Tag: M.W:200-300

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cheng, Ran; Sang, Yueqian; Gao, Xing; Zhang, Shu; Xue, Xiao-Song; Zhang, Xingang researched the compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4 ).Name: Nickel(II) chloride ethylene glycol dimethyl ether complex.They published the article 《Highly γ-Selective Arylation and Carbonylative Arylation of 3-Bromo-3,3-difluoropropene via Nickel Catalysis》 about this compound( cas:29046-78-4 ) in Angewandte Chemie, International Edition. Keywords: regioselective arylation carbonylation bromodifluoropropene nickel catalysis; 3-bromo-3,3-difluoropropene; arylboronic acids; carbonylation; gem-difluoroalkenes; nickel catalysis. We’ll tell you more about this compound (cas:29046-78-4).

A nickel-catalyzed highly γ-regioselective arylation and carbonylative arylation of 3-bromo-3,3-difluoropropene has been developed. The reaction proceeds under mild reaction conditions, providing the gem-difluoroalkenes with high efficiency and good functional group tolerance. The resulting gem-difluoroalkenes can serve as versatile building blocks for diversified synthesis. Preliminary mechanistic studies and d. functional theory calculations reveal that both non-radical and radical pathways are possible for the reaction, and the radical pathway is more likely. The high γ-regioselectivity results from the β-bromide elimination of alkylnickel(II) species or from the reductive elimination of nickel(III) species [(aryl)(CF2=CHCH2)NiIII(Ln)X]. The γ-selective carbonylation of 3-bromo-3,3-difluoropropene under 1 atm CO gas also provides a new way for nickel-catalyzed carbonylation. Thus, e.g., (4-tert-butylphenyl)boronic acid + 3-bromo-3,3-difluoropropene → I (86%, 84% isolated) in presence of NiCl2.DME and bpy.

From this literature《Highly γ-Selective Arylation and Carbonylative Arylation of 3-Bromo-3,3-difluoropropene via Nickel Catalysis》,we know some information about this compound(29046-78-4)Name: Nickel(II) chloride ethylene glycol dimethyl ether complex, but this is not all information, there are many literatures related to this compound(29046-78-4).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: Nickel(II) chloride ethylene glycol dimethyl ether complex. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Evidence for Photocatalyst Involvement in Oxidative Additions of Nickel-Catalyzed Carboxylate O-Arylations. Author is Malik, Jamal A.; Madani, Amiera; Pieber, Bartholomaeus; Seeberger, Peter H..

Dual photocatalysis and nickel catalysis can effect cross-coupling under mild conditions, but little is known about the in situ kinetics of this class of reactions. We report a comprehensive kinetic examination of a model carboxylate O-arylation, comparing a state-of-the-art homogeneous photocatalyst (Ir(ppy)3) with a competitive heterogeneous photocatalyst (graphitic carbon nitride). Exptl. conditions were adjusted such that the nickel catalytic cycle is saturated with excited photocatalyst. This approach was designed to remove the role of the photocatalyst, by which only the intrinsic behaviors of the nickel catalytic cycles are observed The two reactions did not display identical kinetics. Ir(ppy)3 deactivates the nickel catalytic cycle and creates more dehalogenated side product. Kinetic data for the reaction using Ir(ppy)3 supports a turnover-limiting reductive elimination. Graphitic carbon nitride gave higher selectivity, even at high photocatalyst-to-nickel ratios. The heterogeneous reaction also showed a rate dependence on aryl halide, indicating that oxidative addition plays a role in rate determination The results argue against the current mechanistic hypothesis, which states that the photocatalyst is only involved to trigger reductive elimination.

From this literature《Evidence for Photocatalyst Involvement in Oxidative Additions of Nickel-Catalyzed Carboxylate O-Arylations》,we know some information about this compound(29046-78-4)Name: Nickel(II) chloride ethylene glycol dimethyl ether complex, but this is not all information, there are many literatures related to this compound(29046-78-4).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 29046-78-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about NiH-Catalyzed Migratory Defluorinative Olefin Cross-Coupling: Trifluoromethyl-Substituted Alkenes as Acceptor Olefins to Form gem-Difluoroalkenes. Author is Chen, Fenglin; Xu, Xianfeng; He, Yuli; Huang, Genping; Zhu, Shaolin.

We report a NiH-catalyzed migratory defluorinative coupling between two electronically differentiated olefins. A broad range of unactivated donor olefins can be joined directly to acceptor olefins containing an electron-deficient trifluoromethyl substituent in both intra- and intermol. fashion to form gem-difluoroalkenes. This migratory coupling shows both site- and chemoselectivity under mild conditions, with the formation of a tertiary or quaternary carbon center.

There is still a lot of research devoted to this compound(SMILES：COCCOC.Cl[Ni]Cl)Product Details of 29046-78-4, and with the development of science, more effects of this compound(29046-78-4) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Regioselective Hydroalkylation and Arylalkylation of Alkynes by Photoredox/Nickel Dual Catalysis: Application and Mechanism. Author is Yue, Huifeng; Zhu, Chen; Kancherla, Rajesh; Liu, Fangying; Rueping, Magnus.

Alkynes are an important class of organic mols. due to their utility as versatile building blocks in synthesis. Although efforts have been devoted to the difunctionalization of alkynes, general and practical strategies for the direct hydroalkylation and alkylarylation of terminal alkynes under mild reaction conditions are less explored. Herein, a photoredox/nickel dual-catalyzed anti-Markovnikov-type hydroalkylation of terminal alkynes as well as a one-pot arylalkylation of alkynes with alkyl carboxylic acids and aryl bromides via a three-component cross-coupling has been discussed. The results indicate that the transformations proceed via a new mechanism involving a single-electron transfer with subsequent energy-transfer activation pathways. Moreover, steady-state and time-resolved fluorescence-spectroscopy measurements, d. functional theory (DFT) calculations, and wavefunction anal. have been performed to give an insight into the catalytic cycle.

There is still a lot of research devoted to this compound(SMILES：COCCOC.Cl[Ni]Cl)Category: indole-building-block, and with the development of science, more effects of this compound(29046-78-4) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 110-52-1, is researched, Molecular C4H8Br2, about Ultrafast electronic dynamics and vibrational dynamics of SWCNT under alkylation and annealing, the main research direction is carbon nanotube alkylation annealing ultrafast electronic vibrational transient absorption.Reference of 1,4-Dibromobutane.

Using ultrashort visible pulse laser, the authors have performed transient absorption spectroscopy to study the electronic relaxation and vibrational dynamics for 3 single-wall C nanotube (SWCNT) samples of nonsubstituted SWCNT, alkylated SWCNT, and annealed alkylated SWCNT. Estimated lifetimes of ∼100 fs and ∼1 ps can be assigned to intraband and interband relaxation processes, resp. Compared with the nonsubstituted sample, the intraband transition rate is 7% smaller for the alkylated sample and nearly equal to the annealed alkylated sample within 2%. It implies that the intraband relaxation rate is not affected by alkylation itself but inhibited by excess chem. modification. Conversely, the interband relaxation rate shows no difference between the 3 samples. Short-time Fourier transform anal. of the measured traces of pump-probe delay dependent difference absorbance visualizes the change of mol. vibration frequency reflecting the energy transfer from (6,5)-SWCNT to (6,4)-SWCNT and the mol. structure change during the interband transition.

There is still a lot of research devoted to this compound(SMILES：BrCCCCBr)Reference of 1,4-Dibromobutane, and with the development of science, more effects of this compound(110-52-1) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Huang, Mingming; Hu, Jiefeng; Krummenacher, Ivo; Friedrich, Alexandra; Braunschweig, Holger; Westcott, Stephen A.; Radius, Udo; Marder, Todd B. published an article about the compound: 1,4-Dibromobutane( cas:110-52-1,SMILESS:BrCCCCBr ).Related Products of 110-52-1. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:110-52-1) through the article.

A practical and direct method was developed for the production of versatile alkyl boronate esters via transition metal-free borylation of primary and secondary alkyl sulfones. The key to the success of the strategy is the use of bis(neopentyl glycolato) diboron (B2neop2), with a stoichiometric amount of base as a promoter. The practicality and industrial potential of this protocol are highlighted by its wide functional group tolerance, the late-stage modification of complex compounds, no need for further transesterification, and operational simplicity. Radical clock, radical trap experiments, and EPR studies were conducted which show that the borylation process involves radical intermediates.

There is still a lot of research devoted to this compound(SMILES：BrCCCCBr)Related Products of 110-52-1, and with the development of science, more effects of this compound(110-52-1) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Nickel-catalyzed electrochemical reductive decarboxylative coupling of N-hydroxyphthalimide esters with quinoxalinones.Synthetic Route of C4H10Cl2NiO2.

Herein the 1st example of electrochem. enabled, NiCl2-catalyzed reductive decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with quinoxalinones is reported. A range of primary, secondary, tertiary aliphatic carboxylic acids and amino acid-derived esters were tolerated well. This decarboxylative coupling allows access to structurally diverse 3-alkylated quinoxalinones in up to 91% yields.

There is still a lot of research devoted to this compound(SMILES：COCCOC.Cl[Ni]Cl)Synthetic Route of C4H10Cl2NiO2, and with the development of science, more effects of this compound(29046-78-4) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C4H10Cl2NiO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Nickel-Catalyzed Decarboxylative Coupling of Redox-Active Esters with Aliphatic Aldehydes. Author is Xiao, Jichao; Li, Zhenning; Montgomery, John.

The addition of alkyl fragments to aliphatic aldehydes is a highly desirable transformation for fragment couplings, yet existing methods come with operational challenges related to the basicity and instability of the nucleophilic reagents commonly employed. Herein, use of nickel catalyst alongwith a readily available bioxazoline (BiOx) ligand to catalyze the reductive coupling of redox-active esters with aliphatic aldehydes using zinc metal as the reducing agent to deliver silyl-protected secondary alcs. is reported. This protocol is operationally simple, proceeds under mild conditions, and tolerates a variety of functional groups. Initial mechanistic studies suggest a radical chain pathway. Addnl., alkyl tosylates and epoxides are suitable alkyl precursors to this transformation providing a versatile suite of catalytic reactions for the functionalization of aliphatic aldehydes.

There is still a lot of research devoted to this compound(SMILES：COCCOC.Cl[Ni]Cl)COA of Formula: C4H10Cl2NiO2, and with the development of science, more effects of this compound(29046-78-4) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C5H9IO. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-(Iodomethyl)tetrahydrofuran, is researched, Molecular C5H9IO, CAS is 475060-43-6, about Bismuth Compounds in Radical Catalysis: Transition Metal Bismuthanes Facilitate Thermally Induced Cycloisomerizations. Author is Ramler, Jacqueline; Krummenacher, Ivo; Lichtenberg, Crispin.

The controlled radical chem. of Bi compounds is still in its infancy. Further developments are fueled by the properties of these complexes (e.g., low toxicity, high functional group tolerance, low homolytic bond dissociation energies, and reversible homolytic bond dissociations), which are highly attractive for applications in synthetic chem. Here the authors report the 1st catalytic application of transition metal bismuthanes (i.e. compounds with a Bi-TM bond; TM = transition metal). Using the catalyzed radical cycloisomerization of δ-iodoolefins as a model reaction, characteristics complementary or superior to known B, Mn, Cu, Zn, Sn, and alkali metal reagents are demonstrated (including a different crucial intermediate), establishing transition metal bismuthanes as a new class of (pre-)catalysts for controlled radical reactions.

If you want to learn more about this compound(3-(Iodomethyl)tetrahydrofuran)Computed Properties of C5H9IO, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(475060-43-6).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of Nickel(II) chloride ethylene glycol dimethyl ether complex. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Enantioselective Ni-Catalyzed Electrochemical Synthesis of Biaryl Atropisomers. Author is Qiu, Hui; Shuai, Bin; Wang, Yun-Zhao; Liu, Dong; Chen, Yue-Gang; Gao, Pei-Sen; Ma, Hong-Xing; Chen, Song; Mei, Tian-Sheng.

A scalable enantioselective nickel-catalyzed electrochem. reductive homocoupling of aryl bromides has been developed, affording enantioenriched axially chiral biaryls in good yield under mild conditions using electricity as a reductant in an undivided cell [e.g., 2-(benzyloxy)-1-bromonaphthalene → (R)-2,2′-bis(benzyloxy)-1,1′-binaphthyl (72% yield (65% isolated), 93% ee) using a chiral indan-fused oxazoline and NiCl2.glyme in presence of mol. sieves]. Common metal reductants such as Mn or Zn powder resulted in significantly lower yields in the absence of elec. current under otherwise identical conditions, underscoring the enhanced reactivity provided by the combination of transition metal catalysis and electrochem.

If you want to learn more about this compound(Nickel(II) chloride ethylene glycol dimethyl ether complex)Application In Synthesis of Nickel(II) chloride ethylene glycol dimethyl ether complex, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(29046-78-4).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles