The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations was written by Tucker, Thomas J.;Saggar, Sandeep;Sisko, John T.;Tynebor, Robert M.;Williams, Theresa M.;Felock, Peter J.;Flynn, Jessica A.;Lai, Ming-Tain;Liang, Yuexia;McGaughey, Georgia;Liu, Meiquing;Miller, Mike;Moyer, Gregory;Munshi, Vandna;Perlow-Poehnelt, Rebecca;Prasad, Sridhar;Sanchez, Rosa;Torrent, Maricel;Vacca, Joseph P.;Wan, Bang-Lin;Yan, Youwei. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Computed Properties of C9H11NO2S This article mentions the following:
Using a combination of traditional Medicinal Chem./SAR anal., crystallog., and mol. modeling, a series of highly potent NNRTIs that possess broad antiviral activity against a number of key clin. mutations were synthesized. In the experiment, the researchers used many compounds, for example, 5-(Methylsulfonyl)indoline (cas: 387350-92-7Computed Properties of C9H11NO2S).
5-(Methylsulfonyl)indoline (cas: 387350-92-7) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Computed Properties of C9H11NO2S
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles