5-Fluoro-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

Add III-6 (0.50g, 3.07mmol), DMAP (75mg, 0.61mmol), DIEA (1.52mL, 9.21mmol) to 100mL three-necked flask, stir and dissolve with 10mL acetonitrile, slowly add at 05C Benzene 4-trifluoromethylbenzenesulfonyl chloride (IV-7, 0.90 g, 3.68 mmol) in 10 mL of acetonitrile solution, after completion of the addition, stirring was continued for 2 h under low temperature conditions.TLC monitoring of raw material reactionsCompletely, concentrate the reaction solution, dissolve it with 20 mL of ethyl acetate, wash with 25 mL of water, and extract twice with ethyl acetate (15 mL¡Á2)The organic phase is washed with a saturated sodium chloride solution and dried over anhydrous sodium sulfate; suction filtered, and the filtrate is dried and then subjected to column chromatography ( petroleum ether:Ethyl acetate = 10:1 rinse),After drying, 0.91 g of khaki solid V-15 was obtained.The yield was 80.25%., 2338-71-8

As the paragraph descriping shows that 2338-71-8 is playing an increasingly important role.

Reference£º
Patent; China Pharmaceutical University; Xu Yungen; He Guangchao; Huang Qungang; Liang Tingting; Zhang Shan; Zhu Qihua; (35 pag.)CN109942545; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51417-51-7,7-Bromoindole,as a common compound, the synthetic route is as follows.

51417-51-7, General procedure: To a 10 mL flame-dried Schlenk tube equipped with a stirring bar, indole1 (0.2 mmol), alpha-amido-sulfone 2 (0.2 mmol), and K2S2O8 (108.1mg, 0.4 mmol) were added. Toluene (1.2 mL) was injected into thetube at r.t. After stirring for 48 h, the mixture was purified by silica gelchromatography to afford the desired product 3.

As the paragraph descriping shows that 51417-51-7 is playing an increasingly important role.

Reference£º
Article; Wu, Xiaoyan; Xue, Lu; Luo, Shilong; Jia, Shiqi; Ao, Jun; Qin, Wenling; Synthesis; vol. 49; 22; (2017); p. 5017 – 5024;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1074-86-8,1H-Indole-4-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: In a flame-dried Schlenk bottle under argon atmosphere, Grignard reagent B (10.2 mol) was added to the Schlenk bottle. Then, in an ice-water bath, a solution of 1H-indole-4-carbaldehyde A (10 mmol) in anhydrous THF (10 mL) was added to the Schlenk bottle. Subsequently, the reaction mixture was moved to an oil bath, which was refluxed at 70 o C overnight. After the completion of the reaction indicated by TLC, the reaction mixture was quenched by saturated ammonium chloride solution and was extracted by ethyl acetate for three times. The combined organic layer was dried by anhydrous sodium sulfate, which was concentrated under the reduced pressure. The resulted residue was purified through flash chromatography on silica gel to afford the pure 4-indolylmethanols 1.

1074-86-8, As the paragraph descriping shows that 1074-86-8 is playing an increasingly important role.

Reference£º
Article; Liu, Jin-Xi; Zhu, Zi-Qi; Yu, Lei; Du, Bai-Xiang; Mei, Guang-Jian; Shi, Feng; Synthesis; vol. 50; 17; (2018); p. 3436 – 3444;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles