Tag: M.W=150-200

Authors Lardy, SW; Luong, KC; Schmidt, VA in WILEY-V C H VERLAG GMBH published article about NICKEL-CATALYZED AMINATION; CROSS-COUPLING REACTIONS; LONG-LIVED CATALYSTS; ONE-POT CONVERSION; C-H AMINATION; ARYL MIGRATION; AROMATIC-COMPOUNDS; METAL; CLEAVAGE; COPPER in [Lardy, Samuel W.; Luong, Kristine C.; Schmidt, Valerie A.] Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr, La Jolla, CA 92093 USA in 2019, Cited 75. Category: indole-building-block. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

Phenolic, lignin-derived substrates have emerged as desirable biorenewable chemical feedstocks for coupling reactions. A radical-mediated conversion of phenol derivatives to anilines is reported, using unfunctionalized hydroxamic acids as the N-centered radical source. The applicability of this triethyl phosphite mediated O-atom transfer approach, which tolerates a range of steric and electronic demands to naturally occurring phenols and lignin models, has been demonstrated in this work to access the corresponding aniline derivatives.

Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C9H7NO2. Authors Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H in AMER CHEMICAL SOC published article about in [Kummer, David A.] Lundbeck La Jolla Res Ctr Inc, San Diego, CA 92121 USA; [Chheda, Pratik R.; Nishimura, Rachel T.; McClure, Kelly J.; Venkatesan, Hariharan] Janssen Res & Dev, Discovery Chem, San Diego, CA 92121 USA in 2021, Cited 63. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A one-pot, Hantzsch ester-mediated Knoevenagel condensation-reduction reaction has been developed for alkylation of a wide range of substituted 2,4-quinoline diols and 2,4-pyridine diols with aldehydes. The process is operationally simple to perform, scalable, and provides highly useful C-3 alkylated quinoline and pyridine diols in yields of 58-92%. The alkylation products can be converted to 2,4-dihaloquinoline and pyridine substrates for further functionalization.

HPLC of Formula: C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about AGENTS; 4-THIAZOLIDINONES; ANALOGS; THIAZOLIDIN-4-ONE; CYTOTOXICITY; MICROTUBULES; POTENT; QSAR, Saw an article supported by the Department of Pharmaceuticals (DoP), Ministry of Chemicals & Fertilizers, Govt. of India, New Delhi,. Product Details of 120-14-9. Published in ELSEVIER in AMSTERDAM ,Authors: Sigalapalli, DK; Pooladanda, V; Kadagathur, M; Guggilapu, SD; Uppu, JL; Godugu, C; Bathini, NB; Tangellamudi, ND. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Here-in, we present molecular design, chemical synthesis and evaluation of novel chromenyl-based 2-iminothiazolidin-4-one derivatives as tubulin polymerization inhibitors. The newly synthesized compounds were evaluated for their in vitro cytotoxicities against A549 (lung cancer), MDA-MB-231 and BT-471 (breast cancer), HepG2 (liver cancer) and HCT-116 (colon cancer) cell lines by MTT assay. Among the synthesized compounds, compound 12b showed excellent anticancer activity on MDA-MB-231 cell line with IC50 value of 0.95 +/- 1.88 mu M and was verified to be safe in normal human bronchial epithelial cells (Beas-2B). Apoptosis induced by the lead 12b was observed using morphological observations, AO/EB and DAPI staining procedures. Further, dose-dependent increase in the depolarization of mitochondrial membrane was also observed through JC-1 staining. Annexin V-FITC/PI assay confirmed that 12b induced early apoptosis. Additionally, cell cycle analysis indicated that the MDA-MB-231 cells were arrested at sub-G2/M phase and also inhibited tubulin polymerization with IC50 value of 3.54 +/- 0.2 mM. Molecular docking simulations were employed to identify the important binding modes responsible for the tubulin inhibitory activity, thus supporting their effective anticancer potential. (c) 2020 Published by Elsevier B.V.

Product Details of 120-14-9. Welcome to talk about 120-14-9, If you have any questions, you can contact Sigalapalli, DK; Pooladanda, V; Kadagathur, M; Guggilapu, SD; Uppu, JL; Godugu, C; Bathini, NB; Tangellamudi, ND or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 98-17-9. In 2020 CHEM-EUR J published article about PALLADIUM-CATALYZED AMINATION; DIELS-ALDER REACTIONS; ARYL HALIDES; NUCLEOPHILIC-ADDITION; SELECTIVE SYNTHESIS; AMMONIA EQUIVALENT; PRIMARY AMINES; ARYNES; CHEMISTRY; MILD in [Ikawa, Takashi; Masuda, Shigeaki; Akai, Shuji] Osaka Univ, Grad Sch Pharmaceut Sci, Yamadaoka 1-6, Suita, Osaka 5650871, Japan in 2020, Cited 112. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

Benzynes were selectively generated in situ from phenols and trapped regioselectively with potassium hexamethyldisilazide to form primary anilines following acidic workup. The direct conversion of a phenolic hydroxyl group into a free amino group is a useful method for the preparation of primary aryl amines that are hard to synthesize by using coupling reactions involving phenol derivatives with ammonia. Whereas reactions of ortho- and meta-substituted phenols produced meta-substituted anilines exclusively, those of para-substituted phenols provided ortho-silylanilines.

Recommanded Product: 98-17-9. Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Sahoo, H; Ramakrishna, I; Mandal, A; Baidya, M in WILEY-V C H VERLAG GMBH published article about METAL-FREE; STEREOSELECTIVE-SYNTHESIS; ALKENE DERIVATIVES; ACTIVATED ALKYNES; CYCLIZATION; MIGRATION; ACIDS; DIFUNCTIONALIZATION; COUMARINS; BOND in [Sahoo, Harekrishna; Ramakrishna, Isai; Mandal, Anup; Baidya, Mahiuddin] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India in 2019, Cited 70. Application In Synthesis of 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

An oxidative trifunctionalization of aryl alkynoates has been devised via the chalcogenide radical triggered intramolecular 1,4-aryl migration/decarboxylation cascade to prepare 1,1-dichalcogenide tetrasubstituted alkenes in high yields (up to 98 %). This operationally simple reaction proceeds under metal-free conditions, can be executed on gram scale, and highlights formal 1,1-difunctionalization of alkynes. Synthetic potential of this protocol was demonstrated through a twofold cascade rearrangement to access highly conjugated tetra-selenylated alkenes along with a cross-dehydrogenative annulation to prepare fluorene derivative.

Application In Synthesis of 3-(Trifluoromethyl)phenol. Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Preparation of some chromeno[4,3-d]pyrido[1,2-a]pyrimidine derivatives by ultrasonic irradiation using NiFe2O4@SiO2 grafted di(3-propylsulfonic acid) nanoparticles published in 2021. SDS of cas: 120-14-9, Reprint Addresses Khalaj, M (corresponding author), Islamic Azad Univ Buinzahra, Dept Chem, Buinzahra Branch, Buin Zahra, Iran.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

NiFe2O4@SiO2 grafted di(3-propylsulfonic acid) was prepared by a facile method and characterized using XRD, FT-IR, SEM-EDX, TGA, and BET techniques. The XRD pattern shows the characteristic peaks of the cubic structure for NiFe2O4. The presence of sulfonic acid groups was confirmed by FT-IR analysis. The catalyst was used for the preparation of chromeno[4,3-d]pyrido[1,2-a]pyrimidine derivatives via the three-component condensation reaction of 4-hydroxycoumarin, aldehydes, and 2-aminopyridines under US irradiation. The effects of solvent, temperature, and catalyst dosage on product formation under the reaction conditions were investigated. The simple procedure, good yields, short reaction times, and catalyst recovery are some of the key advantages of this method.

Welcome to talk about 120-14-9, If you have any questions, you can contact Khalaj, M; Taherkhani, M; Kalhor, M or send Email.. SDS of cas: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C9H10O3. In 2021.0 J FOOD COMPOS ANAL published article about INSULIN-RESISTANCE; TEA CATECHINS; CDNA CLONING; ANTHOCYANINS; FLAVONOIDS; ACIDS; FOOD; MEAT; PURIFICATION; COLLECTION in [Neacsu, Madalina; Vaughan, Nicholas J.; Perri, Valentina; Russell, Wendy R.] Univ Aberdeen, Rowett Inst, Aberdeen AB25 2ZD, Scotland; [Duncan, Gary J.] Univ Aberdeen, Rowett Inst, Sci Serv, Aberdeen AB25 2ZD, Scotland; [Walker, Robin] SRUC Aberdeen, Craibstone Estate, Aberdeen AB21 9YA, Scotland; [Coleman, Max] Royal Bot Garden Edinburgh, 20A Inverleith Row, Edinburgh EH3 5LR, Midlothian, Scotland in 2021.0, Cited 86.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Apios americana Medik, a native American plant has potential as a commercially viable Northern European-grown motcrop, mainly due to its resistance to extreme climate and nutritional quality. Analysis of A. americana sourced from two UK sites; South (51.4690 degrees N, 1.1150 degrees W) and North (55.9661 degrees N, 3.2063 degrees W) showed that the tubers were a complete source of amino acids (UPLC-TUV analysis), were rich in protein (15.0 +/- 0.0160 and 17.3 +/- 0.0779%; Vario Max CN analysis), fibre (total non-starch polysaccharides, 10.4 +/- 0.570 and 10.6 +/- 0.280%; GC analysis) and micronutrients (calcium, manganese, iron, zinc, molybdenum, potassium and phosphorus; ICP-MS analysis). Apios americana tubers were also rich in bioactive phytochemicals. From the 156 plant metabolites measured using LC-MS/MS analysis, genistein was the major phytophenol in both the Southern- and Northern UK tubers (259 +/- 12.2 mg Kg(-1) and 356 +/- 29.9 mg Kg(-1) respectively); the peel having similar phytochemical profiles. The protein and fibre content of the leaves (17.3 +/- 0.0434% and 11.7 0.0445%) and rhizomes (18.4 +/- 0.0152% and 13.5 +/- 0.590%) were significantly higher (p < 0.05) than the tubers. The leaves were also a good source of anthocyanins; delphinidin and cyanidin (840 +/- 137 and 3934 +/- 176 mg Kg(-1) respectively). Cultivation of A. americana as a high-protein staple-crop has enormous potential in Northern European countries for human nutrition, diet diversification, and use in livestock diets. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Neacsu, M; Vaughan, NJ; Perri, V; Duncan, GJ; Walker, R; Coleman, M; Russell, WR or concate me.. HPLC of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 98-17-9. In 2019 ACS MED CHEM LETT published article about ANTIMICROBIAL RESISTANCE; ANTIBIOTIC-RESISTANCE; 2-COMPONENT SYSTEM; KINASE INHIBITORS; BLAR1 PROTEIN; SYNERGY; EVOLUTION; PATHWAY; ASSAY in [Speri, Enrico; Kim, Choon; De Benedetti, Stefania; Qian, Yuanyuan; Lastochkin, Elena; Fishovitz, Jennifer; Fisher, Jed F.; Mobashery, Shahriar] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA in 2019, Cited 49. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

beta-Lactams are used routinely to treat Staphylococcus aureus infections. However, the emergence of methicillin-resistant S. aureus (MRSA) renders them clinically precarious. We describe a class of cinnamonitrile adjuvants that restore the activity of oxacillin (a penicillin member of the beta-lactams) against MRSA. The lead adjuvants were tested against six important strains of MRSA, one vancomycin-intermediate S. aureus (VISA) strain, and one linezolid-resistant S. aureus strain. Five compounds out of 84 total compounds showed broad potentiation. At 8 mu M (E)-3-(5-(3,4-dichlorobenzy1)-2-(trifluoromethoxy)phenyl)-2-(methylsulfonyl)acrylonitrile (26) potentiated oxacillin with a >4000-fold reduction of its MIC (from 256 to 0.06 mg.L-1). This class of adjuvants holds promise for reversal of the resistance phenotype of MRSA.

Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Dai, H; Huang, ML; Qian, JQ; Liu, J; Meng, C; Li, YY; Ming, GX; Zhang, T; Wang, SL; Shi, YJ; Yao, Y; Ge, SS; Zhang, YN; Ling, Y in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about BIOLOGICAL EVALUATION; COUMARIN DERIVATIVES; MOLECULAR DOCKING; ANTICANCER ACTIVITY; PYRAZOLE; DESIGN; APOPTOSIS; POTENT; AGENTS; METASTASIS in [Dai, Hong; Huang, Meiling; Wang, Senling; Shi, Yujun; Yao, Yong; Ge, Shushan; Ling, Yong] Nantong Univ, Coll Chem & Chem Engn, Nantong 226019, Peoples R China; [Dai, Hong; Huang, Meiling; Qian, Jianqiang; Liu, Ji; Meng, Chi; Li, Yangyang; Ming, Guxu; Zhang, Ting; Ge, Shushan; Zhang, Yanan; Ling, Yong] Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China; [Qian, Jianqiang; Liu, Ji; Meng, Chi; Li, Yangyang; Ming, Guxu; Zhang, Ting; Zhang, Yanan; Ling, Yong] Nantong Univ, Jiangsu Prov Key Lab Inflammat & Mol Drug Target, Nantong 226001, Peoples R China in 2019, Cited 49. SDS of cas: 98-17-9. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

A series of hybrids 10a-v based on coumarin/pyrazole oxime have been synthesized, and exhibit good to excellent antitumor activities. Compound 10n has shown remarkable anticancer effect on SMMC-7721 cells (IC50 = 2.08 mu M), which is considerably lower than 5-FU (IC50 = 37.8 mu M) and similar to ADM (IC50 = 2.67 mu M), with little effect on normal hepatic cells LO2. Notably, the suppression experiments of metastatic activities reveal that 10n also displays significant anti-metastasis effects through inhibiting cell migration and invasion in highly metastatic SMMC-7721 cell line, and dose-dependently reverses TGF-beta 1-induced epithelial-mesenchymal transition (EMT) procedure better than ADM. Finally, 10n also possesses low acute toxicity and potent tumor growth inhibitory property against SMMC-7721 cell lines in vivo. Our findings suggest that novel coumarin/pyrazole oxime hybrids are promising therapeutic agent candidates for further research. (C) 2019 Elsevier Masson SAS. All rights reserved.

SDS of cas: 98-17-9. Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors WOS:000624369300013 published article about CRYSTAL-STRUCTURES in [Salgin-Goksen, Umut; Gokhan-Kelekci, Nesrin] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey; [Salgin-Goksen, Umut] Turkish Med & Med Devices Agcy, Anal & Control Labs, TR-06100 Ankara, Turkey; [Telli, Gokcen; Tel, Banu Cahide] Hacettepe Univ, Fac Pharm, Dept Pharmacol, TR-06100 Ankara, Turkey; [Erikci, Acelya] Lokman Hekim Univ, Fac Pharm, Dept Biochem, TR-06510 Ankara, Turkey; [Dedecengiz, Ezgi; Kaynak, F. Betul] Hacettepe Univ, Dept Phys Engn, Fac Engn, TR-06800 Ankara, Turkey; [Yelekci, Kemal] Kadir Has Univ, Fac Engn & Nat Sci, Dept Bioinformat & Genet, TR-34083 Istanbul, Turkey; [Ucar, Gulberk] Hacettepe Univ, Fac Pharm, Dept Biochem, TR-06100 Ankara, Turkey in 2021.0, Cited 82.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Computed Properties of C9H10O3

Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazoline structure and nine compounds having N’-(1,3-disubstitutedphenylallylidene)-2-(5-substituted- 2-benzoxazolinone-3-yl)-acetohydrazide skeleton were synthesized and evaluated as monoamine oxidase (MAO) inhibitors. All of the compounds exhibited selective MAO-A inhibitor activity in the nanomolar or low micromolar range. The results of the molecular docking for hydrazone derivatives supported the in vitro results. Five compounds, 6 (0.008 mu M, Selectivity Index (SI): 9.70 x 10(-4)), 7 (0.009 mu M, SI: 4.55 x 10(-5)), 14 (0.001 mu M, SI: 8.00 x 10(-4)), 21 (0.009 mu M, SI: 1.37 x 10(-5)), and 42 (0.010 mu M, SI: 5.40 x 10(-6)), exhibiting the highest inhibition and selectivity toward hMAO-A and nontoxic to hepatocytes were assessed for antidepressant activity as acute and subchronic in mice. All of these five compounds showed significant antidepressant activity with subchronic administration consistent with the increase in the brain serotonin levels and the compounds crossed the blood-brain barrier according to parallel artificial membrane permeation assay. Compounds 14, 21, and 42 exhibited an ex vivo MAO-A profile, which is highly consistent with the in vitro data.

Computed Properties of C9H10O3. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles