Computed Properties of C7H5F3O. Palakhachane, S; Ketkaew, Y; Chuaypen, N; Sirirak, J; Boonsombat, J; Ruchirawat, S; Tangkijvanich, P; Suksamrarn, A; Limpachayaporn, P in [Palakhachane, Sarinya; Sirirak, Jitnapa; Limpachayaporn, Panupun] Silpakorn Univ, Fac Sci, Dept Chem, Mueang Nakhon Pathom Dis 73000, Nakhon Pathom, Thailand; [Ketkaew, Yuwaporn; Chuaypen, Natthaya; Tangkijvanich, Pisit] Chulalongkorn Univ, Fac Med, Ctr Excellence Hepatitis & Liver Canc, Dept Biochem, Bangkok 10330, Thailand; [Boonsombat, Jutatip; Ruchirawat, Somsak] Chulabhorn Res Inst, Bangkok 10210, Thailand; [Ruchirawat, Somsak] Chulabhorn Royal Acad, Chulabhorn Grad Inst, Chem Biol Program, Kamphaeng Phet 6 Rd, Bangkok 10210, Thailand; [Suksamrarn, Apichart] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok 10240, Thailand; [Suksamrarn, Apichart] Ramkhamhang Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok 10240, Thailand published Synthesis of sorafenib analogues incorporating a 1,2,3-triazole ring and cytotoxicity towards hepatocellular carcinoma cell lines in 2021, Cited 71. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.
A series of 1,2,3-triazole-containing Sorafenib analogues, in which the aryl urea moiety of Sorafenib (1) was replaced with a 1,2,3-triazole ring linking a substituted phenoxy fragment, were prepared successfully via Huisgen 1,3-dipolar cycloaddition and nucleophilic aromatic substitution. The studies of cytotoxicity towards human hepatocellular carcinoma (HCC) cell lines, HepG2 and Huh7, indicated that p-tert-butylphenoxy analogue 2m showed significant inhibitory activity against Huh7 with IC50 = 5.67 +/- 0.57 mu M. More importantly, 2m showed low cytotoxicity against human embryonal lung fibroblast cell line, MRC-5, with IC50 > 100 mu M, suggesting its highly selective cytotoxic activity (SI > 17.6) towards Huh7 which is much superior to that of Sorafenib (SI = 6.73). The molecular docking studies revealed that the analogue 2m bound B-RAF near the binding position of Sorafenib, while it interacted VEGFR2 efficiently at the same binding position of Sorafenib. However, 2m exhibited moderate inhibitory activity toward B-RAF, implying that its anti-Huh7 effect might not strictly relate to inhibition of B-RAF. Wound healing and BrdU cell proliferation assays confirmed anti-cell migration and anti-cell proliferative activities towards Huh7. With its inhibitory efficiency and high safety profile, 2m has been identified as a promising candidate for the treatment of HCC.
Computed Properties of C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Palakhachane, S; Ketkaew, Y; Chuaypen, N; Sirirak, J; Boonsombat, J; Ruchirawat, S; Tangkijvanich, P; Suksamrarn, A; Limpachayaporn, P or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles