An article Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator WOS:000475543200010 published article about TRANSCRIPTION FACTOR NRF2; PARKINSONS-DISEASE; DOPAMINERGIC-NEURONS; OXIDATIVE STRESS; MOUSE MODEL; DEFICIENCY; MECHANISMS; PARAMETERS; DECLINE; PATHWAY in [Choi, Ji Won; Shin, Su Jeong; Kim, Hyeon Ji; Park, Jong-Hyun; Kim, Hyeon Jeong; Lee, Elijah Hwejin; Pae, Ae Nim; Park, Ki Duk] KIST, Convergence Res Ctr Diag Treatment & Care Syst De, Seoul 02792, South Korea; [Shin, Su Jeong; Kim, Hyeon Ji; Kim, Hyeon Jeong; Bahn, Yong Sun] Yonsei Univ, Dept Biotechnol, Seoul 03722, South Korea; [Pae, Ae Nim; Park, Ki Duk] Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea; [Pae, Ae Nim; Park, Ki Duk] KHU, Dept Converging Sci & Technol, KIST, Seoul 02447, South Korea in 2019.0, Cited 32.0. Application In Synthesis of m-Methoxyphenol. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6
The main pathway responsible for cellular regulation against oxidative stress is nuclear factor E2-related factor-2 (Nrf2) signaling. We previously synthesized and reported a novel vinyl sulfone (1) as an Nrf2 activator with therapeutic potential for Parkinson’s disease (PD). In this study, we changed the vinyl sulfone to vinyl sulfonamide or vinyl sulfonate to improve Nrf2 activating efficacy. We observed that the introduction of vinyl sulfonamide led to a reduction of the effects on Nrf2 activation, whereas vinyl sulfonate compounds exhibited superior activity compared to the vinyl sulfone compounds. Among the vinyl sulfonates, 3c exhibited 6.9- and 83.S-fold higher effects on Nrf2 activation than the corresponding vinyl sulfone (1) and vinyl sulfonamide (2c), respectively. Compound 3c was confirmed to induce expression of the Nrf2-dependent antioxidant enzymes at the protein level in cells. In addition, 3c mitigated PD-associated behavioral deficits by protecting DAergic neurons in the MPTP-induced mouse model of PD.
Application In Synthesis of m-Methoxyphenol. Welcome to talk about 150-19-6, If you have any questions, you can contact Choi, JW; Shin, SJ; Kim, HJ; Park, JH; Kim, HJ; Lee, EH; Pae, AN; Bahn, YS; Park, KD or send Email.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles