Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4771-50-0,7-Methylindole-3-carboxyaldehyde,as a common compound, the synthetic route is as follows.

General procedure: An equimolar mixture of Gewald adducts (5CN, 6CN, 7CN and 8CN) and substituted indole-carboxaldehydes in absolute ethanol with 0.5 mL of acetic acid was stirred under room temperature for 24 hs. Water was addedand the solid that precipitated out was filtered under vacuum, washed with water, dried and recrystallized from absolute ethanol (Scheme 1) according previously methodology [20].

4771-50-0, 4771-50-0 7-Methylindole-3-carboxyaldehyde 260389, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Felix, Mayara B.; de Souza, Edson R.; de Lima, Maria do C.A.; Frade, Daiana Karla G.; Serafim, Vanessa de L.; Rodrigues, Klinger Antonio da F.; Neris, Patricia Lima do N.; Ribeiro, Frederico F.; Scotti, Luciana; Scotti, Marcus T.; de Aquino, Thiago M.; Mendonca Junior, Francisco Jaime B.; de Oliveira, Marcia R.; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 3972 – 3977;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

16136-52-0, 4-Cyanoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The calcium or magnesium salt (0.025 mmol, 10 mol%) and Michael acceptor (0.25 mmol) were dissolved in solvent (0.5 mL), and the mixture was stirred at r.t. for 30 min in a glass vial. The aromatic compound (0.5 mmol) was added and the reaction was stirred at the temperature indicated in Tables 2-9; reaction progress was monitored by TLC. When the reaction was complete, the solvent was evaporated under reduced pressure. The crude residue was purified by column chromatography to afford the product.

16136-52-0, 16136-52-0 4-Cyanoindole 3817602, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Feofanov, Mikhail N.; Anokhin, Maxim V.; Averin, Alexei D.; Beletskaya, Irina P.; Synthesis; vol. 49; 22; (2017); p. 5045 – 5058;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16096-32-5,4-Methyl-1H-indole,as a common compound, the synthetic route is as follows.

General procedure: A mixture of xanthen-9-ol 1 (0.040 g, 0.2 mmol) and 2a (0.024 g, 0.2 mmol) was stirred in a tube at room temperature in BmimBF4 (0.5 mL) until the disappearance of the starting 2a (24 h, checked by thin-layer chromatography, TLC). After completing, the reaction mixture was extracted by ethyl ether (3¡Á15 mL), then concentrated and isolated by flash chromatograph to afford the pure product 3a (0.054 g, yield: 92%).

16096-32-5, 16096-32-5 4-Methyl-1H-indole 85282, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Ling-Yan; Wang, Bing; Yang, Hong-Mei; Chang, Wei-Xing; Li, Jing; Tetrahedron Letters; vol. 52; 43; (2011); p. 5636 – 5639;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15861-24-2,Indole-5-carbonitrile,as a common compound, the synthetic route is as follows.

Compound 14 (15 g) was taken in methanol (300 ml) and water (30 ml) mixture and NaOH (4.6 g) and Kl (20.89 g) were added. Iodine (30.51 g) was added portion wise at RT. Reaction mixture was stirred at RT for 6 hr. Reaction was monitored using LCMS & TLC. Reaction mixture was diluted with water (1000 ml) and the precipitated solid was filtered-off and dried under vac- uum. Yellow solid obtained was dissolved in DCM and dried over sodium sulphate and concentrated under vacuum. 25 g of pure solid compound 15 was obtained. (0552) 1 H NMR 300 MHz, DMSO-d6: delta 12.09 (s, 1 H), 7.82 – 7.73 (m, 2H), 7.64 – 7.47 (m, 2H).

15861-24-2, The synthetic route of 15861-24-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BASF SE; RHEINHEIMER, Joachim; RATH, Rakesh; KULKARNI, Sarang; ROSENBAUM, Claudia; WIEBE, Christine; BRAHM, Lutz; SIEPE, Isabella; HADEN, Egon; ROEHL, Franz; KHANNA, Smriti; SCHIFFER, Helmut; KREMZOW-GRAW, Doris; POONOTH, Manojkumar; (285 pag.)WO2019/57660; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

4769-96-4,4769-96-4, 6-Nitro-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) Step 1 6-Nitroindole (1.0 g, 6.2 mmol) was successively added with acetic acid (2.5 mL), water (5.0 mL), and hexamethylenetetramine (1.2 g, 8.4 mmol), and then the mixture was stirred overnight at 120C in a sealed tube. The reaction mixture was added with water, and the precipitated solid was collected by filtration, and then dried to obtain 6-nitro-1H-indole-3-carboxaldehyde (0.91 g, 77%). 1H NMR (300 MHz, DMSO-d6) delta 8.12 (d, J = 8.8 Hz, 1H), 8.27 (d, J = 8.8 Hz, 1H), 8.44 (s, 1H), 8.66 (s, 1H), 10.02 (s, 1H).

The synthetic route of 4769-96-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi; EP2565192; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

52562-50-2, 5-Methyl-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

52562-50-2, 1-(3-Chloropropyl)-5-methyl-indole-3-carboxaldehyde 1-(3-Chloropropyl)-5-methyl-indole-3-carboxaldehyde was prepared from 5-methylindole-3-carboxaldehyde according to the method described in Example 1 to give 2.26 g (76%) of the product as an off-white solid: mp 89-90 C.; IR numax (Nujol)/cm-1 2956, 1659, 1536, 1403, 1171, 820 and 786; NMR deltaH (400 MHz, CDCl3) 2.27-2.34 (2H, m), 2.47 (3H, s), 3.46 (2H, t, J 6.2 Hz), 4.38 (2H, t, J 6.6 Hz), 7.16 (1H, d, J 10 Hz), 7.28 (1H, d, J 8.4 Hz), 7.70 (1H, s), 8.12 (1H, s) and 9.97 (1H, s); Found: C, 66.12; H, 6.00; N, 5.88%. C13H14ClNO requires: C, 66.24; H, 5.99; N, 5.94%.

52562-50-2 5-Methyl-1H-indole-3-carbaldehyde 259187, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Vernalis Research Limited; US6433175; (2002); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189882-33-5,6-Cyano-7-azaindole,as a common compound, the synthetic route is as follows.

To a solution of lH-pyrrolo[2,3-b]pyridine-6-carbonitrile (2 g, 13.97 mmol, 1 eq) in MeOH (20 mL) and THF (10 mL) was added ammonium sulfide (1.71 g, 25.15 mmol, 1.72 mL, 1.8 eq) at l5C. Then the solution was stirred at l5C for 12 h under N2 atmosphere. The solution was quenched by addition of H20 (30 mL) at l5C, and extracted with EtOAc (30 mLx2). The combined organic layers were washed with brine (20 mLx2), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (Si02, PE/EtOAc=30/l to 1/1) to afford the title compound (1 g, 5.64 mmol, 40.38% yield) as a yellow solid. (Note: The reaction was combined with another reaction (ET19050-19) in 1 g scale for purification and work up.), 189882-33-5

189882-33-5 6-Cyano-7-azaindole 10534776, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; SYROS PHARMACEUTICALS, INC.; MARINEAU, Jason J.; CHUAQUI, Claudio; CIBLAT, Stephane; KABRO, Anzhelika; PIRAS, Henri; WHITMORE, Kenneth Matthew; LUND, Kate-Lyn; (200 pag.)WO2019/143719; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19012-02-3,3-Acetyl-1-methylindole,as a common compound, the synthetic route is as follows.

General procedure: The substituted 1-(1H-indol-3-yl)ethanone (1 mmol), together with the respective benzaldehyde (1 mmol), malononitrile (1 mmol) and ammonium acetate (8 mmol) were dissolved in toluene (30 mL) and heated to reflux for 8 h. The solvent was removed under reduced pressure and absolute ethanol was added to the residue. The precipitate was collected by filtration and purified by silica gel column chromatography to give the desired product.

19012-02-3, 19012-02-3 3-Acetyl-1-methylindole 594156, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 3149 – 3157;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1074-86-8,1H-Indole-4-carbaldehyde,as a common compound, the synthetic route is as follows.

1074-86-8, General procedure: A solution of anhydrous Cu(OAc)2 (1.8 mg, 0.01 mmol) andligand 7d (4.0 mg, 0.01 mmol) in MTBE (1 mL) in a 10mL test tubeequipped with a magnetic stirring bar was stirred at room temperaturefor 30 min. Next, 20 mL DABCO (5M dissolved in n-propanol)was added, followed by stirring for 5 min. After the aldehyde(0.2 mmol) was added to the reaction mixture, we stirred themixture at 10 C for 2 min, and then 2-nitropropane (180 mL,2 mmol) was added to the tube. The reaction was stirred at 10 Cand monitored by TLC. After the complete reaction, the chiralproduct was separated by flash column chromatography (PE/EA 9/1). Enantiomeric excesses were determined by HPLC chiralcolumn.

1074-86-8 1H-Indole-4-carbaldehyde 333703, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Cai, Zedong; Lan, Ting; Ma, Pengfei; Zhang, Jingfang; Yang, Qingqing; He, Wei; Tetrahedron; vol. 75; 34; (2019);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1196-70-9, 1H-Indole-6-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3. Synthesis of (E)-N?-(( 1 H-indol-6-yl)methylene)-2-(2-ethyl-6-methylpyridin-3 – yloxy)acetohydrazide: 2-(2-ethyl-6-methylpyridin-3 -yloxy)acetohydrazide( 100 mg, 0.50 mmol) and 1H-indol-6-carbaldehyde (73 mg, 0.50 mmol) were dissolved in EtOH 3 mL, followed by stirring at 90 C for 4 hours. After the completion of the reaction, the formed solidwas filtered to obtain Compound 293 (46 mg, 29 %).?H NMR (400 MHz, DMSO-d6): 11.43 (bs, 1H), 11.30-11.27 (s, 1H), 8.32-8.06 (2s, 1H), 7.64 (m, IH), 7.42 (m, 2H), 7.36 (m, IH), 7.02 (m, IH), 6.45 (s, 1H), 5.17 (s, IH), 4.66 (s, IH), 2.75 (m, 2H), 2.45 (s, 3H), 1.21 (m, 3H)., 1196-70-9

As the paragraph descriping shows that 1196-70-9 is playing an increasingly important role.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; CHOI, HoJin; LEE, JaeWon; LEE, ChangGon; HA, NiNa; SEO, Su Kil; LEE, SunMi; LEE, Song-Min; WO2014/35149; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles