On March 18, 2022, Tran, Duc N.; Zhdanko, Alexander; Barroso, Santiago; Nieste, Patrick; Rahmani, Ramdane; Holan, Jan; Hoefnagels, Roel; Reniers, Peter; Vermoortele, Frederik; Duguid, Stewart; Cazanave, Lionel; Figlus, Marek; Muir, Colin; Elliott, Alain; Zhao, Peichao; Paden, Warren; Diaz, Cristina Hernandez; Bell, Stephen J.; Hashimoto, Akihiro; Phadke, Avinash; Wiles, Jason A.; Vogels, Ilse; Farina, Vittorio published an article.Electric Literature of 79815-20-6 The title of the article was Development of a Commercial Process for Odalasvir. And the article contained the following:
Odalasvir is a selective inhibitor of hepatitis C virus NS5A protein, a key target for combination therapies. This paper described the chem. process development for the synthesis of this API and the improvements that were achieved over the medicinal chem. Optimization of all the reaction conditions and crystallizations resulted in higher throughput and a highly improved process mass intensity (PMI). The process was robust and it was scaled up to ∼100 kg batches without issues. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6
The Article related to odalasvir preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 79815-20-6
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles