Exploration of moderate conditions and substrate variation in the direct condensation between phthalide and primary amine catalyzed by GaCl3. Are aliphatic amines less reactive than aromatic ones? was written by Takahashi, Ichiro;Nishiwaki, Yoshinori;Saitoh, Kenta;Matsunaga, Takatoshi;Aratake, Akihiro;Morita, Toshio;Hosoi, Shinzo. And the article was included in Heterocycles in 2019.COA of Formula: C14H11NO This article mentions the following:
Direct condensation between phthalide and primary amines RNH2 (R = n-Bu, 2-nitrophenyl, naphthalen-2-yl, etc.) in the presence of Lewis acid was achieved for the first time in organic solvent-diluted reaction systems catalyzed by GaCl3. The peripheral aspect of this reaction is discussed. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1COA of Formula: C14H11NO).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.COA of Formula: C14H11NO
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles