Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52488-36-5,4-Bromo-1H-indole,as a common compound, the synthetic route is as follows.,52488-36-5

[00653] To a solution of 4-bromo-1H-indole (2.0 g, 0.01 mol) in DMF (30 mL) was added NaH (0.6 g, 0.015 mol) at 0 C. The resultant solution was stirred at rt for 30 min, then Mel (1.42 g, 0.01 mol) was added and stirred at for 3 h. The reaction mixture was poured into ice-water and extracted with EtOAc, the organic phase was dried over Na2S04, filtered and concentrated, the crude was purified by SGC to obtain 4-bromo-1-methyl-1H-indole (1.05 g, 50%) as a yellow solid.

As the paragraph descriping shows that 52488-36-5 is playing an increasingly important role.

Reference£º
Patent; NAVITOR PHARMACEUTICALS, INC.; MAHONEY, Sarah; MOLZ, Lisa; NARAYAN, Sridhar; SAIAH, Eddine; (516 pag.)WO2018/191146; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74420-05-6,N-Methyl-4-chloro-7-azaindole,as a common compound, the synthetic route is as follows.,74420-05-6

To a 100 mL reaction vial was added 4-chloro-1-methyl-1H-pyrrole [2,3-b]pyridine (2.29 g, 10 mmol).Sodium sulfide (1.17 g, 15 mmol), N-methylpyrrolidone (30 mL), Heat to 80 C and stir the reaction for 3 hours. Then, cesium carbonate (6.52 g, 20 mmol) was added to the reaction flask. And 2-bromocyclobutylacetate (2.15 g, 11 mmol), Continue to react at 100 C for 2 hours, After completion of the reaction, water (150 mL) was added, and the mixture was extracted three times with ethyl acetate (3¡Á100 ml). The organic layers are combined and washed with saturated brine. Dry with sodium sulfate and filter. After rotary distillation, the intermediate was obtained as an intermediate 50.3 (2.11 g), yield 60%.

The synthetic route of 74420-05-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chengdu Haichuang Pharmaceutical Co., Ltd.; Fan Lei; Du Wu; Xu Kexin; Chen Ke; Wang Fei; Wu Xiaoquan; Luo Tongchuan; Zhang Shaohua; Li Xinghai; Chen Yuanwei; (67 pag.)CN108659000; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37865-86-4,6-Ethoxy-1H-indole,as a common compound, the synthetic route is as follows.

(b) Methyl 2-(6-Ethoxy-1H-indol -3-yl)oxoacetate A 2.0 M solution of oxalyl chloride in methylene chloride (6.65 mL, 13.3 mmol) was added to a solution of 6-ethoxyindole (2.0 g, 12.4 mmol) in ether (25 mL) dropwise over 10 min at 4 C. under N2. The resulting mixture was stirred for 1 h at 4 C. A 25% (w/w) sodium methoxide in methanol solution (6.2 mL, 28.5 mmol) was added at -78 C. The mixture was allowed to warm up to room temperature and stirred for 4 h. The reaction was quenched with water (50 mL) and extracted with methylene chloride. The organic solution was dried (MgSO4) and concentrated at reduced pressure. The residue was stirred in a solution of EtOAc (50 mL) and ether (50 mL) for 10 min. Solid was collected by filtration to give the title compound (2.2 g, 73%) after drying. 1H NR (CDCl3) delta 8.20 (s, 1H), 7.90 (d, J=9 Hz, 1H), 6.92 (s, 1H), 6.82 (d, J=9 Hz, 1H), 4.00 (q, J=6.5 Hz, 2H), 3.78 (s, 3H), 1.30 (t, J=6.5 Hz, 3H), 37865-86-4

As the paragraph descriping shows that 37865-86-4 is playing an increasingly important role.

Reference£º
Patent; Engler, Thomas Albert; Furness, Kelly Wayne; Malhotra, Sushant; Briggs, Stephen Lyle; Brooks, Harold Burns; Clawson, David Keyes; Sanchez-Martinez, Concepcion; Zhang, Faming; Zhu, Guoxin; US2004/48915; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

90923-75-4, 1-Methyl-1H-indole-5-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,90923-75-4

Take (100mg, 0.535mmol)3-Bromo-1,2-phenylenediamine is dissolved in 5 mL of absolute ethanol,Add (102 mg, 0.641 mmol) 1-methylindole-5-aldehyde, (13.81 mg, 0.080 mmol) p-toluenesulfonic acid, and reflux for 24 h.The reaction was monitored by TLC. After the reaction was completed, the reaction solution was concentrated, and the concentrate was extracted with ethyl acetate-water.The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated.After column chromatography of petroleum ether-ethyl acetate 2: 1, 120 mg of solid was obtained with a yield of 68.8%.

90923-75-4 1-Methyl-1H-indole-5-carbaldehyde 7537534, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Southern Medical University; Chen Jianjun; Ren Yichang; Cheng Binbin; (19 pag.)CN110551104; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4769-96-4, 6-Nitro-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of compounds 1-4 (6.13 mmol) in ethanol (30 mL) was treated with 10% Pd/C (20 wt. %of 1-4) and subjected overnight to 50 psi H2 (g) in a Parr hydrogenation apparatus. The reaction mixture was filtered and concentrated in vacuo. Pure products 1M-4M were obtained via flash chromatography by eluting with a gradient of 30%-40% EtOAc/hexanes.

4769-96-4, As the paragraph descriping shows that 4769-96-4 is playing an increasingly important role.

Reference£º
Article; Zhang, Da-Jun; Sun, Wen-Fang; Zhong, Zhao-Jin; Gao, Rong-Mei; Yi, Hong; Li, Yu-Huan; Peng, Zong-Gen; Li, Zhuo-Rong; Molecules; vol. 19; 1; (2014); p. 925 – 939;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

15861-24-2, Indole-5-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

15861-24-2, After introducing 5-cyanoindole, Boc2O, dichloromethane and DMAP into a 100 ml round-bottomed flask, the reaction medium is stirred at 0 C. under nitrogen for 2 hours. After disappearance of the starting cyanoindole, the reaction medium is poured into water and extracted with EtOAc. After drying and evaporating off the solvent, 1.7191 g of N-Boc-5-cyanoindole are obtained in the form of a yellowish powder. Rf (silica)=0.61; 7/3 cyclohexane/EtOAc. LC/MS m/z=242.

As the paragraph descriping shows that 15861-24-2 is playing an increasingly important role.

Reference£º
Patent; Aventis Pharma S.A.; US2004/242559; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4769-96-4, 6-Nitro-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[000423j To a stirred solution of compound 1 (1 g, 1 eq) in DMF (10 mL), NaH (0.22 1 g,1.5 eq) was added at 0 C followed by the addition of methyl iodide (2.3 mL, 3 eq) at same temperature. The reaction mixture was stirred at same temperature for 30 mm. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (3 X 25 mL). Combined organic extracts were washed with brine, dried over anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by column chromatography on silica gel 100-200 mesh using 20% EtOAc-hexane to afford the title compound 2.

4769-96-4, As the paragraph descriping shows that 4769-96-4 is playing an increasingly important role.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; BHAGWAT, Shripad; WANG, Bing; LUEDTKE, Gregory R.; SPYVEE, Mark; (490 pag.)WO2016/57834; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-49-2,3-Indoleglyoxylic Acid,as a common compound, the synthetic route is as follows.

The reagents used for each of the amide bond formation was amino core (4 mumol), carboxylic acid (4 mumol, 1 eq.), DIEA (5 mumol, 1.2 eq.) and HBTU (4.5 mumol, 1.1eq.). A stock of the amino core for synthesis of 102 members requires an amount in excess of 150 fold. Both the starting amino core and the carboxylic acids were prepared as a stock solution of DMSO in a concentration of 0.6 mmol/1500 muL and 4 mumol/10 muL, respectively. HBTU and DIEA were dissolved in DMSO as a concentration of 4.5 mumol/10 muL (V/V) and 5 mumol/10 muL (V/V), respectively. Each of the acid portion was firstly mixed with the solution of HBTU in a plastic tube for 30 sec, followed by the addition of a mixture of the solution of amino core (4 mumol, 10 muL) and DIEA (10 muL) in a total volume of 40 muL. All vials were shaken for 1 min ultrasonically for the subsequent series dilution., 1477-49-2

The synthetic route of 1477-49-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Su, Yuan-Hsiao; Chiang, Li-Wu; Jeng, Kee-Ching; Huang, Ho-Lien; Chen, Jenn-Tzong; Lin, Wuu-Jyh; Huang, Chia-Wen; Yu, Chung-Shan; Bioorganic and Medicinal Chemistry Letters; vol. 21; 5; (2011); p. 1320 – 1324;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348640-06-2,4-Bromo-7-azaindole,as a common compound, the synthetic route is as follows.

c.HNO3 (0.93 mL) was added drop wise to a solution of a H2SO4 (0.64 mL) at 0 C. 4-Bromo-1H-pyrrolo[2,3-b]pyridine (2 g, 10.15 mmol) in c.H2SO4 (9 mL) was added slowly, keeping the temperature at 0 C. After addition the reaction was stirred for a further hour at 0 C. before pouring carefully onto rapidly stirring ice/H2O (100 mL). The suspension was stirred for 30 mins and then the solids separated via filtration. The filter cake was washed with copious amounts of H2O before drying in vacuo at 40 C., to afford the desired compound, 1.9 g, 77.3%

348640-06-2, As the paragraph descriping shows that 348640-06-2 is playing an increasingly important role.

Reference£º
Patent; Vernalis (R&D) Limited; Stokes, Stephen; Graham, Christopher John; Ray, Stuart Christopher; Stefaniak, Emma Jane; US2015/11533; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24621-73-6,4-Chloro-1H-indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.,24621-73-6

Step 1. 4-Chloro-N-methoxy-N-methyl-1H-indole-2-carboxamide A mixture of 4-chloro-1H-indole-2-carboxylic acid (from Ryan Scientific, 1.0 g, 5.1 mmol), O-(benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (2.9 g, 7.7 mmol) and triethylamine (3.6 mL, 26 mmol) in N,N-dimethylformamide (15 mL) was stirred at room temperature for 10 minutes. N,O-Dimethylhydroxylamine hydrochloride (0.75 g, 7.7 mmol) was added and the resulting suspension was stirred at room temperature overnight. The mixture was quenched with water and then extracted with EtOAc. The combined organic layers were dried over MgSO4, concentrated and purified on silica gel (eluting with 0-35% EtOAc in hexane) to give the desired product (0.35 g, 29%). LCMS calculated for C11H12ClN2O2(M+H)+: m/z=239.1; Found: 239.1.

24621-73-6 4-Chloro-1H-indole-2-carboxylic acid 90561, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Li, Yun-Long; Combs, Andrew P.; US2011/312979; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles