Tag: M.W:100-200

6960-42-5, 7-Nitro-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6960-42-5, General procedure: A 50 mL round-bottomed flask equipped with a magnetic stirringbar was charged with the appropriate indole 1 (0.5 mmol,1.0 equiv), 37% aq HCHO (0.5 mmol, 0.0406 g, 1.0 equiv), 25% aqNH3 (1.0 mmol, 0.0681 g, 2.0 equiv), FeCl3 (0.01 mmol, 0.0016 g,2 mol%), and DMF (2 mL). The flask was fitted with a reflux condenser,and the mixture was stirred at 130 C under open air.When the reaction was complete (TLC), the mixture was cooledto r.t., diluted with sat. aq NaCl (10 mL) and 0.5 M aq HCl (2 mL),and extracted with EtOAc (3 x 7 mL). The organic layers werecombined, washed with sat. aq NaHCO3 (10 mL) and sat. aq NaCl(10 mL), dried (Na2SO4), and concentrated under reduced pressure.The residue was purified by flash column chromatography(silica gel, hexane-EtOAc).

6960-42-5 7-Nitro-1H-indole 23396, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Qing-Dong; Zhou, Bin; Yang, Jin-Ming; Fang, Dong; Ren, Jiangmeng; Zeng, Bu-Bing; Synlett; vol. 28; 19; (2017); p. 2670 – 2674;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14805-29-9,exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione,as a common compound, the synthetic route is as follows.

A mixture of bicyclo[2.2.1]heptane-2,3-di-exo-carboximide (prepared as described in Chem. Pharm. Bull., 1991 p 2288; 1.0 g, 6.05 mmol), ethyl chloroacetate (1.3 mL, 12.1 mmol), TBAB (39 mg, 0.12 mmol) and potassium carbonate (1.17 g, 8.48 mmol) were irradiated in microwawe for 10 min at 150 C. (150 W). The mixture was then diluted with water and EtOAc. Organic phase was separated, and aqueous phase was extracted with EtOAc (3¡Á15 mL). Combined organic phases were washed with brine (1¡Á15 mL), dried over Na2SO4, filtered and concentrated to afford the title compound as a brown oil (1.74 g, 114%)., 14805-29-9

As the paragraph descriping shows that 14805-29-9 is playing an increasingly important role.

Reference£º
Patent; Merck Patent GmbH; JORAND-LEBRUN, Catherine; JOHNSON, Theresa L.; GRAEDLER, Ulrich; JIANG, Xuliang; KULKARNI, Santosh; (23 pag.)US2017/283427; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

244-69-9, 5H-Pyrido[4,3-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of 4 mmol carboline (12 or 14) and 4.4 mmol of NaH in DMF was stirred at room temperature for 30 min. After addition of 4.4 mmol of corresponding alkyl halide the solution was stirred for another 4-16 h. The conversion was monitored by TLC and GC/MS. When no further reaction was observed the solution was poured into iced water extracted with dichloromethane and purified by column chromatography and was subsequently converted into its HCl salt in 2-propanol with ethereal HCl., 244-69-9

Big data shows that 244-69-9 is playing an increasingly important role.

Reference£º
Article; Otto, Robert; Penzis, Robert; Gaube, Friedemann; Winckler, Thomas; Appenroth, Dorothea; Fleck, Christian; Traenkle, Christian; Lehmann, Jochen; Enzensperger, Christoph; European Journal of Medicinal Chemistry; vol. 87; (2014); p. 63 – 70;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169674-02-6,4-Chloro-5-fluoro-1H-indole,as a common compound, the synthetic route is as follows.

4-chloro-5-fluoro-1 H-pyrrolo[2,3-b]pyridine (500 mg, 2.931 mmol) in dioxane (12 ml.) was warmed to 40 C until a solution resulted. 4M HCI in dioxane solution (800 muIota_, 3.224 mmol) was added dropwise. The reaction mixture was cooled to room temperature and filtered. The solid was washed with diethyl ether and dried. It was then suspended in acetonitrile (10 ml.) and treated with sodium iodide (2.63 g, 17.55 mmol). The reaction mixture was heated at 80 C overnight. After cooling to room temperature, reaction mixture was treated with 1 N sodium hydroxide solution until it was basic. It was then extracted with ethyl acetate and washed with water. The combined organic layers were washed with saturated aqueous sodium chloride solution, dried, filtered and concentrated under reduced pressure to afford 5-fluoro-4-iodo-1 H-indole., 169674-02-6

169674-02-6 4-Chloro-5-fluoro-1H-indole 11607987, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; GILEAD SCIENCES, INC.; DU, Zhimin; GUERRERO, Juan, Arnaldo; KAPLAN, Joshua, Aaron; KNOX, JR., John Edward; NADUTHAMBI, Devan; PHILLIPS, Barton, W.; VENKATARAMANI, Chandrasekar; WANG, Peiyuan; WATKINS, William, J.; ZABLOCKI, Jeff; WO2015/187684; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120-72-9,1H-Indole,as a common compound, the synthetic route is as follows.

Dimethylsulfoxide (2 mL) was added to a 25 mL pressure-resistant reaction tube, indole (35.1 mg, 0.3 mmol), ethyl trifluoropyruvate(102.0 mg, 0.6 mmol), Cuprous chloride (44.78 mg, 1.5 eq.), The reaction was magnetically stirred in an 80 C oil bath for 12 hours. After the reaction was completed, most of the solvent was distilled off under reduced pressure, and the remaining mixture was purified by column chromatography on petroleum ether / ethyl acetate (10: 1) as eluent to obtain the desired product, As a pale yellow solid, 35.8 mg, yield 56%, 120-72-9

The synthetic route of 120-72-9 has been constantly updated, and we look forward to future research findings.

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Patent; Lishui College; Yan Guobing; Huang Dayun; He Ping; Cao Xihan; Zheng Wanbin; Ke Qiumin; Shen Xuqian; (5 pag.)CN106946758; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.703-80-0,3-Acetylindole,as a common compound, the synthetic route is as follows.

703-80-0, To a solution of 3-acetylindole 8a (1.0 g, 6.3 mmol) in THF (5.0 mL) sodium hydride (60% dispersion in mineral oil, 0.3 g, 6.3 mmol) was added at 0 C and the mixture was stirred at room temperature for 1 h. p-toluenesulfonyl chloride (1.2 g, 6.3 mmol) was added and the mixture was stirred at room temperature for 24 h. The residue was evaporated under reduced pressure, treated with water (20 mL) and extracted with EtOAc (3 ¡Á 20 mL). The organic phase was dried (Na2SO4), evaporated under reduced pressure and purified by column chromatography using DCM as eluent. White solid; yield: 90%; mp: 148-149 C; IR 1662 (CO), 1382, 1299 (SO2) cm-1; 1H NMR (200 MHz, DMSO-d6) delta: 2.33 (s, 3H, CH3), 2.60 (s, 3H, CH3), 7.32-7.39 (m, 2H, H-5, H-6), 7.43 (d, 2H, J = 7.8 Hz, H-3?, H-5?), 7.95 (d, 1H, J = 7.5 Hz, H-7), 8.04 (d, 2H, J = 7.8 Hz, H-2?, H-6?), 8.19 (d, 1H, J = 7.5 Hz, H-4), 8.81 (s, 1H, H-2); 13C NMR (50 MHz, DMSO-d6) delta:21.0 (q), 27.8 (q), 113.0 (d), 120.7 (s), 122.3 (d), 124.8 (d), 125.6 (d), 127.0 (s), 127.2 (2xd), 130.5 (2xd), 133.5 (s), 134.0 (s), 134.2 (d), 146.2 (s), 193.9 (s). Anal. Calcd for: C17H15NO3S: C, 65.16; H, 4.82; N, 4.47. Found: C, 65.28, H, 5.06, N, 4.37.

703-80-0 3-Acetylindole 12802, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Parrino, Barbara; Carbone, Anna; Di Vita, Gloria; Ciancimino, Cristina; Attanzio, Alessandro; Spano, Virginia; Montalbano, Alessandra; Barraja, Paola; Tesoriere, Luisa; Livrea, Maria Antonia; Diana, Patrizia; Cirrincione, Girolamo; Marine Drugs; vol. 13; 4; (2015); p. 1901 – 1924;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1196-69-6,Indole-5-carboxaldehyde,as a common compound, the synthetic route is as follows.

To a solution of indole-3-carboxaldehyde (16, 28.5 g, 100 mmol) in ethanol (500 mL) at room temperature was added potassium hydroxide (6.2 g, 110 mmol); the mixture was stirred until total solubilization. The ethanol was completely removed in a vacuum and acetone (250 mL) was added followed by benzenesulfonyl chloride (19.4 g, 110 mmol). The precipitate was filtered off, and the filtrate was concentrated and recrystallized from methanol to give a white solid. Yield: 40%., 1196-69-6

As the paragraph descriping shows that 1196-69-6 is playing an increasingly important role.

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Article; Chen, Jianjun; Li, Chien-Ming; Wang, Jin; Ahn, Sunjoo; Wang, Zhao; Lu, Yan; Dalton, James T.; Miller, Duane D.; Li, Wei; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4782 – 4795;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

244-76-8, 9H-Pyrido[2,3-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A round bottom flask was charged with 9H-pyrido [2,3-b] indole (3.5 g, 21 mmol)1-bromo-4-iodobenzene (8.83 g, 31 mmol), copper (I) iodide (0.8 g, 4.2 mmol),(¡À) -trans-1,2-diaminocyclohexane (0.48 g, 4.2 mmol),Potassium phosphate tribasic (8.9 g, 42 mmol) was added and dissolved in 160 ml of toluene.Was refluxed and stirred for 24 hours. Thin layer chromatography (TLC) andAfter confirming by HPLC, the reaction was terminated. After filtration, the column (MC: Hex = 1: 4)To obtain a solid compound (5.19 g, yield = 75%)., 244-76-8

The synthetic route of 244-76-8 has been constantly updated, and we look forward to future research findings.

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Patent; LG Display Co., Ltd.; Choi Hye-ok; Lee Seung-jae; Pin Jong-gwan; Seo Bo-min; (39 pag.)KR2018/44695; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169674-01-5,5,6-Difluoroindole,as a common compound, the synthetic route is as follows.

23a) 5,6-Difluoro-1H-indole-3-carbaldehyde Phosphoryl cloride (22.03 g, 143.67 mmol) was added drop wise to an ice-cold N,N-dimethylformamide (DMF) (19.10 g, 261.22 mmol) and the mixture was stirred for 0.5 h at 0-5 C and for 1 h at room temperature. Then the mixture was cooled to 0-5 C and a solution of 5,6-difluoro-1H-indole (20.00 g, 130.61 mmol) in DMF (20 g) was added drop wise. The resulting mixture was stirred for 0.5 h at 0-5 C and for 15 h at room temperature. The mixture was poured onto chopped ice (200 g) and alkalinized with NaOH to pH=10. The crystalline product was filtered off, washed with water and dried to provide the title comound (22.72 g, 96.01 %).

169674-01-5, The synthetic route of 169674-01-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer Schering Pharma Aktiengesellschaft; EP1932831; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1953-54-4, 5-Hydroxyindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Benzylbromide (2.0 mL, 16.8 mmol) and K2CO3 (3.1 g, 22.5 mmol) were added to a solution of 5-hydroxyindole 1 (2.0 g, 15.0 mmol) in DMF (10 mL) and the mixture was stirred and heated at reflux. After 24 h, the mixture was cooled to r.t. and the reaction was quenched with 10% aq HCl. The mixture was extracted with EtOAc (3 50 mL), MgSO4. The solvent was removed and the residue was purified by silica gel column chromatography (EtOAc/hexane, 1:6) to give 2. Yield: 3 g (91%); colorless solid; mp 97-100 C (CHCl3). IR (CHCl3): 3483, 1626, 1581, 1477, 1452, 1281, 1153 cm-1. 1H NMR (500 MHz, CDCl3): delta = 8.03 (br. s, 1H), 7.52 (d, J = 7.5 Hz, 2 H), 7.43 (t, J = 7.5 Hz, 2 H), 7.36 (t, J = 7.5 Hz, 1H), 7.27 (d, J = 8.6 Hz, 1H), 7.24 (d, J = 2.3 Hz, 1H), 7.15 (t, J = 2.8 Hz, 1H), 6.99 (dd, J = 8.6, 2.3 Hz, 1H), 6.51 (t, J = 2.3 Hz, 1H), 5.15 (s, 2 H). 13C NMR (125 MHz, CDCl3): delta = 153.5, 137.8, 131.3, 128.7, 128.4, 127.9, 127.7, 125.1, 113.2, 111.9, 104.1, 102.5, 71.1. HRMS (EI): m/z [M+] calcd for C15H13NO: 223.0997; found: 223.1028., 1953-54-4

1953-54-4 5-Hydroxyindole 16054, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Abe, Takumi; Haruyama, Tomohiro; Yamada, Koji; Synthesis; vol. 49; 18; (2017); p. 4141 – 4150;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles