Tag: M.W=150-200

Authors Obregon-Mendoza, MA; Arias-Olguin, II; Meza-Morales, W; Alvarez-Ricardo, Y; Chavez, MI; Toscano, RA; Cassani, J; Enriquez, RG in MDPI published article about in [Obregon-Mendoza, Marco A.; Arias-Olguin, Imilla I.; Meza-Morales, William; Alvarez-Ricardo, Yair; Isabel Chavez, Maria; Toscano, Ruben A.; Enriquez, Raul G.] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City Cdmx 04510, Mexico; [Cassani, Julia] Univ Autonoma Metropolitana, Dept Sistemas Biol, Unidad Xochimilco, Ciudad De Mexico 04960, Mexico in 2021.0, Cited 32.0. Category: indole-building-block. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The expected (E)-but-3-en-2-ones compounds I and II (half curcuminoids) were obtained by the Claisen-Schmidt reaction between aldehydes 3,4-dimethoxybenzaldehyde or 4-nitrobenzaldehyde with acetone. Concomitantly, 3-methylcyclohex-2-enones compounds III and IV arose from an unexpected reaction of but-3-en-2-ones in the cascade reaction of a Michael-type addition of a second molecule of acetone followed by Robinson annulation under strong basic conditions. Both enones exhibit the (E)-configuration, compound I displays s-trans conformation, whereas compound II exhibits conformational disorder as solid solution of s-cis and s-trans conformations. The related 3-methylcyclohex-2-enones exhibit envelope conformation. Compound III constitutes an example of the rarest case of racemic solid solution (pseudoracemate), where a lack of chiral discrimination with respect to the two enantiomers leads to an enantiomeric disorder of a racemic mixture with different occupancies at the reference site. Due to the lack of strong hydrogen-bond donors in all compounds, the crystal packing is mainly stabilized by weak intermolecular C-H center dot center dot center dot O interactions between the molecules. The present work provides a new perspective on the search for by-products normally overlooked in Claisen-Schmidt condensations.

Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Authors Roy, T; Boateng, ST; Banang-Mbeumi, S; Singh, PK; Basnet, P; Chamcheu, RCN; Ladu, F; Chauvin, I; Spiegelman, VS; Hill, RA; Kousoulas, KG; Nagalo, BM; Walker, AL; Fotie, J; Murru, S; Sechi, M; Chamcheu, JC in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Roy, Tithi; Boateng, Samuel T.; Banang-Mbeumi, Sergette; Basnet, Pratik; Chamcheu, Roxane-Cherille N.; Hill, Ronald A.; Chamcheu, Jean Christopher] Univ Louisiana, Coll Pharm, Sch Basic Pharmaceut & Toxicol Sci, 1800 Bienville Dr,Room 362, Monroe, LA 71209 USA; [Walker, Anthony L.] Univ Louisiana, Coll Pharm, Sch Clin Sci, Monroe, LA 71209 USA; [Basnet, Pratik; Chauvin, Isabel; Murru, Siva] Univ Louisiana, Dept Chem, Monroe, LA 71209 USA; [Singh, Pankaj K.; Ladu, Federico; Sechi, Mario] Univ Sassari, Dept Chem & Pharm, Via Vienna 2, I-07100 Sassari, Italy; [Spiegelman, Vladimir S.] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Pediat,Div Pediat Hematol Oncol, Hershey, PA 17033 USA; [Kousoulas, Konstantin G.] Louisiana State Univ, Sch Vet Med, Div Biotechnol & Mol Med, Baton Rouge, LA 70803 USA; [Kousoulas, Konstantin G.] Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 USA; [Nagalo, Bolni Marius] Mayo Clin Hosp, Div Hematol & Med Oncol, 5777 E Mayo Blvd, Phoenix, AZ 85054 USA; [Fotie, Jean] Southeastern Louisiana Univ, SELU, Dept Chem & Phys, Hammond, LA 70402 USA; [Banang-Mbeumi, Sergette] Louisiana Delta Community Coll, Sch Nursing & Allied Hlth Sci, Monroe, LA 71203 USA in 2021.0, Cited 96.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Due to hurdles, including resistance, adverse effects, and poor bioavailability, among others linked with existing therapies, there is an urgent unmet need to devise new, safe, and more effective treatment modalities for skin cancers. Herein, a series of flavonol-based derivatives of fisetin, a plant-based flavonoid identified as an antitumorigenic agent targeting the mammalian targets of rapamycin (mTOR)-regulated pathways, were synthesized and fully characterized. New potential inhibitors of receptor tyrosine kinases (c-KITs), cyclin-dependent kinase-2 (CDK2), and mTOR, representing attractive therapeutic targets for melanoma and non-melanoma skin cancers (NMSCs) treatment, were identified using inverse-docking, in vitro kinase activity and various cell-based anticancer screening assays. Eleven compounds exhibited significant inhibitory activities greater than the parent molecule against four human skin cancer cell lines, including melanoma (A375 and SK-Mel-28) and NMSCs (A431 and UWBCC1), with IC50 values ranging from 0.12 to < 15 mu M. Seven compounds were identified as potentially potent single, dual or multi-kinase c-KITs, CDK2, and mTOR kinase inhibitors after inverse-docking and screening against twelve known cancer targets, followed by kinase activity profiling. Moreover, the potent compound F20, and the multi-kinase F9 and F17 targeted compounds, markedly decreased scratch wound closure, colony formation, and heightened expression levels of key cancer-promoting pathway molecular targets c-Kit, CDK2, and mTOR. In addition, these compounds downregulated Bcl-2 levels and upregulated Bax and cleaved caspase-3/7/8 and PARP levels, thus inducing apoptosis of A375 and A431 cells in a dose-dependent manner. Overall, compounds F20, F9 and F17, were identified as promising c-Kit, CDK2 and mTOR inhibitors, worthy of further investigation as therapeutics, or as adjuvants to standard therapies for the control of melanoma and NMSCs. Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Roy, T; Boateng, ST; Banang-Mbeumi, S; Singh, PK; Basnet, P; Chamcheu, RCN; Ladu, F; Chauvin, I; Spiegelman, VS; Hill, RA; Kousoulas, KG; Nagalo, BM; Walker, AL; Fotie, J; Murru, S; Sechi, M; Chamcheu, JC or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Manganaro, R; Zonsics, B; Bauer, L; Lopez, ML; Donselaar, T; Zwaagstra, M; Saporito, F; Ferla, S; Strating, JRPM; Coutard, B; Hurdiss, DL; van Kuppeveld, FJM; Brancale, A in [Manganaro, Roberto; Zonsics, Birgit; Lopez, Moira Lorenzo; Saporito, Fabiana; Ferla, Salvatore; Brancale, Andrea] Cardiff Univ, Sch Pharm & Pharmaceut Sci, King Edward VII Ave, Cardiff CF10 3NB, Wales; [Bauer, Lisa; Donselaar, Tim; Zwaagstra, Marleen; Strating, Jeroen R. P. M.; Hurdiss, Daniel L.; van Kuppeveld, Frank J. M.] Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Virol Div, NL-3584 CL Utrecht, Netherlands; [Coutard, Bruno] UVE Aix Marseille Univ, Inserm 1207, IHU Mediterranee Infect, Unite Virus Emergents,IRD 190, Marseille, France; [Coutard, Bruno] Aix Marseille Univ, CNRS, AFMB UMR 7257, Marseille, France published Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors in 2020, Cited 24. Quality Control of 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

Enteroviruses (EV) are a group of positive-strand RNA ( + RNA) viruses that include many important human pathogens (e.g. poliovirus, coxsackievirus, echovirus, numbered enteroviruses and rhinoviruses). Fluoxetine was identified in drug repurposing screens as potent inhibitor of enterovirus B and enterovirus D replication. In this paper we are reporting the synthesis and the antiviral effect of a series of fluoxetine analogues. The results obtained offer a preliminary insight into the structure-activity relationship of its chemical scaffold and confirm the importance of the chiral configuration. We identified a racemic fluoxetine analogue, 2b, which showed a similar antiviral activity compared to (S)-fluoxetine. Investigating the stereochemistry of 2b revealed that the Senantiomer exerts potent antiviral activity and increased the antiviral spectrum compared to the racemic mixture of 2b. In line with the observed antiviral effect, the Senantiomer displayed a dose-dependent shift in the melting temperature in thermal shift assays, indicative for direct binding to the recombinant 2C protein.

Quality Control of 3-(Trifluoromethyl)phenol. Welcome to talk about 98-17-9, If you have any questions, you can contact Manganaro, R; Zonsics, B; Bauer, L; Lopez, ML; Donselaar, T; Zwaagstra, M; Saporito, F; Ferla, S; Strating, JRPM; Coutard, B; Hurdiss, DL; van Kuppeveld, FJM; Brancale, A or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Regioselective Monobromination of Phenols with KBr and ZnAl-BrO3–Layered Double Hydroxides WOS:000522454500150 published article about N-BROMOSUCCINIMIDE NBS; AROMATIC-COMPOUNDS; OXIDATIVE BROMINATION; SELECTIVE MONOBROMINATION; SUBSTITUTED PHENOLS; EFFICIENT SYNTHESIS; MILD; BROMIDE; ACID; ANILINES in [Wang, Ligeng; Feng, Chun; Zhang, Yan; Hu, Jun] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310004, Peoples R China in 2020, Cited 69. Safety of 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl-BrO3–layered double hydroxides (abbreviated as ZnAl-BrO3–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols.

Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.. Safety of 3-(Trifluoromethyl)phenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C9H10O3. Gu, XK; Guan, MY; Jiang, CY; Song, QH; Li, X; Sun, N; Chen, J; Qiu, JY in [Gu, Xiaoke; Guan, Mingyu; Jiang, Chunyu; Song, Qinghua; Li, Xin; Sun, Nan; Chen, Jing; Qiu, Jingying] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China published Assessment of Thiosemicarbazone-Containing Compounds as Potential Antileukemia Agents against P-gp Overexpressing Drug Resistant K562/A02 Cells in 2021.0, Cited 28.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

P-Glycoprotein (P-gp) overexpression is considered to be the leading cause of multidrug resistance (MDR) and failure of chemotherapy for leukemia. In this study, seventeen thiosemicarbazone-containing compounds were prepared and evaluated as potential antileukemia agents against drug resistant K562/A02 cell overexpressing P-gp. Among them, N-hydroxy-6-({(2E)-2-[(3-nitrophenyl)methylidene]hydrazinecarbothioyl}amino)hexanamide could significantly inhibit K562/A02 cells proliferation with an IC50 value of 0.96 mu M. Interestingly, N-hydroxy-6-({(2E)-2-[(3-nitrophenyl)methylidene]hydrazinecarbothioyl}amino)hexanamide could dose-dependently increase ROS levels of drug resistant K562/A02 cells, thus displaying a potential collateral sensitivity (CS)-inducing effect and selectively killing K562/A02 cells. Furthermore, N-hydroxy-6-({(2E)-2-[(3-nitrophenyl)methylidene]hydrazinecarbothioyl}amino)hexanamide possessed potent inhibitory effect on HDAC1 and HDAC6, and could promote K562/A02 cells apoptosis via dose-dependently increasing Bax expression, reducing Bcl-2 protein level, and inducing the cleavage of PARP and caspase3. These present findings suggest that N-hydroxy-6-({(2E)-2-[(3-nitrophenyl)methylidene]hydrazinecarbothioyl}amino)hexanamide might be a promising lead to discover novel antileukemia agents against P-gp overexpressing leukemic cells.

COA of Formula: C9H10O3. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Song, ZH; Wang, GT; Li, W; Li, SK in [Song, Zehua; Wang, Guotong; Li, Wei; Li, Shengkun] Nanjing Agr Univ, Coll Plant Protect, Dept Pesticide Sci, Weigang 1, Nanjing 210095, Jiangsu, Peoples R China published Innate pharmacophore assisted selective C-H functionalization to therapeutically important nicotinamides in 2019, Cited 39. Category: indole-building-block. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

The application of the pre-validated pharmacophore 2-(2-oxazolinyl) aniline as an innate directing group in the C-H etherification and amination of nicotinamides for the efficient synthesis of drug-and agrochemical- like molecules was determined. An operationally simple, and regioselective C-H functionalization of nicotinamides was first accomplished using a complicated variation of copper salts. All the specific procedures used were easy to utilize, without external oxidants or ligands. The feasibility is highlighted using an alternative synthesis of diflufenican with a rapid synthesis of niacin related pharmaceuticals or analogues.

Category: indole-building-block. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Song, ZH; Wang, GT; Li, W; Li, SK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021.0 ORG LETT published article about DIRECT ARYLATION; POLYSUBSTITUTED PYRROLES; CYCLOADDITION; 2H-AZIRINES; DESIGN in [Chen, Lai; Huo, Jing-Qian; Kou, Song; Zhang, Jin-Lin] Hebei Agr Univ, Coll Plant Protect, Baoding 071001, Peoples R China; [Si, He-Long] Hebei Agr Univ, Coll Life Sci, Baoding 071001, Peoples R China; [Xu, Xin-Yu; Mao, Jianyou] Nanjing Tech Univ, Sch Chem & Mol Engn, Tech Inst Fluorochem TIF, Inst Adv Synth, Nanjing 211816, Peoples R China in 2021.0, Cited 48.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Formula: C9H10O3

The first base-mediated intermolecular cyclization of arylaldehydes and terminal arylacetylenes for the synthesis of a wide range of pyrroles in a single step has been described. The developed methodology used commercially available starting materials and tolerated a broad range of functional groups affording 2,3,5-triaryl-substituted-1H-pyrroles with good yields (up to 92% yield) under mild conditions. The possible mechanism was also discussed.

Formula: C9H10O3. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 120-14-9. Authors Shahari, MSB; Junaid, A; Tiekink, ERT; Dolzhenko, AV in GEORG THIEME VERLAG KG published article about in [Shahari, Muhammad Syafiq Bin; Dolzhenko, Anton, V] Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul, Malaysia; [Junaid, Ahmad] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA; [Tiekink, Edward R. T.] Sunway Univ, Res Ctr Crystalline Mat, Sch Med & Life Sci, 5 Jalan Univ, Bandar Sunway 47500, Selangor Darul, Malaysia; [Dolzhenko, Anton, V] Curtin Univ, Fac Hlth Sci, Sch Pharm & Biomed Sci, Curtin Hlth Innovat Res Inst, GPO Box U1987, Perth, WA 6845, Australia in 2021.0, Cited 47.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The synthesis is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction in the presence of hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) into the targeted compounds via aromatic dehydrogenation in the presence of alkali. The reaction tolerated various aromatic aldehydes (including heterocyclic) and cyclic amities. Crystal structures of two representative 4-aryl-6-morpholino-1,3,5-triazin-2-amines were established by X-ray crystallography. The results of preliminary biological screening identified potent antileukemic activity for 6-[3,4-dihydroisoquinolin-2(1H)-yl]-4- phenyl-1,3,5-triazin-2-amine.

Recommanded Product: 120-14-9. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 120-14-9. Recently I am researching about TO-HEAD DIMERIZATION; NONAROMATIC CATECHOL BIOISOSTERES; AZA-CLAISEN REARRANGEMENT; TERMINAL ARYL ALKYNES; CONJUGATED ENYNES; SELECTIVE DIMERIZATION; CATALYZED DIMERIZATION; PALLADIUM COMPLEXES; TAIL DIMERIZATION; PALLADACYCLE, Saw an article supported by the . Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Pfeffer, C; Wannenmacher, N; Frey, W; Peters, R. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Enynes are important motifs in bioactive compounds. They can be synthesized by alkyne-alkyne couplings for which a number of mechanisms have been suggested depending on catalyst type and dominant product isomers. Regarding bimetallic pathways, hydrometalations and anti-carbopalladations have been discussed to account for the formation of geminally substituted and (Z)-configured enynes, respectively. Here we report a bimetallic alkyne-alkyne coupling that yields (E)-configured enynes. An unusual type of acetylide Pd bridging was found in putative catalytic intermediates which is arguably responsible for the regio- and stereochemical reaction outcome. Mechanistic studies suggest that a double mu-kappa:eta(2) acetylide bridging enables a bimetallic syn-carbometalation. Interestingly, depending on the reaction conditions, it is also possible to form the geminal regioisomer as major product with the same catalyst. This regiodivergent outcome is explained by bi-versus monometallic reaction pathways.

Product Details of 120-14-9. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019 ORG LETT published article about 3-AMINOCHROMAN DERIVATIVES; INTERRUPTED PUMMERER; ARYL SULFOXIDES; INTRAMOLECULAR CAPTURE; OXIDATIVE BROMINATION; QUINONE METHIDES; SWERN OXIDATION; ALPHA-ARYLATION; LEWIS-ACIDS; PHENOLS in [Acosta-Guzman, Paola; Rodriguez-Lopez, Alvaro; Gamba-Sanchez, Diego] Univ Andes, Dept Chem, Lab Organ Synth Bio & Organocatalysis, Cra 1 18A-12 Q 305, Bogota 111711, Colombia in 2019, Cited 77. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Application In Synthesis of 3-(Trifluoromethyl)phenol

The competition between an unprecedented reductive chlorination and the Pummerer reaction was studied and applied to the synthesis of benzofused oxygen heterocycles including 3-aminochromanes and in the intramolecular chlorination of activated aromatic rings. The use of (COCl)(2) as a Pummerer activator showed substantial activity, producing alpha-chlorinated sulfides that can undergo Pummerer-Friedel-Crafts cyclization. If the aromatic ring has electron-donating groups in position three, then the reaction follows a different pathway, yielding the reductive chlorination products, where the chlorine atom comes from a sulfonium salt.

Application In Synthesis of 3-(Trifluoromethyl)phenol. Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles