El-Malah, A; Mahmoud, Z; Salem, HH; Abdou, AM; Soliman, MMH; Hassan, RA in [El-Malah, Afaf; Mahmoud, Zeinab; Hassan, Rasha A.] Cairo Univ, Fac Pharm, Pharmaceut Organ Chem Dept, 33 Kasr El Aini St, Cairo 11562, Egypt; [El-Malah, Afaf] King Abdulaziz Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Jeddah, Saudi Arabia; [Hamed Salem, Heba] King Khalid Univ, Fac Pharm, Abha, Saudi Arabia; [Hamed Salem, Heba] Cairo Univ, Biochem Dept, Fac Pharm, Cairo, Egypt; [Abdou, Amr M.; Soliman, Mona M. H.] Natl Res Ctr, Microbiol & Immunol Dept, Giza, Dokki, Egypt published Design, ecofriendly synthesis, anticancer and antimicrobial screening of innovative Biginelli dihydropyrimidines using beta-aroylpyruvates as synthons in 2021, Cited 50. Computed Properties of C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.
New ecofriendly Biginelli reaction procedures have been adapted to prepare new dihydropyrimidines (DHPMs) using a multicomponent one-pot reaction. All the synthesized compounds were evaluated for their anticancer activity against 59 human cancer cell lines and evaluated for their antimicrobial activities against representatives of both Gram-positive and Gram-negative bacteria. Compound 4 showed marked wide spectrum anticancer activity towards most of the tested cancer cell lines with a percentage of growth inhibition of 29.04-71.68% against leukemia cell line (K-562 and SR), lung cancer cell line (NCI-H522), five colon cancer cell lines (HCT-116, HCT-15, HT29, KM12 and SW-620), CNS cancer cell line (SF-295 and SNB-75), melanoma cell lines (MALME-3M and M14), renal cancer cell line (CAKI-1) and breast cancer cell lines (MCF7 and MDA-MB-468). The highest observed anticancer activity was against leukemia cell lines K-562 and SR with inhibition percentages of 64.97 and 71.68%, respectively. The renal cancer cell line (UO-31) was particularly sensitive towards all the evaluated compounds. Compounds including 2b and 5c exhibited antibacterial activity against S. aureus while 2a and 5b exhibited antifungal activity against C. albicans. The results also showed that compounds 2c and 5e exhibited both antibacterial and antifungal activity against S. aureus and C. albicans respectively.
About 4-Methoxybenzaldehyde, If you have any questions, you can contact El-Malah, A; Mahmoud, Z; Salem, HH; Abdou, AM; Soliman, MMH; Hassan, RA or concate me.. Computed Properties of C8H8O2
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles