Recently I am researching about ACUTE LIVER-INJURY; OXIDATIVE STRESS; SELECTIVE VISUALIZATION; PHOTODYNAMIC THERAPY; RAT-LIVER; ACID; MITOCHONDRIA; NEUTROPHILS; CANCER; MACROPHAGES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21874059]. HPLC of Formula: C8H8O2. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Long, LL; Han, YY; Liu, WG; Chen, Q; Yin, DD; Li, LL; Yuan, F; Han, ZX; Gong, AH; Wang, K. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone
Hypochlorite (ClO-) and singlet oxygen (O-1(2)) commonly coexist in living systems and exert important interplaying roles in many diseases. To dissect their complex inter-relationship, it is urgently required to construct a fluorescent probe that can discriminate ClO- and O-1(2) in living organisms. Herein, by taking the 3-(aliphaticthio)-propan-1-one group as the unique recognition unit for both ClO- and O-1(2), we proposed the first fluorescent probe, Hy-2, to simultaneously discriminate ClO- and O-1(2) with high sensitivity and selectivity. Probe Hy-2 itself showed fluorescence in blue channel. After treatment with ClO- and O-1(2), respectively, pronounced fluorescence enhancements were observed in the green channel and red channel correspondingly. Moreover, upon development of the probe with aggregation-induced emission (AIE) characteristics, the probe could work well in a solution with high water volume fraction. Probe Hy-2 was also able to accumulate into mitochondria and was utilized as an effective tool to image exogenous and endogenous ClO- and O-1(2) in mitochondria. Significantly, as the first trial, probe Hy-2 was employed to simultaneously monitor the variation of ClO- and O-1(2) level in cecal tissues of rat in the cecal ligation and puncture (CLP)-induced polymicrobial sepsis model. The results demonstrated that the expressed ClO- and O-1(2) levels were tightly correlated with the severity of sepsis, inferring that the overproduction of ClO- and O-1(2) is an important factor in the pathogenesis of sepsis. The probe illustrated herein may provide a guide for further exploring the functions of ClO- and O-1(2) in various diseases.
About 4′-Hydroxyacetophenone, If you have any questions, you can contact Long, LL; Han, YY; Liu, WG; Chen, Q; Yin, DD; Li, LL; Yuan, F; Han, ZX; Gong, AH; Wang, K or concate me.. HPLC of Formula: C8H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles