Tag: M.W=150-200

Application In Synthesis of 3-(Trifluoromethyl)phenol. I found the field of Chemistry very interesting. Saw the article Vapochromic Luminescent pi-Conjugated Systems with Reversible Coordination-Number Control of Hypervalent Tin(IV)-Fused Azobenzene Complexes published in 2021, Reprint Addresses Tanaka, K (corresponding author), Kyoto Univ, Grad Sch Engn, Dept Polymer Chem, Nishikyo Ku, Kyoto 6158510, Japan.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol.

The dynamic and reversible changes of coordination numbers between five and six in solution and solid states, based on hypervalent tin(IV)-fused azobenzene (TAz) complexes, are reported. It was found that the TAz complexes showed deep-red emission owing to the hypervalent bond composed of an electron-donating three-center four-electron (3c-4e) bond and an electron-accepting nitrogen-tin (N-Sn) coordination. Furthermore, hypsochromic shifts in optical spectra were observed in Lewis basic solvents because of alteration of the coordination number from five to six. In particular, vapochromic luminescence was induced by attachment of dimethyl sulfoxide (DMSO) vapor to the coordination point at the tin atom accompanied with a crystal-crystal phase transition. Additionally, the color-change mechanism and degree of binding constants were well explained by theoretical calculation. To the best of our knowledge, this is the first example of vapochromic luminescence by using stable and variable coordination numbers of hypervalent bonds.

Application In Synthesis of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Gon, M; Tanaka, K; Chujo, Y or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 3-(Trifluoromethyl)phenol. Yin, WY; Pan, XZ; Leng, WX; Chen, J; He, HF in [Yin, Weiyan; Pan, Xizhi; Leng, Wenxi] Wuhan Text Univ, Hubei Key Lab Biomass Fibers & Ecodyeing & Finish, Sch Chem & Chem Engn, Wuhan 430073, Hubei, Peoples R China; [Chen, Jian] Wuhan Univ Technol, Sch Chem Chem Engn & Lift Sci, Wuhan 430070, Hubei, Peoples R China; [He, Haifeng] Jiangxi Sci & Technol Normal Univ, Sch Chem & Chem Engn, Nanchang 330013, Jiangxi, Peoples R China published The highly efficient air oxidation of aryl and alkyl boronic acids by a microwave-assisted protocol under transition metal-free conditions in 2019, Cited 30. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

Molecular oxygen is the most important green-oxidant due to its excellent properties. However, the effective utilization of molecular oxygen remains a major challenge in modern chemistry. Herein, we report the development a rapid, green and efficient microwave-assisted protocol for the air oxidation of boronic acids to phenols and alcohols under transition metal-free conditions. In the presence of KOH and DMSO, high yields of the expected phenols and alcohol were obtained with microwave-assistance, and a variety of functional groups were tolerated in this procedure. Notably, this transition metal-free method represents a breakthrough in both organic synthesis and green chemistry for the oxidative hydroxylation of boronic acids to phenols and alcohols.

Name: 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Yin, WY; Pan, XZ; Leng, WX; Chen, J; He, HF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Catalytic O-H bond insertion reactions using surface modified sewage sludge as a catalyst WOS:000519903900026 published article about WET AIR OXIDATION; ARYL-ALPHA-DIAZOACETATES; FENTON-LIKE DEGRADATION; SI-H; CARBENE INSERTION; NATURAL-PRODUCTS; DIAZO-COMPOUNDS; N-H; HYDROGEN-ATOM; M-CRESOL in [Zhang, Zhipeng; Huang, Fei; Huang, He] Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China; [Zhang, Zhipeng] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou 510006, Peoples R China; [Yu, Yang; He, Yide] Nanjing Tech Univ, Sch Environm Sci & Engn, Nanjing 211816, Peoples R China; [Yi, Xiangyan; Baell, Jonathan B.; Huang, He] Nanjing Tech Univ, Sch Pharmaceut Sci, Nanjing 211816, Peoples R China; [Xu, Yao] Soochow Univ, Affiliated Hosp 1, Suzhou 215006, Peoples R China; Monash Univ, Monash Inst Pharmaceut Sci, Med Chem, Parkville, Vic 3052, Australia in 2020, Cited 108. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Computed Properties of C7H5F3O

Developing a greener, sustainable catalyst is a very important but challenging task in organic synthesis. Herein, for the first time, we choose more economical and greener surface modified sewage sludge-derived carbonaceous materials (SW) treated by perchloric acid as a new catalyst for carbene insertion of alpha-aryl alpha-diazoacetates into O-H bonds of phenols with good yields and high functional group tolerance. Significantly, we explored the scope of natural phenols with compelling biological activity, and successfully afforded the O-H insertion and meta C-H functionalization products. Their structures have been confirmed by single-crystal X-ray crystallography. Furthermore, the bioactivities (anti-tumor and anti-inflammatory) of the majority of O-H insertion products are better than those of the natural phenols themselves. The IC50 values indicated that the remarkable compounds 7a (IC50 = 16.80 mu M) and 7c (IC50 = 16.48 mu M) had better inhibition for tumor cell A-549 than positive control DDP (IC50 = 20.62 mu M). It should be noted that these transformations may provide a new strategy to derive natural products and discover new drugs.

Computed Properties of C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Zhang, ZP; Yu, Y; Huang, F; Yi, XY; Xu, Y; He, YD; Baell, JB; Huang, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of N-Acyl Sulfamates from Fluorosulfates and Amides WOS:000456632800058 published article about SIDEROPHORE BIOSYNTHESIS; NUCLEOSIDE ANTIBIOTICS; ARYL FLUOROSULFONATES; MECHANISM; FLUORIDE; ACYLTRANSFERASE; TUBERCULOSIS; ASCAMYCIN; PHENOLS; TARGET in [Gilles, Philippe; Veryser, Cedrick; Vangrunderbeeck, Sarah; Ceusters, Sam; De Borggraeve, Wim M.] Katholieke Univ Leuven, Dept Chem, Mol Design & Synth, Celestijnenlaan 200F,Box 2404, B-3001 Leuven, Belgium; [Van Meervelt, Luc] Katholieke Univ Leuven, Dept Chem, Biochem Mol & Struct Biol, Celestijnenlaan 200F,Box 2404, B-3001 Leuven, Belgium in 2019, Cited 34. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Formula: C7H5F3O

A novel synthetic strategy toward N-acyl sulfamates was developed. Interestingly, fluorosulfates, a new emerging class of electrophiles, were used to construct the sulfamate core. This precludes handling of chlorosulfonyl isocyanate and sulfamoyl chloride. In combination with amides, a wide and diverse set of N-acyl sulfamates was synthesized, including functionalized bioactive compounds. Furthermore, initial results showed that this method is also amenable to access N-thioacyl sulfamates.

Formula: C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Gilles, P; Veryser, C; Vangrunderbeeck, S; Ceusters, S; Van Meervelt, L; De Borggraeve, WM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Marjani, AP; Khalafy, J; Farajollahi, A in WILEY published article about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER in [Marjani, Ahmad Poursattar; Khalafy, Jabbar; Farajollahi, Ayda] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran in 2019, Cited 41. Name: 4-Hydroxyquinolin-2(1H)-one. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.. Name: 4-Hydroxyquinolin-2(1H)-one

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C7H5F3O. Recently I am researching about METAL-FREE; STEREOSELECTIVE-SYNTHESIS; ALKENE DERIVATIVES; ACTIVATED ALKYNES; CYCLIZATION; MIGRATION; ACIDS; DIFUNCTIONALIZATION; COUMARINS; BOND, Saw an article supported by the DST-SERB India; UGCUniversity Grants Commission, India; IIT-Madras. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Sahoo, H; Ramakrishna, I; Mandal, A; Baidya, M. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

An oxidative trifunctionalization of aryl alkynoates has been devised via the chalcogenide radical triggered intramolecular 1,4-aryl migration/decarboxylation cascade to prepare 1,1-dichalcogenide tetrasubstituted alkenes in high yields (up to 98 %). This operationally simple reaction proceeds under metal-free conditions, can be executed on gram scale, and highlights formal 1,1-difunctionalization of alkynes. Synthetic potential of this protocol was demonstrated through a twofold cascade rearrangement to access highly conjugated tetra-selenylated alkenes along with a cross-dehydrogenative annulation to prepare fluorene derivative.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Sahoo, H; Ramakrishna, I; Mandal, A; Baidya, M or concate me.. Computed Properties of C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Hu, SY; Zhao, TP; Xu, K; Ji, SH; Cao, LF; Teng, B in ELSEVIER GMBH published article about in [Hu, Siyuan; Zhao, Tongpeng; Xu, Kai; Ji, Shaohua; Cao, Lifeng; Teng, Bing] Qingdao Univ, Coll Phys, Qingdao 266071, Peoples R China; [Hu, Siyuan; Zhao, Tongpeng; Xu, Kai; Ji, Shaohua; Cao, Lifeng; Teng, Bing] Natl Demonstrat Ctr Expt Appl Phys Educ, Qingdao 266071, Peoples R China; [Hu, Siyuan; Zhao, Tongpeng; Xu, Kai; Ji, Shaohua; Cao, Lifeng; Teng, Bing] Qingdao Univ, Univ Ind Joint Ctr Ocean Observat & Broadband Com, Coll Phys, Qingdao 266071, Peoples R China in 2021.0, Cited 32.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

1-(4-methoxyphenyl)-3-(3, 4-dimethoxyphenyl)-2-propen-1-one(DMMC), a chalcone derivative was synthesized by Claisen-Schmidt condensation reaction method. The growth of DMMC in methanol was used the slow evaporation technique. Single crystal X-ray diffraction revealed that the space group of DMMC is P2(1). The intermolecular interaction of crystal was analyzed by Hirshfeld surface. The second harmonic generation efficiency of DMMC was measured by Kurtz-Perry powder method. When the particle size was between 250 and 300 mu m, the SHG efficiency of DMMC was the largest, which was about 60 times that of the KDP with the same particle size. All functional groups of the crystal were identified by FT-IR and H-1 NMR spectral. This crystal had a wide transmission range in the region of 350-2000 nm with the cut off wavelength is 400 nm. The thermal properties of the sample were tested, and the melting point was at 95.59 degrees C. The dielectric constant of the compounds was found to be 17 below 45 degrees C.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Hu, SY; Zhao, TP; Xu, K; Ji, SH; Cao, LF; Teng, B or concate me.. Recommanded Product: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Dai, H; Huang, ML; Qian, JQ; Liu, J; Meng, C; Li, YY; Ming, GX; Zhang, T; Wang, SL; Shi, YJ; Yao, Y; Ge, SS; Zhang, YN; Ling, Y in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about BIOLOGICAL EVALUATION; COUMARIN DERIVATIVES; MOLECULAR DOCKING; ANTICANCER ACTIVITY; PYRAZOLE; DESIGN; APOPTOSIS; POTENT; AGENTS; METASTASIS in [Dai, Hong; Huang, Meiling; Wang, Senling; Shi, Yujun; Yao, Yong; Ge, Shushan; Ling, Yong] Nantong Univ, Coll Chem & Chem Engn, Nantong 226019, Peoples R China; [Dai, Hong; Huang, Meiling; Qian, Jianqiang; Liu, Ji; Meng, Chi; Li, Yangyang; Ming, Guxu; Zhang, Ting; Ge, Shushan; Zhang, Yanan; Ling, Yong] Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China; [Qian, Jianqiang; Liu, Ji; Meng, Chi; Li, Yangyang; Ming, Guxu; Zhang, Ting; Zhang, Yanan; Ling, Yong] Nantong Univ, Jiangsu Prov Key Lab Inflammat & Mol Drug Target, Nantong 226001, Peoples R China in 2019, Cited 49. Formula: C7H5F3O. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

A series of hybrids 10a-v based on coumarin/pyrazole oxime have been synthesized, and exhibit good to excellent antitumor activities. Compound 10n has shown remarkable anticancer effect on SMMC-7721 cells (IC50 = 2.08 mu M), which is considerably lower than 5-FU (IC50 = 37.8 mu M) and similar to ADM (IC50 = 2.67 mu M), with little effect on normal hepatic cells LO2. Notably, the suppression experiments of metastatic activities reveal that 10n also displays significant anti-metastasis effects through inhibiting cell migration and invasion in highly metastatic SMMC-7721 cell line, and dose-dependently reverses TGF-beta 1-induced epithelial-mesenchymal transition (EMT) procedure better than ADM. Finally, 10n also possesses low acute toxicity and potent tumor growth inhibitory property against SMMC-7721 cell lines in vivo. Our findings suggest that novel coumarin/pyrazole oxime hybrids are promising therapeutic agent candidates for further research. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Dai, H; Huang, ML; Qian, JQ; Liu, J; Meng, C; Li, YY; Ming, GX; Zhang, T; Wang, SL; Shi, YJ; Yao, Y; Ge, SS; Zhang, YN; Ling, Y or concate me.. Computed Properties of C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article One-Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols WOS:000522553300023 published article about PALLADIUM-CATALYZED AMINATION; DIELS-ALDER REACTIONS; ARYL HALIDES; NUCLEOPHILIC-ADDITION; SELECTIVE SYNTHESIS; AMMONIA EQUIVALENT; PRIMARY AMINES; ARYNES; CHEMISTRY; MILD in [Ikawa, Takashi; Masuda, Shigeaki; Akai, Shuji] Osaka Univ, Grad Sch Pharmaceut Sci, Yamadaoka 1-6, Suita, Osaka 5650871, Japan in 2020, Cited 112. Category: indole-building-block. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

Benzynes were selectively generated in situ from phenols and trapped regioselectively with potassium hexamethyldisilazide to form primary anilines following acidic workup. The direct conversion of a phenolic hydroxyl group into a free amino group is a useful method for the preparation of primary aryl amines that are hard to synthesize by using coupling reactions involving phenol derivatives with ammonia. Whereas reactions of ortho- and meta-substituted phenols produced meta-substituted anilines exclusively, those of para-substituted phenols provided ortho-silylanilines.

Category: indole-building-block. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Ikawa, T; Masuda, S; Akai, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 86-95-3. In 2020 MONATSH CHEM published article about DERIVATIVES; INHIBITORS; FUROQUINOLINE; ALKALOIDS; MODEL in [Aly, Ashraf A.; Mohamed, Asmaa H.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Ishak, Esam] Al Azhar Univ, Fac Sci, Dept Chem, Assiut, Egypt; [Ishak, Esam] Jouf Univ, Coll Sci & Arts, Dept Chem, Alquurrayate, Saudi Arabia; [Shwaky, Ahmed M.] Umm Al Qura Univ, STU, Mecca, Saudi Arabia in 2020, Cited 31. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Quinoline-2,4-diones reacted with 2-[bis(methylthio)methylene]malononitrile in DMF/Et3N to produce 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carbonitriles and 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides in state of 2-imino-substituted 4-(methylthio)-5,6-dihydro-2H-pyrano[3,2-c]quinolone-3-carbonitriles. The structures of all new products were proved using NMR, IR, and mass spectral data. The possible mechanism for the reaction is also discussed. Graphic abstract

SDS of cas: 86-95-3. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles