Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2338-71-8,5-Fluoro-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A solution of the xanthate 3 (1.37 g, 4.87 mmol) and the corresponding indole (4a-4g) (0.353 g, 2.21 mmol) in degassed 1,2-dichloroethane (DCE) (9 mL) was heated at reflux, and dilauroyl peroxide (DLP) (2.21 g, 5.54 mmol) in solid form was added in several portions (0.92 mmol/h). The reaction was monitored by TLC and was stopped after 6 h. The solvent was removed under reduced pressure, and the crude residues were extracted with acetonitrile and washed with hexane. The polar phase was then concentrated under reduced pressure and purified by chromatography on a silica gel column using hexane-ethyl acetate as the eluent to obtain the desired products., 2338-71-8

Big data shows that 2338-71-8 is playing an increasingly important role.

Reference£º
Article; Canche Chay, Cristina I.; Cansino, Rocio Gomez; Espitia Pinzon, Clara I.; Torres-Ochoa, Ruben O.; Martinez, Roberto; Marine Drugs; vol. 12; 4; (2014); p. 1757 – 1772;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

883535-89-5, 2-(2-Methyl-1H-indol-1-yl)ethanamine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,883535-89-5

General procedure: A solution of 2-(2-methyl-1H-indol-1-yl)ethanamine (4a) (65 mg, 0.373 mmol) and 4-(piperidin-1-yl)benzoic acid (5) (76 mg, 1 eq.), and dimethylaminopyridine (catalytic, ?5 mg) in dichloromethane (6 mL) was added 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide.hydrochloride (EDCI) (92 mg, 1.3 eq.) at room temperature. The resulting reaction mixture was stirred for 6h. At the conclusion of the reaction (TLC), water (15 mL) was added to quench the reaction. The product was extracted with ethyl acetate (20mL¡Á3). Organics were washed with dilute HCl (10 mL), saturated NaHCO3 solution (10 mL), water (10 mL) and brine solution (10 mL) and dried over Na2SO4 and concentrated. The resulting crude product was subjected to silica gel chromatography eluting with 0-40% ethyl acetate in hexane to furnish 7k (TG7-152) (100mg, 74% yield). 1H NMR (CDCl3): delta 7.52 (d, J=5.6Hz, 1H), 7.49 (d, J=8.8Hz, 2H), 7.30 (d, J=8Hz, 1H), 7.07 (m, 2H), 6.80 (d, J=8.2Hz, 2H), 6.23 (s, 1H), 5.98 (t, J=5.4Hz, 1H), 4.33 (t, J=6Hz, 2H), 3.76 (q, J=6Hz, 2H), 3.25 (t, J=4.8Hz, 4H), 2.37 (s, 3H), 1.6 (m, 6H). LCMS (ESI): >97% purity at lambda 254, MS; m/z, 362 [M+H]+. Anal. Calcd. for C23H27N3O: C, 76.42; H, 7.53; N, 11.62; found; C, 76.48; H, 7.55; N, 11.59.

As the paragraph descriping shows that 883535-89-5 is playing an increasingly important role.

Reference£º
Article; Ganesh, Thota; Jiang, Jianxiong; Dingledine, Ray; European Journal of Medicinal Chemistry; vol. 82; (2014); p. 521 – 535;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

15317-58-5, 1H-Indole-3-carbohydrazide is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of indole-3-carbonylhydrazide (5,1.0 mmol) in absolute ethanol (100 mL) was added a solution of substitutedphenyl/benzyl isothiocyanate (6a-j) in ethanol (50 mL) with continuousstirring. The reaction mixture was heated under reflux for 1 h. After coolingto room temperature, the precipitate formed was collected by filtration, andwashed with ice-cold ethanol (30 mL) to give the correspondingthiosemicarbazide (7a-j), which was used in the next step without furtherpurification.

15317-58-5, The synthetic route of 15317-58-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hamdy, Rania; Ziedan, Noha I.; Ali, Samia; Bordoni, Cinzia; El-Sadek, Mohamed; Lashin, Elsaid; Brancale, Andrea; Jones, Arwyn T.; Westwell, Andrew D.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 1037 – 1040;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-50-5,1H-Indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

(iii) 1H-Indole-2-carboxylic acid methyl ester 2 g of 1H-Indole-2-carboxylic acid was dissolved in 15 ml of methanolic hydrochloric acid (8M) and the mixture was stirred at RT for 16 h. After removal of the solvent under reduced pressure, reisidual volatiles were removed by codistillation twice with 10 ml toluene. The remaining slightly yellow solid was subjected to the subsequent reaction without further purification. Yield: 2.3 g, 1477-50-5

The synthetic route of 1477-50-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nazare, Marc; Essrich, Melanie; Will, David William; Matter, Hans; Ritter, Kurt; Wehner, Volkmar; US2003/199689; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

120-72-9, 1H-Indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of lH-indole (0.38 g, 3.244 mmol) in DMF (15 ml) was added TFAA (0.451 ml, 3.244 mmol) at room temperature. The reaction was stirred at 40 C for 2 hr. The mixture was poured into sodium bicarbonate solution (400 mL). The precipitate was filtered and washed with H20. The solid was dissolved in EtOAc and purified by silica gel column chromatography to give the title compound (650 mg). LCMS m/z = 214.2 [M+H]+; NMR (400 MHz, CD3OD) delta ppm 7.28-7.37 (m, 2H), 7.49-7.56 (m, 1H), 8.20-8.24 (m, 1H), 8.25-8.29 (m, 1H)., 120-72-9

120-72-9 1H-Indole 798, aindole-building-block compound, is more and more widely used in various fields.

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Patent; ARENA PHARMACEUTICALS, INC.; SEMPLE, Graeme; BEHAN, Dominic P.; FEICHTINGER, Konrad; GLICKLICH, Alan; GROTTICK, Andrew J.; KAM, Maria Matilde Sanchez; KASEM, Michelle; LEHMANN, Juerg; REN, Albert S.; SCHRADER, Thomas O.; SHANAHAN, William R.; WONG, Amy Siu-Ting; ZHU, Xiuwen; WO2015/66344; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

5318-27-4, 6-Aminoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Five mmol 2,4-dichloro-5-substitued-pyrimidines (8a-8g) or 4,6-dichloro-1H-pyrazolo [3,4-d]pyrimidine (8h) and DIPEA (1.2mL, 7.5mmol) were dissolved in DMF (4mL) and cooled to -60C. Indol-5-amine or amines 9a-9i (5mmol) dissolved in DMF (2mL) were added dropwise. The reaction mixture was stirred at -60C for about 1h. Next, the cooling bath was removed, the reaction mixture was stirred at room temperature for 2h, and was poured to 10mL cooled water after the reaction was complete as monitored by TLC. The formed precipitate was collected by filtration, washed with ethanol yielding compounds 10a-10h, 11a-11j, which were dried and used in the next step without further purification., 5318-27-4

5318-27-4 6-Aminoindole 256096, aindole-building-block compound, is more and more widely used in various fields.

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Article; Chen, Lingfeng; Fu, Weitao; Feng, Chen; Qu, Rong; Tong, Linjiang; Zheng, Lulu; Fang, Bo; Qiu, Yinda; Hu, Jie; Cai, Yuepiao; Feng, Jianpeng; Xie, Hua; Ding, Jian; Liu, Zhiguo; Liang, Guang; European Journal of Medicinal Chemistry; vol. 140; (2017); p. 510 – 527;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1075-35-0,5-Chloro-2-methylindole,as a common compound, the synthetic route is as follows.

10305] A 50 mE autoclave was charged with 6.3 mg (0.01 mmol, S/C100) of RuBF4((S,S)-N-Me-Msdpen) (p-cymene) obtained in Synthesis Example 18 serving as a catalyst, 0.16 12 g (1 mmol) of 5-chloro-2-methylindole, and 1.2 mE of HFIP, and the reaction was allowed to proceed at30 C. for 20 hours under a hydrogen pressure of 5 MPa. The conversion and the optical purity determined by GC analysis were 99.1% cony. (conversion) and 94.3% cc (optical purity)., 1075-35-0

The synthetic route of 1075-35-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKASAGO INTERNATIONAL CORPORATION; TOUGE, Taichiro; NARA, Hideki; (32 pag.)US2016/347678; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.830-96-6,3-Indolepropionic acid,as a common compound, the synthetic route is as follows.

3-indole propionic acid (3.78 g, 20 mmol) was dissolved in methanol (50 ml) in argon. Thionyl chloride (4.7 g, 2.9 ml, 40 mmol) was added very slowly to this solution in drops. During this, the temperature rose to 35 C. The mixture was then heated to reflux for 7 h and stirred overnight at room temperature. Complete conversion was evident in the DC. The LC/MS shows slight traces of a by-product. The batch was concentrated to low volume under the exhaust hood and co-distilled with methanol. The residue was a brown oil, which was thus used for the next reaction step.

830-96-6, The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GRUNENTHAL GMBH; US2009/247573; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1953-54-4,5-Hydroxyindole,as a common compound, the synthetic route is as follows.

General procedure: K2CO3 (1.56 g, 11.3 mmol) was added to indoline (3.8 mmol) and benzyl bromide (5.6 mmol) in acetone (50 mL). The solution was heated under reflux overnight. After the reaction, undissolved solid was filtered off, and the filtrate was evaporated under reduced pressure. The crude product was purified by column chromatography on silica gel using hexane/ethyl acetate (10:1, v/v) as eluent. Yield=68%. 1H NMR (CDCl3, 400 MHz): delta=8.04 (1H, br), 7.53 (2H, d, J=7.4 Hz), 7.22-7.47 (5H, m), 7.16 (1H, t, J=2.7 Hz), 7.00 (1H, dd, J=2.2 and 8.8 Hz), 6.51 (1H, m), 5.15 (2H, s). 13C{1H} NMR (CDCl3, 100 MHz) delta=153.4, 137.8, 131.2, 128.6, 128.3, 127.9, 127.7, 125.0, 113.1, 111.8, 104.0, 102.4, 71.0, 1953-54-4

1953-54-4 5-Hydroxyindole 16054, aindole-building-block compound, is more and more widely used in various fields.

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Patent; THE REGENTS OF HE UNIVERSITY OF CALIFORNIA; Nomura, Daniel K.; Zoncu, Roberto; Rpberts, Allison M.; Cho, Kelvin F.; Chung, Yik Sham Clive; Shin, Hijai; Croze, Benjamin; (127 pag.)US2019/112268; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

32387-21-6, 1-Methyl-1H-indole-3-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: One of compounds 4a-4f (5 mmol) was dissolved in THF (25 mL) and DCC (1.24 g, 6 mmol), and DMAP (0.12 g, 1 mmol) was slowly added and the mixture was stirred for 30 min. Compounds 2a-2c (5 mmol) was added and the mixture was stirred for 7-9 h. The by-product, N,N’-dicyclohexylurea, was removed by filtration. The filtrate was concentrated in vacuum to give a solid which was dissolved in CH2Cl2 and the product 5a-5n was filtered off.

32387-21-6, 32387-21-6 1-Methyl-1H-indole-3-carboxylic acid 854040, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Letter; Zhang; Xu; Wang; Kang; Russian Journal of General Chemistry; vol. 87; 12; (2017); p. 3006 – 3016;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles