Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.272-49-1,4-Azaindole,as a common compound, the synthetic route is as follows.

Intermediate 48: Synthesis of 3-(4-azetidin-l-ylcyclohex-l-en-l-yl)-li/-pyrrolo[3,2- b] pyridine1. Synthesis of 3-(l,4-dioxaspiro[4.51dec-7-en-8-yl)-lH-pyrrolo[3,2-blpyridine.Potassium hydroxide (41.0 mmol) was added to a mixture of 4-azaindole (13.5 mmol) and 1 ,4-cyclohexanedione monoethylene acetal (13.5 mmol) in methanol (30 mL) and the reaction mixture was heated at reflux for 4h. The reaction mixture was diluted with ice water(200 mL) and the precipitated solids were collected by filtration, washed with water, and air dried. The residue was purified by Flash chromatography (70/30 to 50/50 hexane/ethyl acetate) to provide 3-(l,4-dioxaspiro[4.5]dec-7-en-8-yl)-lH-pyrrolo[3,2-b]pyridine. Data: 1H NMR (CDCl3) 6 8.51 (dd, J= 4.7, 1.4, IH), 8.15 (br, IH), 7.63 (dd, J= 8.2, 1.4, IH), 7.36 (s, IH), 7.15(m, IH), 7.11 (dd, J = 8.2, 4.7, IH), 4.03 (s, 4H), 2.8-2.6 (m, 2H), 2.6-2.4 (m, 2H), 1.8-2.2 (m,2H).

272-49-1, 272-49-1 4-Azaindole 9226, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; SCHUMACHER, Richard, A.; TEHIM, Ashok; XIE, Wenge; WO2010/24980; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1912-33-0,Methyl 2-(1H-indol-3-yl)acetate,as a common compound, the synthetic route is as follows.

(2) in a 500 ml round bottom flask methyl indole acetic acid is added in 9.46g (48mmol), ethylene glycol monomethyl ether (40 ml), 5 ml of hydrazine hydrate, 115 ¡ãC heating reflux reaction about 20 hours, thin layer chromatography (TLC) detecting raw material point dematerialised, stop the reaction, cooling to room temperature, adding water (50 ml), static separating white solid, filtering to get the crude product, using ethanol is recrystallized to get indole acetic acid hydrazide white solid 9.2 g.

1912-33-0, As the paragraph descriping shows that 1912-33-0 is playing an increasingly important role.

Reference£º
Patent; Kunming University of Science and Technology; Yunnan University; Xia, Xueshan; He, Yanping; Feng, Yue; Fan, Mengran; Gao, Fengpin; Zhang, Yufang; Li, Cong; (21 pag.)CN105732468; (2016); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128562-95-8,4-(Trifluoromethyl)-1H-indole,as a common compound, the synthetic route is as follows.

A. 1 -(2-Methoxy-ethyl)-4-trifluoromethyl-1 H-indole A mixture of 4-trifluoromethyl-1 H-indole (105 mg, 0.57 mmol), powder KOH (159 mg, 2.83 mmol) in DMSO (6 mL) is stirred at r.t. for 5 min. 2-Methoxyethyl bromide (80 muIota_, 0.85 mmol) is added. After the reaction mixture is stirred at r.t. overnight, it is partitioned between H2O and Et2O. The two layers are separated, and the aqueous layer is extracted with Et2O (3x). The combined organic extracts are washed with H2O and brine, dried over MgSO , filtered, and concentrated in vacuo. The crude material is purified on silica gel with heptane/EtOAc (100/0 to 70/30) as eluent to yield the product (100 mg, 72%) as a clear colorless liquid.1 H NMR (300 MHz, CDCI3) delta 7.53 (d, J = 8.2 Hz, 1 H), 7.40 (d, J = 7.3 Hz, 1 H), 7.35- 7.20 (m, 2H), 6.69 (s, 1 H), 4.32 (t, J = 5.4 Hz, 2H), 3.71 (t, J = 5.4 Hz, 2H), 3.31 (s, 3H);19F NMR (300 MHz, CDCI3) delta -60.99 (s, 3F);LC Rt: 3.21 min; MS 244 (M+H, 100%)., 128562-95-8

128562-95-8 4-(Trifluoromethyl)-1H-indole 19803703, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; SANOFI; CHOI-SLEDESKI, Yong Mi; LIANG, Guyan; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng; WO2011/79102; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

15861-24-2, Indole-5-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,15861-24-2

Compound 1 (142.2g, 1.0mol) was dissolved in dichloromethane (1.5L), the internal temperature was controlled at 0-5 C, and anhydrous zinc chloride (150g, 1.1mol) was added.After the addition was completed, the temperature was lowered to about -10 C, and 1-bromo-4-chlorobutane (Compound 3) (188.6g, 1.1mol) was added dropwise.After the dropwise addition was completed, the temperature was raised to a reaction temperature of 0 C and the reaction was conducted for 2 hours.After the reaction was completed, dichloromethane (0.5 L) was diluted, and ice water (1 L) was destroyed. Subsequently, 1 N sodium hydroxide solution was added to neutralize to adjust pH = 7, and extraction and liquid separation were performed.The organic phase was washed with saturated brine (0.5 L) and separated.After the organic phase was concentrated to dryness, the residue was recrystallized from isopropyl acetate (0.5 L),205 g of the product (I) was obtained, the yield was 88%, and the HPLC purity was 99.62%.

As the paragraph descriping shows that 15861-24-2 is playing an increasingly important role.

Reference£º
Patent; Shanghai Institute of Technology; Fang Yahui; Li Huixia; (6 pag.)CN111087340; (2020); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1670-83-3, Indole-7-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 23; Preparation of 1H-Indole-7-carboxylic acid (4-tert-butyl-benzyl)-phenethyl-amide; To a solution of 48 mg (0.3 mmol) of 1H-indole-7-carboxylic acid and 96 mg of TBTU (0.3 mmol) in 4 ml DMF, were added 0.26 ml (1.5 mmol) of N,N-diisopropylethyl amine. After stirring for 5 min at rt, 80 mg (0.3 mmol) of (4-tert-butyl-benzyl)-phenethyl-amine in 1 ml DMF were added. After stirring for 5 h at rt, the reaction mixture was diluted with 50 ml water and extracted with 2¡Á50 ml EtOAc. The combined organic phases were washed with water and brine, dried with magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (8 g silica gel; EtOAc/heptane 1:6) to give 100 mg white solid (80%). MS (ISP) 411.5 (M+H)+.

1670-83-3, The synthetic route of 1670-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Conte-Mayweg, Aurelia; Kuehne, Holger; Luebbers, Thomas; Maugeais, Cyrille; Mueller, Werner; Pflieger, Philippe; US2006/30613; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

52562-50-2, 5-Methyl-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

52562-50-2, General procedure: A mixture of 1 (20 mmol) and 2 (10 mmol) and water (5 ml) was refluxed at 100 C1 h. At the end of this period, an orange-colored solid was separated from the reaction mixture which was collected by filtration. The isolated solid was washed with hot water (10 ml 9 3), dried, and recrystallized from ethanol to obtain pure 4.

52562-50-2 5-Methyl-1H-indole-3-carbaldehyde 259187, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Madhu, Bandi; Raja sekar; Venkata Ramana Reddy; Dubey; Research on Chemical Intermediates; vol. 43; 12; (2017); p. 6993 – 7012;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288385-88-6,4-Fluoro-5-hydroxy-2-methylindole,as a common compound, the synthetic route is as follows.

The above product was mixed with DMAP (1.5 eq), 2-methyl-4-fluoro-5-hydroxyindole (WO0047212) (1 eq) in dioxane (20 ml). The reaction was refluxed for three days and diluted with EtOAc, water and extracted with EtOAc three times. The combined organic layer was washed with water, brine and dried. The solution was evaporated and purified with silica gel column to give the titled product (300 mg). Mass: (M+1), 451

288385-88-6, The synthetic route of 288385-88-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Advenchen Laboratories, LLC; US2008/227811; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6960-42-5,7-Nitro-1H-indole,as a common compound, the synthetic route is as follows.,6960-42-5

General procedure: Phthaldialdehyde (1 mmol) was dissolved in glacial acetic acid (15 mL). Then, the corresponding indole (2 mmol) was added to the solution. The mixture was stirred under reflux conditions at 100 C until all of the starting phthaldialdehyde had disappeared, according to TLC-monitoring in CH2Cl2 (100%). The reaction time varied from 2 to 12 h. The reaction mixture was worked up by a dropwise neutralizing of the acid with NaOH (10%) until a pH of 7 was reached, followed extraction with CH2Cl2 (50 mL) for three times. The organic layer was washed with water and brine each for three times.Then it was dried over sodium sulphate, filtered and concentrated in vacuum. The reaction products were given after column chromatography using silica gel and ethyl acetate/cyclohexane mixtures as eluent. The resulting fractions (each 10 mL) were analyzed by TLC to identify the compound containing fractions which were unified and evaporated to dryness to give the target compounds. 11-(1H-Indol-3-yl)-5H-benzo[b]carbazole (3a).

6960-42-5 7-Nitro-1H-indole 23396, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Ashraf, Kerolos; Yasrebi, Kaveh; Hertlein, Tobias; Ohlsen, Knut; Lalk, Michael; Hilgeroth, Andreas; Molecules; vol. 22; 12; (2017);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.398487-76-8,4-Fluoro-2-methyl-1H-indol-5-amine,as a common compound, the synthetic route is as follows.

Step 12f: Ethyl 7-(7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-ylamino)quinazolin-6-yloxy)-heptanoate (compound 601-20) The title compound 601-20 (100 mg, 52%) was prepared as a dark solid from compound 507-20 (150 mg, 0.34 mmol) and 402 (67 mg, 0.41 mmol) using a procedure similar to that described for compound 601-18 (Example 10): LCMS: 571 [M+1]+; 1H NMR (DMSO-d6): delta 11.22 (s, 1H), 9.33 (s, 1H), 8.20 (s, 1H), 7.84 (s, 1H), 7.50 (d, J=8.4 Hz, 2H), 7.43-7.32 (m, 3H), 7.21 (s, 1H), 7.10 (d, J=8.4 Hz, 1H), 6.97 (t, J=8.4 Hz, 1H), 6.19 (s, 1H), 5.29 (s, 2H), 4.11 (t, J=8.7 Hz, 2H), 4.00 (q, J=6.00 Hz, 2H), 2.38 (s, 3H), 2.26 (t, J=7.5 Hz, 2H), 1.82-1.76 (m, 2H), 1.57-1.35 (m, 6H), 1.14 (t, J=7.5 Hz, 3H)., 398487-76-8

The synthetic route of 398487-76-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qian, Changgeng; Cai, Xiong; Zhai, Haixiao; US2009/76044; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.387-44-0,7-Fluoroindole,as a common compound, the synthetic route is as follows.

EXAMPLE 18 7-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole Beginning with 2.0 gm (14.8 mMol) 7-fluoro-1H-indole and 4.6 gm (30.0 mMol) 4-piperidone hydrochloride monohydrate, 2.1 gm (66%) of the title compound were recovered as a white solid. m.p.=186-188 C. MS(FD): m/e=216 (M+) EA: Calculated for: C13 H13 N2 F: Theory: C, 72.20; H, 6.06; N, 12.95. Found: C, 72.41; H, 6.24; N, 13.09.

387-44-0, The synthetic route of 387-44-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eli Lilly and Company; US5846982; (1998); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles