The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene( cas:141556-42-5 ) is researched.COA of Formula: C21H24N2.Brown, Alexandra C.; Suess, Daniel L. M. published the article 《Controlling Substrate Binding to Fe4S4 Clusters through Remote Steric Effects》 about this compound( cas:141556-42-5 ) in Inorganic Chemistry. Keywords: tetranuclear imidazolylidene iron sulfide cluster preparation crystal structure; crystal structure tetranuclear imidazolylidene iron sulfide cluster; mol structure tetranuclear imidazolylidene iron sulfide cluster. Let’s learn more about this compound (cas:141556-42-5).
The extraordinary reactivity exhibited by many Fe-S enzymes is due in large part to the influence of the protein scaffold on substrate binding and activation. In principle, the coordination chem. of synthetic Fe-S clusters could similarly be controlled through remote steric effects. Toward this end, the authors report the synthesis of 3:1 site-differentiated [Fe4S4] clusters ligated by N-heterocyclic carbene (NHC) ligands with variable steric profiles: IMes (1,3-dimesitylimidazol-2-ylidene) and IiPrMe (1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene). Treatment of (IMes)3Fe4S4Cl with NaBArF4 in ethereal solvents (Et2O and THF) gives an ether adduct, [(IMes)3Fe4S4(solv)][BArF4]; solvent can be displaced by addition of tBuNC to form the unusual monoisocyanide adduct [(IMes)3Fe4S4(CNtBu)][BArF4]. Carrying out the same reactions with the less sterically encumbered cluster (IiPrMe)3Fe4S4Cl results in more typical reactivity: undesired ligand redistribution to form the homoleptic cluster [(IiPrMe)4Fe4S4][BArF4] and generation of the triisocyanide adduct [(IiPrMe)3Fe4S4(CNtBu)3][BArF4]. The increased steric profile of the IMes ligands disfavors ligand redistribution and defines a binding pocket at the apical Fe, thereby enabling the generation of a coordinatively unsaturated and substitutionally labile Fe site. This method of controlling the coordination chem. at the apical Fe site by modifying the sterics of ligands bound to adjacent Fe sites complements existing strategies for generating site-differentiated Fe-S clusters and provides new opportunities to direct reactivity at cuboidal metalloclusters.
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Reference:
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