Isoindolinone Synthesis: Selective Dioxane-Mediated Aerobic Oxidation of Isoindolines was written by Thapa, Pawan;Corral, Esai;Sardar, Sinjinee;Pierce, Brad S.;Foss, Frank W.. And the article was included in Journal of Organic Chemistry in 2019.Related Products of 5388-42-1 This article mentions the following:
N-Alkyl and N-aryl-isoindolinones were prepared by a dioxane-mediated oxidation of isoindoline precursors. The transformation exhibits unique chemoselectivity for isoindonlines. A chiral tertiary (3闂?-benzylic position was not racemized during oxidation, and Me indoprofen was prepared by late stage oxidation Mechanistic studies suggest a selective H atom transfer, which avoids many known oxidation (by-)products of isoindolinones. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Related Products of 5388-42-1).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Related Products of 5388-42-1
Referemce:
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles