An article A readily accessible and modular carbohydrate-derived thioether/selenoether-phosphite ligand library for Pd-catalyzed asymmetric allylic substitutions WOS:000481917100024 published article about OXAZOLINE LIGANDS; CHIRAL LIGANDS; ALKYLATION; ALLYLATION; THIOETHER; ENANTIOSELECTIVITY; ETHERIFICATION; P,N-LIGANDS; VERSATILE; AMINATION in [Margalef, Jessica; Borras, Carlota; Alegre, Sabina; Pamies, Oscar; Dieguez, Montserrat] Univ Rovira & Virgili, Dept Quim Fis & Inorgan, C Marcelli Domingo 1, E-43007 Tarragona, Spain in 2019.0, Cited 91.0. Recommanded Product: Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
A large library of thioether/selenoether-phosphite ligands have been tested in the Pd-catalyzed asymmetric allylic substitution reaction. The presented ligands are derived from cheap and available carbohydrates and they are air-stable solids and easy to handle. Their highly modular nature has made it possible to achieve excellent enantioselectivities in the substitution of a range of hindered and unhindered substrates (ees up to 99% and 91%, respectively). In addition, twelve C-, N- and O-nucleophiles can be efficiently introduced, independently of their nature. Among the whole library, ligands that contain an additional chiral centre in the alkyl backbone chain next to the phosphite group and an enantiopure biaryl phosphite group provided the best enantioselectivities. In general, there is a cooperative effect between these two chiral elements, and therefore, a matched combination between them is necessary to achieve the highest enantioselectivities. However, in the case of cyclic substrates, this cooperative effect is less pronounced and advantageously, both enantiomers of the product can be obtained by setting up the desired configuration of the biaryl phosphite group. Studies of the key Pd-pi-allyl intermediates allowed us to better understand the enantioselectivities obtained experimentally.
Recommanded Product: Benzyl Alcohol. Welcome to talk about 100-51-6, If you have any questions, you can contact Margalef, J; Borras, C; Alegre, S; Pamies, O; Dieguez, M or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles