HPLC of Formula: C8H8O2. Awad, SM; Mohamed, MS; Khodair, MA; Abd El-Hameed, RH in [Awad, Samir M.; Mohamed, Mosaad S.; Khodair, Marwa Abd El-Fattah; Abd El-Hameed, Rania H.] Helwan Univ, Dept Organ Pharmaceut Chem, Fac Pharm, Cairo, Egypt; [Awad, Samir M.] Al Zahrawi Univ Coll, Dept Pharm, Carbalaa, Iraq published Synthesis and Evaluation of Cytotoxic Activity of Certain Benzo[h]chromene Derivatives in 2021.0, Cited 53.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.
Background: Benzo[h]chromenes attracted great attention because of their widespread biological activities, including anti-proliferate activity, and the discovery of novel effective anti-cancer agents is imperative. Objective: The main objective was to synthesize new benzo[h]chromene derivatives and some reported derivatives, and then test all of them for their anti-cancer activities Methods: The structures of the newly synthesized derivatives were confirmed by elemental and spectral analysis (IR, Mass, H-1-NMR and C-13-NMR). 35 compounds were selected by the National Cancer Institute (NCI) for single-dose testing against 60 cell lines and 3 active compounds were selected for 5-doses testing. Also, these 3 compounds were tested as EGFR-inhibitors; using sorafenib as standard, and as Tubulin polymerization inhibitors using colchicines as a standard drug. Moreover, molecular docking study for the most active derivative on these 2 enzymes was also carried out. Results: Compounds 1a, 1c and 2b have the highest activities among all 35 tested compounds especially compound 1c. Conclusion: compound 1c has promising anti-cancer activities compared to the used standards and may need further modification and investigations.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles