Tag: M.W:200-300

SDS of cas: 110-52-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,4-Dibromobutane, is researched, Molecular C4H8Br2, CAS is 110-52-1, about Potassium reduced graphite functionalization: Architectural aesthetics and electrical excellence. Author is Bai, Li; Xu, Yongqi; Hu, Cheng-Min; Dong, Lei; Wang, Xinping; Li, Wei-Shi; Zhao, Fu-Gang.

Rational functionalization plays an important role to push forward graphene applications in multifarious cutting-edge technologies. A key topic that how to program the regular distribution of functional groups, however, remains a big challenge. Herein, we developed a very simple, high-throughput graphite reduction methodol. to attain the neg.-charged graphene which carried ultrahigh-d. and evenly-distributed neg. charges. Guided by these neg. charges, electrophiles were regularly attached to graphene sheets. On the other hand, potassium reduction will not break the carbon-carbon σ-bonds, hence graphene hexagonal lattice was kept as perfect as the pristine pattern. Structural advantages of the neg.-charged graphene derivatives allowed a far more excellent conductivity and electron mobility than the counterparts derived from the prevalent graphene oxide precursor.

There is still a lot of research devoted to this compound(SMILES：BrCCCCBr)SDS of cas: 110-52-1, and with the development of science, more effects of this compound(110-52-1) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 110-52-1, is researched, Molecular C4H8Br2, about Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues, the main research direction is dihydrexidine SKF catecholamine analog dopamine receptor binding; D1R agonists; D2R and DAT; Dihydrexidine; Dopamine analogs; SKF 38393.Application of 110-52-1.

Dopamine is an important neurotransmitter that regulates numerous essential functions, including cognition and voluntary movement. As such, it serves as an important scaffold for synthesis of novel analogs as part of drug development effort to obtain drugs for treatment of neurodegenerative diseases, such as Parkinson′s disease. To that end, similarity search of the ZINC database based on two known dopamine-1 receptor (D1R) agonists, dihydrexidine (DHX) and SKF 38393, resp., was used to predict novel chem. entities with potential binding to D1R. Three compounds that showed the highest similarity index were selected for synthesis and bioactivity profiling. All main synthesis products as well as the isolated intermediates, were properly characterized. The physico-chem. analyses were performed using HRESIMS, GC/MS, LC/MS with UV-Vis detection, and FTIR, 1H NMR and 13C NMR spectroscopy. Binding to D1 and D2 receptors and inhibition of dopamine reuptake via dopamine transporter were measured for the synthesized analogs of DHX and SKF 38393.

Here is a brief introduction to this compound(110-52-1)Application of 110-52-1, if you want to know about other compounds related to this compound(110-52-1), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,4-Dibromobutane( cas:110-52-1 ) is researched.COA of Formula: C4H8Br2.Feng, Yiyue; Lu, Yingmei; Li, Junfang; Zhang, Honghua; Li, Zhao; Feng, Hanzhong; Deng, Xuemei; Liu, Dan; Shi, Tao; Jiang, Weifan; He, Yongxing; Zhang, Jian; Wang, Zhen published the article 《Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo》 about this compound( cas:110-52-1 ) in European Journal of Medicinal Chemistry. Keywords: o aminobenzamide antigastric cancer agents; Cell cycle analysis; Gastric cancer; Migration and invasion; Structure-activity relationship; o-Aminobenzamide derivatives. Let’s learn more about this compound (cas:110-52-1).

Although gastric cancer has become a major public health problem, oral agents applied in clinics for gastric cancer therapy are scarce. Therefore, to explore new oral chem. entities with high efficiency and low toxicity, 41 o-aminobenzamide derivatives based on the scaffolds of MS-275 and SAHA were designed, synthesized, and evaluated for their anti-gastric cancer abilities in vitro and in vivo. Structure-activity relationships were discussed, leading to the identification of compounds F8 (IC50 = 0.28 μM against HGC-27 cell) and T9 (IC50 = 1.84 μM against HGC-27 cell) with improved cytotoxicity, anti-gastric cancer proliferation potency, induction of cell apoptosis and cell cycle arrest ability, inhibition of cell migration and invasion. What is worth mentioning is that compound F8 was more efficient and less toxic than the pos. drug capecitabine in vivo on the HGC-27-xenograft model. Meanwhile, compound F8 exhibited suitable pharmacokinetic properties and less acute toxicity (LD50 > 1000 mg/kg). Besides, western blotting anal., IHC anal., differentially expressed proteins anal. and ABPP experiment indicated that compound F8 could modulate mol. pathways involved in apoptosis and cell cycle progression. Consequently, compound F8 is a strong candidate for the development of human gastric cancer therapy.

If you want to learn more about this compound(1,4-Dibromobutane)COA of Formula: C4H8Br2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(110-52-1).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Kim, Weonjeong; Koo, Jangwoo; Lee, Hong Geun published the article 《Benzylic C(sp3)-C(sp2) cross-coupling of indoles enabled by oxidative radical generation and nickel catalysis》. Keywords: benzylic indole preparation; indole aryl halide arylation cross coupling photocatalyst; acyl indole preparation; acid anhydride indole acylation cross coupling photocatalyst.They researched the compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4 ).Recommanded Product: 29046-78-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:29046-78-4) here.

A mechanistically unique functionalization strategy for a benzylic C(sp3)-H bond was developed based on facile oxidation event of indole substrates. This novel pathway was initiated by efficient radical generation at benzylic position of substrate, with subsequent transition metal catalysis to complete overall transformation. Ultimately, an aryl or an acyl group could be effectively delivered from an aryl (pseudo)halide or an acid anhydride coupling partner, resp. The developed method utilized mild conditions and exhibited a wide substrate scope for both substituted indoles and C(sp2)-based reaction counterparts. Mechanistic studies showed that competitive hydrogen atom transfer (HAT) processes, which were frequently encountered in conventional methods, are not involved in the product formation process of the developed strategy.

If you want to learn more about this compound(Nickel(II) chloride ethylene glycol dimethyl ether complex)Recommanded Product: 29046-78-4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(29046-78-4).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C4H10Cl2NiO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Simplified and versatile access to low valent Ni complexes by metal-free reduction of NiII precursors. Author is Moser, Emile; Jeanneau, Erwann; Mezailles, Nicolas; Olivier-Bourbigou, Helene; Breuil, Pierre-Alain R..

The reduction of [Ni(DME)Cl2] with 2 equiv of bis(trimethylsilyl)-1,4-tetramethyldihydropyrazine in the presence of a ligand L and an excess of olefin cleanly leads to [Ni(L)(alkene)2] complexes. When reduction is performed in the presence of 1,5-cyclooctadiene (COD), [Ni(COD)2] is obtained. Such an approach also allows access to the NiI dimer [Ni(bis(dicyclohexylphosphino)propane)Cl]2.

Here is a brief introduction to this compound(29046-78-4)COA of Formula: C4H10Cl2NiO2, if you want to know about other compounds related to this compound(29046-78-4), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C4H10Cl2NiO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Enantio- and Regioselective NiH-Catalyzed Reductive Hydroarylation of Vinylarenes with Aryl Iodides. Author is He, Yuli; Liu, Chuang; Yu, Lei; Zhu, Shaolin.

A highly enantio- and regioselective hydroarylation process of vinylarenes with aryl halides has been developed using a NiH catalyst and a new chiral bis imidazoline ligand. A broad range of structurally diverse, enantio-enriched 1,1-diarylalkanes, a structure found in a number of biol. active mols., have been obtained with excellent yields and enantio-selectivities under extremely mild conditions.

Here is a brief introduction to this compound(29046-78-4)Formula: C4H10Cl2NiO2, if you want to know about other compounds related to this compound(29046-78-4), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 29046-78-4, is researched, Molecular C4H10Cl2NiO2, about Photoreductive chlorine elimination from a Ni(III)Cl2 complex supported by a tetradentate pyridinophane ligand, the main research direction is crystal structure MO electrochem nickel pyridinophane complex preparation; photoreductive chlorine elimination nickel pyridinophane complex.Reference of Nickel(II) chloride ethylene glycol dimethyl ether complex.

The authors report the isolation, characterization, and photoreactivity of a stable NiIII dichloride complex supported by a tetradentate pyridinophane N-donor ligand. Upon irradiation, this complex undergoes an efficient photoreductive chlorine elimination reaction, both in solution and the solid-state. Subsequently, the NiIIICl2 species can be regenerated via a reaction with PhICl2.

Here is a brief introduction to this compound(29046-78-4)Reference of Nickel(II) chloride ethylene glycol dimethyl ether complex, if you want to know about other compounds related to this compound(29046-78-4), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C4H10Cl2NiO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Cross-Electrophile Coupling of Unactivated Alkyl Chlorides. Author is Sakai, Holt A.; Liu, Wei; Le, Chi “Chip”; MacMillan, David W. C..

Overcoming intrinsic limitations of C(sp3)-Cl bond activation, the development of a novel organosilane reagent Si(TMS)3(N)R1R2 (R1 = adamantyl, tert-Bu, i-Pr, n-Bu; R2 = H) that can participate in chlorine atom abstraction under mild photocatalytic conditions were reported. In particular, the application of this mechanism to a dual nickel/photoredox catalytic protocol that enables the first cross-electrophile coupling of unactivated alkyl chlorides R3Cl (R3 = cyclohexyl, oxan-4-yl, 4-cyanobutyl, etc.) and aryl chlorides R4Cl (R4 = pyridin-4-yl, quinolin-3-yl, 2-(methylsulfanyl)pyrimidin-5-yl, etc.) was described. Employing these low-toxicity, abundant, and com. available organochloride building blocks, this methodol. allows access to a broad array of highly functionalized C(sp2)-C(sp3) coupled adducts, e.g., I including numerous drug analogs.

Here is a brief introduction to this compound(29046-78-4)Formula: C4H10Cl2NiO2, if you want to know about other compounds related to this compound(29046-78-4), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: Nickel(II) chloride ethylene glycol dimethyl ether complex. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Selective, Intermolecular Alkylarylation of Alkenes via Photoredox/Nickel Dual Catalysis. Author is Guo, Lei; Tu, Hai-Yong; Zhu, Shengqing; Chu, Lingling.

A regioselective, intermol. 1,2-alkylarylation of alkenes with aryl halides and alkyl oxalates has been developed via photoredox/nickel dual catalysis. This dual-catalytic protocol involves a radical relay process, where radical addition is followed by a nickel-assisted coupling, forging two consecutive C-C bonds in a single operation. The mild and redox-neutral conditions allow for good compatibility in the scope of olefins, (hetero)aryl halides, as well as alkyl oxalates.

Here is a brief introduction to this compound(29046-78-4)Recommanded Product: Nickel(II) chloride ethylene glycol dimethyl ether complex, if you want to know about other compounds related to this compound(29046-78-4), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

20289-27-4, 7-(Benzyloxy)-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a) 1-Methyl-indol-7-ol A mixture of 7-benzyloxyindole (300 mg, 1.34 mmol), dimethyl oxalate (317 mg, 2.68 mmol) and potassium tert-butoxide (302 mg, 2.68 mmol) in 5 mL DMF was stirred at 110 C. overnight. The solution was poured into NaHCO3 saturated solution (20 mL) and extracted with EtOAc. The organic layer was separated, washed with brine and dried over Na2SO4. The solvent was removed in vacuo to yield 200 mg of 7-benzyloxy-1-methylindole, which was hydrogenated by 5% Pd/C in 20 mL methanol under H2 (50 psi) to yield 90 mg (45.5%) of the title compound. 1H NMR (CDCl3): 7.19-7.16 (m, 1H), 6.94 (d, J=3 Hz, 1H), 6.86 (t, J=7.5 Hz, 1H), 6.48-6.46 (m, 1H), 6.40 (d, J=3 Hz, 1H), 5.05 (s, 1H), 4.07 (s, 3H).

20289-27-4, As the paragraph descriping shows that 20289-27-4 is playing an increasingly important role.

Reference：
Patent; Cytovia, Inc.; US2003/65018; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles