Tag: M.W=150-200

Recently I am researching about THIACROWN ETHERS; X-RAY; COMPLEXATION; MALONONITRILE; DERIVATIVES; SCAFFOLDS; BEHAVIOR; SULFUR, Saw an article supported by the Russian Science FoundationRussian Science Foundation (RSF) [19-73-00070]; Russian Ministry of Education and ScienceMinistry of Education and Science, Russian Federation [2019-05-595-000-058]; [AAAA-A19-119022290010-9]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Akhmadiev, NS; Mescheryakova, ES; Akhmetova, VR; Ibragimov, AG. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde. SDS of cas: 120-14-9

The first synthesis of 5,12-diamino-7,14-bis(aryl)-1,4,8,11-tetrathiacyclotetradeca-5,12-diene-6,13-dicarbonitriles was performed as a multicomponent macroheterocyclization of malononitrile, aryl aldehydes, and 1,2-ethanedithiol in the presence of a catalytic amount of triethylamine in ethanol. The structures of the obtained macroheterocycles were confirmed by spectral methods, X-ray diffraction, and MALDI TOF mass spectrometry.

SDS of cas: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Akhmadiev, NS; Mescheryakova, ES; Akhmetova, VR; Ibragimov, AG or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 3,4-Dimethoxybenzaldehyde. In 2021 RSC ADV published article about ONE-POT; MAGNETIC NANOPARTICLES; CLAISEN REARRANGEMENT; DERIVATIVES; EFFICIENT; GLYCALS; DRUGS; DECONTAMINATION; HETEROCYCLES; ANTICANCER in [Torabi, Morteza; Yarie, Meysam; Zolfigol, Mohammad Ali] Buali Sina Univ, Fac Chem, Dept Organ Chem, Hamadan 6517838683, Hamadan, Iran; [Rouhani, Shamila; Msagati, Titus A. M.] Univ South Africa, Coll Sci Engn & Technol, Inst Nanotechnol & Water Sustainabil iNanoWS, ZA-1709 Johannesburg, South Africa; [Azizi, Shohreh; Maaza, Malik] Univ South Africa, Coll Grad Studies, UNESCO UNISA Africa Chair Nanosci & Nanotech, POB 392, Pretoria, South Africa; [Azizi, Shohreh] iThemba LABS Natl Res Fdn, Nanosci African Network NANOAFNET, 1 Old Faure Rd,POB 722, ZA-7129 Western Cape, South Africa; [Olomola, Temitope O.] Obafemi Awolowo Univ, Dept Chem, Ife 220005, Nigeria; [Msagati, Titus A. M.] Nelson Mandela African Inst Sci & Technol, Sch Life Sci & Bioengn, POB 447, Arusha, Tanzania in 2021, Cited 96. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

In the present study, we reported the synthesis of a novel quinoline-based dendrimer-like ionic liquid. After characterization of the mentioned ionic liquid with suitable techniques such as Fourier transform infrared spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDX), elemental mapping, thermogravimetric analysis (TGA) and derivative thermogravimetry (DTG), its catalytic performance was investigated in the synthesis of new pyridines with sulfonamide moiety via a cooperative vinylogous anomeric-based oxidation mechanism under mild reaction conditions. All target molecules were achieved in short reaction times and high yields.

Name: 3,4-Dimethoxybenzaldehyde. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3,4-Dimethoxybenzaldehyde. In 2021.0 TETRAHEDRON published article about SOLVENT-FREE; CHEMOSELECTIVE ACETALIZATION; EFFICIENT CATALYST; HIGHLY EFFICIENT; ACID CATALYSTS; ALDEHYDES; ACETALS; MILD; KETALIZATION in [Wang, Di; Cao, Fu-Rong; Lu, Guangying; Ren, Jiangmeng; Zeng, Bu-Bing] East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China in 2021.0, Cited 72.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

A novel PVP-I catalyzed acetalizations/transacetalizations of carbonyl compounds has been developed processing with a mild and easy handling fashion. Different types of Acyclic and cyclic acetals were prepared from carbonyl compounds or their acetals successfully. Further applications of newly developed catalytic combination were testified. This protocol featured with simplicity of operation, mild reaction condition, short reaction time, recyclable of catalyst and broad substrates scope with excellent yields. (c) 2021 Elsevier Ltd. All rights reserved.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Wang, D; Cao, FR; Lu, GY; Ren, JM; Zeng, BB or concate me.. Recommanded Product: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 120-14-9. Authors Chu, PC; Wu, YC; Chen, CY; Hung, YS; Chang, CS in FUTURE SCI LTD published article about in [Chu, Po-Chen] China Med Univ, Dept Cosmeceut, Taichung 40402, Taiwan; [Chu, Po-Chen] China Med Univ, Grad Inst Cosmeceut, Taichung 40402, Taiwan; [Chu, Po-Chen; Chang, Chih-Shiang] China Med Univ, Drug Dev Ctr, Taichung 40402, Taiwan; [Wu, Yu-Chieh; Chen, Chien-Yu; Hung, Yu-Syuan; Chang, Chih-Shiang] China Med Univ, Sch Pharm, Coll Pharm, Taichung 40402, Taiwan in 2021, Cited 35. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Aim: Tumor cells adapt to hypoxic microenvironments by releasing the key transcription factor HIF-1 alpha, which promotes angiogenesis, glycolytic phenotype, metastasis and erythropoiesis, allowing proliferation amid low oxygen levels. Therefore, therapeutic targeting of HIF-1 alpha represents a viable strategy for cancer therapy. Methods & Results: The authors synthesized a series of novel tetrahydroquinazoline derivatives in six steps and demonstrated that their development had a unique ability to suppress HIF-1 alpha expression through proteasomal degradation. Conclusion: Among these compounds, CDMP-TQZ (8bf) exhibited the highest antiproliferative potency in human cancer cells, in part through downregulation of HIF-1 alpha.

Product Details of 120-14-9. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor WOS:000464108100012 published article about GROWTH-FACTOR RECEPTOR; NF-KAPPA-B; NITRIC-OXIDE; ACTIVATION; PATHWAY; MACROPHAGES in [Elkamhawy, Ahmed; Roh, Eun Joo] KIST, Chem Kin Res Ctr, Seoul 02792, South Korea; [Elkamhawy, Ahmed] Mansoura Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Mansoura 35516, Egypt; [Hassan, Ahmed H. E.] Mansoura Univ, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt; [Hassan, Ahmed H. E.; Lee, Yong Sup] Kyung Hee Univ, Coll Pharm, Dept Pharm, Med Chem Lab, Seoul 02447, South Korea; [Paik, Sora; Lee, Yong Sup] Kyung Hee Univ, Coll Pharm, Dept Fundamental Pharmaceut Sci, Seoul 02447, South Korea; [Lee, Hwi-Ho; Shin, Ji-Sun; Lee, Kyung-Tae] Kyung Hee Univ, Coll Pharm, Dept Life & Nanopharmaceut Sci, Seoul 02447, South Korea; [Lee, Hwi-Ho; Shin, Ji-Sun; Lee, Kyung-Tae] Kyung Hee Univ, Coll Pharm, Dept Pharmaceut Biochem, Seoul 02447, South Korea; [Roh, Eun Joo] Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea in 2019, Cited 44. Product Details of 98-17-9. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

EGFR inhibitors are well-known as anticancer agents. Quite differently, we report our effort to develop EGFR inhibitors as anti-inflammatory agents. Pyrimidinamide EGFR inhibitors eliciting low micromolar IC50 and the structurally close non-EGFR inhibitor urea analog were synthesized. Comparing their nitric oxide (NO) production inhibitory activity in peritoneal macrophages and RAW 246.7 macrophages indicated that their anti-inflammatory activity in peritoneal macrophages might be a sequence of EGFR inhibition. Further evaluations proved that compound 4d significantly and dose-dependently inhibits LPS-induced iNOS expression and IL-1 beta, IL-6, and TNF-alpha production via NF-kappa B inactivation in peritoneal macrophages. Compound 4d might serve as a lead compound for development of a novel class of anti-inflammatory EGFR inhibitors.

Product Details of 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Elkamhawy, A; Hassan, AHE; Paik, S; Lee, YS; Lee, HH; Shin, JS; Lee, KT; Roh, EJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3-(Trifluoromethyl)phenol. In 2019 TETRAHEDRON LETT published article about ARYLBORONIC ACIDS; IPSO-HYDROXYLATION; HETEROGENEOUS CATALYST; PHOTOREDOX CATALYSIS; EFFICIENT SYNTHESIS; ORGANIC FRAMEWORK; ROOM-TEMPERATURE; BOND-CLEAVAGE; PHENOLS; METAL in [Ding, Aishun; Chen, Yang; Hu, Jianhua] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China; [Ding, Aishun; Chen, Yang; Hu, Jianhua] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China; [Zhang, Yanbin; Guo, Hao] Fudan Univ, Dept Chem, 2005 Songhu Rd, Shanghai 200438, Peoples R China; [Guo, Hao] Fudan Univ, Acad Engn & Technol, 220 Handan Rd, Shanghai 200433, Peoples R China; [Rios, Ramon] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England in 2019, Cited 52. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

We report herein a visible light-induced aerobic oxidative hydroxylation of boronic acids. The reaction employed 7H-benzo[c]thioxanthen-7-one as metal-free catalyst and dimethyl carbonate as green solvent. Scale-up experiment was achieved using 0.1 mol% catalyst in a good yield with column-free purification. This reaction showed great green chemistry features and potential in synthetic applications. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of 3-(Trifluoromethyl)phenol. Welcome to talk about 98-17-9, If you have any questions, you can contact Ding, AS; Zhang, YB; Chen, Y; Rios, R; Hu, JH; Guo, H or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 120-14-9. Authors Bornadiego, A; Neo, AG; Marcos, CF in MDPI published article about in [Bornadiego, Ana; Neo, Ana G.; Marcos, Carlos F.] Univ Extremadura, Dept Organ & Inorgan Chem, Lab Bioorgan Chem & Membrane Biophys LOBO, Caceres 10003, Spain in 2021.0, Cited 54.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery. Combining these two heterocycles provides unique rigid polycyclic peptidomimetics with drug-like properties including many points of diversity that could be modulated to interact with different biological receptors. This work describes an efficient multicomponent approach to condensed chromenopiperazines based on the novel enol-Ugi reaction. Importantly, this strategy involves the first reported post-condensation transformation of an enol-Ugi adduct.

SDS of cas: 120-14-9. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H in AMER CHEMICAL SOC published article about in [Kummer, David A.] Lundbeck La Jolla Res Ctr Inc, San Diego, CA 92121 USA; [Chheda, Pratik R.; Nishimura, Rachel T.; McClure, Kelly J.; Venkatesan, Hariharan] Janssen Res & Dev, Discovery Chem, San Diego, CA 92121 USA in 2021, Cited 63. Category: indole-building-block. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A one-pot, Hantzsch ester-mediated Knoevenagel condensation-reduction reaction has been developed for alkylation of a wide range of substituted 2,4-quinoline diols and 2,4-pyridine diols with aldehydes. The process is operationally simple to perform, scalable, and provides highly useful C-3 alkylated quinoline and pyridine diols in yields of 58-92%. The alkylation products can be converted to 2,4-dihaloquinoline and pyridine substrates for further functionalization.

Welcome to talk about 86-95-3, If you have any questions, you can contact Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H or send Email.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 86-95-3. Choo, HJ; Ahn, JH in [Choo, Hye Jeong; Ahn, Joong-Hoon] Konkuk Univ, Bio Mol Informat Ctr, Dept Biosci & Biotechnol, Seoul 05029, South Korea published Synthesis of Three Bioactive Aromatic Compounds by Introducing Polyketide Synthase Genes into Engineered Escherichia coli in 2019, Cited 31. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Intermediates in aromatic amino acid biosynthesis can serve as substrates for the synthesis of bioactive compounds. In this study we used two intermediates in the shikimate pathway of Escherichia coli, chorismate and anthranilate, to synthesize three bioactive compounds: 4-hydroxycoumarin (4-HC), 2,4-dihydroxyquinoline (DHQ), and 4-hydroxy-1-methyl-2(1H)-quinolone (NMQ). We introduced genes for the synthesis of salicylic acid from chorismate to supply the substrate for 4-HC and the gene encoding N-methyltransferase for the synthesis of N-methylanthranilate from anthranilate. Polyketide synthases and coenzyme (Co)A ligases were tested to determine the optimal combination of genes for the synthesis of each compound. We also tested several constructs and identified the best one for increasing levels of endogenous substrates for chorismate, anthranilate, and malonyl-CoA. With the use of these strategies, 255.4 mg/L 4-HC, 753.7 mg/L DHQ, and 17.5 mg/L NMQwere synthesized. This work provides a basis for the synthesis of diverse coumarin and quinoline derivatives with potential medical applications.

Recommanded Product: 86-95-3. Bye, fridends, I hope you can learn more about C9H7NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH in [Aly, Ashraf A.; Mohamed, Asmaa H.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Ishak, Esam] Al Azhar Univ, Fac Sci, Dept Chem, Assiut, Egypt; [Ishak, Esam] Jouf Univ, Coll Sci & Arts, Dept Chem, Alquurrayate, Saudi Arabia; [Shwaky, Ahmed M.] Umm Al Qura Univ, STU, Mecca, Saudi Arabia published Formation of furo[3,2-c]quinolone-2-carbonitriles and 4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides from reaction of quinoline-2,4-diones with 2-[bis(methylthio)methylene]malononitrile in 2020, Cited 31. SDS of cas: 86-95-3. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Quinoline-2,4-diones reacted with 2-[bis(methylthio)methylene]malononitrile in DMF/Et3N to produce 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carbonitriles and 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides in state of 2-imino-substituted 4-(methylthio)-5,6-dihydro-2H-pyrano[3,2-c]quinolone-3-carbonitriles. The structures of all new products were proved using NMR, IR, and mass spectral data. The possible mechanism for the reaction is also discussed. Graphic abstract

SDS of cas: 86-95-3. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles