Tag: M.W=150-200

Quality Control of 3,4-Dimethoxybenzaldehyde. In 2021.0 OPT MATER published article about 2-PHOTON ABSORPTION in [Undavalli, Gopi; Rao, G. Nageswara] Sri Sathya Sai Inst Higher Learning, Dept Chem, Prasanthinilayam 515134, Andhra Pradesh, India; [Joseph, Mary] Christ Coll, Dept Phys, Irinjalakuda 680121, Kerala, India; [Arjun, K. K.; Philip, Reji] Raman Res Inst, Light & Matter Phys Grp, CV Raman Ave, Bangalore 560080, Karnataka, India; [Anand, Benoy] St Josephs Coll, Dept Phys, Irinjalakuda 680121, Kerala, India in 2021.0, Cited 23.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Development of tunable photonic devices having molecular dimensions is an active research area in nonlinear optics which continues to evolve and impact many technologies. Here, we demonstrate the tailoring of nonlinear optical properties of nitrochalcone derivatives by engineering the donor-acceptor configurations on either end of the molecules, to control the intramolecular charge transfer process. The central pi-bridge in chalcones provides delocalized electrons which lead to the nonlinear polarizability observed in these molecules. Optical nonlinearity is studied by means of second harmonic generation (SHG) and open aperture Z-scan measurements. Samples show optical limiting behaviour in the nanosecond excitation regime due to excited state absorption (ESA) and two-photon absorption (2PA) phenomena. Our study highlights the importance of structure-property correlations in molecular designs.

Quality Control of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Undavalli, G; Joseph, M; Arjun, KK; Philip, R; Anand, B; Rao, GN or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER, Saw an article supported by the Urmia University. Category: indole-building-block. Published in WILEY in HOBOKEN ,Authors: Marjani, AP; Khalafy, J; Farajollahi, A. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

Welcome to talk about 86-95-3, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or send Email.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Shahari, MSB; Junaid, A; Tiekink, ERT; Dolzhenko, AV in GEORG THIEME VERLAG KG published article about in [Shahari, Muhammad Syafiq Bin; Dolzhenko, Anton, V] Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul, Malaysia; [Junaid, Ahmad] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA; [Tiekink, Edward R. T.] Sunway Univ, Res Ctr Crystalline Mat, Sch Med & Life Sci, 5 Jalan Univ, Bandar Sunway 47500, Selangor Darul, Malaysia; [Dolzhenko, Anton, V] Curtin Univ, Fac Hlth Sci, Sch Pharm & Biomed Sci, Curtin Hlth Innovat Res Inst, GPO Box U1987, Perth, WA 6845, Australia in 2021.0, Cited 47.0. Safety of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The synthesis is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction in the presence of hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) into the targeted compounds via aromatic dehydrogenation in the presence of alkali. The reaction tolerated various aromatic aldehydes (including heterocyclic) and cyclic amities. Crystal structures of two representative 4-aryl-6-morpholino-1,3,5-triazin-2-amines were established by X-ray crystallography. The results of preliminary biological screening identified potent antileukemic activity for 6-[3,4-dihydroisoquinolin-2(1H)-yl]-4- phenyl-1,3,5-triazin-2-amine.

Safety of 3,4-Dimethoxybenzaldehyde. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about CANDIDA-ALBICANS; PYRIDINIUM DYES; RESISTANCE; COMBINATION; DERIVATIVES; AZOLES; AGENTS; PATHOGENICITY; FLUCONAZOLE; MECHANISMS, Saw an article supported by the European Social Fund under The Development of Competences of Scientists, other Researchers and Students through Practical Research Activities measure [09.3.-LMT-K-712-02-0200]; Latvian group [NFI/R/2014/051]; Research Council of Lithuania (LMTLT)Research Council of Lithuania (LMTLT). Published in WILEY in HOBOKEN ,Authors: Vaitkiene, S; Kuliesiene, N; Sakalauskaite, S; Bekere, L; Krasnova, L; Vigante, B; Duburs, G; Daugelavicius, R. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde. HPLC of Formula: C9H10O3

We synthesized a set of 13 new and earlier described styrylpyridinium compounds (N-alkyl styrylpyridinium salts with bromide or tosylate anions) in order to evaluate antifungal activity againstC. albicanscells, to assay the possible synergism with fluconazole, and to estimate cytotoxicity to mammalian cells. All compounds were synthesized according to a well-known two-step procedure involving alkylation of gamma-picoline with appropriate alkyl bromide and further condensation with substituted benzaldehyde. Compounds with longN-alkyl chains(C18H37-C20H41) had no antifungal activity against the cells of all testedC. albicansstrains. Other styrylpyridinium compounds were able to inhibit yeast growth at the concentrations of 0.06-16 mu g/ml. At fungicidal concentrations, the compound with the CN- group was least toxic to mammalian cells, showed the most effective synergism with fluconazole, and only slightly inhibited the respiration ofC. albicans. The compound with the 4 ‘-diethylamino group exhibited the strongest fungicidal properties and effectively blocked the respiration ofC. albicanscells. However, toxicity to mammalian cells was also high. Summarizing, the results of our study indicate that styrylpyridinium compounds are promising candidates in the development of new antifungal drugs.

HPLC of Formula: C9H10O3. Welcome to talk about 120-14-9, If you have any questions, you can contact Vaitkiene, S; Kuliesiene, N; Sakalauskaite, S; Bekere, L; Krasnova, L; Vigante, B; Duburs, G; Daugelavicius, R or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Ning, L; Wang, SM; Du, L; Guo, BY; Zhang, JJ; Lu, HZ; Dong, YH in ROYAL SOC CHEMISTRY published article about in [Ning, Lei; Wang, Simin; Guo, Bingyi; Zhang, Jianjun; Lu, Huizhe; Dong, Yanhong] China Agr Univ, Dept Chem, Beijing 100193, Peoples R China; [Ning, Lei; Wang, Simin; Guo, Bingyi; Zhang, Jianjun; Lu, Huizhe; Dong, Yanhong] China Agr Univ, Innovat Ctr Pesticide Res, Beijing 100193, Peoples R China; [Du, Lin] China Agr Univ, Coll Agron & Biotechnol, Beijing 100193, Peoples R China in 2021, Cited 41. Name: 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

A series of azamacrolides containing the carbamate or urea moiety were synthesized and evaluated for their fungicidal activities against several agriculturally important pathogens. In addition, they were investigated for their ability to inhibit quorum sensing in Agrobacterium tumefaciens. The results showed that most of the derivatives had moderate to high fungicidal activities against the tested fungi, especially towards Sclerotinia sclerotiorum. Additionally, D16-19 could be used as a potential broad-spectrum fungicide while D16-4 exhibited a fungicidal activity (EC50 = 1.87 mg L-1) similar to that of carbendazim (EC50 = 1.34 mg L-1) against S. sclerotiorum. The three-dimensional Quantitative Structure-Activity Relationship (3D-QSAR) models were also established based on the experimental results and they would provide valuable information for further optimization. Moreover, D16-17 not only showed a better fungicidal activity against S. sclerotiorum but also had the highest ability to inhibit quorum sensing. These findings suggested that some azamacrolide compounds hold potential for the development of novel fungicides or inhibitors of quorum sensing.

Name: 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Ning, L; Wang, SM; Du, L; Guo, BY; Zhang, JJ; Lu, HZ; Dong, YH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3,4-Dimethoxybenzaldehyde. Authors Polaquini, CR; Marques, BC; Ayusso, GM; Morao, LG; Sardi, JCO; Campos, DL; Silva, IC; Cavalca, LB; Scheffers, DJ; Rosalen, PL; Pavan, FR; Ferreira, H; Regasini, LO in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Polaquini, Carlos R.; Marques, Beatriz C.; Ayusso, Gabriela M.; Regasini, Luis O.] Sao Paulo State Univ Unesp, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil; [Morao, Luana G.; Cavalca, Lucia B.; Ferreira, Henrique] Sao Paulo State Univ Unesp, Inst Biosci, Dept Biochem & Microbiol, BR-13050690 Rio Claro, SP, Brazil; [Sardi, Janaina C. O.; Rosalen, Pedro L.] Univ Campinas Unicamp, Piracicaba Dent Sch, Dept Physiol Sci, BR-13414903 Campinas, SP, Brazil; [Sardi, Janaina C. O.] Fed Univ Mato Grosso do Sul Ufms, Sch Pharmaceut Sci Food & Nutr, BR-79070900 Campo Grande, MS, Brazil; [Campos, Debora L.; Silva, Isabel C.; Pavan, Fernando R.] Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Dept Biol Sci, BR-14800903 Araraquara, SP, Brazil; [Cavalca, Lucia B.; Scheffers, Dirk-Jan] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, NL-9747 AG Groningen, Netherlands; [Rosalen, Pedro L.] Fed Univ Alfenas Unifal, Sch Dent, BR-37130000 Alfenas, MG, Brazil in 2021, Cited 75. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Curcumin (CUR) is a symmetrical dicarbonyl compound with antibacterial activity. On the other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic application. Monocarbonyl analogs of curcumin (MACs) have been shown to overcome these barriers. We synthesized and investigated the antibacterial activity of a series of unsymmetrical MACs derived from acetone against Mycobacterium tuberculosis and Gram-negative and Gram-positive species. Phenolic MACs 4, 6 and 8 showed a broad spectrum and potent activity, mainly against M. tuberculosis, Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA), with MIC (minimum inhibitory concentration) values ranging from 0.9 to 15.6 mu g/mL. The investigation regarding toxicity on human lung cells (MRC-5 and A549 lines) revealed MAC 4 was more selective than MACs 6 and 8, with SI (selectivity index) values ranging from 5.4 to 15.6. In addition, MAC 4 did not demonstrate genotoxic effects on A549 cells and it was more stable than CUR in phosphate buffer (pH 7.4) for 24 h at 37 degrees C. Fluorescence and phase contrast microscopies indicated that MAC 4 has the ability to disrupt the divisome of Bacillus subtilis without damaging its cytoplasmic membrane. However, biochemical investigations demonstrated that MAC 4 did not affect the GTPase activity of B. subtilis FtsZ, which is the main constituent of the bacterial divisome. These results corroborated that MAC 4 is a promising antitubercular and antibacterial agent.

Quality Control of 3,4-Dimethoxybenzaldehyde. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Chen, YX; Yao, XF; Wang, XL; Zhang, XF; Zhou, HC; He, RX; Liu, QS in ROYAL SOC CHEMISTRY published article about TRANSFER HYDROGENATION; GAMMA-VALEROLACTONE; LEVULINIC ACID; ANAEROBIC-DIGESTION; CONVERSION; BIOMASS; REDUCTION; PRETREATMENT; CHEMICALS; RESIDUES in [Chen, Yuxin; Yao, Xuefeng; Wang, Xiaolu; Zhou, Huacong; He, Runxia; Liu, Quansheng] Inner Mongolia Univ Technol, Inner Mongolia Key Lab High Value Funct Utilizat, Coll Chem Engn, Hohhot 010051, Inner Mongolia, Peoples R China; [Zhang, Xuefeng] Chifeng Pharmaceut Co Ltd, Chifeng 240000, Inner Mongolia, Peoples R China in 2021.0, Cited 45.0. Application In Synthesis of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The oxytetracycline fermentation broth residue (OFR) is an abundant solid waste in the fermentation industry, which is hazardous but tricky to treat. The resource utilization of the waste OFR is still challenging. In this study, a novel route of using OFR was proposed that OFR was used as the organic ligands to construct a new hafnium based catalyst (Hf-OFR) for Meerwein-Ponndorf-Verley (MPV) reactions of biomass-derived platforms. The acidic groups in OFR were used to coordinate with Hf4+, and the carbon skeleton structures in OFR were used to form the spatial network structures of the Hf-OFR catalyst. The results showed that the synthesized Hf-OFR catalyst could catalyze the MPV reduction of various carbonyl compounds under relatively mild reaction conditions, with high conversions and yields. Besides, the Hf-OFR catalyst could be recycled at least 5 times with excellent stability in activity and structures. The prepared Hf-OFR catalyst possesses the advantages of high efficiency, a simple preparation process, and low cost in ligands. The proposed strategy of constructing catalysts using OFR may provide new routes for both valuable utilization of the OFR solid waste in the fermentation industry and the construction of efficient catalysts for biomass conversion.

Welcome to talk about 120-14-9, If you have any questions, you can contact Chen, YX; Yao, XF; Wang, XL; Zhang, XF; Zhou, HC; He, RX; Liu, QS or send Email.. Application In Synthesis of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about FLUOROQUINOLONES; DERIVATIVES; INHIBITORS; MECHANISM; DESIGN; SIGNAL, Saw an article supported by the Egyptian Mission, Ministry of higher education, Egypt; DFG FoundationGerman Research Foundation (DFG). Published in MDPI in BASEL ,Authors: Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S; Polamo, M; Nieger, M; Brown, AB. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one. Application In Synthesis of 4-Hydroxyquinolin-2(1H)-one

Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c ‘]difuro[2,3-c:4,5-c ‘]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl- butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.

Application In Synthesis of 4-Hydroxyquinolin-2(1H)-one. Welcome to talk about 86-95-3, If you have any questions, you can contact Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S; Polamo, M; Nieger, M; Brown, AB or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article 3,7-bis-benzylidene hydrazide ciprofloxacin derivatives as promising antiproliferative dual TOP I & TOP II isomerases inhibitors published in 2021. Category: indole-building-block, Reprint Addresses Abdel-Aziz, M (corresponding author), Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt.; Abuo-Rahma, GEDA (corresponding author), Deraya Univ, Fac Pharm, Dept Pharmaceut Chem, New Minia, Minia, Egypt.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

We report herein design and synthesis of a new series of 3,7-bis-benzylidenes of ciprofloxacin. Most of the target compounds revealed good cytotoxic activity; the most potent 4e and 4i achieved strong broad spectrum antiproliferative activity with comparable activity to Doxorubicin with IC50 (M-mu) of 1.21 +/- 0.02, 0.87 +/- 0.04, 1.21 +/- 0.02; 0.41 +/- 0.02, 0.57 +/- 0.06, 1.31 +/- 0.04 and 1.26 +/- 0.01, 1.79 +/- 0.04, 0.63 +/- 0.01 against leukemia cancer cell line HL-60 (TB), colon cancer cell line HCT-116 and breast cancer cell line MCF7, respectively. Moreover, the most potent derivative 4i induced apoptosis at G2/M phase Investigating the mechanism of action of compounds 4e, 4 h and 4i exhibited promising dual TOP I alpha and TOP IIB % inhibition comparable to Camptothecin and Etoposide; respectively. Docking of 4e, 4 h and 4i into the active site of topo I and II proteins compared to Camptothein and Etoposide revealed acceptable binding score and augmented enzyme assay data. Hence, 4e and 4i are promising targeted antiproliferative dual acting TOP I alpha TOP IIB inhibitors that require further optimization.

Welcome to talk about 120-14-9, If you have any questions, you can contact Samir, M; Ramadan, M; Abdelrahman, MH; Abdelbaset, MS; Abourehab, MAS; Abdel-Aziz, M; Abuo-Rahma, GEDA or send Email.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C9H10O3. Authors Kulkarni, MR; Lad, NP; Khedkar, VM; Gaikwad, ND in WILEY published article about in [Kulkarni, Mahesh R.; Lad, Nitin P.; Gaikwad, Nitin D.] KRT Arts BH Commerce & AM Sci Coll, Dept Chem, Organ Chem Res Ctr, Gangapur Rd, Nasik 422002, India; [Khedkar, Vijay M.] Vishwakarma Univ, Sch Pharm, Pune, Maharashtra, India in 2021.0, Cited 22.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

With the aim of expanding the scope of SAR on piperlongumine (PL), a naturally occurring anticancer molecule, we have designed a novel hybrid molecule bearing 3,4-dihydroisoquinolin-1(2H)-one and trans-cinnamic acids. The structure, based on hybridization strategy, is used for hybridization of naturally occurring scaffolds. We have synthesized 14 hybrid molecules by coupling 3,4-dihydroisoquinolin-1(2H)-one core with cinnamic acids using the mix anhydride approach. The newly synthesized inhibitors were evaluated for cell viability against breast cancer MCF-7 and cervical cancer HeLa cell lines. Furthermore, the active compounds were screened for their potential in breast cancer MDA-MB-231, cervical cancer C33A cell lines, prostate cancer DU-145, PC-3, and normal VERO cells. From the series, compound 10g was seen to inhibit MCF-7 cell growth significantly with GI(50) < 0.1 mu M along with growth inhibition in MDA-MB-231 (GI(50) = 20 mu M) and C33A (GI(50) = 3.2 mu M). While the inhibitor 10i inhibits MCF-7 breast cancer cell growth GI(50) = 3.42 mu M along with inhibition of cell growth in MDA-MB-231 (GI(50) = 30 mu M), HeLa (GI(50) = 7.67 mu M), C33A (GI(50) = 13 mu M), DU-145 (GI(50) = 6.45 mu M), PC-3 (GI(50) = 8.68 mu M), and VERO (GI(50) = 2.93 mu M), respectively. Furthermore, molecular docking study demonstrated these compounds could bind tightly to the colchicine domain of tubulin through a network of favorable steric and electrostatic interactions and thus act as a tubulin polymerization inhibitor. Welcome to talk about 120-14-9, If you have any questions, you can contact Kulkarni, MR; Lad, NP; Khedkar, VM; Gaikwad, ND or send Email.. COA of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles