Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16502-01-5,2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole,as a common compound, the synthetic route is as follows.

To a stirred solution of tryptoline (2,3,4,9-tetrahydro-1 /-/-pyrido[4,3-b]indole) (150 g, 0.871 mol) in THF (1 .5 L) at 0 C, triethylamine (243 ml_, 1 .74 mol) and di-ferf-butyl dicarbonate (228 g, 1.04 mol) were added and the reaction mixture was stirred at 25 C for 12 h. After the completion of the reaction (monitored by TLC), water was added to the reaction mixture under ice-cooling and extracted with ethyl acetate (2 x 500 ml_). The combined organic extracts were washed with brine (1 x 250 ml_), dried over anhydrous Na2S04,filtered and evaporated under reduced pressure to get the crude product. The crude material was stirred with diethyl ether (200 mL) and the solid thus obtained was filtered, washed with diethyl ether (2 x 100 mL) and dried to afford the title compound as brown solid (200 g, 84 %).1H-NMR (400 MHz, CDCI3) d = 7.94 (br-s, 1 H), 7.51 (d, J = 7.60 Hz, 1 H), 7.33-7.34 (m, 1 H), 7.1 1 -7.13 (m, 2H), 4.67 (s, 2H), 3.79 (br-s, 2H), 2.83 (br-s, 2H), 1.53 (s, 9H).MS: 273.2 (M+H)+., 16502-01-5

16502-01-5 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole 107838, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (0 pag.)WO2019/233883; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4769-96-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4769-96-4,6-Nitro-1H-indole,as a common compound, the synthetic route is as follows.

To a solution of 6-nitro indole (1 eq.) in a mixture of acetic acid(0.15 M) and hydrochloric acid (0.6 M), SnCl2 (10 eq.) was added.The reaction mixture proceeded and 1H NMR was recorded, aspreviously reported

4769-96-4 6-Nitro-1H-indole 78502, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Hendy, Moataz S.; Ali, Aya A.; Ahmed, Lubna; Hossam, Reham; Mostafa, Alaa; Elmazar, Mohamed M.; Naguib, Bassem H.; Attia, Yasmeen M.; Ahmed, Mahmoud Salama; European Journal of Medicinal Chemistry; vol. 166; (2019); p. 281 – 290;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.387-43-9,4-Fluoroindole,as a common compound, the synthetic route is as follows.

To a solution of 4-fluoro-lH-indole (150 g, l . l lmol) and DMAP (4.5 g, 3percentWt) in THF (2.5 L) was added (Boc)20 (255 g, 1.16 mol) dropwise. The mixture was stirred at room temperature overnight. The organic solvent was removed in vacuum, and the residue was purified by column chromatography (PE) to give tert-butyl 4-fluoro-lH-indole-l-carboxylate (250 g, yield: 96percent). 1H- MR (CDC13, 400 MHz) delta 7.92 (d, J= 8.4 Hz, 1H), 7.55 (d, J= 3.6 Hz, 1H), 7.23 (m, 1H), 6.90 (m, 1H), 6.66 (d, J = 3.6 Hz, 1H), 1.67 (s, 9H). MS (M+H)+: 236.

387-43-9, 387-43-9 4-Fluoroindole 2774502, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; HE, Shuwen; DAI, Xing; PALANI, Anandan; NARGUND, Ravi; LAI, Zhong; ZORN, Nicolas; XIAO, Dong; DANG, Qun; LI, Peng; PENG, Xuanjia; SOLL, Richard; WO2014/121418; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5457-28-3,1H-Indole-3-carbonitrile,as a common compound, the synthetic route is as follows.

To a 1 L four-neck flask were added dioxane (200 mL), THF (100 mL) and 3- cyanoindole (30 g, 211 mmol). The solution was cooled to 0 oC and LiAlH4 (30 g, 780 mmol) was added portion-wise. After stirring at 0 oC for 10 minutes, the mixture was heated to reflux for 0.5 h until TLC showed completion. The mixture was carefully quenched with water (300 mL) at 0 oC, filtered, and the filtrate was separated. The aqueous layer was extracted with EA (500 mL x 2). The combined organic layers were dried over sodium sulfate, concentrated and washed with PE/EA to give 3-aminomethylindole (21 g, 70percent) as a brick red solid. (2137) 1H NMR (300 MHz, DMSO-d6) 10.80 (br, 1 H), 7.59 (d, J = 7.5 Hz, 1 H), 7.34 (d, J = 8.1 Hz, 1 H), 7.20 (s, 1 H), 7.09- 7.04 (m, 1 H), 6.99- 6.94 (m, 1 H), 3.87 (s, 2 H)., 5457-28-3

5457-28-3 1H-Indole-3-carbonitrile 230282, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; CS PHARMASCIENCES, INC.; SONG, Yuntao; BRDIGES, Alexander, James; (524 pag.)WO2017/120429; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1912-33-0, Methyl 2-(1H-indol-3-yl)acetate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methyl indole-3-acetate (2.00 g, 10.57 mmol) was dissolved in dichloromethane (30 ml). To this solution, tetrabutylammonium iodide (TBAI, 30.0 mg, 0.081 mmol) and a 30% aqueous sodium hydroxide solution (24 ml) were added, and the mixture was cooled to 0 C. To the reaction solution, methyl formate chloride (1.96 g, 20.73 mmol) was added, and the mixture was stirred at 0 C. for 2 hours. After the reaction was confirmed by TLC to be complete, the reaction was terminated by the addition of 6 N hydrochloric acid. Water (50 ml) was added thereto, followed by extraction with chloroform (50 ml) three times. The organic layer was washed twice with saturated saline and dehydrated over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and then, the residue was purified using silica gel column chromatography (hexane:ethyl acetate=8:2) to obtain methyl N-methoxycarbonylindole-3-acetate (2.26 g, yield: 87%): 1H NMR (400 MHz, CDCl3): delta 8.18 (d, J=7.0 Hz, 1H), 7.59 (s, 1H), 7.53 (d, J=7.7 Hz, 1H), 7.35 (t, J=7.5 Hz, 1H), 7.27 (t, J=7.4 Hz, 1H), 4.00 (s, 3H), 3.72 (s, 3H), 3.71 (s, 2H); 13C NMR (100 MHz, CDCl3): delta 171.1, 151.1, 135.2, 129.9, 124.6, 123.8, 122.8, 118.9, 115.0, 113.8, 53.5, 51.9, 30.6; IR (neat): 1746, 1455, 1382, 1258, 1164, 1089, 1018 cm-1; EI-MS: m/z 247 [M]+., 1912-33-0

As the paragraph descriping shows that 1912-33-0 is playing an increasingly important role.

Reference£º
Patent; Tohoku University; Kake Educational Institution; Abe, Takaaki; Katori, Yukio; Honkura, Yohei; Nanto, Fumika; Hayashi, Kenichiro; (77 pag.)US2019/224165; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52488-36-5,4-Bromo-1H-indole,as a common compound, the synthetic route is as follows.

Under a nitrogen atmosphere, cuprous iodide (3.0 mol%, 0.7 mg), sodium iodide (1.0 equiv., 18.7 mg) and magnets were added to a previously baked 10 mL glass pressure tube. Dioxane (0.2 mL), 4-bromoindole (0.125 mmol, 1.0 equiv., 24.5 mg) and N,N’-dimethylethylenediamine (10.0 mol%, 1.1 mg) were then added. After the addition, the glass pressure tube was placed in a metal module that had been preheated to 100 C. and stirred for 10 hours. Cooled to room temperature, cuprous oxide was added under a nitrogen atmosphere (20mol%, 3.6mg), nine carbonyl iron (3mol%, 1.4mg), N- methylpyrrolidinone (0.5mL) and phenyl silane (3.0equiv., 40.6 Mg). The tube was purged of air and charged with carbon dioxide (5.0 equiv., 15 mL) and ammonia gas (5.0 equiv., 15 mL). After the addition was completed, the reactor was placed in a metal module preheated to 160C and stirred for 10 hours. After the reaction was completed, the reaction system was cooled to room temperature and pressure was slowly released. Use of dodecane as an internal standard through gas chromatography The working curve determines that the yield is 84%., 52488-36-5

52488-36-5 4-Bromo-1H-indole 676494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute Suzhou Institute; Li Yuehui; Wang Hua; Dong Yanan; Ke Lisitian¡¤shanduofu; (20 pag.)CN108017557; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1953-54-4, 5-Hydroxyindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 5 g (37.55 mmol) of 5-hydroxy-indole, 6.13 g (39.4 mmol) of tert-butyldimethylsilyl chloride and 5.37 g (68.1 mmol) of imidazole in 50 ml DMF was stirred for 20 h at RT. The reaction mixture was taken up in ether, washed with 1N HCl and water and the ether solution was then concentrated under reduced pressure, to give 9.4 g (quant.) of clean 5-(tert-butyl-dimethyl-silanyloxy)-1H-indole. MS: 248.1 (M+H)+.

1953-54-4, 1953-54-4 5-Hydroxyindole 16054, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Ackermann, Jean; Aebi, Johannes; Binggeli, Alfred; Grether, Uwe; Hirth, Georges; Kuhn, Bernd; Maerki, Hans-Peter; Meyer, Markus; Mohr, Peter; Wright, Matthew Blake; US2005/96353; (2005); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

387-44-0, 7-Fluoroindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Quinoline moiety – General Procedure Q In microwave vessel, quinoline (2.oeq) and indole (i.oeq) were mixed together and the system was sealed and placed under nitrogen, after a purge with vacuum/N2 (3 times). Then, HC1 solution 4 M in 1,4-dioxane (i.2eq) was added with the needle immersed in the mixture (exothermic reaction). The reaction mixture was heated with microwave during 2 h at 160 C. The reaction mixture was taken up with a minimum of MeOH and when the residue was dissolved, it was transferred in mixture of AcOEt and saturated NaHC03 solution. The resulting solution was extracted and the aqueous phase was washed with AcOEt (x2). The organic layers were combined, washed with o.oi M critic acid solution, saturated NaHC03 solution, dried over Na2S04 and concentrated to dryness under reduced pressure. Finally, the crude was purified by automated combi-flash to afford the good compound., 387-44-0

387-44-0 7-Fluoroindole 2774504, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; THE UNIVERSITY OF BRITISH COLUMBIA; SIMON FRASER UNIVERSITY; RENNIE, Paul; TCHERKASSOV, Artem; YOUNG, Robert, N.; ANDRE, Christophe, M.; WO2015/154169; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1202-04-6,Methyl 1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

Add 0.063 g (0.5 mmol) of 2-indolecarboxylic acid methyl ester to the reaction flask.Diphenylphosphine oxide 0.202 g (1 mmol),0.013 g (0.05 mmol) of silver carbonate,4 A molecular sieve 0.2 g,Magnesium nitrate 0.148 g (1 mmol) and 30 ml ethanol,60 C reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography ( petroleum ether: ethyl acetate = 4:1).The target product was obtained (yield 95%), 1202-04-6

As the paragraph descriping shows that 1202-04-6 is playing an increasingly important role.

Reference£º
Patent; Suzhou University Zhangjiagang Industry Technology Institute; Soochow University (Suzhou); Zou Jianping; Xue Jianfei; Zhou Shaofang; Zhang Peizhi; (12 pag.)CN104926868; (2018); B;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15861-24-2,Indole-5-carbonitrile,as a common compound, the synthetic route is as follows.

General procedure: Typical procedure for the Friedel-Crafts reaction of indoles to alpha,beta-unsaturated ketones: To a stirred mixture of indole (117 mg, 1mmol), and methyl vinyl ketone (85 mg, 1.2 mmol) in H2O/THF (7:3, 2 mL ) solution, GO (20 mg) was added. The reaction mixture was allowed to stir at room temparature and progress of the reaction was monitored by TLC. After complete consumption of indole, water (5 mL) was added and the aqueous layer was extracted with ethyl acetate (2 X 5 mL). The combined organic extracts were dried with anhydrous Na2SO4. The solvent and volatiles were completely removed under vacuum to give the crude product, which was passed through a short pad of silica gel (petroleum ether/ethyl acetate) to afford the analytically pure product in 94% yield.The aqueous layer containing the catalyst was filtered and washed with acetone,water and dried in a dessicator and used for the next cyle., 15861-24-2

The synthetic route of 15861-24-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vijay Kumar; Rama Rao; Tetrahedron Letters; vol. 52; 40; (2011); p. 5188 – 5191;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles