Tag: M.W=150-200

Category: indole-building-block. Recently I am researching about ANTIFUNGAL ACTIVITY; DESIGN; PYRIMETHANIL; DERIVATIVES; INHIBITOR, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31772182]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Deng, XL; Zheng, WN; Jin, C; Bai, LY. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Fenclorim is a commercial herbicide safener with fungicidal activity used for chloroacetanilide herbicides, which might be suitable as a lead compound for screening novel fungicides. However, little has been reported so far on the structure-activity relationship of fungicidal activities of fenclorim or its analogues. Here, a series of 4-chloro-6-substituted phenoxy-2-phenylpyrimidine derivatives was synthesized by a substructure splicing route using fenclorim as a lead compound. The structures of synthesized derivatives were characterized by H-1 NMR, C-13 NMR, and HRMS. Their fungicidal and herbicide safening activities were then evaluated. The results revealed that compound 11 had the best fungicidal activity against Sclerotinia sclerotiorum and Thanatephorus cucumeris, which was better than that of the control pyrimethanil. Moreover, compounds 3, 5, and 25 exhibited excellent safening activities against fresh weight, plant height, and root length, respectively. Such activities were significantly improved when compared to fenclorim. In summary, these findings look promising for the preparation of new fungicides and herbicide safeners based on the structure of fenclorim.

Category: indole-building-block. Welcome to talk about 98-17-9, If you have any questions, you can contact Deng, XL; Zheng, WN; Jin, C; Bai, LY or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Palladium (II)-catalyzed homogeneous alcohol oxidations: Disclosing the crucial contribution of palladium nanoparticles in catalysis WOS:000590610700001 published article about NONREDOX METAL-IONS; SELECTIVE OXIDATION; AEROBIC OXIDATION; DIOXYGEN ACTIVATION; PD NANOPARTICLES; OXYGEN; HECK; COMPLEXES; FRONTIER; LIGAND in [Zeng, Miao; Lou, Chenlin; Xue, Jing-Wen; Jiang, Hongwu; Li, Kaiwen; Chen, Zhuqi; Fu, Shitao; Yin, Guochuan] Huazhong Univ Sci & Technol, Hubei Key Lab Mat Chem & Serv Failure, Key Lab Mat Chem Energy Convers & Storage, Sch Chem & Chem Engn,Minist Educ, Wuhan 430074, Peoples R China in 2021, Cited 35. Recommanded Product: 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Versatile redox catalysts play the significant roles in alcohol oxidations, in which the mechanisms for homogeneous and heterogeneous alcohol oxidations are generally different. This work introduced a Lewis acid (LA) promoted homogeneous alcohol oxidation with Pd (OAc)(2) catalyst by using oxygen balloon as the oxidant source. It was found that adding Lewis acid such as Sc (OTf)(3) significantly accelerated Pd (II)-catalyzed alcohol oxidations; notably, the time courses of oxidations monitored by GC and H-1 NMR disclosed that there existed two processes including the initial sluggish oxidation followed by a rapid oxidation. The promotional effect of Lewis acid was attributed to the formation of heterobimetallic Pd (II)/LA species, which improved the oxidizing power of the palladium (II) species, thus accelerating alcohol oxidation in the induction period. Correlating the sizes of in situ generated palladium nanoparticles with the time course of alcohol oxidation further disclosed that the loosely, spherically large nanoparticles, which were composed of many tiny nanoparticles having the size less than 10 nm, were responsible for the rapid oxidation, whereas those highly dispersed, tiny nanoparticles having the size less than 10 nm were not responsible for the rapid oxidation.

Recommanded Product: 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Zeng, M; Lou, CL; Xue, JW; Jiang, HW; Li, KW; Chen, ZQ; Fu, ST; Yin, GC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S in SAGE PUBLICATIONS LTD published article about in [Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Brase, Stefan] Karlsruhe Inst Technol, Inst Biol & Chem Syst Funct Mol Syst IBCS FMS, Eggenstein Leopoldshafen, Germany in 2020, Cited 13. Quality Control of 4-Hydroxyquinolin-2(1H)-one. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A novel series of 7,8-dichlorobenzofuro[3,2-c]quinoline-6,9,10(5H)-triones was obtained regioselectively in good yields. The products were formed by the reactions of the 4-hydroxy-2(1H)-quinolinones with 3,4,5,6-tetrachloro-1,2-benzoquinone in tetrahydrofuran as the solvent. Infrared, nuclear magnetic resonance (two-dimensional nuclear magnetic resonance), mass spectra and elemental analysis were used to elucidate the structures of new compounds.

Quality Control of 4-Hydroxyquinolin-2(1H)-one. Bye, fridends, I hope you can learn more about C9H7NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Recently I am researching about ANTIFUNGAL ACTIVITY; DESIGN; PYRIMETHANIL; DERIVATIVES; INHIBITOR, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31772182]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Deng, XL; Zheng, WN; Jin, C; Bai, LY. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Fenclorim is a commercial herbicide safener with fungicidal activity used for chloroacetanilide herbicides, which might be suitable as a lead compound for screening novel fungicides. However, little has been reported so far on the structure-activity relationship of fungicidal activities of fenclorim or its analogues. Here, a series of 4-chloro-6-substituted phenoxy-2-phenylpyrimidine derivatives was synthesized by a substructure splicing route using fenclorim as a lead compound. The structures of synthesized derivatives were characterized by H-1 NMR, C-13 NMR, and HRMS. Their fungicidal and herbicide safening activities were then evaluated. The results revealed that compound 11 had the best fungicidal activity against Sclerotinia sclerotiorum and Thanatephorus cucumeris, which was better than that of the control pyrimethanil. Moreover, compounds 3, 5, and 25 exhibited excellent safening activities against fresh weight, plant height, and root length, respectively. Such activities were significantly improved when compared to fenclorim. In summary, these findings look promising for the preparation of new fungicides and herbicide safeners based on the structure of fenclorim.

Category: indole-building-block. Welcome to talk about 98-17-9, If you have any questions, you can contact Deng, XL; Zheng, WN; Jin, C; Bai, LY or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Palladium (II)-catalyzed homogeneous alcohol oxidations: Disclosing the crucial contribution of palladium nanoparticles in catalysis WOS:000590610700001 published article about NONREDOX METAL-IONS; SELECTIVE OXIDATION; AEROBIC OXIDATION; DIOXYGEN ACTIVATION; PD NANOPARTICLES; OXYGEN; HECK; COMPLEXES; FRONTIER; LIGAND in [Zeng, Miao; Lou, Chenlin; Xue, Jing-Wen; Jiang, Hongwu; Li, Kaiwen; Chen, Zhuqi; Fu, Shitao; Yin, Guochuan] Huazhong Univ Sci & Technol, Hubei Key Lab Mat Chem & Serv Failure, Key Lab Mat Chem Energy Convers & Storage, Sch Chem & Chem Engn,Minist Educ, Wuhan 430074, Peoples R China in 2021, Cited 35. Recommanded Product: 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Versatile redox catalysts play the significant roles in alcohol oxidations, in which the mechanisms for homogeneous and heterogeneous alcohol oxidations are generally different. This work introduced a Lewis acid (LA) promoted homogeneous alcohol oxidation with Pd (OAc)(2) catalyst by using oxygen balloon as the oxidant source. It was found that adding Lewis acid such as Sc (OTf)(3) significantly accelerated Pd (II)-catalyzed alcohol oxidations; notably, the time courses of oxidations monitored by GC and H-1 NMR disclosed that there existed two processes including the initial sluggish oxidation followed by a rapid oxidation. The promotional effect of Lewis acid was attributed to the formation of heterobimetallic Pd (II)/LA species, which improved the oxidizing power of the palladium (II) species, thus accelerating alcohol oxidation in the induction period. Correlating the sizes of in situ generated palladium nanoparticles with the time course of alcohol oxidation further disclosed that the loosely, spherically large nanoparticles, which were composed of many tiny nanoparticles having the size less than 10 nm, were responsible for the rapid oxidation, whereas those highly dispersed, tiny nanoparticles having the size less than 10 nm were not responsible for the rapid oxidation.

Recommanded Product: 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Zeng, M; Lou, CL; Xue, JW; Jiang, HW; Li, KW; Chen, ZQ; Fu, ST; Yin, GC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S in SAGE PUBLICATIONS LTD published article about in [Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Brase, Stefan] Karlsruhe Inst Technol, Inst Biol & Chem Syst Funct Mol Syst IBCS FMS, Eggenstein Leopoldshafen, Germany in 2020, Cited 13. Quality Control of 4-Hydroxyquinolin-2(1H)-one. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A novel series of 7,8-dichlorobenzofuro[3,2-c]quinoline-6,9,10(5H)-triones was obtained regioselectively in good yields. The products were formed by the reactions of the 4-hydroxy-2(1H)-quinolinones with 3,4,5,6-tetrachloro-1,2-benzoquinone in tetrahydrofuran as the solvent. Infrared, nuclear magnetic resonance (two-dimensional nuclear magnetic resonance), mass spectra and elemental analysis were used to elucidate the structures of new compounds.

Quality Control of 4-Hydroxyquinolin-2(1H)-one. Bye, fridends, I hope you can learn more about C9H7NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Oboudatian, HS; Naeimi, H; Moradian, M in ROYAL SOC CHEMISTRY published article about in [Oboudatian, Hourieh Sadat; Naeimi, Hossein; Moradian, Mohsen] Univ Kashan, Dept Organ Chem, Fac Chem, Kashan 87317, Iran in 2021.0, Cited 58.0. Category: indole-building-block. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

In this study, simple and effective methods were used for the preparation of an ionic liquid that immobilized magnetite nanoparticles. Fe3O4 nanoparticles were prepared via a chemical co-precipitation method. Then, a SiO2 shell was coated on the magnetic core via the Stober method. Finally, CPTES (chloropropyltriethoxysilane) and morpholine were coated on the SiO2 shell. Morpholine sulfate, an acidic ionic liquid, was successfully bound to magnetite nanoparticles (Mag@Morph-AIL) and this was used as an efficient catalyst for the preparation of 3,4-dihydropyrimidinones. Compared to previous works, the easy separation of the nanocatalyst using an external magnet and the recyclability, non-toxicity, versatility, and high stability of the catalyst, combined with low reaction times and excellent yields, make the present protocol very useful for the synthesis of the title products. The synthesized products and catalyst were confirmed via(1)H-NMR, C-13-NMR, FT-IR, scanning electron microscope, X-ray diffraction, and elemental analysis.

Category: indole-building-block. Welcome to talk about 120-14-9, If you have any questions, you can contact Oboudatian, HS; Naeimi, H; Moradian, M or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Al-Ahmed, ZA; Habib, IHI; Khattab, RR; Abdelhameed, RM; El-Naggar, M; Abu Bieh, MH; Pisarevd, SA; Voronkov, A; El Sayed, MT in [Al-Ahmed, Zehbah Ali] King Khalid Univ, Coll Art & Sci Dhahran Aljounb, Abha, Saudi Arabia; [Habib, Ibrahim H. I.; Abdelhameed, Reda M.; El Sayed, Mardia T.] Natl Res Ctr, Chem Ind Res Div, Appl Organ Chem Dept, Giza 12311, Egypt; [Khattab, Reham R.; Abu Bieh, Moursi H.] Natl Res Ctr, Chem Ind Res Div, Photochem Dept, Giza, Egypt; [El-Naggar, Mohamed] Univ Sharjah, Dept Chem, Fac Sci, Sharjah, U Arab Emirates; [Pisarevd, Sergey A.] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka, Russia; [Voronkov, Andrey] Digital Bio Pharm Ltd, 145-157 St John St, London EC1V 4PW, England published Synthesis, spectrophotometric, voltammetric, and density functional theory studies of tetrahydro[3,2-b]indolocarbazoles for sensing small molecules in 2021.0, Cited 39.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Absorption spectra of tetrahydro[3,2-b]indolocarbazoles (THICZs) with respective molecular property and alkyl substituents have been prerecorded in diverse solvents in the scope between 200 and 600 nm for very fewer times in the literary study. The photo-physical behavior of liquified THICZs belonging to the existence surroundings. The solvatochromic behaviors of THICZs and solvent substance physical phenomenon can be analyzed by implementation of linear solvating energy state conception. Compound 4 shows excellent properties for sensing small molecules. The electrochemical behavior of some THICZs was investigated at carbon paste electrode where two electrode reactions were involved, irreversible oxidation-one electron transfer and quasi-reversible redox reactions forming phenolic followed by quinolone moiety electro active species. The density functional theory which means calculated molecular orbital energies (B3LYP/6-31G) and HOMO-LUMO gap/space for some presented indolocarbazoles have been performed.

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Al-Ahmed, ZA; Habib, IHI; Khattab, RR; Abdelhameed, RM; El-Naggar, M; Abu Bieh, MH; Pisarevd, SA; Voronkov, A; El Sayed, MT or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, Synthesis, and Anticancer Screening for Repurposed Pyrazolo[3,4-d]pyrimidine Derivatives on Four Mammalian Cancer Cell Lines WOS:000655074500001 published article about SERUM; INHIBITION; MECHANISMS; CELECOXIB; ANTITUMOR in [Othman, Eman M.; Dandekar, Thomas] Univ Wurzburg, Bioctr, Dept Bioinformat, D-97074 Wurzburg, Germany; [Othman, Eman M.; Bekhit, Amany A.] Minia Univ, Fac Pharm, Dept Biochem, Al Minya 61519, Egypt; [Anany, Mohamed A.] Univ Hosp Wuerzburg, Dept Internal Med 2, Div Mol Internal Med, D-97080 Wurzburg, Germany; [Anany, Mohamed A.] Natl Res Ctr, Dept Microbial Biotechnol, Div Genet Engn & Biotechnol, Giza 12622, Egypt; [Ragab, Hanan M.] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21500, Egypt; [Wahid, Ahmed] Alexandria Univ, Fac Pharm, Dept Pharmaceut Biochem, Alexandria 21500, Egypt in 2021.0, Cited 44.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Name: 3,4-Dimethoxybenzaldehyde

The present study reports the synthesis of new purine bioisosteres comprising a pyrazolo[3,4-d]pyrimidine scaffold linked to mono-, di-, and trimethoxy benzylidene moieties through hydrazine linkages. First, in silico docking experiments of the synthesized compounds against Bax, Bcl-2, Caspase-3, Ki67, p21, and p53 were performed in a trial to rationalize the observed cytotoxic activity for the tested compounds. The anticancer activity of these compounds was evaluated in vitro against Caco-2, A549, HT1080, and Hela cell lines. Results revealed that two (5 and 7) of the three synthesized compounds (5, 6, and 7) showed high cytotoxic activity against all tested cell lines with IC50 values in the micro molar concentration. Our in vitro results show that there is no significant apoptotic effect for the treatment with the experimental compounds on the viability of cells against A549 cells. Ki67 expression was found to decrease significantly following the treatment of cells with the most promising candidate: drug 7. The overall results indicate that these pyrazolopyrimidine derivatives possess anticancer activity at varying doses. The suggested mechanism of action involves the inhibition of the proliferation of cancer cells.

Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. Name: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Synthesis of Ethyl 2-Amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates by a One-pot, Three-Component Reaction in the Presence of TPAB published in 2019. Computed Properties of C9H7NO2, Reprint Addresses Marjani, AP (corresponding author), Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran.. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.. Computed Properties of C9H7NO2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles