An article Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors WOS:000576785800014 published article about RESPIRATORY SYNDROME CORONAVIRUS; DISCOVERY in [Lee, Jun Young; Shin, Young Sup; Kwon, Sunoh; Jin, Young-hee; Jang, Min Seong; Song, Jong Hwan; Kim, Hyoung Rae; Park, Chul Min] Korea Res Inst Chem Technol, Ctr Convergent Res Emerging Virus Infect CEVI, 141 Gajeong Ro, Daejeon 34114, South Korea; [Lee, Jihye; Kim, Seungtaek] Inst Pasteur Korea, Zoonot Virus Lab, Seongnam Si 13488, Gyeonggi Do, South Korea; [Kwon, Sunoh] Korea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South Korea; [Jin, Young-hee] Korea Inst Oriental Med, KM Applicat Ctr, Daegu 41062, South Korea; [Jang, Min Seong] Korea Inst Toxicol, Dept Nonclin Studies, Daejeon 34114, South Korea in 2020.0, Cited 19.0. Quality Control of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4
New therapies for treating coronaviruses are urgently needed. A series of 4-anilino-6-aminoquinazoline derivatives were synthesized and evaluated to show high anti-MERS-CoV activities. N-4-(3-Chloro-4-fluorophenyl)-N-6-(3-methoxybenzyl)quinazoline-4,6-diamine (1) has been identified in a random screen as a hit compound for inhibiting MERS-CoV infection. Throughout optimization process, compound 20 was found to exhibit high inhibitory effect (IC50 = 0.157 mu M, SI = 25) with no cytotoxicity and moderate in vivo PK properties.
About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Lee, JY; Shin, YS; Lee, J; Kwon, S; Jin, YH; Jang, MS; Kim, S; Song, JH; Kim, HR; Park, CM or concate me.. Quality Control of 3-Hydroxybenzaldehyde
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles