Tag: M.W:300-400

In homogeneous catalysis, the catalyst is in the same phase as the reactant. 252978-89-5. The number of collisions between reactants and catalyst is at a maximum.In a patent, 252978-89-5, name is tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate, introducing its new discovery.

An asymmetric nitrogen-oxygen ligand and Ti, Zr, Hf complex preparation method and application (by machine translation)

The invention discloses an asymmetric nitrogen-oxygen ligand and Ti, Zr, Hf complex preparation method and application. The complex preparation method comprises the following steps: in order to replace salicyldehyde and 2-ammonia methylpyridinio and containing different substituents shall phenol system asymmetric nitrogen-oxygen ligand; and the asymmetric nitrogen-oxygen ligand TiCl 4, ZrCl 4, HfCl 4 the reaction is carried out in toluene, containing asymmetric nitrogen oxygen multi-teeth ligand is Ti, Zr, Hf complex. This kind of complex is mainly used for ring-opening polymerization of lactide, has a high catalytic activity and good stereoselectivity. The ligand of this invention and Ti, Zr, Hf complex, easy availability of raw materials, the preparation method is simple, the structure is easy to modulation, ligand construction through the change, can adjust and control the nature of the complex, improve its catalytic performance, can be used for preparing molecular weight distribution is relatively narrow, the stereo regular the high molecular material of biodegradation and polylactide, is suitable for popularization. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.252978-89-5, you can also check out more blogs about252978-89-5

Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In homogeneous catalysis, the catalyst is in the same phase as the reactant. 252978-89-5. The number of collisions between reactants and catalyst is at a maximum.In a patent, 252978-89-5, name is tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate, introducing its new discovery.

An asymmetric nitrogen-oxygen ligand and Ti, Zr, Hf complex preparation method and application (by machine translation)

The invention discloses an asymmetric nitrogen-oxygen ligand and Ti, Zr, Hf complex preparation method and application. The complex preparation method comprises the following steps: in order to replace salicyldehyde and 2-ammonia methylpyridinio and containing different substituents shall phenol system asymmetric nitrogen-oxygen ligand; and the asymmetric nitrogen-oxygen ligand TiCl 4, ZrCl 4, HfCl 4 the reaction is carried out in toluene, containing asymmetric nitrogen oxygen multi-teeth ligand is Ti, Zr, Hf complex. This kind of complex is mainly used for ring-opening polymerization of lactide, has a high catalytic activity and good stereoselectivity. The ligand of this invention and Ti, Zr, Hf complex, easy availability of raw materials, the preparation method is simple, the structure is easy to modulation, ligand construction through the change, can adjust and control the nature of the complex, improve its catalytic performance, can be used for preparing molecular weight distribution is relatively narrow, the stereo regular the high molecular material of biodegradation and polylactide, is suitable for popularization. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.252978-89-5, you can also check out more blogs about252978-89-5

Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

875781-44-5, 5-Bromo-3-iodo-4,7-diazaindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,875781-44-5

2-bromo-7-iodo-5-(phenylsulfonyl)-5H-pyrrolor3,2-blpyrazine (V-E-I); A mixture of (IV-E-I) (7.74 g, 23.9 mmol), PhSO2Cl (6.54 g , 4.73 mL , 37.04 mmol), Bu4NHSO4 (1.217 g , 3.584 mmol) and 50% aqueous NaOH (5 mL, 7.65 g, 95.6 mmol) in CH2Cl2 (100 mL) was stirred vigorously at RT for 3 h. A saturated solution of NaHCO3 (50 mL) was added and the mixture was extracted with CH2Cl2 (4 x 50 mL). The combined organic extracts were dried (MgSO4), concentrated, and the residue was triturated with MeOH (100 mL). The solid was filtered off and dried in vacuo to afford V-E-I (9.34 g, 85%) as yellow solid. 1H NMR (400 MHz, CDCl3) delta 7.49-7.60 (m, 2H), 7.62-7.73 (m, IH), 8.15 (d, J0.51, IH), 8.16-8.21 (m, 2H), 8.44 (d, J0.38, IH). MS (ES) M+ m/e = 464.

The synthetic route of 875781-44-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EISAI R & D MANAGEMENT CO. LTD; GRACZYK, Piotr; BHATIA, Gurpreet, Singh; WO2010/15803; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1601-18-9, Methyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methyl-1 -hydro-indol-3-yl) acetate (0.71 g, 2 mmol) was dissolved in 10 mL of a solution of methylmagnesium bromide After water, methanol was added, and 3.5 mL of the above-mentioned hydroxylamine potassium (NH2OK) solution was added thereto. After 0.5 hours, methanol was distilled off, and the solution was acidified to pH 3-4 with 2 mol / L hydrochloric acid solution. The mixture was extracted with ethyl acetate and the combined ethyl acetate layer was washed with saturated brine, dried over anhydrous magnesium sulfate and evaporated to dryness to give The crude product was recrystallized from ethyl acetate to give 0.32 g of a white powder. Yield: 44%., 1601-18-9

The synthetic route of 1601-18-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qingdao University; Zhang, Lei; Han, Yantao; Bian, Jiang; Zhang, Jian; Xu, Wenfang; (11 pag.)CN105418480; (2016); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348640-11-9,1-Boc-3-Bromo-5-methoxyindole,as a common compound, the synthetic route is as follows.

A stirred solution of 3-bromo-5-methoxy-indole-1-carboxylic acid tert-butyl ester [50 g, Reference Example 11(a)] in tetrahydrofuran (800 mL), under nitrogen, was treated with tributylborate (49.5 mL) then cooled to -100 C. and then treated with a solution of n-butyllithium in hexanes (94 mL, 2.5M) whilst keeping the temperature below -90 C. Once the addition was complete the mixture was allowed to warm slowly to room temperature over 1 hour and quenched by the addition of ice (10 g). The organics were removed under reduced pressure and the residue was partitioned between ethyl acetate (500 mL) and water (400 mL). The organic layer was dried over magnesium sulfate and then evaporated., 348640-11-9

348640-11-9 1-Boc-3-Bromo-5-methoxyindole 22477274, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Cox, Paul J.; Majid, Tahir N.; Lai, Justine Y.Q.; Morley, Andrew D.; Amendola, Shelley; Deprets, Stephanie D.; Edlin, Christopher; US2004/9983; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.252978-89-5,tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

EXAMPLE 13 1-[(2,5-Dichloro-3-thienyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride (Scheme 1) The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 2,5-dichloro-3-thienylsulfonyl chloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) delta 9.24 (br, 1H), 7.78 (d, J=5 Hz, 1H), 7.72 (s, 1H), 7.57 (d, J=8 Hz, 1H), 7.29 (t, J=8 Hz, 1H), 7.01 (d, J=5 Hz, 1H), 6.86 (d, J=8 Hz, 1H), 3.31 (m, 8H). MS (ESI+) for m/z 416 (M+H)+., 252978-89-5

Big data shows that 252978-89-5 is playing an increasingly important role.

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Patent; Caldirola, Patrizia; Nilsson, Bjorn M.; Johansson, Gary; US2002/165251; (2002); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1000340-34-0,4-Bromo-3-iodo-7-azaindole,as a common compound, the synthetic route is as follows.,1000340-34-0

Method A:Sodium hydride (2.403 g, 60.1 mmol) was added portionwise to a cooled mixture 4- bromo-3-iodo-lH-pyrrolo[2,3-b]pyridine (D6) (13.86 g, 42.9 mmol) in DMF (200 mL) at 0 C and was stirred at that temperature for 15 min. 2-iodopropane (5.15 ml, 51.5 mmol) was then added and the reaction mixture was allowed to warm to RT and stirred overnight. The reaction mixture was cooled to 0 C again and quenched with saturated NH4C1 solution (ca. 5 mL) and further diluted with water (ca. 200 mL). The aqueous layer was extracted with ethyl acetate (3 x 200 mL). The organic layer was dried and concentrated down. The residue was purified on silica, eluting with ethyl acetate in cyclohexane (0-10%) to give the title compound (14 g). LCMS (A): m/z (M+H)+ 365/367, C10H10BrIN2 requires 364/366 (acidic).

The synthetic route of 1000340-34-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO WELLCOME MANUFACTURING PTE LTD; CHEN, Deborah, W.; DUNCAN, Sarah; KING, Nigel, Paul; LEE, Kiew, Ching; MAK, Sing, Yeung; RIVERS, Dean, Andrews; WO2012/170752; (2012); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348640-11-9,1-Boc-3-Bromo-5-methoxyindole,as a common compound, the synthetic route is as follows.

Example 93A tert-butyl 5-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate To 1,1’bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (0.449 g, 0.55 mmol), potassium acetate (1.805 g, 18.39 mmol), and bis(pinacolato)diboron (2.57 g, 10.12 mmol) under an atmosphere of nitrogen was added methylsulfoxide (46.0 mL), followed by tert-butyl 3-bromo-5-methoxy-1H-indole-1-carboxylate (3.0 g, 9.20 mmol), and the reaction was stirred at 80 C. over night. The reaction was cooled to room temperature and quenched by the addition of water and dichloromethane. The layers were separated, and the aqueous layer was extracted with additional dichloromethane. The combined organics were dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give crude product. The residue was purified by flash chromatography on silica gel, eluting with hexanes, to give the title compound. MS DCI(+) m/z 374.1 [M+H]+.

348640-11-9, The synthetic route of 348640-11-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; US2011/281842; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles