Product Details of 123-11-5. D’Hollander, ACA; Romero, E; Vijayakumar, K; Le Houerou, C; Retailleau, P; Dodd, RH; Iorga, BI; Cariou, K in [D’Hollander, Agathe C. A.; Romero, Eugenie; Vijayakumar, Kamsana; Le Houerou, Camille; Retailleau, Pascal; Dodd, Robert H.; Iorga, Bogdan I.; Cariou, Kevin] Univ Paris Saclay, Inst Chim Subst Nat, LabEx LERMIT, CNRS,UPR 2301, F-91198 Gif Sur Yvette, France; [Cariou, Kevin] PSL Univ, Inst Chem Life & Hlth Sci, Lab Inorgan Chem Biol, CNRS,Chim ParisTech, F-75005 Paris, France published Base-Mediated Generation of Ketenimines from Ynamides: [3+2] Annulation with Azaallyl Anions in 2021.0, Cited 38.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.
Under basic conditions and heat, ynamides can serve as precursors to ketenimines, whose synthetic potential is often hampered by their difficulty of access. Herein, we report that they can undergo a [3+2] cycloaddition with 2-azaallyl anions, obtained from benzylimines under the same reaction conditions. This reaction between two highly reactive intermediates, both generated in situ from bench stable starting materials, gives access to various nitrogen-rich heterocycles. The reaction usually proceeds with excellent diastereoselectivity, in favor of the cis adduct. Deuteration experiments and DFT calculations helped rationalize the regio- and stereoselectivity of the process as well as the formation of side products.
Product Details of 123-11-5. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles