Tag: M.W=250-300

Hiremath, Shivayogi P. published the artcileSynthesis of 11H-1,2,4-triazolo[4,3-b]pyridazino[4,5-b]indoles, Name: Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate, the publication is Indian Journal of Heterocyclic Chemistry (1994), 3(3), 145-8, database is CAplus.

4-Oxo-5H-pyridazino[4,5-b]indoles, obtained from the corresponding 3-formylindole-2-carboxylates, were subjected to chlorination to obtain the corresponding 4-chloro-5H-pyridazino[4,5-b]indoles which on reaction with hydrazine hydrate in the presence of K₂CO₃ give 4-hydrazino-5H-pyridazino[4,5-b]indole. The latter were treated with acetic acid/benzoyl chloride to yield the desired title compounds I (R = Me, OMe, Br, OEt, Cl; R¹ = Me, Ph). These compounds were screened for their antimicrobial activity.

Indian Journal of Heterocyclic Chemistry published new progress about 100123-25-9. 100123-25-9 belongs to indole-building-block, auxiliary class Indole,Bromide,Ester,Aldehyde, name is Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate, and the molecular formula is C12H10BrNO3, Name: Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Curzon, G. published the artcileA method for the determination of urinary indoxyl sulfate (indican), Product Details of C8H6KNO4S, the publication is Clinica Chimica Acta (1962), 657-63, database is CAplus and MEDLINE.

The method is based on the Ehrlich reaction of indoxyl sulfate with p-dimethylaminobenzaldehyde in acid solution When the solution is made alk., an intense red color is produced. This is extracted into petr. ether, in which it is yellow, and determined colorimetrically at 464 mμ. Urea is the only substance which interferes significantly. Thus, urine determinations are corrected for urea interference by multiplying by a factor of 1.18. Using this corrected factor, exptl. found recoveries of added K indoxyl sulfate from 10 urines (50 γ/ml. urine) varied from 94 to 108%. Normal subjects excreted 48.2 ± 19.1 mg. K indoxyl sulfate per 24 hrs.

Clinica Chimica Acta published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Product Details of C8H6KNO4S.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Eastabrook, Andrew S. published the artcileA Procedure for Transforming Indoles into Indolequinones, Application of 2-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole, the publication is Journal of Organic Chemistry (2015), 80(2), 1006-1017, database is CAplus and MEDLINE.

A procedure that converts a series of structurally diverse, readily available indole derivatives to their corresponding indolequinones is described. The three-step route commences with an iridium catalyzed C-H borylation to give a 7-borylindole that upon oxidation-hydrolysis affords the 7-hydroxyindole. Subsequent oxidation provides the indolequinone.

Journal of Organic Chemistry published new progress about 919119-59-8. 919119-59-8 belongs to indole-building-block, auxiliary class Indole,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole, and the molecular formula is C15H20BNO2, Application of 2-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chen, Hu published the artcileA copper-catalyzed aerobic domino process for the synthesis of isoindolin-1-ylidene derivatives, Synthetic Route of 167015-84-1, the publication is Tetrahedron (2015), 71(22), 3632-3636, database is CAplus.

A convenient and efficient copper-catalyzed aerobic cascade reaction was developed for the synthesis of the pharmacol. relevant isoindolin-1-ylidene scaffold. Various ortho-formyl cinnamates could react smoothly with different amines in the presence of a com. available copper catalyst under mild aerobic conditions. Isoindolin-1-ylidene derivatives were assembled in one pot in moderate to good yields. This method features amine annulation and double dehydrogenation, representing high at. efficiency. Its product could be further converted to the privileged isoindolinone pharmacophore.

Tetrahedron published new progress about 167015-84-1. 167015-84-1 belongs to indole-building-block, auxiliary class Indols, name is tert-Butyl 3-(2-aminoethyl)-1H-indole-1-carboxylate, and the molecular formula is C15H20N2O2, Synthetic Route of 167015-84-1.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ma, Jiajia published the artcileDirect Dearomatization of Pyridines via an Energy-Transfer-Catalyzed Intramolecular [4+2] Cycloaddition, Quality Control of 167015-84-1, the publication is Chem (2019), 5(11), 2854-2864, database is CAplus.

A catalytic, dearomative cycloaddition reaction with pyridines, e.g., I using photoinduced energy transfer catalysis has been reported, thereby advancing dearomatization methodol. and increasing the topol. of pyridine dearomatization products, e.g., II. This unprecedented method features high yields, broad substrate scope, excellent functional group tolerance, and facile scalability. Furthermore, a recyclable and sustainable polymer immobilized photocatalyst was employed. Computational and exptl. investigations support a mechanism in which a cinnamyl moiety is promoted to its corresponding excited triplet state through visible-light-mediated energy transfer catalysis, followed by a regioselective and dearomative [4+2] cycloaddition to pyridines. This work demonstrates the contribution of visible light catalysis toward enabling thermally challenging organic transformations.

Chem published new progress about 167015-84-1. 167015-84-1 belongs to indole-building-block, auxiliary class Indols, name is tert-Butyl 3-(2-aminoethyl)-1H-indole-1-carboxylate, and the molecular formula is C15H20N2O2, Quality Control of 167015-84-1.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hickman, Zachary L. published the artcileA concise synthesis of 3-hydroxyindole-2-carboxylates by a modified Baeyer-Villiger oxidation, Category: indole-building-block, the publication is Tetrahedron Letters (2000), 41(43), 8217-8220, database is CAplus.

Indole-2-carboxylates are converted in good yields to 3-hydroxyindole-2-carboxylates by use of a Vilsmeier-Haack/Baeyer-Villiger reaction sequence. A systematic examination of the various indole substituents revealed this route to be general in scope.

Tetrahedron Letters published new progress about 100123-25-9. 100123-25-9 belongs to indole-building-block, auxiliary class Indole,Bromide,Ester,Aldehyde, name is Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate, and the molecular formula is C12H10BrNO3, Category: indole-building-block.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Liu, Chengjun published the artcileGold(I)-catalyzed pathway-switchable tandem cycloisomerizations to indolizino[8,7-b]indole and indolo[2,3-a]quinolizine derivatives, Formula: C15H20N2O2, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(96), 14418-14421, database is CAplus and MEDLINE.

Exptl. and theor. explorations were performed on the pathways of the cascade cycloisomerizations of tryptamine-N-ethynylpropiolamide substrates. The methodol. provided a common strategy to access either indolizino[8,7-b]indoles or indolo[2,3-a]quinolizines in a switchable fashion.

Chemical Communications (Cambridge, United Kingdom) published new progress about 167015-84-1. 167015-84-1 belongs to indole-building-block, auxiliary class Indols, name is tert-Butyl 3-(2-aminoethyl)-1H-indole-1-carboxylate, and the molecular formula is C15H20N2O2, Formula: C15H20N2O2.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ma, Jiajia published the artcileDirect Dearomatization of Pyridines via an Energy-Transfer-Catalyzed Intramolecular [4+2] Cycloaddition, Quality Control of 167015-84-1, the publication is Chem (2019), 5(11), 2854-2864, database is CAplus.

A catalytic, dearomative cycloaddition reaction with pyridines, e.g., I using photoinduced energy transfer catalysis has been reported, thereby advancing dearomatization methodol. and increasing the topol. of pyridine dearomatization products, e.g., II. This unprecedented method features high yields, broad substrate scope, excellent functional group tolerance, and facile scalability. Furthermore, a recyclable and sustainable polymer immobilized photocatalyst was employed. Computational and exptl. investigations support a mechanism in which a cinnamyl moiety is promoted to its corresponding excited triplet state through visible-light-mediated energy transfer catalysis, followed by a regioselective and dearomative [4+2] cycloaddition to pyridines. This work demonstrates the contribution of visible light catalysis toward enabling thermally challenging organic transformations.

Chem published new progress about 167015-84-1. 167015-84-1 belongs to indole-building-block, auxiliary class Indols, name is tert-Butyl 3-(2-aminoethyl)-1H-indole-1-carboxylate, and the molecular formula is C15H20N2O2, Quality Control of 167015-84-1.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hickman, Zachary L. published the artcileA concise synthesis of 3-hydroxyindole-2-carboxylates by a modified Baeyer-Villiger oxidation, Category: indole-building-block, the publication is Tetrahedron Letters (2000), 41(43), 8217-8220, database is CAplus.

Indole-2-carboxylates are converted in good yields to 3-hydroxyindole-2-carboxylates by use of a Vilsmeier-Haack/Baeyer-Villiger reaction sequence. A systematic examination of the various indole substituents revealed this route to be general in scope.

Tetrahedron Letters published new progress about 100123-25-9. 100123-25-9 belongs to indole-building-block, auxiliary class Indole,Bromide,Ester,Aldehyde, name is Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate, and the molecular formula is C12H10BrNO3, Category: indole-building-block.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yamashita, Mitsuaki published the artcileOne-pot synthesis of polyhydropyrido[1,2-a]indoles and tetracyclic quinazolinones from 2-arylindoles using copper-mediated oxidative tandem reactions, Recommanded Product: 5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole, the publication is Tetrahedron (2016), 72(27-28), 4123-4131, database is CAplus.

We developed facile one-pot methods for the transformation of 2-arylindoles to polyhydropyrido[1,2-a]indoles and tetracyclic quinazolinones. The copper-catalyzed oxidation of 2-arylindoles to C-acylimines followed by aza-Diels-Alder reactions or oxidative ring-expansion reactions afforded significant polycyclic heterocycles, e. g., I.

Tetrahedron published new progress about 1256358-91-4. 1256358-91-4 belongs to indole-building-block, auxiliary class Indole,Chloride,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole, and the molecular formula is C5H8N2O, Recommanded Product: 5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles