Product Details of 123-11-5. In 2021 NAT PROD RES published article about (+)-USNIC ACID in [Van-Kieu Nguyen; Chavasiri, Warinthorn] Chulalongkorn Univ, Fac Sci, Ctr Excellence Nat Prod Chem, Dept Chem, Bangkok, Thailand; [Sichaem, Jirapast] Thammasat Univ, Fac Sci & Technol, Lampang Campus, Lampang, Thailand; [Huu-Hung Nguyen; Thi-Phuong Nguyen] Nguyen Tat Thanh Univ, Fac Biotechnol & Environm, Ho Chi Minh City, Vietnam; [Xuan Hieu Nguyen; Thi-Thu-Loi Huynh; Duc-Dung Pham] Ho Chi Minh City Univ Educ, Dept Chem, Ho Chi Minh City, Vietnam; [Niamnont, Nakorn] King Mongkuts Univ Technol Thonburi, Fac Sci, Dept Chem, Organ Synth Electrochem & Nat Prod Res Unit, Bangkok, Thailand; [Dinh-Hung Mac] Ha Noi Natl Univ, Univ Sci, Dept Organ Chem, Hanoi, Vietnam; [Kim-Phi-Phung Nguyen] Natl Univ Ho Chi Minh City, Univ Sci, Dept Organ Chem, Ho Chi Minh City, Vietnam; [Thuc-Huy Duong] Ton Duc Thang Univ, Dept Management Sci & Technol Dev, Ho Chi Minh City, Vietnam; [Thuc-Huy Duong] Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City, Vietnam in 2021, Cited 13. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.
A series of usnic acid benzylidene derivatives (groups I-V) were designed, synthesized and evaluated for their anticancer activity in the search for potentially new anticancer agents. Compounds 1a, 5b, 2b, 2e and 2f exhibited the most potent cytotoxcity against K562 cell line with IC50 values of 10.0 +/- 3.6, 5.6 +/- 0.4, 8.8 +/- 1.0, 4.5 +/- 0.1 and 8.4 +/- 0.4 mu M, respectively. It is noteworthy that compound 2e displayed potent cytotoxicity against K562 cells without any cytotoxic effect on HEK293 normal cell line.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles