Tag: M.W:300-400

Recommanded Product: 141556-42-5. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene, is researched, Molecular C21H24N2, CAS is 141556-42-5, about Synthesis of ultra-high-molecular-weight ethylene-propylene copolymer via quasi-living copolymerization with N-heterocyclic carbene ligated vanadium complexes.

The quasi-living copolymerization of ethylene with propylene was achieved by using N-heterocyclic carbene (NHC) ligated vanadium complex (V3, VOCl3[1,3-(2,6-iPr2C6H3)2(NCH:)2C:]) due to the stabilization of active center by the introduction of bulky and electron rich NHC ligand with bulky iso-Pr substituents at the ortho positions of the Ph rings. The weight-average mol. weight (Mw) of the resulting copolymer increases linearly with its weight in 20 min. The ultra-high-mol.-weight (UHMW) ethylene-propylene copolymer (Mw = 1612 kg mol-1) can be synthesized with V3/Et3Al2Cl3 catalytic system. The novel complex V4′ (VCl3[1,3-(2,4,6-Me3C6H2)2(NCH:)2C:]·2THF) was constructed by the introduction of two coordinated THF mols. and decrease in steric hindrance at the ortho positions of Ph rings. The UHMW ethylene-propylene copolymer (Mw = 1167 kg mol-1) can also be synthesized by using V4’/Et3Al2Cl3 catalytic system. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018.

If you want to learn more about this compound(1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene)Recommanded Product: 141556-42-5, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(141556-42-5).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 132098-59-0, is researched, SMILESS is C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1, Molecular C19H18N2O2Journal, Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) called Heterogeneous catalysts for asymmetric hydrogenation of enamides using molecular imprinting technology, Author is Liu, Xiao-Chuan; Lee, Justine; Bernard, Steven, the main research direction is heterogeneous catalyst asym hydrogenation enamides mol imprinting.Reference of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane.

We have successfully synthesized a new class of heterogeneous catalysts for asym. hydrogenation of enamides combining transition metal catalysis and mol. imprinting technol. These new catalysts are MIPs made from rhodium (I) and copper (II) complexes with the bis(oxazoline) chiral ligands. One of the Rh-MIPs showed 87% ee toward L- enantiomeric product while the Cu-MIP showed 82% ee toward D- enantiomeric product. Both MIPs are easy to sep. and reusable.

If you want to learn more about this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane)Reference of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application of 132098-59-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Enantioselective Free Radical Carbon-Carbon Bond Forming Reactions: Chiral Lewis Acid Promoted Acyclic Additions. Author is Wu, Jason Hongliu; Radinov, Rumen; Porter, Ned A..

The reaction of the acrylamide derived from the parent achiral oxazolidinone, I, with alkyl iodides (R-I), and allyltributylstannane has been investigated. The free radical reaction is promoted by Lewis acids such that clean conversion to the (1:1:1, R:I:allyl) adduct II, takes place in low temperature reactions initiated with triethylborane. In the presence of zinc triflate and chiral bis(oxazolines), III, derived from amino alcs., excellent yields of the (1:1:1) adduct are formed. Furthermore, this adduct is formed with good to excellent enantioselectivity. A model is suggested involving an intermediate complex of the radical, zinc ion, and the chiral ligand. The product is hydrolyzed and methylated to give the corresponding Me ester and the configuration of this ester is determined to be S if the bis(oxazoline) has the S,S configuration.

If you want to learn more about this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane)Application of 132098-59-0, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene(SMILESS: CC1=CC(C)=CC(C)=C1[N+]2=[C-]N(C3=C(C)C=C(C)C=C3C)C=C2,cas:141556-42-5) is researched.Related Products of 221012-82-4. The article 《Isolation of Carbene-Stabilized Arsenic Monophosphide [AsP] and its Radical Cation [AsP]+• and Dication [AsP]2+》 in relation to this compound, is published in Chemistry – A European Journal. Let’s take a look at the latest research on this compound (cas:141556-42-5).

Arsenic monophosphide (AsP) species supported by two different N-heterocyclic carbenes were prepared by reaction of (IDipp)PSiMe3 (1) (IDipp=1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene) with (IMes)AsCl3 (2) (IMes=1,3-bis(2,4,6-trimethylphenyl)imidazolin-2-ylidene) to afford the dichloride [(IMes)As(Cl)P(IDipp)]Cl (3), which upon reduction with KC8 furnished heteroleptic [(IMes)AsP(IDipp)] (4). The corresponding mono- and dications [(IMes)AsP(IDipp)][PF6], [5]PF6, and [(IMes)AsP(IDipp)][GaCl4]2, [6][GaCl4]2, resp., were prepared by one-electron oxidation of 4 with ferrocenium hexafluorophosphate, [Fc]PF6, or by chloride abstraction from 3 with two equivalent of GaCl3, resp. Compounds 4-6 represent rare examples of heterodiat. interpnictogen compounds, and X-ray crystal structure determinations together with d. functional theory (DFT) calculations reveal a consecutive shortening of the As-P bond lengths and increasing bond order, in agreement with the presence of an arsenic-phosphorus single bond in 4 and a double bond in 62+. The EPR signal of the cationic radical [5]+a. indicates a sym. spin distribution on the AsP moiety through strong hyperfine coupling with the 75As and 31P nuclei.

If you want to learn more about this compound(1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene)Application In Synthesis of 1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(141556-42-5).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C21H24N2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene, is researched, Molecular C21H24N2, CAS is 141556-42-5, about NHC-Stabilized 1,2-Dihalodiborenes: Synthesis, Characterization, and Reactivity Toward Elemental Chalcogens. Author is Stoy, Andreas; Arrowsmith, Merle; Eysselein, Maximilian; Dellermann, Theresa; Mies, Jan; Radacki, Krzysztof; Kupfer, Thomas; Braunschweig, Holger.

The 2-fold reduction of B2X4(NHC)2 (X = Cl, Br, I; NHC = (un)saturated N-heterocyclic carbene) yields the corresponding green-colored 1,2-dihalodiborenes B2X2(NHC)2, the 11B NMR resonances of which are strongly upfield-shifted upon descending the halide group. The diborenes crystallize as the trans isomers, with relatively short B=B double bonds (1.513(9) to 1.568(4) Å). Cyclic voltammetric experiments with these diborenes reveal reversible one-electron oxidation processes to the corresponding diboron radical cation (E1/2 = -1.16 to -1.50 V); the reducing power of B2X2(NHC)2 increasing with the electronegativity of the halide and for the less π-accepting unsaturated NHCs. The main UV-vis absorption (393-463 nm), which corresponds mainly to a HOMO → LUMO transition, undergoes a blue shift upon descending the halide group and shows some dependence on the stereoelectronics of the NHC ligands. Computational analyses show that the HOMO of B2X2(NHC)2 is mostly localized on the B=B π bond, with the contribution from halide p orbitals decreasing down the group, and the saturated NHCs affording some π-bonding delocalization over the B-CNHC bonds. The calculated HOMO and LUMO energies decrease upon descending the halide group, while the HOMO-LUMO gap also decreases, correlating well with the cyclovoltammetry and UV-vis data. The reactions of B2Br2(NHC)2 with elemental sulfur and red selenium lead to the formation of the corresponding diborathiiranes and seleniranes, resp., which were characterized by NMR and UV-vis spectroscopy, cyclic voltammetry, and X-ray diffraction analyses. In one case, an addnl. one-electron oxidation yields a unique cyclic B2Se radical cation. Computational analyses show that the localization of the HOMO and HOMO – 1 of the diboraseleniranes is inverted compared to the diborathiiranes.

Here is a brief introduction to this compound(141556-42-5)COA of Formula: C21H24N2, if you want to know about other compounds related to this compound(141556-42-5), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron Letters called Asymmetric catalytic cyclopropanation of olefins: bis-oxazoline copper complexes, Author is Lowenthal, Richard E.; Abiko, Atsushi; Masamune, Satoru, which mentions a compound: 132098-59-0, SMILESS is C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1, Molecular C19H18N2O2, Computed Properties of C19H18N2O2.

Bis-oxazolines were prepared from di-Et malonate and chiral amino alcs. and converted into their Cu(II) complexes which, upon activation, exhibit high enantioselectivity of up to 99% ee for catalytic cyclopropanation of olefins. Thus, cyclopropanation of styrene with ethyl diazoacetate catalyzed by bis-oxazoline copper complex I activated by phenylhydrazine in THF gave 80% cyclopropanecarboxylates II with 97% trans enantiomeric excess and 77% cis enantiomeric excess.

Here is a brief introduction to this compound(132098-59-0)Computed Properties of C19H18N2O2, if you want to know about other compounds related to this compound(132098-59-0), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Synthesis and chiroptical properties of enantiomerically pure bis- and trisadducts of C60 with an inherent chiral addition pattern.Recommanded Product: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane.

In this paper we describe facile access to enantiomerically pure bis- and trisadducts of C60 with four different inherent chiral addition patterns, namely fC- and fA-I,II* (trans-2), fC- and fA-I,III* (trans-3), fC- and fA-I,III*,III* (trans-3,trans-3,trans-3) and fC- and fA-I,eI,eII (e,e,e), obtained by cyclopropanation of [6,6] double bonds with C2-sym. bisoxazolines and subsequent chromatog. separation of the corresponding diastereomers on achiral stationary phases. The CD spectra of the related pairs of diastereomers, whose addition patterns represent pairs of enantiomers, reveal pronounced Cotton effects and mirror-image behavior. It is the chiral arrangement of the conjugated π-electron system within the fullerene core itself that predominantly determines the chiroptical properties. We show that the magnitude of the Cotton effects strongly depends on the extent of chiral distortion of the π-electron system within the fullerene cage.

Here is a brief introduction to this compound(132098-59-0)Recommanded Product: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, if you want to know about other compounds related to this compound(132098-59-0), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170147-29-2,tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate,as a common compound, the synthetic route is as follows.

170147-29-2, Step 2: teri-Butyl 5-(benzyloxy)-3-carbamoyl-lH-indole-l-carboxyIate (206) [0651] To a solution of compound 205 (2 g, 6.19 mmol) in MeCN (40 mL) at 0 C was drop-wise added chlorosultonyi isocyanate (0,57 mL, 6.50 mol). The reaction was stirred at room temperature overnight and then acetone (40 mL) and H2O (5 mL) was added followed by drop- wise addition of 10% aq.KOH solution (2 mL). The mixture was stirred at room temperature for 30 min and extracted with ethyl acetate (50 mL x 2). The combined organic phases was washed with brine, dried over anhydrous NaiSO-s, filtered and concentrated to dryness. The residue was further washed with EtOAc to give the title compound (1.7 g, 75% yield) as white solid. LC/MS (ESI); m/z 31 1 (M-56+H) +

As the paragraph descriping shows that 170147-29-2 is playing an increasingly important role.

Reference：
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (386 pag.)WO2017/35355; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1145678-74-5, (1-Tosyl-1H-indol-4-yl)methanamine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 31-((1H-indol-4-yl)methyl)-9-(4,6-dimethylpyrimidin-2-yl)-1,9-diazaspiro[5.5]undecan-2-one a) tert-butyl 4-allyl-4-((1-tosyl-1H-indol-4-yl)methylamino)piperidine-1-carboxylate; To a stirred mixture of 1-Boc-piperidin-4-one (0.25 g, 1.256 mmol), 4 molecular sieves (0.25 g), allyl boronic acid pinacol ester (0.255 g, 1.507 mmol) in toluene (10.0 mL), 1-tosyl-1H-indol-4-yl)methanamine (0.45 g, 1.507 mmol) was added and the reaction mixture was heated to reflux for 16 h. The mixture was filtered through a pad of celite. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (eluent: 10% ethyl acetate in hexane) to yield the title compound as a white solid (0.2 g, 70%). [LCMS RtE=0.341, [M+H]+=524.0]

1145678-74-5, 1145678-74-5 (1-Tosyl-1H-indol-4-yl)methanamine 67262154, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; BADIGER, Sangamesh; BEHNKE, Dirk; BETSCHART, Claudia; COTESTA, Simona; HINTERMANN, Samuel; OFNER, Silvio; PANDIT, Chetan; ROY, Bernard Lucien; US2012/101110; (2012); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1059630-08-8,(4aS,9bR)-Ethyl 6-bromo-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate,as a common compound, the synthetic route is as follows.

Example 4: Production of [4aS,9bR] -ethyl 5-(2-amino-2-oxoethyl)-6-bromo- 3,4,4a,5-tetrahydro-lH-pyrido[4,3-b]indole-2(9bH)-carboxylate; (4aS,9bR)-ethyl 5-(2-amino-2-oxoethyl)-6-bromo-3,4,4a,5-tetrahydro- lH-pyrido[4,3-b]indole-2(9bH)-carboxylate may be prepared by heating to a reflux a suspension of (4aS,9bR)-ethyl 6-bromo-3,4,4a,5-tetrahydro- 1 H-pyrido[4,3-b]indole- 2(9bH)-carboxylate (5.648g, 17.4mmol), 2-chloroacetamide (7.32g, 78.2mmol), potassium iodide (19.2g, 77.7mol) and diisopropylethylamine (19mL, 115mmol) in acetonitrile (8OmL) for 27 hours. The solvent is removed in a vacuo and water (20OmL) is added to the residue and stirred for 1 hour. The resulting white solid is filtered off, washed with ethanol and dried., 1059630-08-8

1059630-08-8 (4aS,9bR)-Ethyl 6-bromo-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate 59317960, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; INTRA-CELLULAR THERAPIES, INC.; WO2008/112280; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles