I found the field of Chemistry; Science & Technology – Other Topics; Materials Science; Physics very interesting. Saw the article Synthesis of Poly(Malic Acid) Derivatives End-Functionalized with Peptides and Preparation of Biocompatible Nanoparticles to Target Hepatoma Cells published in 2021.0. Application In Synthesis of Benzyl Alcohol, Reprint Addresses Cammas-Marion, S (corresponding author), Univ Rennes, Ecole Natl Super Chim Rennes, CNRS, ISCR,UMR 6226,ScanMAT,UMS2001, F-35000 Rennes, France.; Loyer, P; Lepareur, N; Cammas-Marion, S (corresponding author), Univ Rennes, INSERM, INRAE,UMR S 1241, Inst NUMECAN Nutr Metabol & Canc UMR 1341 A 1341, F-35000 Rennes, France.; Lepareur, N (corresponding author), Comprehens Canc Ctr Eugene Marquis, F-35000 Rennes, France.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol
Recently, short synthetic peptides have gained interest as targeting agents in the design of site-specific nanomedicines. In this context, our work aimed at developing new tools for the diagnosis and/or therapy of hepatocellular carcinoma (HCC) by grafting the hepatotropic George Baker (GB) virus A (GBVA10-9) and Plasmodium circumsporozoite protein (CPB)-derived peptides to the biocompatible poly(benzyl malate), PMLABe. We successfully synthesized PMLABe derivatives end-functionalized with peptides GBVA10-9, CPB, and their corresponding scrambled peptides through a thiol/maleimide reaction. The corresponding nanoparticles (NPs), varying by the nature of the peptide (GBVA10-9, CPB, and their scrambled peptides) and the absence or presence of poly(ethylene glycol) were also successfully formulated using nanoprecipitation technique. NPs were further characterized by dynamic light scattering (DLS), electrophoretic light scattering (ELS) and transmission electron microscopy (TEM), highlighting a diameter lower than 150 nm, a negative surface charge, and a more or less spherical shape. Moreover, a fluorescent probe (DiD Oil) has been encapsulated during the nanoprecipitation process. Finally, preliminary in vitro internalisation assays using HepaRG hepatoma cells demonstrated that CPB peptide-functionalized PMLABe NPs were efficiently internalized by endocytosis, and that such nanoobjects may be promising drug delivery systems for the theranostics of HCC.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles