Authors Alqahtani, AM; Bayazeed, AA in ELSEVIER published article about DESIGN; ANTIOXIDANT; INHIBITORS; APOPTOSIS in [Alqahtani, Alaa M.] Umm Al Qura Univ, Coll Pharm, Pharmaceut Chem Dept, Mecca 21955, Saudi Arabia; [Bayazeed, Abrar A.] Umm Al Qura Univ, Coll Appl Sci, Chem Dept, Mecca 21955, Saudi Arabia in 2021, Cited 49. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
Ten new pyridine linked various substituted thiazole hybrids through (hydrazonomethyl) phenoxy-acetamide spacer were synthesized. The synthetic strategy was based on the reaction of the precursor 2-(4-((2-carbamothioylhydrazono)methyl)phenoxy)-N-(pyridin-2-yl)acetamide (3) with various alpha-halogenated carbonyl compounds (namely; phenacyl bromides, ethyl bromoacetate, diethyl bromomalonate and 3-chloropentane-2,4-dione). Moreover, the cytotoxicity properties of the synthesized compounds have been studied against liver carcinoma (HepG2), laryngeal carcinoma (Hep-2), prostate cancer (PC3), breast cancer (MCF-7) and normal fibroblast cells (W138). The pyridine-thiazole compounds 7 and 10 revealed promising anticancer activity against MCF-7 and HepG2 cell lines with IC50 values in the range 5.36-8.76 mu M compared to the activity of 5-fluorouracil. Docking study provided valuable insights for binding sites of the synthesized compounds with Rho-associated protein kinase (ROCK-1). (C) 2020 The Authors. Published by Elsevier B.V. on behalf of King Saud University.
Recommanded Product: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Alqahtani, AM; Bayazeed, AA or concate me.
Reference:
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles