An article Synthesis and antitumor activity of sacroflavonoside WOS:000479490300001 published article about CELL; RESVERATROL; APOPTOSIS; AUTOPHAGY; CASPASE-3; PROGNOSIS in [Wang, Qinghu; Xin, Ying; Pa, Biligetu; He, Xiang; Bao, Wenqiang] Inner Mongolia Univ Nationalities, Coll Tradit Mongolian Med, Tongliao 028000, Inner Mongolia, Peoples R China in 2021, Cited 19. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Computed Properties of C8H8O2
Sacroflavonoside, a new derivative of diphenylethene, was isolated from Artemisia sacrorum, which have been found to possess the inhibitory effect on the proliferation of gastric carcinoma cells (MKN-45) in vitro in our previous studies. With anisaldehyde (SM-A) as starting material, the sacroflavonoside was synthesized by nucleophilic addition, electrophilic substitution and dehydration cyclization. The structure of sacroflavonoside was established by 1 D (H-1 NMR and C-13 NMR) and 2 D-NMR (HSQC and HMBC) spectral analysis. The antitumor activity and potential mechanism against MKN-45 cells of sacroflavonoside were evaluated in vitro. The results showed that sacroflavonoside could significantly induce MKN-45 cells apoptosis and autophagy by increasing the expression of Bax, Caspase-3, Beclin1 and LC3-II proteins and decreasing the expression of Bcl-2 protein at low micromole level. This investigation provided a valuable lead structure for the development of antitumor drugs. [GRAPHICS] .
Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wang, QH; Xin, Y; Pa, B; He, X; Bao, WQ or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles