Tag: M.W=150-200

Authors Marjani, AP; Khalafy, J; Farajollahi, A in WILEY published article about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER in [Marjani, Ahmad Poursattar; Khalafy, Jabbar; Farajollahi, Ayda] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran in 2019, Cited 41. Formula: C9H7NO2. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.. Formula: C9H7NO2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Recently I am researching about ARENES, Saw an article supported by the Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [CRC 1459, SFB 858, IRTG 2027]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Dalton, T; Gressies, S; Das, M; Niehues, M; Schrader, ML; Gutheil, C; Ravoo, BJ; Glorius, F. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Hydroarylation is an effective strategy to rapidly increase the complexity of organic structures by transforming flat alkene moieties into three-dimensional frameworks. Many strategies have already been developed to achieve the hydroarylation of styrenes, however most of these reports examine the hydroarylation of unpolar, beta-mono- or beta-unsubstituted styrenes, while exploring mainly electron-rich benzene nucleophiles. Herein, we report a mild and general catalytic system for the selective hydroheteroarylation of multiply substituted styrenes and heteroaromatic styrenes. Mechanistic analysis of the reaction led to the discovery of commercially available 2,2 ‘:5 ‘,2 ”-terthiophene as a key reagent.

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Dalton, T; Gressies, S; Das, M; Niehues, M; Schrader, ML; Gutheil, C; Ravoo, BJ; Glorius, F or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 86-95-3. Recently I am researching about NONCANONICAL POLY(A) POLYMERASE; POLYADENYLATION SIGNAL; MOLECULAR-BIOLOGY; STEM-LOOP; VIRUS; DEGRADATION; EXOSOME; TRAMP; DECAY; TRANSCRIPTS, Saw an article supported by the Hepatitis B Foundation; Commonwealth of Pennsylvania. Published in ELSEVIER in AMSTERDAM ,Authors: Block, TM; Young, JAT; Javanbakht, H; Sofia, MJ; Zhou, TL. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

Inhibition of the host RNA polyadenylating polymerases, PAPD5 and PAPD7 (PAPD5/7), with dihydroquinolizinone, a small orally available, molecule, results in a rapid and selective degradation of hepatitis B virus (HBV) RNA, and hence reduction in the amounts of viral gene products. DHQ, is a first in class investigational agent and could represent an entirely new category of HBV antivirals. PAPD5 and PAPD7 are noncanonical, cell specified, polyadenylating polymerases, also called terminal nucleotidyl transferases 4B and 4A (TENT4B/A), respectively. They are involved in the degradation of poor-quality cell transcripts, mostly noncoding RNAs and in the maturation of a sub-set of transcripts. They also appear to play a role in shielding some mRNA from degradation. The results of studies with DHQ, along with other recent findings, provide evidence that repression of the PAPD5/7 arm of the cell RNA quality control pathway, causes a profound (multifold) reduction rather than increase, in the amount of HBV pre-genomic, pre-core and HBsAg mRNA levels in tissue culture and animal models, as well. In this review we will briefly discuss the need for new HBV therapeutics and provide background about HBV transcription. We also discuss cellular degradation of host transcripts, as it relates to a new family of anti-HBV drugs that interfere with these processes. Finally, since HBV mRNA maturation appears to be selectively sensitive to PAPD5/7 inhibition in hepatocytes, we discuss the possibility of targeting host RNA quality control as an antiviral strategy.

SDS of cas: 86-95-3. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Block, TM; Young, JAT; Javanbakht, H; Sofia, MJ; Zhou, TL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C7H5F3O. In 2020 PEST MANAG SCI published article about ACETOLACTATE SYNTHASE; COMPUTATIONAL DESIGN; RESISTANCE; HERBICIDES; MUTATIONS; EVOLUTION; WEEDS in [Qu, Ren-Yu; Yang, Jing-Fang; Chen, Qiong; Yang, Wen-Chao; Yang, Guang-Fu] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol, Coll Chem,Chem Biol Ctr,Minist Educ, Wuhan, Peoples R China; [Niu, Cong-Wei; Xi, Zhen] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin, Peoples R China; [Yang, Guang-Fu] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China in 2020, Cited 40. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

BACKGROUND Intensifying weed resistance has challenged the use of existing acetohydroxyacid synthase (AHAS)-inhibiting herbicides. Hence, there is currently an urgent requirement for the discovery of a new AHAS inhibitor to effectively control AHAS herbicide-resistant weed species produced by target mutation. RESULTS To combat weed resistance caused by AHAS with P197L mutation, we built a structure library consisting of pyrimidinyl-salicylic acid derivatives. Using the pharmacophore-linked fragment virtual screening (PFVS) approach, hit compound 8 bearing 6-phenoxymethyl substituent was identified as a potential AHAS inhibitor with antiresistance effect. Subsequently, derivatives of compound 8 were synthesized and evaluated for their inhibitory activities. The study of the enzyme-based structure-activity relationship and structure-resistance relationship studies led to the discovery of a qualified candidate, 28. This compound not only significantly inhibited the activity of wild-type Arabidopsis thaliana (At) AHAS and P197L mutant, but also exhibited good antiresistance properties (RF = 0.79). Notably, compared with bispyribac at 37.5-150 g of active ingredient per hectare (g a.i. ha(-1)), compound 27 exhibited higher growth inhibition against both sensitive and resistant Descurainia sophia, CONCLUSION The title compounds have great potential to be developed as new leads to effectively control herbicide-resistant weeds comprising AHAS with P197L mutation. Also, our study provided a positive case for discovering novel, potent and antiresistance inhibitors using a fragment-based drug design approach. (c) 2020 Society of Chemical Industry

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Qu, RY; Yang, JF; Chen, Q; Niu, CW; Xi, Z; Yang, WC; Yang, GF or concate me.. Computed Properties of C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3-(Trifluoromethyl)phenol. In 2021 ACS APPL MATER INTER published article about IRIDIUM(III) COMPLEXES; EN-ROUTE; DESIGN; PHOTOPHYSICS; FUNDAMENTALS; TUNABILITY in [Tai, Wun-Shan; Gnanasekaran, Premkumar; Chi, Yun] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan; [Tai, Wun-Shan; Gnanasekaran, Premkumar; Chi, Yun] Natl Tsing Hua Univ, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu 30013, Taiwan; [Chen, Yi-Yang; Hung, Wen-Yi] Natl Taiwan Ocean Univ, Dept Optoelect & Mat Technol, Keelung 20224, Taiwan; [Zhou, Xiuwen] Univ Queensland, Sch Math & Phys, Brisbane, Qld 4072, Australia; [Chou, Tai-Che; Lee, Gene-Hsiang; Chou, Pi-Tai] Natl Taiwan Univ, Dept Chem, Taipei 10617, Taiwan; [You, Caifa; Chi, Yun] City Univ Hong Kong, Dept Mat Sci & Engn, Dept Chem, Kowloon, Kowloon 999077, Peoples R China; [You, Caifa; Chi, Yun] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Kowloon, Kowloon 999077, Peoples R China in 2021, Cited 57. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

A new class of bis-tridentate Ir(III) complexes (Dap-1-4) was synthesized using carbene pincer pro-chelates PC1 center dot H-3(PF6)(2) or PC2 center dot H-3(PF6)(2) with either imidazolylidene or imidazo[4,5-b]pyridin-2-ylidene appendages, together with a second cyclometalating 2,6-diaryoxypyridine chelate, L1H(2) and L2H(2), differed by a NMe2 donor at the central pyridinyl fragment. The respective emission tuning between the ultraviolet and blue region was rationalized using time-dependent density functional theory (TD-DFT) approaches. Next, a highly efficient blue emitter (Dap-5) was synthesized by concomitant addition of two methyl groups and a single CF3 substituent at the central phenyl and peripheral imidazo[4,5-b]pyridin-2-ylidene entities of the carbene pincer chelate, respectively. The organic light-emitting diode (OLED) device with 15 wt % Dap-5 in DPEPO shows electroluminescence at 468 nm and with CIE (0.14, 0.15) and a max external quantum efficiency (max EQE) of 16.8% with low efficiency roll-off (EQE of 14.4% at 1000 cd m(-2)); the latter is attributed to the relatively shortened triplet excited-state radiative lifetime. These results highlight the adequateness of bis-tridentate Ir(III) phosphors in fabrication of practical blue-emitting OLEDs.

Quality Control of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Tai, WS; Gnanasekaran, P; Chen, YY; Hung, WY; Zhou, XW; Chou, TC; Lee, GH; Chou, PT; You, CF; Chi, Y or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Elnagar, MM; Samir, S; Shaker, YM; Abdel-Shafi, AA; Sharmoukh, W; Abdel-Aziz, MS; Abou-El-Sherbini, KS in [Elnagar, Mohamed M.; Sharmoukh, Walid; Abou-El-Sherbini, Khaled S.] Natl Res Ctr, Dept Inorgan Chem, 33 El Bohouth St, Giza 12622, Egypt; [Samir, Safia] Theodor Bilharz Res Inst, Dept Biochem & Mol Biol, Giza, Egypt; [Shaker, Yasser M.] Natl Res Ctr, Div Pharmaceut & Drug Ind, Dept Chem Nat & Microbial Prod, Giza, Egypt; [Abdel-Shafi, Ayman A.] Ain Shams Univ, Fac Sci, Cairo, Egypt; [Abdel-Aziz, Mohamed S.] Natl Res Ctr, Dept Microbial Chem, Giza, Egypt published Synthesis, characterization, and evaluation of biological activities of new 4 ‘-substituted ruthenium (II) terpyridine complexes: Prospective anti-inflammatory properties in 2021.0, Cited 71.0. Category: indole-building-block. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

The synthesis and characterization of Ru (II) terpyridine complexes derived from 4 ‘ functionalized 2,2 ‘:6 ‘,2 ”-terpyridine (tpy) ligands are reported. The heteroleptic complexes comprise the synthesized ligands 4 ‘-(2-thienyl)- 2,2 ‘:6 ‘,2 ”-terpyridine) or (4 ‘-(3,4-dimethoxyphenyl)-2,2 ‘:6 ‘,2 ”-terpyridine and (dimethyl 5-(pyrimidin-5-yl)isophthalate). The new complexes [Ru(4 ‘-(2-thienyl)-2,2 ‘:6 ‘,2 ”-terpyridine)(5-(pyrimidin-5-yl)-isophthalic acid)Cl-2] (9), [Ru(4 ‘-(3,4-dimethoxyphenyl)-2,2 ‘:6 ‘,2 ”-terpyridine)(5-(pyrimidin-5-yl)-isophthalic acid)Cl-2] (10), and [Ru(4 ‘-(2-thienyl)-2,2 ‘:6 ‘,2 ”-terpyridine)(5-(pyrimidin-5-yl)-isophthalic acid)(NCS)(2)] (11) were characterized by(1)H- and(13)C-NMR spectroscopy, C, H, N, and S elemental analysis, UPLC-ESI-MS, TGA, FT-IR, and UV-Vis spectroscopy. The biological activities of the synthesized ligands and their Ru (II) complexes as anti-inflammatory, antimicrobial, and anticancer agents were evaluated. Furthermore, the toxicity of the synthesized compounds was studied and compared with the standard drugs, namely, diclofenac potassium and ibuprofen, using hemolysis assay. The results indicated that the ligands and the complex9possess superior anti-inflammatory activities inhibiting albumin denaturation (89.88-100%) compared with the standard drugs (51.5-88.37%) at a concentration of 500 mu g g(-1). These activities were related to the presence of the chelating N-atoms in the ligands and the exchangeable chloro- groups in the complex. Moreover, the chloro- and thiophene groups in complex9produce a higher anticancer activity compared with its isothiocyanate derivative in the complex11and the 3,4-dimethoxyphenyl moiety in complex10. Considering the toxicity results, the synthesized ligands are nontoxic or far less toxic compared with the standard drugs and the metal complexes. Therefore, these newly synthesized compounds are promising anti-inflammatory agents in addition to their moderate unique broad antimicrobial activity.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Elnagar, MM; Samir, S; Shaker, YM; Abdel-Shafi, AA; Sharmoukh, W; Abdel-Aziz, MS; Abou-El-Sherbini, KS or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Cheng, XC; Qin, Z; Yang, QL; Liu, HM; Wang, XD; Liu, YL in NORTH CAROLINA STATE UNIV DEPT WOOD & PAPER SCI published article about KRAFT LIGNIN; SOLVENT FRACTIONATION; ETHANOL; PRECIPITATION; HOMOGENEITY; SOFTWOOD; TOOL in [Cheng, Xi-Chuang; Qin, Zhao; Yang, Qiao-Li; Liu, Hua-Min; Wang, Xue-De; Liu, Yu-Lan] Henan Univ Technol, Coll Food Sci & Technol, Zhengzhou 450001, Henan, Peoples R China in 2021.0, Cited 33.0. Product Details of 120-14-9. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Lignin from the Chinese quince (Chaenomeles sinensis) fruit offers a promising source of natural antioxidant for industrial applications. However, the utilization of Chinese quince fruit lignin is restricted by its inhomogeneous nature. Accordingly, Chinese quince fruit lignin was sequentially fractionated with organic solvents of increasing dissolving capacity to prepare homogeneous lignin fractions. The GPC (gel permeation chromatography) results showed that the molecular weights of lignin fractions increased from dichloromethane fraction to dioxane/water fraction. The five lignin fractions were also compared with respect to yield, carbohydrate content, thermal stability, inter-unit linkages, S/G ratios, and phenolic OH content. Among the five fractions, the ethyl acetate fraction showed a lower proportion of p-o-tv linkages (48.4%), the highest thermal stability, the highest phenolic OH content (2.8 mmol/g), and the highest DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging index and reducing power. The high antioxidant performance of the ethyl acetate fraction implies that it can be used as a natural antioxidant. This study shows that sequential solvent fractionation of lignin can produce homogeneous fractions with enhanced antioxidant performance. In addition, it demonstrates that Chinese quince fruits are a potentially valuable natural resource.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Cheng, XC; Qin, Z; Yang, QL; Liu, HM; Wang, XD; Liu, YL or concate me.. Product Details of 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Gold-Catalyzed Hydrophenoxylation of Propargylic Alcohols and Amines: Synthesis of Phenyl Enol Ethers published in 2019. Quality Control of 3-(Trifluoromethyl)phenol, Reprint Addresses Sheppard, TD (corresponding author), UCL, Dept Chem, 20 Gordon St, London WC1H 0AJ, England.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

A practical method for the synthesis of phenyl enol ethers is reported. The combination of a gold(I) catalyst and potassium carbonate selectively mediates the addition of phenols to propargylic alcohols/amines in a chemo-, regio-, and stereoselective fashion in high yield. The resulting enol ethers are formed exclusively with a Z-configuration and can be obtained from a wide array of phenols and propargylic alcohols or amines with the reaction showing excellent functional group tolerance.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Laserna, V; Rojas, CJ; Sheppard, TD or concate me.. Quality Control of 3-(Trifluoromethyl)phenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3-(Trifluoromethyl)phenol. In 2019 EUR J MED CHEM published article about ANDROGEN-RECEPTOR; TRIFLUOROMETHYL GROUP; BIOLOGICAL-ACTIVITY; FLUORINE; INHIBITORS; ANALOGS; PHARMACOKINETICS; CHEMISTRY; LIGANDS; BINDING in [Pertusati, Fabrizio; Ferla, Salvatore; Bassetto, Marcella; Brancale, Andrea; Khandil, Sahar; Westwell, Andrew D.; McGuigan, Christopher] Sch Pharm & Pharmaceut Sci, Redwood Bldg,King Edwards 7 Ave, Cardiff CF10 3NB, S Glam, Wales in 2019, Cited 76. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

SAR studies on bicalutamide, enobosarm and enzalutamide analogues, functionalised with polyfluorinated groups, is presented. Among the novel bicalutamide and enobosarm derivatives synthesised, several displayed significantly improved in vitro anticancer activity, with IC50 values in the low micromolar range against four different prostate cancer cell lines (LNCaP, VCaP, DU-145 and 22Rv1), showing up to 48-fold increase in comparison with the parent structures. In particular, SF5 enobosarm analogues were found to be most potent compounds, full AR antagonists and with favourable ADME properties. The most promising compound (48a) was evaluated for its in vivo efficacy in PC xenograft mouse model (22Rv1) with results comparable to the standard-of-care docetaxel. (C) 2019 Published by Elsevier Masson SAS.

Safety of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Pertusati, F; Ferla, S; Bassetto, M; Brancale, A; Khandil, S; Westwell, AD; McGuigan, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Electrochemical Reductive Smiles Rearrangement for C-N Bond Formation published in 2019. COA of Formula: C7H5F3O, Reprint Addresses Guo, C (corresponding author), Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

A conceptually new and synthetically valuable radical Smiles rearrangement reaction is reported under undivided electrolytic conditions. This protocol employs an entirely new strategy for the electrochemical radical Smiles rearrangement. Remarkably, an amidyl radical generated from the cleavage of the N-O bond under reductive electrolytic conditions plays a crucial role in this transformation. Various hydroxylamine derivatives bearing different substituents are suitable in this electrochemical transformation, furnishing the corresponding amides in up to 86% yield.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Chang, XH; Zhang, QL; Guo, C or concate me.. COA of Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles