An article Indole alkaloids indigodoles A-C from aerial parts of Strobilanthes cusia in the traditional Chinese medicine Qing Dai have anti-IL-17 properties WOS:000469157200005 published article about NAIL PSORIASIS; NATURALIS OINTMENT; OBSERVER-BLIND; EFFICACY; EXTRACT; SAFETY in [Lee, Chia-Lin] China Med Univ, Dept Cosmeceut, Taichung 40402, Taiwan; [Lee, Chia-Lin; Wu, Yang-Chang] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40447, Taiwan; [Lee, Chia-Lin; Wang, Chien-Ming; Yen, Hung-Rong; Song, Ying-Chyi; Yu, Sheng-Jie] China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan; [Hu, Hao-Chun; Wu, Yang-Chang] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan; [Yen, Hung-Rong] China Med Univ, Grad Inst Chinese Med, Sch Chinese Med, Coll Chinese Med, Taichung 40402, Taiwan; [Yen, Hung-Rong] China Med Univ Hosp, Dept Chinese Med, Taichung 40447, Taiwan; [Yen, Hung-Rong; Song, Ying-Chyi; Yu, Sheng-Jie] China Med Univ Hosp, Dept Med Res, Res Ctr Tradit Chinese Med, Taichung 40447, Taiwan; [Chen, Chao-Jung] China Med Univ, Grad Inst Integrated Med, Taichung 40402, Taiwan; [Chen, Chao-Jung] China Med Univ Hosp, Dept Med Res, Prote Core Lab, Taichung 40447, Taiwan; [Li, Wei-Chu] Sheng Chang Pharmaceut Co, Taoyuan 32050, Taiwan in 2019.0, Cited 19.0. Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4
Qing Dai (Naturalis Indigo) is a traditional Chinese medicine (TCM) used as a topical agent in moderate psoriasis, targeting interleukin-17 (IL-17). In this study, it was prepared from the aerial parts of Strobilanthes cusia. Three undescribed indole alkaloid derivatives, indigodoles A-C, along with seven known compounds were isolated from this preparation of Qing Dai and their structures were elucidated from spectroscopic data, including NMR, MS, UV, IR, optical rotation, and CD. As well, most compounds were tested against IL-17. Indigodole C and tryptanthrin could significantly inhibit IL-17 production of Th17 cells. In addition, indigodole A and indirubin showed notably anti-IL-17 gene expression in dose-dependent effects without cytotoxicities toward Th17 and Jurkat cells, respectively. Overall, our studies indicate that the aforementioned indole alkaloids could contribute to anti-IL 17 properties of Qing Dai.
Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Lee, CL; Wang, CM; Hu, HC; Yen, HR; Song, YC; Yu, SJ; Chen, CJ; Li, WC; Wu, YC or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles