Tag: M.W:300-400

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 13739-02-1, Name is Diacerein, SMILES is O=C(C1=C2C(OC(C)=O)=CC=C1)C3=CC(C(O)=O)=CC(OC(C)=O)=C3C2=O, belongs to indole-building-block compound. In a document, author is Ganesh, K. Ravi, introduce the new discover, SDS of cas: 13739-02-1.

Microwave Assisted Solvent Free One Pot Synthesis of N-acetyl-bis-indoles

The synthesis of various N-acetyl-bis-indole compounds has been achieved by one pot reaction of indole and acid chloride in the presence of silica sulfuric acid as a catalyst under microwave irradiation to moderate yields. The reaction has also been studied with different acid chlorides and solvents.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 13739-02-1 is helpful to your research. SDS of cas: 13739-02-1.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 31430-18-9, Name is Nocodazole, SMILES is O=C(OC)NC1=NC2=CC=C(C(C3=CC=CS3)=O)C=C2N1, belongs to indole-building-block compound. In a document, author is Hiwarkar, A. D., introduce the new discover, Recommanded Product: 31430-18-9.

Electro-chemical mineralization of recalcitrant indole by platinum-coated titanium electrode: multi-response optimization, mechanistic and sludge disposal study

Indole is a highly recalcitrant aromatic heterocyclic organic compound consisting of a five-membered nitrogen-containing pyrrole ring fused to a six-membered benzene ring. This study presents the results of the electro-chemical mineralization of indole in an aqueous solution using platinum-coated titanium (Pt/Ti) electrode. A central composite design was used to investigate the effect of four parameters namely initial pH (pH(o)), current density (j), conductivity (k) and treatment time (t) at 5 levels. Multiple responses namely chemical oxygen demand (COD) removal (Y-1) and specific energy consumption (Y-2) were simultaneously maximized and minimized, respectively, by optimizing the parameters affecting the mineralization of indole by using the desirability function approach. At the operating conditions of pH 8.6, j = 161 A/m(2), k = 6.7 mS/cm and t = 150 min, 83.8% COD removal with specific energy consumption of 36.3 kWh/kg of COD removed was observed. Ultra performance liquid chromatography, UV-visible spectroscopy, Fourier transform infrared spectroscopy and cyclic voltammetry of the indole solution were performed at the optimum condition of the treatment so as to report a plausible mechanism of indole degradation. Field emission scanning electron microscopy analysis of electrodes before and after treatment was performed for determining the changes on anode surface during the treatment. Thermal analysis of the solid residue (scum) obtained was also performed for exploring its disposal prospects. Present study shows that electro-chemical oxidation can be used for mineralization of nitrogenous heterocyclic compounds such as indole.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 31430-18-9 is helpful to your research. Recommanded Product: 31430-18-9.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 36322-90-4, Name is 4-Hydroxy-2-methyl-N-(pyridin-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide. In a document, author is Jia, Yanshu, introducing its new discovery. Recommanded Product: 36322-90-4.

Current scenario of indole derivatives with potential anti-drug-resistant cancer activity

Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to anticancer agents represents one of the major obstacles for the effective cancer treatment. Indole derivatives have the potential to act on diverse targets in cancer cells and exhibit promising activity against drug-resistant cancers. Moreover, some indole-containing compounds such as Semaxanib, Sunitinib, Vinorelbine, and Vinblastine have already been applied in clinics for various kinds of cancer even drug-resistant cancer therapy. Thus, indole derivatives are one of significant resources for the development of novel anti-drug-resistant cancer agents. This review focuses on the recent development of indole derivatives with potential therapeutic application for drug-resistant cancers, and the mechanisms of action, the critical aspects of design as well as structure-activity relationships, covering articles published from 2010 to 2020. (C) 2020 Elsevier Masson SAS. All rights reserved.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Snak, Aline, once mentioned the application of 157115-85-0, Name is Noopept, molecular formula is C17H22N2O4, molecular weight is 318.37, MDL number is MFCD00941121, category is indole-building-block. Now introduce a scientific discovery about this category, Recommanded Product: 157115-85-0.

Genome sequencing and analysis of plant growth-promoting attributes from Leclercia adecarboxylata

Plant growth-promoting bacteria are ecological alternatives for fertilization, mainly for gramineous. Since plant x bacteria interaction is genotype and strain dependent, searching for new strains may contribute to the development of new biofertilizers. We aim to characterize plant growth-promoting capacity of Leclercia adecarboxylata strain Palotina, formerly isolated by our group in corn. A single isolated colony was taken and its genome was sequenced using Illumina technology. The whole genome was compared to other Leclercia adecarboxylata strains, and their biological and growth-promoting traits, such as P solubilization and auxin production, were tested. Following that, a 4.8 Mb genome of L. adecarboxylata strain Palotina was assembled and the functional annotation was carried out. This paper is the first to report the genes associated with plant growth promotion demonstrating in vitro indole acid production by this strain. These results project the endophyte as a potential biofertilizer for further commercial exploitation.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 283173-50-2, Name is Rucaparib, SMILES is O=C1NCCC2=C(C3=CC=C(CNC)C=C3)NC4=C2C1=CC(F)=C4, in an article , author is Kathiravan, Arunkumar, once mentioned of 283173-50-2, Formula: https://www.ambeed.com/products/283173-50-2.html.

Synthesis, density functional theory and sensitization of indole dyes

Herein, the two typical anchoring groups are tethered into the indole chromophore and studied their impact on the molecular orbital energy levels and titania sensitization. The synthesized indole derivatives were meticulously characterized. The photophysical and time dependent density functional theory results were revealed that the indole connected rhodanine-3-acetic acid group is an efficient light harvester. The favorable electronic excitation from the highest occupied molecular orbital to the lowest unoccupied molecular orbital indicated that the dye comprised with rhodanine-3-acetic acid could be used as a prospective material for dye-sensitized solar cell applications. (c) 2020 Elsevier B.V. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 283173-50-2, you can contact me at any time and look forward to more communication. Formula: https://www.ambeed.com/products/283173-50-2.html.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Electric Literature of 202409-33-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 202409-33-4, Name is 5-Chloro-6′-methyl-3-(4-(methylsulfonyl)phenyl)-2,3′-bipyridine, SMILES is O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O, belongs to indole-building-block compound. In a article, author is Cao, Xiaoji, introduce new discover of the category.

Comparing the fragmentation reactions of protonated cyclic indolyl -amino esters in quadrupole/orbitrap and quadrupole time-of-flight mass spectrometers

RationaleThe comparative study of higher-energy collisional dissociation (HCD) and collision-induced dissociation (CID) mechanisms for protonated cyclic indolyl -amino esters in quadrupole/orbitrap (Q/Orbitrap) and quadrupole time-of-flight (QTOF) mass spectrometers, respectively, is helpful to study the structures and properties of biologically active indole derivatives using tandem mass spectrometry (MS/MS) technology. MethodsHCD and CID experiments were carried out using electrospray ionization Q/Orbitrap MS and QTOFMS in positive ion mode, respectively. Only the labile hydrogens were exchanged with deuterium in hydrogen/deuterium exchange (HDX) experiments and only the aromatic indole C-H hydrogens were substituted with deuterium in regiospecific hydrogen-deuterium labeling experiments. Theoretical calculations were carried out using the density functional theory (DFT) method at the B3LYP level with the 6-311G(d,p) basis set in the Gaussian 03 package of programs. ResultsIn Q/Orbitrap MS/MS, when the added proton on the N-8 position of protonated cyclic indolyl -amino esters migrated in a stepwise fashion to the C-3 position via two sequential 1,4-H shifts, an ion-neutral complex INC1 of [protonated cyclic N-sulfonyl ketimino esters/indoles] was formed by a charge-directed heterolytic cleavage of the C-3-C-10 bond, while an ion-neutral complex INC3 of [cyclic N-sulfonyl ketimino esters/protonated indoles] was formed when another labile hydrogen on the N-8 position successively migrated to the C-4 position. Direct decomposition of INC1 and INC3 resulted in protonated cyclic N-sulfonyl ketimino esters and protonated indoles, respectively, while proton transfer led to protonated indoles and protonated cyclic N-sulfonyl ketimino esters. The HDX reaction with residual water in the HCD cell was also observed. In QTOF-MS/MS, protonated cyclic N-sulfonyl ketimino esters and protonated indoles resulted from direct decomposition of INC1 and INC3, respectively, rather than proton transfer. ConclusionsDue to the specific construction of the Q/Orbitrap and QTOF mass spectrometers, different fragmentation mechanisms medicated by ion-neutral complexes of protonated cyclic indolyl -amino esters were proposed. This study is desirable for qualitative and quantitive investigation of indole derivatives using MS/MS technology.

Electric Literature of 202409-33-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 202409-33-4.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 491-54-3, Name is Kaempferide, SMILES is O=C1C(O)=C(C2=CC=C(OC)C=C2)OC3=C1C(O)=CC(O)=C3, in an article , author is Park, Kyoung Jin, once mentioned of 491-54-3, Safety of Kaempferide.

Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis

A new indole alkaloid, pulveratinol (1), and two new anthranilic acid derivatives (2 and 3) were isolated from Indigo Pulverata Levis, together with 12 known compounds (4-15). The structures of the new compounds (1-3) were determined through spectroscopic methods. The absolute configuration of 1 was confirmed further by electronic circular dichroism (ECD) data analysis and computational method with advanced statistics (DP4). All isolated compounds (1-15) were evaluated for their potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells. (C) 2018 Published by Elsevier Ltd.

Interested yet? Read on for other articles about 491-54-3, you can contact me at any time and look forward to more communication. Safety of Kaempferide.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 2447-57-6, Name is Sulfadoxine, SMILES is O=S(C1=CC=C(N)C=C1)(NC2=NC=NC(OC)=C2OC)=O, in an article , author is Mondol, Md. Mahmudul Hassan, once mentioned of 2447-57-6, Formula: C12H14N4O4S.

A remarkable adsorbent for removal of nitrogenous compounds from fuel: A metal-organic framework functionalized both on metal and ligand

Efficient elimination of nitrogenous compounds (NCs) from fuel is an important issue. Recently, metal organic frameworks (MOFs), both pristine and modified ones, have attracted continuous attention as an adsorbent for the purification of fuel. In this study, we used, for the first time, MOFs functionalized on both metal (via coordination on open metal site) and ligand, in the purification of fuel. A highly stable MOF, MIL-101(Cr), was modified to introduce amino groups both on the ligand and metal sites, and the NH2-MIL-101 was further reacted with oxalyl chloride to obtain a multifunctional adsorbent named OC-ED-A-M101. This adsorbent showed an outstanding performance in adsorptive denitrogenation of fuels. Or, the OC-ED-A-M101 had 11.7 and 9.3 times adsorption capacity for indole and quinoline, respectively, that of an activated carbon. Moreover, the new adsorbent showed the highest and the second highest adsorption capacity for indole and quinoline, respectively, compared with any reported MOF-based adsorbents. The noticeable performances of OC-ED-A-M101 could be interpreted with H-bonding because of ample hydrogen donor and hydrogen acceptor sites on the OC-ED-A-M101. Adsorption over other M101s could be explained with the combination of H-bonding, acid-base interaction, and base-base repulsion. Finally, the studied MOF could be easily reactivated by washing with ethanol. Therefore, OC-ED-A-M101 might be a potential adsorbent for the purification of fuel containing NCs.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 2447-57-6, you can contact me at any time and look forward to more communication. Formula: C12H14N4O4S.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemistry, like all the natural sciences, Safety of Divalproex Sodium, begins with the direct observation of nature— in this case, of matter.76584-70-8, Name is Divalproex Sodium, SMILES is CCCC(CCC)C([O-])=O.CCCC(CCC)C(O)=O.[Na+], belongs to indole-building-block compound. In a document, author is Sheryn, Wong, introduce the new discover.

In-vitro cytotoxicity of synthesized phthalide-fused indoles and indolines against HL-60 and HepG2 cells

Phthalide derivatives bearing indole or indoline moieties were successfully synthesized via eco-friendly method and were evaluated for their antiproliferative activity on HL-60 and HepG2 cell lines in vitro. At a final concentration of 100 mu M, most of the compounds showed moderate potency on both the cell lines tested. Compound 3b bearing 5-chloro substituted indoline had the best potency against HL-60 and HepG2 cell lines with IC50 values of 45.4 and 57.7 mu M, respectively. It was also found that replacement of a conjugated indoline to indole moiety gave better antiproliferative activity on HL-60 cells by almost two-fold. Morphological observation demonstrated numerous fragmented nuclei which are indicative of apoptosis. Molecular docking studies predicted non-covalent interactions and H-bonding of selected compounds with the P2 binding hot spot of the anti-apoptotic protein, Bcl-2, formed by Asp108, Phe109, Met112, Leu134, Arg143, Ala146 and Val153. Overall, our work highlights the potential of synthesized phthalide-fused indoles or indolines as antitumor agents. (C) 2019 Production and hosting by Elsevier B.V. on behalf of King Saud University.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 76584-70-8. Safety of Divalproex Sodium.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 491-54-3, Name is Kaempferide, molecular formula is C16H12O6. In an article, author is Savvidou, Anatoli,once mentioned of 491-54-3, Safety of Kaempferide.

Synthesis of Benzofuran and Indole Derivatives Catalyzed by Palladium on Carbon

Benzofurans and indoles are key moieties in many natural products and pharmaceuticals. Herein, we describe a cheap and easy-to-execute strategy for the synthesis of benzofurans and indoles, employing Pd/C as the promoter. A variety of substituted allyl-anilines and allyl-phenols were converted into the desired products in good to excellent yields. Recycling of Pd/C was possible up to five cycles, keeping similar levels of reactivity.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles