Mechanochemical Cobalt-Catalyzed C-H Bond Functionalizations by Ball Milling
Ball milling techniques have been applied in the development of a mechanosynthesis of [Cp*Co(CO)I-2], which proved highly efficient as catalyst in mechanochemical C-H bond amidations of indoles in a mixer ball mill. A wide range of amidated products is obtained in excellent yields. Compared to the solution-based methods, the procedure opens a more feasible and environmentally-friendly access to both the cobalt(III) catalyst and 2-amidated indoles.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles