Category: indole-building-blockIn 2021 ,《Silver-Catalyzed Asymmetric Dearomatization of Electron-Deficient Heteroarenes via Interrupted Barton-Zard Reaction》 appeared in Angewandte Chemie, International Edition. The author of the article were Wan, Qian; Xie, Jia-Hao; Zheng, Chao; Yuan, Yao-Feng; You, Shu-Li. The article conveys some information:
Herein a catalytic asym. dearomatization reaction of electron-deficient heteroarenes with α-substituted isocyanoacetates through an interrupted Barton-Zard reaction was reported. A range of optically active pyrrolo[3,4-b]indole derivatives such as I [R1 = Ac, CO2Me, Ts, etc.; R2 = H, 4-Me, 5-OBn, etc.; R3 = Me, t-Bu, Bn, etc.; R4 = Me, allyl, Ph, etc.] was obtained in good yields (up to 97%) with high stereoselectivities (up to >20:1 dr and 97% ee), using a catalytic system consisting of a cinchona-derived amino-phosphine and silver oxide. This reaction featured wide substrate scope and mild conditions, and provided a new strategy for developing asym. dearomatization reactions. The results came from multiple reactions, including the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Category: indole-building-block)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles