Tag: M.W=150-200

I found the field of Chemistry very interesting. Saw the article Synthesis, structure, characterization and biological evaluation of 3-substituted 1-pyridin-2-ylimidazo[1,5-a]pyridine-based copper(I)-phosphine complexes for anticancer drug screening published in 2021. COA of Formula: C9H10O3, Reprint Addresses Velusamy, M (corresponding author), North Eastern Hill Univ, Dept Chem, Shillong 793022, Meghalaya, India.; Murali, M (corresponding author), Natl Coll Autonomous, Dept Chem, Coordinat & Bioinorgan Chem Res Lab, Tiruchirappalli 620001, Tamil Nadu, India.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Copper(I) complexes of the types [Cu(N-N)(PPh3)(2)]NO3(LC41-LC44) and [Cu(N-N)(PPh3)(NO3)] (LC45) carrying 3-substituted 1-pyridine-2-ylimidazo[1,5-a]pyridine (N-N) derivatives and triphenylphosphine (PPh3) ligands have been prepared. The synthesized copper(I)-phosphine complexes were fully characterized by NMR, IR, ESI-MS and UV-visible spectroscopy as well as by cyclic voltammetry. Selected structures such as LC42, LC43 and LC45 were additionally analysed by single-crystal X-ray method, which show that copper(I) centre adopts a highly distorted tetrahedral geometry. The(1)H and(13)C NMR spectral data of the complexes throw light on the nature of metal-ligand bonding. They display d pi-pi* metal-to-ligand charge transfer (MLCT) transition and show quasireversible Cu-I/Cu(II)metal oxidation. Among the copper(I)-phosphine complexes, LC41-LC44 exhibit moderate cytotoxicity (IC50: 24 h, 67-74 mu M; 48 h, 58-70 mu M) against human lung epithelial adenocarcinoma A549 cells, whereas LC45 displays the best activity (IC50: 24 h, 42 mu M; 48 h, 34 mu M) for A549 cancer cell line, which is better than that of the commercial antitumor drug cisplatin. All the complexes also displayed excellent selectivity by being relatively inactive against the human lung epithelial L132 normal cell line with selectivity index (SI) values ranging from 3.4 to 7.4. The complexes block cell cycle progression of A549 cells in G(0)/G(1)phase. FACSVerse analyses are suggestive of reactive oxygen species (ROS) generation and apoptotic cell death induced by the LC41, LC43 and LC45. The induction of apoptosis in A549 cells was shown by Annexin V with propidium iodide (PI) and 4 ‘,6-diamidino-2-phenylindole (DAPI) staining methods and established the ability of LC41, LC43 and LC45 to accumulate in the cell nuclei.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Pathaw, L; Khamrang, T; Selvakumaran, B; Murali, M; Prakash, PA; Jaabir, MSM; Velusamy, M or concate me.. COA of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about MEISENHEIMER COMPLEX-FORMATION; PHENOXIDE ION; SOFT ACIDS; NUCLEOPHILIC-ADDITION; ARYLOXIDE IONS; BASES HSAB; ALKYLATION; CARBON; KINETICS; OXYGEN, Saw an article supported by the Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [SFB 749]; Fonds der Chemischen Industrie (Kekule fellowship)Fonds der Chemischen Industrie. SDS of cas: 98-17-9. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Mayer, RJ; Breugst, M; Hampel, N; Ofial, AR; Mayr, H. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Prompted by the observation that the regioselectivities of phenolate reactions (C versus O attack) are opposite to the predictions by the principle of hard and soft acids and bases, we performed a comprehensive experimental and computational investigation of phenolate reactivities. Rate and equilibrium constants for the reactions of various phenolate ions with benzhydrylium ions (Aryl(2)CH(+)) and structurally related quinone methides have been determined photometrically in polar aprotic solvents. Quantum chemical calculations at the SMD(MeCN)/M06-2X/6-31+G(d,p) level confirmed that O attack is generally favored under kinetically controlled conditions, whereas C attack is favored under thermodynamically controlled conditions. Exceptions are diffusion limited reactions with strong electrophiles, which give mixtures of products arising from O and C attack, as well as reactions with metal alkoxides in nonpolar solvents, where oxygen attack is blocked by strong ion pairing. The Lewis basicity (LB) and nucleophilicity (N, s(N)) parameters of phenolates determined in this work can be used to predict whether their reactions with electrophiles are kinetically or thermodynamically controlled and whether the rates are activation-or diffusion-limited. Comparison of the measured rate constants for the reactions of phenolates with carbocations with the Gibbs energies for single electron transfer manifests that these reactions proceed via polar mechanisms.

SDS of cas: 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Mayer, RJ; Breugst, M; Hampel, N; Ofial, AR; Mayr, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Biomimetic Synthesis Enables the Structure Revision of Furoerioaustralasine WOS:000494553300055 published article about ERIOSTEMON; SYNTHASE in [Coleman, Matthew A.; Burchill, Laura; Sumby, Christopher J.; George, Jonathan H.] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia in 2019, Cited 12. Category: indole-building-block. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

The structure of furoerioaustralasine, a unique Australian alkaloid, has been revised based on a concise, biomimetic synthesis. The key step is a stereospecific, intramolecular ring opening of an epoxide to form a central dihydrofuran fused to a quinoline ring system.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Coleman, MA; Burchill, L; Sumby, CJ; George, JH or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about CATALYZED DENITROGENATIVE TRANSANNULATION; N-SULFONYL AZIDES; TERMINAL ALKYNES; DIASTEREOSELECTIVE SYNTHESIS; AZAVINYL CARBENES; DIRECT ARYLATION; REACTIVITY; N-SULFONYL-1,2,3-TRIAZOLES; 1,2,3-TRIAZOLES; ANNULATION, Saw an article supported by the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [GM120281]; National Science FoundationNational Science Foundation (NSF) [CHE-1663779]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zhang, ZY; Yadagiri, D; Gevorgyan, V. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol. Formula: C7H5F3O

A highly efficient and practical method for incorporation of the arylmethylpyridyl moiety into diverse molecules has been developed. This method features the transition metal-free light-induced room temperature transformation of pyridotriazoles into pyridyl carbenes, which are capable of smooth arylation, X-H insertion, and cyclopropanation reactions. The synthetic usefulness of the developed method was illustrated in a facile synthesis of biologically active molecules.

Formula: C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Zhang, ZY; Yadagiri, D; Gevorgyan, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 98-17-9. Recently I am researching about VERLEY-TYPE REDUCTION; ALCOHOLIC SUSPENSIONS; ROOM-TEMPERATURE; AQUEOUS-PHASE; CHEMOSELECTIVE REDUCTION; PHOTOINDUCED REDUCTION; DIOXIDE; NITROBENZENE; NANOPARTICLES; ALKENES, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [17H03462, 17H04967]; Precursory Research for Embryonic Science and Technology (PRESTO); Japan Science and Technology Agency (JST)Japan Science & Technology Agency (JST); MEXT-Supported Program for the Strategic Research Foundation at Private UniversitiesMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT); MEXT and Kindai University; Japan Society for the Promotion of Science (JSPS)Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [15J11412]; Faculty of Science and Engineering, Kindai University. Published in ELSEVIER in AMSTERDAM ,Authors: Kinoshita, A; Nakanishi, K; Yagi, R; Tanaka, A; Hashimoto, K; Kominami, H. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Since photocatalytic reactions are almost consistent with the concept of green chemistry, substance conversion using photocatalysts has recently attracted the attention of researchers in the fields of organic chemistry, physical chemistry and material chemistry. We investigated photoinduced ring hydrogenation of phenol over a metal-loaded titanium(IV) oxide (TiO2) photocatalyst without the use of H-2 gas and we report here the effects of various parameters, including the type and amount of metal co-catalyst loaded on TiO2 and the kinds of solvents and hole scavengers, on the ring hydrogenation. We found that the combination of an Rh co-catalyst, water and oxalic acid resulted in the highest yield of cyclohexanol. Detailed analyses revealed that phenol was first hydrogenated to cyclohexanone via keto-enol tautomerism of cyclohexenol followed by hydrogenation of cyclohexanone to cyclohexanol and that adsorption of phenol onto Rh-TiO2 is a factor of great importance for the ring hydrogenation.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Kinoshita, A; Nakanishi, K; Yagi, R; Tanaka, A; Hashimoto, K; Kominami, H or concate me.. SDS of cas: 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ryzhkov, FV; Ryzhkova, YE; Elinson, MN; Vorobyev, SV; Fakhrutdinov, AN; Vereshchagin, AN; Egorov, MP in [Ryzhkov, Fedor, V; Ryzhkova, Yuliya E.; Elinson, Michail N.; Fakhrutdinov, Artem N.; Vereshchagin, Anatoly N.; Egorov, Mikhail P.] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Leninsky Pr 47, Moscow 119991, Russia; [Vorobyev, Stepan V.] Gubkin Russian State Univ Oil & Gas, Dept Organ Chem & Petr Chem, 65 Leninsky Prospect, Moscow 119991, Russia published Catalyst-Solvent System for PASE Approach to Hydroxyquinolinone-Substituted Chromeno[2,3-b]pyridines Its Quantum Chemical Study and Investigation of Reaction Mechanism in 2020, Cited 63. Application In Synthesis of 4-Hydroxyquinolin-2(1H)-one. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

The Pot, Atom, and Step Economy (PASE) approach is based on the Pot economy principle and unites it with the Atom and Step Economy strategies; it ensures high efficiency, simplicity and low waste formation. The PASE approach is widely used in multicomponent chemistry. This approach was adopted for the synthesis of previously unknown hydroxyquinolinone substituted chromeno[2,3-b]pyridines via reaction of salicylaldehydes, malononitrile dimer and hydroxyquinolinone. It was shown that an ethanol-pyridine combination is more beneficial than other inorganic or organic catalysts. Quantum chemical studies showed that chromeno[2,3-b]pyridines has potential for corrosion inhibition. Real time H-1 NMR monitoring was used for the investigation of reaction mechanism and 2-((2H-chromen-3-yl)methylene)malononitrile was defined as a key intermediate in the reaction.

Application In Synthesis of 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Ryzhkov, FV; Ryzhkova, YE; Elinson, MN; Vorobyev, SV; Fakhrutdinov, AN; Vereshchagin, AN; Egorov, MP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Marjani, AP; Khalafy, J; Farajollahi, A in WILEY published article about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER in [Marjani, Ahmad Poursattar; Khalafy, Jabbar; Farajollahi, Ayda] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran in 2019, Cited 41. Category: indole-building-block. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones WOS:000496249500151 published article about FLUOROQUINOLONES; DERIVATIVES; INHIBITORS; MECHANISM; DESIGN; SIGNAL in [Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Braese, Stefan] Karlsruhe Inst Technol, Inst Organ Chem, D-76131 Karlsruhe, Germany; [Braese, Stefan] Karlsruhe Inst Technol, Inst Toxicol & Genet, D-76344 Eggenstein Leopoldshafen, Germany; [Polamo, Mika; Nieger, Martin] Univ Helsinki, Dept Chem, POB 55,AI Virtasen Aukio 1, Helsinki 00014, Finland; [Brown, Alan B.] Florida Inst Technol, Chem Program, Melbourne, FL 32901 USA in 2019, Cited 31. SDS of cas: 86-95-3. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c ‘]difuro[2,3-c:4,5-c ‘]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl- butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S; Polamo, M; Nieger, M; Brown, AB or concate me.. SDS of cas: 86-95-3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C9H10O3. Recently I am researching about CRYSTAL-STRUCTURE; ORGANIC-CRYSTAL; Z-SCAN; GROWTH; ABSORPTION; STABILIZATION; MOLECULES, Saw an article supported by the King Saud University, Riyadh, Saudi ArabiaKing Saud University [RSP2020/78]. Published in SPRINGER INTERNATIONAL PUBLISHING AG in CHAM ,Authors: Raghavendra, S; Kumar, CSC; Kumar, DJM; Al-Ghorbani, M; Alsalme, A; Quah, CK; Raghavendra, PV; Serrao, FJ; Dharmaprakash, SM. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Herein, we report the third-order nonlinear absorption and optical limiting property of fluorinated polymorphic nonlinear optical (NLO) material 1-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl) prop-2-en-1-one (abbreviated as PDPFO) based on reverse saturable absorption. The FTIR studies of optically transparent PDPFO single crystals confirm the presence of various functional groups. PDPFO is optically transparent in the visible wavelength region. The open aperture Z-scan technique showed the intensity-dependent nonlinear absorption. A decrease in normalized transmittance with input intensity indicated the optical limiting behavior at the wavelength 532 nm. The excited-state absorption cross-section value (sigma(ex)= 1.72 x 10(-16) cm(2)) is much greater than ground-state absorption cross-section value (sigma(g)= 2.49 x 10(-22) cm(2)), suggesting that optical limiting phenomena are due to RSA.

COA of Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Raghavendra, S; Kumar, CSC; Kumar, DJM; Al-Ghorbani, M; Alsalme, A; Quah, CK; Raghavendra, PV; Serrao, FJ; Dharmaprakash, SM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of Ethyl 2-Amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates by a One-pot, Three-Component Reaction in the Presence of TPAB WOS:000455256500030 published article about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER in [Marjani, Ahmad Poursattar; Khalafy, Jabbar; Farajollahi, Ayda] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran in 2019, Cited 41. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3. Safety of 4-Hydroxyquinolin-2(1H)-one

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.. Safety of 4-Hydroxyquinolin-2(1H)-one

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles