Tag: M.W=150-200

Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH in [Aly, Ashraf A.; Mohamed, Asmaa H.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Ishak, Esam] Al Azhar Univ, Fac Sci, Dept Chem, Assiut, Egypt; [Ishak, Esam] Jouf Univ, Coll Sci & Arts, Dept Chem, Alquurrayate, Saudi Arabia; [Shwaky, Ahmed M.] Umm Al Qura Univ, STU, Mecca, Saudi Arabia published Formation of furo[3,2-c]quinolone-2-carbonitriles and 4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides from reaction of quinoline-2,4-diones with 2-[bis(methylthio)methylene]malononitrile in 2020, Cited 31. Formula: C9H7NO2. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Quinoline-2,4-diones reacted with 2-[bis(methylthio)methylene]malononitrile in DMF/Et3N to produce 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carbonitriles and 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides in state of 2-imino-substituted 4-(methylthio)-5,6-dihydro-2H-pyrano[3,2-c]quinolone-3-carbonitriles. The structures of all new products were proved using NMR, IR, and mass spectral data. The possible mechanism for the reaction is also discussed. Graphic abstract

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH or concate me.. Formula: C9H7NO2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article The construction of C(sp(3))-O bond via copper porphyrin catalyzed cross-dehydrogenative coupling reaction: Substituent and electronic effect of the catalysts published in 2021. Recommanded Product: 3-(Trifluoromethyl)phenol, Reprint Addresses Liu, HY; Yuan, GQ (corresponding author), South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Dept Chem, Guangzhou, Peoples R China.; Shi, L (corresponding author), Guangdong Univ Educ, Dept Chem, Guangzhou, Peoples R China.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

The push-pull electronic and steric effect of copper porphyrin catalysts on the cross-dehydrogenative coupling (CDC) reaction between the hydroxyl group of phenol substrates and C(sp(3))-H bond have been investigated. Results showed that copper porphyrin bearing electron-withdrawing, bulky steric hindrance or heteroatom of pyridyl groups could increase the catalytic activity in the reaction. 5,10,15,20-(tetrakis(4-pyridyl)porphyrin)copper (CuTPyP) was found the best among all tested catalysts. Phenol substrates bearing various functional groups afforded moderate to excellent yields (99%). Significantly, as compared to other tested copper porphyrins, CuTPyP not only exhibited remarkable higher activity but also could shorten the reaction time from 12 to 6 h.

Recommanded Product: 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Wang, FH; Liu, ZY; Yang, S; Shi, L; Lin, DZ; Liu, HY; Yuan, GQ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Coleman, MA; Burchill, L; Sumby, CJ; George, JH in AMER CHEMICAL SOC published article about ERIOSTEMON; SYNTHASE in [Coleman, Matthew A.; Burchill, Laura; Sumby, Christopher J.; George, Jonathan H.] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia in 2019, Cited 12. Safety of 4-Hydroxyquinolin-2(1H)-one. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

The structure of furoerioaustralasine, a unique Australian alkaloid, has been revised based on a concise, biomimetic synthesis. The key step is a stereospecific, intramolecular ring opening of an epoxide to form a central dihydrofuran fused to a quinoline ring system.

Safety of 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Coleman, MA; Burchill, L; Sumby, CJ; George, JH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Pike, SJ; Lavagnini, E; Varley, LM; Cook, JL; Hunter, CA in [Pike, Sarah J.; Lavagnini, Ennio; Hunter, Christopher A.] Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England; [Varley, Lisa M.] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England; [Cook, Joanne L.] Unilever R&D Port Sunlight, Quarry Rd East, Wirral CH63 3JW, Merseyside, England published H-Bond donor parameters for cations in 2019, Cited 70. Product Details of 98-17-9. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

UV/Vis absorption and NMR spectroscopy titrations have been used to investigate the formation of complexes between cations and neutral H-bond acceptors in organic solvents. Complexes formed by two different H-bond acceptors with fifteen different cations were studied in acetone and in acetonitrile. The effects of water and ion pairing with the counter-anion were found to be negligible in the two polar solvents employed for this study. The data were used to determine self-consistent H-bond donor parameters (a) for a series of organic and inorganic cations; guanidinium, primary, tertiary and quaternary ammonium, imidazolium, methylpyridinium, lithium, sodium, potassium, rubidium and caesium. The results demonstrate the transferability of a parameters for cations between different solvents and different H-bond acceptor partners, allowing reliable prediction of cation recognition properties in different environments. Lithium and protonated nitrogen cations form the most stable complexes, but the a parameter is only 5.0, which is similar to the neutral H-bond donor 3-trifluoromethyl, 4-nitrophenol (a 1/4 5.1). Quaternary ammonium is the weakest H-bond donor investigated with an a value of 2.7, which is comparable to an alcohol. The a parameters for alkali metal cations decrease down the group from 5.0 (Li+) to 3.5 (Cs+).

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Pike, SJ; Lavagnini, E; Varley, LM; Cook, JL; Hunter, CA or concate me.. Product Details of 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 ARCH PHYSIOL BIOCHEM published article about CARBONIC-ANHYDRASE INHIBITORS; TROUT ONCORHYNCHUS-MYKISS; ERYTHROCYTE ISOZYMES I; CRYSTAL-STRUCTURE; ANTICHOLINERGIC ACTIVITIES; BIOLOGICAL EVALUATION; MEDICINAL CHEMISTRY; 1ST SYNTHESIS; HALOGEN BOND; ACETYLCHOLINESTERASE in [Burmaoglu, Serdar] Erzincan Binali Yildirim Univ, Tercan Vocat High Sch, TR-24800 Erzincan, Turkey; [Burmaoglu, Serdar; Yilmaz, Ali Osman; Gulcin, Ilhami] Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey; [Polat, M. Fatih] Erzincan Binali Yildirim Univ, Fac Pharm, Dept Pharmaceut Basic Sci, Erzincan, Turkey; [Kaya, Ruya] Ibrahim Cecen Univ Agri, Cent Res & Applicat Lab, Agri, Turkey; [Algul, Oztekin] Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, Mersin, Turkey in 2021, Cited 86. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Name: 3,4-Dimethoxybenzaldehyde

In this study, we report the synthesis of novel tris-chalcones and testing of human carbonic anhydrase I, and II isoenzymes (hCA I, and hCA II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase (alpha-Gly) inhibitors for the development of novel chalcone structures towards for treatment of some diseases. The compounds demonstrated K-i values between 13.6 +/- 1.1 and 50.0 +/- 17.1 nM on hCA I, 9.9 +/- 0.8 and 39.5 +/- 15.1 nM on hCA II, 3.1 +/- 0.2 and 20.1 +/- 1.9 nM on AChE, 4.9 +/- 0.4 and 14.7 +/- 5.2 nM on BChE and 3.9 +/- 0.2 and 22.4 +/- 10.7 nM on alpha-Gly enzymes. The results revealed that novel tris-chalcones can have promising drug potential for glaucoma, leukaemia, epilepsy; Alzheimer’s disease that was associated with the high enzymatic activity of hCA I, hCA II, AChE, and BChE enzymes.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Burmaoglu, S; Yilmaz, AO; Polat, MF; Kaya, R; Gulcin, I; Algul, O or concate me.. Name: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3,4-Dimethoxybenzaldehyde. In 2021.0 NEW J CHEM published article about ENANTIOSELECTIVE CONSTRUCTION; STEREOCENTERS; CYCLOPROPANATION; DEAROMATIZATION; STRYCHNINE; ALKALOIDS in [Devi, Manju; Jadhav, Amol P.; Singh, Ravi P.] Indian Inst Technol, Dept Chem, Hauz Khas, New Delhi 110016, India in 2021.0, Cited 47.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

The stereoselective synthesis of 3,3 ‘-disubstituted oxindoles having all-carbon quaternary stereocenters has been achieved using KOH as a base with an excellent diastereomeric ratio (98 : 2). The practicability of the present methodology has been validated with the synthesis of a series of substrates in good to excellent yields. The aesthetic simplicity, accessibility, and eco-friendly base (KOH) have prompted the broader application of the present methodology in organic synthesis.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Devi, M; Jadhav, AP; Singh, RP or concate me.. Safety of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Chauhan, DS; Quraishi, MA; Qurashi, A in ELSEVIER published article about in [Chauhan, Dheeraj Singh; Quraishi, M. A.] King Fahd Univ Petr & Minerals, Ctr Res Excellence Corros, Res Inst, Dhahran 31261, Saudi Arabia; [Qurashi, Ahsanulhaq] Khalifa Univ Sci & Technol, Dept Chem, Main Campus,POB 127788, Abu Dhabi, U Arab Emirates in 2021.0, Cited 133.0. Quality Control of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The oil and gas industry suffers from severe economic impact due to the corrosion of pipelines during the industrial oil-well acidizing process and because of the sweet corrosion of steel. One of the most common solutions to counter this issue is applying organic compounds as corrosion inhibitors. Conventionally used inhibitors are quite cumbersome to synthesize, are costly, and most are toxic. Therefore, there exists a need for research and development of novel, cost-effective, and eco-friendly corrosion inhibitors showing efficient inhibition performance. The present work describes the basics of corrosion, its economic impact, and the main strategies to counter this issue. Fundamentals of sweet corrosion, the mechanism involved, the influence of various governing factors, and the limitations of the existing inhibitor chemistries are explained. Some of the prominent classes of the environmentally benign sweet corrosion inhibitors such as the biopolymers, heterocyclic molecules, and pharmaceutical products are also outlined. The focus is on the recent research work in this area, and some of the prospective research aspects are envisaged. (C) 2020 Published by Elsevier B.V.

Quality Control of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Chauhan, DS; Quraishi, MA; Qurashi, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 3,4-Dimethoxybenzaldehyde. I found the field of Chemistry very interesting. Saw the article LaMnO3 Supported Ionic Liquid; an Efficient Catalyst for One-Pot Three-Component Synthesis of Tetrahydrobenzo[b]Pyran Derivatives Under Solvent-Free Conditions published in 2021, Reprint Addresses Saadati-Moshtaghin, HR (corresponding author), Islamic Azad Univ, Islamshahr Branch, Young Researchers & Elite Club, Islamshahr 19166, Iran.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde.

A new recyclable nanocatalyst consisting of heteropoly acid grafted on ionic liquid modified LaMnO3 nanoparticles was synthesized and accomplished as an efficient catalyst in condensation reaction for the preparation of tetrahydrobenzo[b]pyrans under solvent-free conditions. In addition, it was clarified that supported heteropoly acid (HPA) is the active site for the catalytic reaction, whereas the LaMnO3, ionic liquid functionalized lanthanum manganite nanoparticles are inactive. Different physicochemical methods such as Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), and field emission scanning electron microscopy (FESEM) were used to characterize the hybrid nanomaterial. The nanocatalyst reusability was affirmed by the use of five consecutive runs. Compared with the various previously reported catalyst, the new synthesized catalyst was found to be the most efficient with regard to reaction time, yield and ease of catalyst separation.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Saadati-Moshtaghin, HR; Abbasinohoji, F or concate me.. Name: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 4-Hydroxyquinolin-2(1H)-one. Aly, AA; El-Sheref, EM; Bakheet, MEM; Mourad, MAE; Brase, S; Ibrahim, MAA; Nieger, M; Garvalov, BK; Dalby, KN; Kaoud, TS in [Aly, Ashraf A.; El-Sheref, Essmat M.; Bakheet, Momtaz E. M.; Ibrahim, Mahmoud A. A.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Mourad, Mai A. E.] Port Said Univ, Med Chem Dept, Fac Pharm, Port Said 42526, Egypt; [Kaoud, Tamer S.] Menia Univ, Fac Pharm, Dept Med Chem, El Minia 61519, Egypt; [Brase, Stefan] Karlsruhe Inst Technol, Inst Toxikol & Genet, Hermann von Helmholts Pl 1,Campus Nord, D-76344 Eggenstein Leopoldsha, Germany; [Brase, Stefan] Inst Toxikol & Genet, Hermann von Helmholts Pl 1,Campus Nord, D-76344 Eggenstein Leopoldsha, Germany; [Nieger, Martin] Univ Helsinki, Dept Chem, POB 55, Helsinki 00014, Finland; [Garvalov, Boyan K.] Mannhe Univ Heidelberg, Ctr Biomed & Med Technol Mannheim, Med Fac, D-68167 Mannheim, Germany; [Dalby, Kevin N.; Kaoud, Tamer S.] Univ Texas Austin, Div Chem Biol & Med Chem, Austin, TX 78712 USA published Design, synthesis and biological evaluation of fused naphthofuro[3,2-c]quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma in 2019, Cited 57. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Approximately 60% of human cancers exhibit enhanced activity of ERK1 and ERK2, reflecting their multiple roles in tumor initiation and progression. Acquired drug resistance, especially mechanisms associated with the reactivation of the MAPK (RAF/MEK/ERK) pathway represent a major challenge to current treatments of melanoma and several other cancers. Recently, targeting ERK has evolved as a potentially attractive strategy to overcome this resistance. Herein, we report the design and synthesis of novel series of fused naphthofuro[3,2-c] quinoline-6,7,12-triones 3a-f and pyrano[3,2-c]quinoline-6,7,8,13-tetraones 5a,b and 6, as potential ERK inhibitors. New inhibitors were synthesized and identified by different spectroscopic techniques and X-ray crystallography. They were evaluated for their ability to inhibit ERK1/2 in an in vitro radioactive kinase assay. 3b and 6 inhibited ERK1 with IC50s of 0.5 and 0.19 mu M, and inhibited ERK2 with IC50s of 0.6 and 0.16 mu M respectively. Kinetic mechanism studies revealed that the inhibitors are ATP-competitive inhibitors where 6 inhibited ERK2 with a K-i of 0.09 mu M. Six of the new inhibitors were tested for their in vitro anticancer activity against the NCI-60 panel of tumor cell lines. Compound 3b and 6 were the most potent against most of the human tumor cell lines tested. Moreover, 3b and 6 inhibited the proliferation of the BRAF mutant A375 melanoma cells with IC50s of 3.7 and 0.13 mu M, respectively. In addition, they suppressed anchorage-dependent colony formation. Treatment of the A375 cell line with 3b and 6 inhibited the phosphorylation of ERK substrates p-90RSK and ELK-1 and induced apoptosis in a dose dependent manner. Finally, a molecular docking study showed the potential binding mode of 3b and 6 within the ATP catalytic binding site of ERK2.

Application In Synthesis of 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; El-Sheref, EM; Bakheet, MEM; Mourad, MAE; Brase, S; Ibrahim, MAA; Nieger, M; Garvalov, BK; Dalby, KN; Kaoud, TS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 BIOORG CHEM published article about FLUOROQUINOLONE DERIVATIVES; ANTICANCER ACTIVITY; ANTIBACTERIAL; APOPTOSIS; DNA; MECHANISM; ANTITUMOR; PROLIFERATION; GYRASE; TARGET in [Samir, Mohamed; Ramadan, Mohamed; Abdelrahman, Mostafa H.; Abdelbaset, Mahmoud S.] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71524, Egypt; [Abourehab, Mohammed A. S.] Menia Univ, Fac Pharm, Dept Pharmaceut, Al Minya 61519, Egypt; [Abourehab, Mohammed A. S.] Umm Al Qura Univ, Fac Pharm, Dept Pharmaceut, Mecca 21955, Saudi Arabia; [Abdel-Aziz, Mohamed; Abuo-Rahma, Gamal El-Din A.] Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt; [Abuo-Rahma, Gamal El-Din A.] Deraya Univ, Fac Pharm, Dept Pharmaceut Chem, New Minia, Minia, Egypt in 2021, Cited 26. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. HPLC of Formula: C9H10O3

We report herein design and synthesis of a new series of 3,7-bis-benzylidenes of ciprofloxacin. Most of the target compounds revealed good cytotoxic activity; the most potent 4e and 4i achieved strong broad spectrum antiproliferative activity with comparable activity to Doxorubicin with IC50 (M-mu) of 1.21 +/- 0.02, 0.87 +/- 0.04, 1.21 +/- 0.02; 0.41 +/- 0.02, 0.57 +/- 0.06, 1.31 +/- 0.04 and 1.26 +/- 0.01, 1.79 +/- 0.04, 0.63 +/- 0.01 against leukemia cancer cell line HL-60 (TB), colon cancer cell line HCT-116 and breast cancer cell line MCF7, respectively. Moreover, the most potent derivative 4i induced apoptosis at G2/M phase Investigating the mechanism of action of compounds 4e, 4 h and 4i exhibited promising dual TOP I alpha and TOP IIB % inhibition comparable to Camptothecin and Etoposide; respectively. Docking of 4e, 4 h and 4i into the active site of topo I and II proteins compared to Camptothein and Etoposide revealed acceptable binding score and augmented enzyme assay data. Hence, 4e and 4i are promising targeted antiproliferative dual acting TOP I alpha TOP IIB inhibitors that require further optimization.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Samir, M; Ramadan, M; Abdelrahman, MH; Abdelbaset, MS; Abourehab, MAS; Abdel-Aziz, M; Abuo-Rahma, GEDA or concate me.. HPLC of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles